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Entry version 155 (02 Jun 2021)
Sequence version 2 (10 Jan 2006)
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Protein

Teashirt homolog 1

Gene

TSHZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).

Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri246 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri307 – 331C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri416 – 440C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi885 – 955Homeobox; atypicalAdd BLAST71
Zinc fingeri970 – 992C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1037 – 1060C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZSZ6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teashirt homolog 1
Alternative name(s):
Antigen NY-CO-33
Serologically defined colon cancer antigen 33
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSHZ1
Synonyms:SDCCAG33, TSH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10669, TSHZ1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614427, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZSZ6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000179981.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aural atresia, congenital (CAA)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare anomaly of the ear that involves some degree of failure of the development of the external auditory canal. The malformation can also involve the tympanic membrane, ossicles and middle ear space. The inner ear development is most often normal. Different CAA forms are known. CAA type I is characterized by bony or fibrous atresia of the lateral part of the external auditory canal and an almost normal medial part and middle ear. CAA type II is the most frequent type and is characterized by partial or total aplasia of the external auditory canal. CAA type IIA involves an external auditory canal with either complete bony atresia of the medial part or partial aplasia that ends blindly in a fistula leading to a rudimentary tympanic membrane. CAA type IIB is characterized by bony stenosis of the total length of the external auditory canal. CAA type III involves bony atresia of the external auditory canal and a very small or absent middle-ear cavity.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
10194

MalaCards human disease database

More...
MalaCardsi
TSHZ1
MIMi607842, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000179981

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
141074, External auditory canal aplasia/hypoplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35599

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZSZ6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSHZ1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85683261

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470621 – 1077Teashirt homolog 1Add BLAST1077

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei765PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZSZ6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZSZ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZSZ6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZSZ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZSZ6

PeptideAtlas

More...
PeptideAtlasi
Q6ZSZ6

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZSZ6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68249 [Q6ZSZ6-1]
68250 [Q6ZSZ6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZSZ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZSZ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179981, Expressed in cerebellar vermis and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZSZ6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZSZ6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000179981, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115489, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZSZ6, 1 interactor

Molecular INTeraction database

More...
MINTi
Q6ZSZ6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323584

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZSZ6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZSZ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 109DisorderedSequence analysisAdd BLAST109
Regioni139 – 195DisorderedSequence analysisAdd BLAST57
Regioni269 – 298DisorderedSequence analysisAdd BLAST30
Regioni467 – 549DisorderedSequence analysisAdd BLAST83
Regioni647 – 720DisorderedSequence analysisAdd BLAST74
Regioni848 – 873DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 39Acidic residuesSequence analysisAdd BLAST15
Compositional biasi53 – 88Polar residuesSequence analysisAdd BLAST36
Compositional biasi139 – 156Polar residuesSequence analysisAdd BLAST18
Compositional biasi166 – 195Polar residuesSequence analysisAdd BLAST30
Compositional biasi469 – 493Polar residuesSequence analysisAdd BLAST25
Compositional biasi494 – 549Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi647 – 664Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi675 – 710Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi848 – 866Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri246 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri307 – 331C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri416 – 440C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri970 – 992C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1037 – 1060C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RJS7, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010469_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZSZ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
ASSHHNG

Database of Orthologous Groups

More...
OrthoDBi
106971at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZSZ6

