Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TBC1 domain family member 9

Gene

TBC1D9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei562Arginine fingerBy similarity1
Sitei601Glutamine fingerBy similarity1

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 9
Alternative name(s):
TBC1 domain family member 9A
Gene namesi
Name:TBC1D9
Synonyms:KIAA0882, TBC1D9A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109436.7
HGNCiHGNC:21710 TBC1D9
MIMi618035 gene
neXtProtiNX_Q6ZT07

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi23158
OpenTargetsiENSG00000109436
PharmGKBiPA128394607

Polymorphism and mutation databases

BioMutaiTBC1D9
DMDMi148887054

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884991 – 1266TBC1 domain family member 9Add BLAST1266

Proteomic databases

EPDiQ6ZT07
MaxQBiQ6ZT07
PaxDbiQ6ZT07
PeptideAtlasiQ6ZT07
PRIDEiQ6ZT07
ProteomicsDBi68251

PTM databases

iPTMnetiQ6ZT07
PhosphoSitePlusiQ6ZT07

Expressioni

Gene expression databases

BgeeiENSG00000109436 Expressed in 231 organ(s), highest expression level in cerebellum
CleanExiHS_TBC1D9
GenevisibleiQ6ZT07 HS

Organism-specific databases

HPAiHPA000262
HPA006317
HPA006503

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116771, 22 interactors
IntActiQ6ZT07, 7 interactors
STRINGi9606.ENSP00000411197

Structurei

3D structure databases

ProteinModelPortaliQ6ZT07
SMRiQ6ZT07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 213GRAM 1Add BLAST68
Domaini293 – 361GRAM 2Add BLAST69
Domaini515 – 702Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST188
Domaini886 – 921EF-handPROSITE-ProRule annotationAdd BLAST36

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00930000150890
HOGENOMiHOG000276905
HOVERGENiHBG054142
InParanoidiQ6ZT07
KOiK19951
OMAiEWLEHNL
OrthoDBiEOG091G00RI
PhylomeDBiQ6ZT07
TreeFamiTF313145

Family and domain databases

CDDicd13351 PH-GRAM1_TCB1D9_TCB1D9B, 1 hit
cd13354 PH-GRAM2_TCB1D9_TCB1D9B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036014 TCB1D9/TCB1D9B_PH-GRAM1
IPR036017 TCB1D9/TCB1D9B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZT07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWVNPEEVLL ANALWITERA NPYFILQRRK GHAGDGGGGG GLAGLLVGTL
60 70 80 90 100
DVVLDSSARV APYRILYQTP DSLVYWTIAC GGSRKEITEH WEWLEQNLLQ
110 120 130 140 150
TLSIFENEND ITTFVRGKIQ GIIAEYNKIN DVKEDDDTEK FKEAIVKFHR
160 170 180 190 200
LFGMPEEEKL VNYYSCSYWK GKVPRQGWMY LSINHLCFYS FLMGREAKLV
210 220 230 240 250
IRWVDITQLE KNATLLLPDV IKVSTRSSEH FFSVFLNINE TFKLMEQLAN
260 270 280 290 300
IAMRQLLDNE GFEQDRSLPK LKRKSPKKVS ALKRDLDARA KSERYRALFR
310 320 330 340 350
LPKDEKLDGH TDCTLWTPFN KMHILGQMFV STNYICFTSK EENLCSLIIP
360 370 380 390 400
LREVTIVEKA DSSSVLPSPL SISTRNRMTF LFANLKDRDF LVQRISDFLQ
410 420 430 440 450
QTTSKIYSDK EFAGSYNSSD DEVYSRPSSL VSSSPQRSTS SDADGERQFN
460 470 480 490 500
LNGNSVPTAT QTLMTMYRRR SPEEFNPKLA KEFLKEQAWK IHFAEYGQGI
510 520 530 540 550
CMYRTEKTRE LVLKGIPESM RGELWLLLSG AINEKATHPG YYEDLVEKSM
560 570 580 590 600
GKYNLATEEI ERDLHRSLPE HPAFQNEMGI AALRRVLTAY AFRNPNIGYC
610 620 630 640 650
QAMNIVTSVL LLYAKEEEAF WLLVALCERM LPDYYNTRVV GALVDQGVFE
660 670 680 690 700
ELARDYVPQL YDCMQDLGVI STISLSWFLT LFLSVMPFES AVVVVDCFFY
710 720 730 740 750
EGIKVIFQLA LAVLDANVDK LLNCKDDGEA MTVLGRYLDS VTNKDSTLPP
760 770 780 790 800
IPHLHSLLSD DVEPYPEVDI FRLIRTSYEK FGTIRADLIE QMRFKQRLKV
810 820 830 840 850
IQTLEDTTKR NVVRTIVTET SFTIDELEEL YALFKAEHLT SCYWGGSSNA
860 870 880 890 900
LDRHDPSLPY LEQYRIDFEQ FKGMFALLFP WACGTHSDVL ASRLFQLLDE
910 920 930 940 950
NGDSLINFRE FVSGLSAACH GDLTEKLKLL YKMHVLPEPS SDQDEPDSAF
960 970 980 990 1000
EATQYFFEDI TPECTHVVGL DSRSKQGADD GFVTVSLKPD KGKRANSQEN
1010 1020 1030 1040 1050
RNYLRLWTPE NKSKSKNAKD LPKLNQGQFI ELCKTMYNMF SEDPNEQELY
1060 1070 1080 1090 1100
HATAAVTSLL LEIGEVGKLF VAQPAKEGGS GGSGPSCHQG IPGVLFPKKG
1110 1120 1130 1140 1150
PGQPYVVESV EPLPASLAPD SEEHSLGGQM EDIKLEDSSP RDNGACSSML
1160 1170 1180 1190 1200
ISDDDTKDDS SMSSYSVLSA GSHEEDKLHC EDIGEDTVLV RSGQGTAALP
1210 1220 1230 1240 1250
RSTSLDRDWA ITFEQFLASL LTEPALVKYF DKPVCMMARI TSAKNIRMMG
1260
KPLTSASDYE ISAMSG
Length:1,266
Mass (Da):143,229
Last modified:May 29, 2007 - v2
Checksum:i4A300EE192685088
GO

