UniProtKB - Q6ZSZ5 (ARHGI_HUMAN)
Protein
Rho guanine nucleotide exchange factor 18
Gene
ARHGEF18
Organism
Homo sapiens (Human)
Status
Functioni
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).5 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 310 – 334 | C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: MGI
- metal ion binding Source: UniProtKB-KW
- Rho guanyl-nucleotide exchange factor activity Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: MGI
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of stress fiber assembly Source: ARUK-UCL
- positive regulation of apoptotic process Source: Reactome
- protein localization to cell-cell junction Source: ARUK-UCL
- regulation of cell shape Source: MGI
- regulation of Rho protein signal transduction Source: GO_Central
- regulation of small GTPase mediated signal transduction Source: Reactome
- small GTPase mediated signal transduction Source: MGI
- transforming growth factor beta receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6ZSZ5 |
Reactomei | R-HSA-193648, NRAGE signals death through JNK R-HSA-194840, Rho GTPase cycle R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-416482, G alpha (12/13) signalling events |
SIGNORi | Q6ZSZ5 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho guanine nucleotide exchange factor 18Alternative name(s): 114 kDa Rho-specific guanine nucleotide exchange factor Short name: p114-Rho-GEF Short name: p114RhoGEF Septin-associated RhoGEF Short name: SA-RhoGEF |
Gene namesi | Name:ARHGEF18 Synonyms:KIAA0521 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17090, ARHGEF18 |
MIMi | 616432, gene |
neXtProti | NX_Q6ZSZ5 |
VEuPathDBi | HostDB:ENSG00000104880.17 HostDB:ENSG00000263264.1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
- Apical cell membrane 1 Publication
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: In unactivated eosinophils, distributed around the cell periphery in the perimembranous region (PubMed:29601110). In activated eosinophils, relocates to the tip of the nucleopod, a membrane structure formed during activation when the nucleus moves to one end of the cell, and is also concentrated in membrane protrusions at the opposite end of the cell (PubMed:29601110). Localizes to the apical cell membrane in epithelial cells (PubMed:22006950).2 Publications
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: HPA
Other locations
- apical part of cell Source: MGI
- cell junction Source: Reactome
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Involvement in diseasei
Retinitis pigmentosa 78 (RP78)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP78 inheritance is autosomal recessive.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078919 | 458 | T → A in RP78; decreased function in positive regulation of Rho protein signal transduction; loss of function in regulation of actomyosin structure organization. 1 PublicationCorresponds to variant dbSNP:rs987233144Ensembl. | 1 | |
Natural variantiVAR_078920 | 854 – 1361 | Missing in RP78. 1 PublicationAdd BLAST | 508 | |
Natural variantiVAR_078921 | 1066 – 1361 | Missing in RP78. 1 PublicationAdd BLAST | 296 | |
Natural variantiVAR_078922 | 1101 – 1108 | Missing in RP78; no effect on function in positive regulation of Rho protein signal transduction; decreased function in regulation of actomyosin structure organization. 1 Publication | 8 |
Keywords - Diseasei
Disease variant, Retinitis pigmentosaOrganism-specific databases
DisGeNETi | 23370 |
MalaCardsi | ARHGEF18 |
MIMi | 617433, phenotype |
OpenTargetsi | ENSG00000104880 |
Orphaneti | 791, Retinitis pigmentosa |
PharmGKBi | PA128394630 |
Miscellaneous databases
Pharosi | Q6ZSZ5, Tbio |