TreeFam database of animal gene trees

More...
TreeFami
TF328447

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001356, Homeobox_dom
IPR027008, Teashirt_fam
IPR026808, Tshz1
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR12487, PTHR12487, 1 hit
PTHR12487:SF6, PTHR12487:SF6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZSZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRRKQQAPR RSAAYVPEEE LKAAEIDEEH VEDDGLSLDI QESEYMCNEE
60 70 80 90 100
TEIKEAQSYQ NSPVSSATNQ DAGYGSPFSE SSDQLAHFKG SSSREEKEDP
110 120 130 140 150
QCPDSVSYPQ DSLAQIKAVY ANLFSESCWS SLALDLKKSG STTSTNDASQ
160 170 180 190 200
KESSAPTPTP PTCPVSTTGP TTSTPSTSCS SSTSHSSTTS TSSSSGYDWH
210 220 230 240 250
QAALAKTLQQ TSSYGLLPEP SLFSTVQLYR QNNKLYGSVF TGASKFRCKD
260 270 280 290 300
CSAAYDTLVE LTVHMNETGH YRDDNRDKDS EKTKRWSKPR KRSLMEMEGK
310 320 330 340 350
EDAQKVLKCM YCGHSFESLQ DLSVHMIKTK HYQKVPLKEP VPAITKLVPS
360 370 380 390 400
TKKRALQDLA PPCSPEPAGM AAEVALSESA KDQKAANPYV TPNNRYGYQN
410 420 430 440 450
GASYTWQFEA RKAQILKCME CGSSHDTLQQ LTAHMMVTGH FLKVTTSASK
460 470 480 490 500
KGKQLVLDPV VEEKIQSIPL PPTTHTRLPA SSIKKQPDSP AGSTTSEEKK
510 520 530 540 550
EPEKEKPPVA GDAEKIKEES EDSLEKFEPS TLYPYLREED LDDSPKGGLD
560 570 580 590 600
ILKSLENTVS TAISKAQNGA PSWGGYPSIH AAYQLPGTVK PLPAAVQSVQ
610 620 630 640 650
VQPSYAGGVK SLSSAEHNAL LHSPGSLTPP PHKSNVSAME ELVEKVTGKV
660 670 680 690 700
NIKKEERPPE KEKSSLAKAA SPIAKENKDF PKTEEVSGKP QKKGPEAETG
710 720 730 740 750
KAKKEGPLDV HTPNGTEPLK AKVTNGCNNL GIIMDHSPEP SFINPLSALQ
760 770 780 790 800
SIMNTHLGKV SKPVSPSLDP LAMLYKISNS MLDKPVYPAT PVKQADAIDR
810 820 830 840 850
YYYENSDQPI DLTKSKNKPL VSSVADSVAS PLRESALMDI SDMVKNLTGR
860 870 880 890 900
LTPKSSTPST VSEKSDADGS SFEEALDELS PVHKRKGRQS NWNPQHLLIL
910 920 930 940 950
QAQFASSLRE TTEGKYIMSD LGPQERVHIS KFTGLSMTTI SHWLANVKYQ
960 970 980 990 1000
LRRTGGTKFL KNLDTGHPVF FCNDCASQFR TASTYISHLE THLGFSLKDL
1010 1020 1030 1040 1050
SKLPLNQIQE QQNVSKVLTN KTLGPLGATE EDLGSTFQCK LCNRTFASKH
1060 1070
AVKLHLSKTH GKSPEDHLIY VTELEKQ
Length:1,077
Mass (Da):117,916
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15D44BA498DCEA37
GO
Isoform 2 (identifier: Q6ZSZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Show »
Length:1,032
Mass (Da):112,705
Checksum:i12194FC86313C970
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN23H0YN23_HUMAN
Teashirt homolog 1
TSHZ1
276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKA1H0YKA1_HUMAN
Teashirt homolog 1
TSHZ1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC18047 differs from that shown. Reason: Frameshift.Curated
The sequence BAE06124 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti513A → T in BAD97265 (Ref. 5) Curated1
Sequence conflicti700 – 701GK → WE in AAC18047 (PubMed:9610721).Curated2
Sequence conflicti736H → R in BAC86800 (PubMed:14702039).Curated1
Sequence conflicti886K → E in BAC86800 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061926666L → P. Corresponds to variant dbSNP:rs55679337Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0408771 – 45Missing in isoform 2. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK127042 mRNA Translation: BAC86800.1
AB210042 mRNA Translation: BAE06124.1 Different initiation.
AC025105 Genomic DNA No translation available.
AF039698 mRNA Translation: AAC18047.1 Frameshift.
AK223545 mRNA Translation: BAD97265.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12009.1 [Q6ZSZ6-2]
CCDS77199.1 [Q6ZSZ6-1]