Sequence cautioni

The sequence BAA74905 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86789 differs from that shown. Aberrant splicing.Curated
The sequence BAC86789 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1204S → G in BAC86789 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0525397E → K. Corresponds to variant dbSNP:rs13108827Ensembl.1
Natural variantiVAR_052540779E → K. Corresponds to variant dbSNP:rs13118702Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449892 mRNA Translation: BAH16635.1
AB020689 mRNA Translation: BAA74905.2 Different initiation.
CH471056 Genomic DNA Translation: EAX05092.1
CH471056 Genomic DNA Translation: EAX05094.1
BC146758 mRNA Translation: AAI46759.1
AK127020 mRNA Translation: BAC86789.1 Sequence problems.
CCDSiCCDS47136.1
RefSeqiNP_055945.2, NM_015130.2
UniGeneiHs.480819
Hs.595450

Genome annotation databases

EnsembliENST00000442267; ENSP00000411197; ENSG00000109436
GeneIDi23158
KEGGihsa:23158
UCSCiuc010ioj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449892 mRNA Translation: BAH16635.1
AB020689 mRNA Translation: BAA74905.2 Different initiation.
CH471056 Genomic DNA Translation: EAX05092.1
CH471056 Genomic DNA Translation: EAX05094.1
BC146758 mRNA Translation: AAI46759.1
AK127020 mRNA Translation: BAC86789.1 Sequence problems.
CCDSiCCDS47136.1
RefSeqiNP_055945.2, NM_015130.2
UniGeneiHs.480819
Hs.595450

3D structure databases

ProteinModelPortaliQ6ZT07
SMRiQ6ZT07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116771, 22 interactors
IntActiQ6ZT07, 7 interactors
STRINGi9606.ENSP00000411197

PTM databases

iPTMnetiQ6ZT07
PhosphoSitePlusiQ6ZT07

Polymorphism and mutation databases

BioMutaiTBC1D9
DMDMi148887054

Proteomic databases

EPDiQ6ZT07
MaxQBiQ6ZT07
PaxDbiQ6ZT07
PeptideAtlasiQ6ZT07
PRIDEiQ6ZT07
ProteomicsDBi68251

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442267; ENSP00000411197; ENSG00000109436
GeneIDi23158
KEGGihsa:23158
UCSCiuc010ioj.4 human

Organism-specific databases

CTDi23158
DisGeNETi23158
EuPathDBiHostDB:ENSG00000109436.7
GeneCardsiTBC1D9
HGNCiHGNC:21710 TBC1D9
HPAiHPA000262
HPA006317
HPA006503
MIMi618035 gene
neXtProtiNX_Q6ZT07
OpenTargetsiENSG00000109436
PharmGKBiPA128394607
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00930000150890
HOGENOMiHOG000276905
HOVERGENiHBG054142
InParanoidiQ6ZT07
KOiK19951
OMAiEWLEHNL
OrthoDBiEOG091G00RI
PhylomeDBiQ6ZT07
TreeFamiTF313145

Miscellaneous databases

ChiTaRSiTBC1D9 human
GeneWikiiTBC1D9
GenomeRNAii23158
PROiPR:Q6ZT07
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109436 Expressed in 231 organ(s), highest expression level in cerebellum
CleanExiHS_TBC1D9
GenevisibleiQ6ZT07 HS

Family and domain databases

CDDicd13351 PH-GRAM1_TCB1D9_TCB1D9B, 1 hit
cd13354 PH-GRAM2_TCB1D9_TCB1D9B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036014 TCB1D9/TCB1D9B_PH-GRAM1
IPR036017 TCB1D9/TCB1D9B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBCD9_HUMAN
AccessioniPrimary (citable) accession number: Q6ZT07
Secondary accession number(s): A6H8U8, D3DNZ1, O94958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again