Genetic variation databases
BioMutai | - ARHGEF18 |
DMDMi | 296439444 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341415 | 1 – 1361 | Rho guanine nucleotide exchange factor 18Add BLAST | 1361 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 912 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 921 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1289 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1291 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6ZSZ5 |
jPOSTi | Q6ZSZ5 |
MassIVEi | Q6ZSZ5 |
PaxDbi | Q6ZSZ5 |
PeptideAtlasi | Q6ZSZ5 |
PRIDEi | Q6ZSZ5 |
ProteomicsDBi | 46652 68246 [Q6ZSZ5-1] 68247 [Q6ZSZ5-2] |
PTM databases
iPTMneti | Q6ZSZ5 |
PhosphoSitePlusi | Q6ZSZ5 |
Expressioni
Tissue specificityi
Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils (PubMed:29601110). Isoform 2: Expressed in eosinophils (PubMed:29601110). Isoform 3: Expressed in eosinophils (PubMed:29601110). Isoform 4: Not detected in eosinophils (PubMed:29601110).4 Publications
Gene expression databases
Bgeei | ENSG00000263264, Expressed in blood and 91 other tissues |
ExpressionAtlasi | Q6ZSZ5, baseline and differential |
Genevisiblei | Q6ZSZ5, HS |
Organism-specific databases
HPAi | ENSG00000104880, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: MGI
- Rho guanyl-nucleotide exchange factor activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 116950, 11 interactors |
CORUMi | Q6ZSZ5 |
IntActi | Q6ZSZ5, 6 interactors |
STRINGi | 9606.ENSP00000352995 |
Miscellaneous databases
RNActi | Q6ZSZ5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 447 – 644 | DHPROSITE-ProRule annotationAdd BLAST | 198 | |
Domaini | 684 – 786 | PHPROSITE-ProRule annotationAdd BLAST | 103 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1038 – 1148 | Sequence analysisAdd BLAST | 111 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1042 – 1142 | Arg-richPROSITE-ProRule annotationAdd BLAST | 101 | |
Compositional biasi | 1292 – 1346 | Pro-richPROSITE-ProRule annotationAdd BLAST | 55 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 310 – 334 | C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502SGX7, Eukaryota KOG3520, Eukaryota |
GeneTreei | ENSGT00940000157375 |
HOGENOMi | CLU_002466_0_0_1 |
InParanoidi | Q6ZSZ5 |
OrthoDBi | 69816at2759 |
PhylomeDBi | Q6ZSZ5 |
TreeFami | TF325887 |
Family and domain databases
CDDi | cd15794, PH_ARHGEF18, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR037744, ARHGEF18_PH IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF17838, PH_16, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZSZ5-4) [UniParc]FASTAAdd to basket
Also known as: LOCGEF-X31 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDDQEDDFP RRLSESMEDL SLDLGALQGS EYLQDLGLGA PSHSQPGETP
60 70 80 90 100
DSRPTGEEPG RDSLFSSLAG SQDLSRRRSW ERSRSCSESW RRLSLDASAV
110 120 130 140 150
DEEPCLPRTL ASLALNLPGG GLKTWTQGCL SGGGTPAESP GKECDSPKKR
160 170 180 190 200
GRSRSVPVSF YEIRSPEISP GLEVPTPPVQ GLEPPVLECM EKDHVEPDHV
210 220 230 240 250
LIVQQVLQEL RQYHGARQRA CMSASPGGAH SNLTWFEFLS ESEDGAGKNE
260 270 280 290 300
KSDKSTSVKR RLSCLRSRVT RQKEKGKSPA HLKDKGQDAR ERRECVNGHQ
310 320 330 340 350
LLQGTFSGPS SCPLCGKPFL SSASLKEHPR GTLLSDGSPA LSRNVGMTVS
360 370 380 390 400
QKGGPQPTPS PAGPGTQLGP ITGEMDEADS AFLKFKQTAD DSLSLTSPNT
410 420 430 440 450
ESIFVEDPYT ASLRSEIESD GHEFEAESWS LAVDAAYAKK QKREVVKRQD
460 470 480 490 500
VLYELMQTEV HHVRTLKIML KVYSRALQEE LQFSSKAIGR LFPCADDLLE
510 520 530 540 550
THSHFLARLK ERRQESLEEG SDRNYVIQKI GDLLVQQFSG ENGERMKEKY
560 570 580 590 600
GVFCSGHNEA VSHYKLLLQQ NKKFQNLIKK IGNFSIVRRL GVQECILLVT
610 620 630 640 650
QRITKYPVLV ERIIQNTEAG TEDYEDLTQA LNLIKDIISQ VDAKVSECEK
660 670 680 690 700
GQRLREIAGK MDLKSSSKLK NGLTFRKEDM LQRQLHLEGM LCWKTTSGRL