NCBI Reference Sequences

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RefSeqi
NP_001295139.1, NM_001308210.1 [Q6ZSZ6-1]
NP_005777.3, NM_005786.5 [Q6ZSZ6-2]
XP_005266698.1, XM_005266641.3 [Q6ZSZ6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000322038; ENSP00000323584; ENSG00000179981 [Q6ZSZ6-2]
ENST00000580243; ENSP00000464391; ENSG00000179981 [Q6ZSZ6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10194

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10194

UCSC genome browser

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UCSCi
uc002lly.4, human [Q6ZSZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127042 mRNA Translation: BAC86800.1
AB210042 mRNA Translation: BAE06124.1 Different initiation.
AC025105 Genomic DNA No translation available.
AF039698 mRNA Translation: AAC18047.1 Frameshift.
AK223545 mRNA Translation: BAD97265.1
CCDSiCCDS12009.1 [Q6ZSZ6-2]
CCDS77199.1 [Q6ZSZ6-1]
RefSeqiNP_001295139.1, NM_001308210.1 [Q6ZSZ6-1]
NP_005777.3, NM_005786.5 [Q6ZSZ6-2]
XP_005266698.1, XM_005266641.3 [Q6ZSZ6-2]

3D structure databases

SMRiQ6ZSZ6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115489, 5 interactors
IntActiQ6ZSZ6, 1 interactor
MINTiQ6ZSZ6
STRINGi9606.ENSP00000323584

PTM databases

iPTMnetiQ6ZSZ6
PhosphoSitePlusiQ6ZSZ6

Genetic variation databases

BioMutaiTSHZ1
DMDMi85683261

Proteomic databases

EPDiQ6ZSZ6
jPOSTiQ6ZSZ6
MassIVEiQ6ZSZ6
MaxQBiQ6ZSZ6
PaxDbiQ6ZSZ6
PeptideAtlasiQ6ZSZ6
PRIDEiQ6ZSZ6
ProteomicsDBi68249 [Q6ZSZ6-1]
68250 [Q6ZSZ6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1827, 186 antibodies

The DNASU plasmid repository

More...
DNASUi
10194

Genome annotation databases

EnsembliENST00000322038; ENSP00000323584; ENSG00000179981 [Q6ZSZ6-2]
ENST00000580243; ENSP00000464391; ENSG00000179981 [Q6ZSZ6-1]
GeneIDi10194
KEGGihsa:10194
UCSCiuc002lly.4, human [Q6ZSZ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10194
DisGeNETi10194

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSHZ1
HGNCiHGNC:10669, TSHZ1
HPAiENSG00000179981, Low tissue specificity
MalaCardsiTSHZ1
MIMi607842, phenotype
614427, gene
neXtProtiNX_Q6ZSZ6
OpenTargetsiENSG00000179981
Orphaneti141074, External auditory canal aplasia/hypoplasia
PharmGKBiPA35599
VEuPathDBiHostDB:ENSG00000179981.9

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RJS7, Eukaryota
GeneTreeiENSGT00950000183051
HOGENOMiCLU_010469_0_0_1
InParanoidiQ6ZSZ6
OMAiASSHHNG
OrthoDBi106971at2759
PhylomeDBiQ6ZSZ6
TreeFamiTF328447

Enzyme and pathway databases

PathwayCommonsiQ6ZSZ6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10194, 6 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSHZ1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10194
PharosiQ6ZSZ6, Tbio

Protein Ontology

More...
PROi
PR:Q6ZSZ6
RNActiQ6ZSZ6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179981, Expressed in cerebellar vermis and 220 other tissues
ExpressionAtlasiQ6ZSZ6, baseline and differential
GenevisibleiQ6ZSZ6, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356, Homeobox_dom
IPR027008, Teashirt_fam
IPR026808, Tshz1
IPR013087, Znf_C2H2_type
PANTHERiPTHR12487, PTHR12487, 1 hit
PTHR12487:SF6, PTHR12487:SF6, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00355, ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSH1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZSZ6
Secondary accession number(s): O60534, Q4LE29, Q53EU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: June 2, 2021
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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