710 720 730 740 750
KDILAILLTD VLLLLQEKDQ KYVFASVDSK PPVISLQKLI VREVANEEKA
760 770 780 790 800
MFLISASLQG PEMYEIYTSS KEDRNAWMAH IQRAVESCPD EEEGPFSLPE
810 820 830 840 850
EERKVVEARA TRLRDFQERL SMKDQLIAQS LLEKQQIYLE MAEMGGLEDL
860 870 880 890 900
PQPRGLFRGG DPSETLQGEL ILKSAMSEIE GIQSLICRQL GSANGQAEDG
910 920 930 940 950
GSSTGPPRRA ETFAGYDCTN SPTKNGSFKK KVSSTDPRPR DWRGPPNSPD
960 970 980 990 1000
LKLSDSDIPG SSEESPQVVE APGTESDPRL PTVLESELVQ RIQTLSQLLL
1010 1020 1030 1040 1050
NLQAVIAHQD SYVETQRAAI QEREKQFRLQ STRGNLLLEQ ERQRNFEKQR
1060 1070 1080 1090 1100
EERAALEKLQ SQLRHEQQRW ERERQWQHQE LERAGARLQE REGEARQLRE
1110 1120 1130 1140 1150
RLEQERAELE RQRQAYQHDL ERLREAQRAV ERERERLELL RRLKKQNTAP
1160 1170 1180 1190 1200
GALPPDTLAE AQPPSHPPSF NGEGLEGPRV SMLPSGVGPE YAERPEVARR
1210 1220 1230 1240 1250
DSAPTENRLA KSDVPIQLLS ATNQFQRQAA VQQQIPTKLA ASTKGGKDKG
1260 1270 1280 1290 1300
GKSRGSQRWE SSASFDLKQQ LLLNKLMGKD ESTSRNRRSL SPILPGRHSP
1310 1320 1330 1340 1350
APPPDPGFPA PSPPPADSPS EGFSLKAGGT ALLPGPPAPS PLPATPLSAK
1360
EDASKEDVIF F
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZG4 | A0A087WZG4_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF18 | 1,173 | Annotation score: | ||
M0QZS0 | M0QZS0_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF18 | 812 | Annotation score: | ||
A0A3B3IPE9 | A0A3B3IPE9_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF18 | 1,119 | Annotation score: | ||
M0R125 | M0R125_HUMAN | Rho guanine nucleotide exchange fac... | ARHGEF18 | 86 | Annotation score: |
Sequence cautioni
The sequence BAA25447 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 371 | I → V in BAC86801 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1295 | P → S in BAC86801 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078919 | 458 | T → A in RP78; decreased function in positive regulation of Rho protein signal transduction; loss of function in regulation of actomyosin structure organization. 1 PublicationCorresponds to variant dbSNP:rs987233144Ensembl. | 1 | |
Natural variantiVAR_078920 | 854 – 1361 | Missing in RP78. 1 PublicationAdd BLAST | 508 | |
Natural variantiVAR_044066 | 889 | Q → R2 PublicationsCorresponds to variant dbSNP:rs2287918Ensembl. | 1 | |
Natural variantiVAR_044067 | 940 | R → Q. Corresponds to variant dbSNP:rs2287920Ensembl. | 1 | |
Natural variantiVAR_078921 | 1066 – 1361 | Missing in RP78. 1 PublicationAdd BLAST | 296 | |
Natural variantiVAR_078922 | 1101 – 1108 | Missing in RP78; no effect on function in positive regulation of Rho protein signal transduction; decreased function in regulation of actomyosin structure organization. 1 Publication | 8 | |
Natural variantiVAR_063099 | 1207 | N → S2 PublicationsCorresponds to variant dbSNP:rs9329368Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059874 | 1 – 346 | Missing in isoform 4. 1 PublicationAdd BLAST | 346 | |
Alternative sequenceiVSP_059875 | 1 – 322 | MGDDQ…PFLSS → MVTVGTNILPSRPAASANTA REDAALFSRRIPPRHKNGAA QPGAAPGPGAPGANMGNAHS KSGDRHSALPGRPELSFYGS FPRKWSENVFLDNELLTSKI LSMLRPQSERGFRAGDLRYP THFLSTNSVLASVT in isoform 5. CuratedAdd BLAST | 322 | |
Alternative sequenceiVSP_059876 | 1 – 16 | Missing in isoform 3. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_059877 | 1 – 5 | MGDDQ → MTTVA in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011093 mRNA Translation: BAA25447.1 Different initiation. AK127045 mRNA Translation: BAC86801.1 AC008878 Genomic DNA No translation available. AC119396 Genomic DNA No translation available. AC126754 Genomic DNA No translation available. BC077721 mRNA Translation: AAH77721.1 Sequence problems. |
CCDSi | CCDS12177.1 [Q6ZSZ5-2] |
RefSeqi | NP_001124427.1, NM_001130955.1 NP_056133.2, NM_015318.3 [Q6ZSZ5-2] XP_006722768.1, XM_006722705.3 XP_006722769.1, XM_006722706.3 [Q6ZSZ5-4] XP_006722771.1, XM_006722708.2 XP_011526140.1, XM_011527838.2 [Q6ZSZ5-5] XP_011526141.1, XM_011527839.2 [Q6ZSZ5-6] XP_011526142.1, XM_011527840.1 [Q6ZSZ5-2] |
Genome annotation databases
Ensembli | ENST00000319670; ENSP00000319200; ENSG00000104880 [Q6ZSZ5-2] |
GeneIDi | 23370 |
KEGGi | hsa:23370 |
UCSCi | uc002mgh.4, human [Q6ZSZ5-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011093 mRNA Translation: BAA25447.1 Different initiation. AK127045 mRNA Translation: BAC86801.1 AC008878 Genomic DNA No translation available. AC119396 Genomic DNA No translation available. AC126754 Genomic DNA No translation available. BC077721 mRNA Translation: AAH77721.1 Sequence problems. |
CCDSi | CCDS12177.1 [Q6ZSZ5-2] |
RefSeqi | NP_001124427.1, NM_001130955.1 NP_056133.2, NM_015318.3 [Q6ZSZ5-2] XP_006722768.1, XM_006722705.3 XP_006722769.1, XM_006722706.3 [Q6ZSZ5-4] XP_006722771.1, XM_006722708.2 XP_011526140.1, XM_011527838.2 [Q6ZSZ5-5] XP_011526141.1, XM_011527839.2 [Q6ZSZ5-6] XP_011526142.1, XM_011527840.1 [Q6ZSZ5-2] |
3D structure databases
SMRi | Q6ZSZ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116950, 11 interactors |
CORUMi | Q6ZSZ5 |
IntActi | Q6ZSZ5, 6 interactors |
STRINGi | 9606.ENSP00000352995 |
PTM databases
iPTMneti | Q6ZSZ5 |
PhosphoSitePlusi | Q6ZSZ5 |
Genetic variation databases
BioMutai | - ARHGEF18 |
DMDMi | 296439444 |
Proteomic databases
EPDi | Q6ZSZ5 |
jPOSTi | Q6ZSZ5 |
MassIVEi | Q6ZSZ5 |
PaxDbi | Q6ZSZ5 |
PeptideAtlasi | Q6ZSZ5 |
PRIDEi | Q6ZSZ5 |
ProteomicsDBi | 46652 68246 [Q6ZSZ5-1] 68247 [Q6ZSZ5-2] |
Protocols and materials databases
Antibodypediai | 24427, 265 antibodies |
Genome annotation databases
Ensembli | ENST00000319670; ENSP00000319200; ENSG00000104880 [Q6ZSZ5-2] |
GeneIDi | 23370 |
KEGGi | hsa:23370 |
UCSCi | uc002mgh.4, human [Q6ZSZ5-4] |
Organism-specific databases
CTDi | 23370 |
DisGeNETi | 23370 |
GeneCardsi | ARHGEF18 |
HGNCi | HGNC:17090, ARHGEF18 |
HPAi | ENSG00000104880, Low tissue specificity |
MalaCardsi | ARHGEF18 |
MIMi | 616432, gene 617433, phenotype |
neXtProti | NX_Q6ZSZ5 |
OpenTargetsi | ENSG00000104880 |
Orphaneti | 791, Retinitis pigmentosa |
PharmGKBi | PA128394630 |
VEuPathDBi | HostDB:ENSG00000104880.17 HostDB:ENSG00000263264.1 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SGX7, Eukaryota KOG3520, Eukaryota |
GeneTreei | ENSGT00940000157375 |
HOGENOMi | CLU_002466_0_0_1 |
InParanoidi | Q6ZSZ5 |
OrthoDBi | 69816at2759 |
PhylomeDBi | Q6ZSZ5 |
TreeFami | TF325887 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZSZ5 |
Reactomei | R-HSA-193648, NRAGE signals death through JNK R-HSA-194840, Rho GTPase cycle R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-416482, G alpha (12/13) signalling events |
SIGNORi | Q6ZSZ5 |
Miscellaneous databases
BioGRID-ORCSi | 23370, 6 hits in 872 CRISPR screens |
ChiTaRSi | ARHGEF18, human |
GenomeRNAii | 23370 |
Pharosi | Q6ZSZ5, Tbio |
PROi | PR:Q6ZSZ5 |
RNActi | Q6ZSZ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000263264, Expressed in blood and 91 other tissues |
ExpressionAtlasi | Q6ZSZ5, baseline and differential |
Genevisiblei | Q6ZSZ5, HS |
Family and domain databases
CDDi | cd15794, PH_ARHGEF18, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR037744, ARHGEF18_PH IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF17838, PH_16, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARHGI_HUMAN | |
Accessioni | Q6ZSZ5Primary (citable) accession number: Q6ZSZ5 Secondary accession number(s): A8MV62 Q6DD92 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | October 10, 2018 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot