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UniProtKB - Q6ZSZ5 (ARHGI_HUMAN)

Entry version 153 (10 Feb 2021)
Sequence version 4 (10 Oct 2018)
Previous versions | rss
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Protein

Rho guanine nucleotide exchange factor 18

Gene

ARHGEF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri310 – 334C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZSZ5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193648, NRAGE signals death through JNK
R-HSA-194840, Rho GTPase cycle
R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-416482, G alpha (12/13) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6ZSZ5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 18
Alternative name(s):
114 kDa Rho-specific guanine nucleotide exchange factor
Short name:
p114-Rho-GEF
Short name:
p114RhoGEF
Septin-associated RhoGEF
Short name:
SA-RhoGEF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF18
Synonyms:KIAA0521
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17090, ARHGEF18

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616432, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZSZ5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000104880.17
HostDB:ENSG00000263264.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinitis pigmentosa 78 (RP78)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP78 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078919458T → A in RP78; decreased function in positive regulation of Rho protein signal transduction; loss of function in regulation of actomyosin structure organization. 1 PublicationCorresponds to variant dbSNP:rs987233144Ensembl.1
Natural variantiVAR_078920854 – 1361Missing in RP78. 1 PublicationAdd BLAST508
Natural variantiVAR_0789211066 – 1361Missing in RP78. 1 PublicationAdd BLAST296
Natural variantiVAR_0789221101 – 1108Missing in RP78; no effect on function in positive regulation of Rho protein signal transduction; decreased function in regulation of actomyosin structure organization. 1 Publication8

Keywords - Diseasei

Disease variant, Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...DisGeNETi		23370

MalaCards human disease database

More...MalaCardsi		ARHGEF18
MIMi617433, phenotype

Open Targets

More...OpenTargetsi		ENSG00000104880

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		791, Retinitis pigmentosa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394630

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZSZ5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		-
ARHGEF18

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439444

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003414151 – 1361Rho guanine nucleotide exchange factor 18Add BLAST1361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei912PhosphothreonineBy similarity1
Modified residuei921PhosphoserineBy similarity1
Modified residuei1289PhosphoserineBy similarity1
Modified residuei1291PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZSZ5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZSZ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZSZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZSZ5

PeptideAtlas

More...PeptideAtlasi		Q6ZSZ5

PRoteomics IDEntifications database

More...PRIDEi		Q6ZSZ5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		46652
68246 [Q6ZSZ5-1]
68247 [Q6ZSZ5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZSZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZSZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils (PubMed:29601110). Isoform 2: Expressed in eosinophils (PubMed:29601110). Isoform 3: Expressed in eosinophils (PubMed:29601110). Isoform 4: Not detected in eosinophils (PubMed:29601110).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000263264, Expressed in blood and 91 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZSZ5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZSZ5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104880, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SEPT9; the interaction may inhibit GEF activity (PubMed:15558029).

Interacts with Gbetagamma subunits GNB1 and GNG2 (PubMed:14512443).

Interacts with EPB41L4B (PubMed:22006950).

Interacts with PATJ (via C-terminus) (PubMed:22006950).

3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116950, 11 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6ZSZ5

Protein interaction database and analysis system

More...IntActi		Q6ZSZ5, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352995

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZSZ5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZSZ5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini447 – 644DHPROSITE-ProRule annotationAdd BLAST198
Domaini684 – 786PHPROSITE-ProRule annotationAdd BLAST103

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1038 – 1148Sequence analysisAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1042 – 1142Arg-richPROSITE-ProRule annotationAdd BLAST101
Compositional biasi1292 – 1346Pro-richPROSITE-ProRule annotationAdd BLAST55

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri310 – 334C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SGX7, Eukaryota
KOG3520, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157375

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002466_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZSZ5

Database of Orthologous Groups

More...OrthoDBi		69816at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZSZ5

TreeFam database of animal gene trees

More...TreeFami		TF325887

Family and domain databases

Conserved Domains Database

More...CDDi		cd15794, PH_ARHGEF18, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037744, ARHGEF18_PH
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17838, PH_16, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZSZ5-4) [UniParc]FASTAAdd to basket
Also known as: LOCGEF-X31 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDDQEDDFP RRLSESMEDL SLDLGALQGS EYLQDLGLGA PSHSQPGETP 
        60         70         80         90        100
DSRPTGEEPG RDSLFSSLAG SQDLSRRRSW ERSRSCSESW RRLSLDASAV 
       110        120        130        140        150
DEEPCLPRTL ASLALNLPGG GLKTWTQGCL SGGGTPAESP GKECDSPKKR 
       160        170        180        190        200
GRSRSVPVSF YEIRSPEISP GLEVPTPPVQ GLEPPVLECM EKDHVEPDHV 
       210        220        230        240        250
LIVQQVLQEL RQYHGARQRA CMSASPGGAH SNLTWFEFLS ESEDGAGKNE 
       260        270        280        290        300
KSDKSTSVKR RLSCLRSRVT RQKEKGKSPA HLKDKGQDAR ERRECVNGHQ 
       310        320        330        340        350
LLQGTFSGPS SCPLCGKPFL SSASLKEHPR GTLLSDGSPA LSRNVGMTVS 
       360        370        380        390        400
QKGGPQPTPS PAGPGTQLGP ITGEMDEADS AFLKFKQTAD DSLSLTSPNT 
       410        420        430        440        450
ESIFVEDPYT ASLRSEIESD GHEFEAESWS LAVDAAYAKK QKREVVKRQD 
       460        470        480        490        500
VLYELMQTEV HHVRTLKIML KVYSRALQEE LQFSSKAIGR LFPCADDLLE 
       510        520        530        540        550
THSHFLARLK ERRQESLEEG SDRNYVIQKI GDLLVQQFSG ENGERMKEKY 
       560        570        580        590        600
GVFCSGHNEA VSHYKLLLQQ NKKFQNLIKK IGNFSIVRRL GVQECILLVT 
       610        620        630        640        650
QRITKYPVLV ERIIQNTEAG TEDYEDLTQA LNLIKDIISQ VDAKVSECEK 
       660        670        680        690        700
GQRLREIAGK MDLKSSSKLK NGLTFRKEDM LQRQLHLEGM LCWKTTSGRL 
       710        720        730        740        750
KDILAILLTD VLLLLQEKDQ KYVFASVDSK PPVISLQKLI VREVANEEKA 
       760        770        780        790        800
MFLISASLQG PEMYEIYTSS KEDRNAWMAH IQRAVESCPD EEEGPFSLPE 
       810        820        830        840        850
EERKVVEARA TRLRDFQERL SMKDQLIAQS LLEKQQIYLE MAEMGGLEDL 
       860        870        880        890        900
PQPRGLFRGG DPSETLQGEL ILKSAMSEIE GIQSLICRQL GSANGQAEDG 
       910        920        930        940        950
GSSTGPPRRA ETFAGYDCTN SPTKNGSFKK KVSSTDPRPR DWRGPPNSPD 
       960        970        980        990       1000
LKLSDSDIPG SSEESPQVVE APGTESDPRL PTVLESELVQ RIQTLSQLLL 
      1010       1020       1030       1040       1050
NLQAVIAHQD SYVETQRAAI QEREKQFRLQ STRGNLLLEQ ERQRNFEKQR 
      1060       1070       1080       1090       1100
EERAALEKLQ SQLRHEQQRW ERERQWQHQE LERAGARLQE REGEARQLRE 
      1110       1120       1130       1140       1150
RLEQERAELE RQRQAYQHDL ERLREAQRAV ERERERLELL RRLKKQNTAP 
      1160       1170       1180       1190       1200
GALPPDTLAE AQPPSHPPSF NGEGLEGPRV SMLPSGVGPE YAERPEVARR 
      1210       1220       1230       1240       1250
DSAPTENRLA KSDVPIQLLS ATNQFQRQAA VQQQIPTKLA ASTKGGKDKG 
      1260       1270       1280       1290       1300
GKSRGSQRWE SSASFDLKQQ LLLNKLMGKD ESTSRNRRSL SPILPGRHSP 
      1310       1320       1330       1340       1350
APPPDPGFPA PSPPPADSPS EGFSLKAGGT ALLPGPPAPS PLPATPLSAK 
      1360 
EDASKEDVIF F
Length:1,361
Mass (Da):151,642
Last modified:October 10, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3028B14BC119FBDC
GO
Isoform 2 (identifier: Q6ZSZ5-5) [UniParc]FASTAAdd to basket
Also known as: LOCGEF-X41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MGDDQ → MTTVA

Show »
Length:1,361
Mass (Da):151,600
Checksum:iE31BF415EEAE44A9
GO
Isoform 3 (identifier: Q6ZSZ5-6) [UniParc]FASTAAdd to basket
Also known as: LOCGEF-X51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:1,345
Mass (Da):149,764
Checksum:i6A774DF92EB5CFC8
GO
Isoform 4 (identifier: Q6ZSZ5-2) [UniParc]FASTAAdd to basket
Also known as: p1141 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.

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Length:1,015
Mass (Da):114,077
Checksum:i03BD1D9224E422BD
GO
Isoform 5 (identifier: Q6ZSZ5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-322: MGDDQEDDFP...PLCGKPFLSS → MVTVGTNILP...STNSVLASVT

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Length:1,173
Mass (Da):130,813
Checksum:i9C96A4ED4C18FF88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZG4A0A087WZG4_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF18
1,173Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZS0M0QZS0_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF18
812Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IPE9A0A3B3IPE9_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF18
1,119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R125M0R125_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF18
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH77721 differs from that shown. Aberrant splicing.Curated
The sequence BAA25447 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti371I → V in BAC86801 (PubMed:14702039).Curated1
Sequence conflicti1295P → S in BAC86801 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078919458T → A in RP78; decreased function in positive regulation of Rho protein signal transduction; loss of function in regulation of actomyosin structure organization. 1 PublicationCorresponds to variant dbSNP:rs987233144Ensembl.1
Natural variantiVAR_078920854 – 1361Missing in RP78. 1 PublicationAdd BLAST508
Natural variantiVAR_044066889Q → R2 PublicationsCorresponds to variant dbSNP:rs2287918Ensembl.1
Natural variantiVAR_044067940R → Q. Corresponds to variant dbSNP:rs2287920Ensembl.1
Natural variantiVAR_0789211066 – 1361Missing in RP78. 1 PublicationAdd BLAST296
Natural variantiVAR_0789221101 – 1108Missing in RP78; no effect on function in positive regulation of Rho protein signal transduction; decreased function in regulation of actomyosin structure organization. 1 Publication8
Natural variantiVAR_0630991207N → S2 PublicationsCorresponds to variant dbSNP:rs9329368Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0598741 – 346Missing in isoform 4. 1 PublicationAdd BLAST346
Alternative sequenceiVSP_0598751 – 322MGDDQ…PFLSS → MVTVGTNILPSRPAASANTA REDAALFSRRIPPRHKNGAA QPGAAPGPGAPGANMGNAHS KSGDRHSALPGRPELSFYGS FPRKWSENVFLDNELLTSKI LSMLRPQSERGFRAGDLRYP THFLSTNSVLASVT in isoform 5. CuratedAdd BLAST322
Alternative sequenceiVSP_0598761 – 16Missing in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0598771 – 5MGDDQ → MTTVA in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB011093 mRNA Translation: BAA25447.1 Different initiation.
AK127045 mRNA Translation: BAC86801.1
AC008878 Genomic DNA No translation available.
AC119396 Genomic DNA No translation available.
AC126754 Genomic DNA No translation available.
BC077721 mRNA Translation: AAH77721.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12177.1 [Q6ZSZ5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001124427.1, NM_001130955.1
NP_056133.2, NM_015318.3 [Q6ZSZ5-2]
XP_006722768.1, XM_006722705.3
XP_006722769.1, XM_006722706.3 [Q6ZSZ5-4]
XP_006722771.1, XM_006722708.2
XP_011526140.1, XM_011527838.2 [Q6ZSZ5-5]
XP_011526141.1, XM_011527839.2 [Q6ZSZ5-6]
XP_011526142.1, XM_011527840.1 [Q6ZSZ5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000319670; ENSP00000319200; ENSG00000104880 [Q6ZSZ5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23370

UCSC genome browser

More...UCSCi		uc002mgh.4, human [Q6ZSZ5-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011093 mRNA Translation: BAA25447.1 Different initiation.
AK127045 mRNA Translation: BAC86801.1
AC008878 Genomic DNA No translation available.
AC119396 Genomic DNA No translation available.
AC126754 Genomic DNA No translation available.
BC077721 mRNA Translation: AAH77721.1 Sequence problems.
CCDSiCCDS12177.1 [Q6ZSZ5-2]
RefSeqiNP_001124427.1, NM_001130955.1
NP_056133.2, NM_015318.3 [Q6ZSZ5-2]
XP_006722768.1, XM_006722705.3
XP_006722769.1, XM_006722706.3 [Q6ZSZ5-4]
XP_006722771.1, XM_006722708.2
XP_011526140.1, XM_011527838.2 [Q6ZSZ5-5]
XP_011526141.1, XM_011527839.2 [Q6ZSZ5-6]
XP_011526142.1, XM_011527840.1 [Q6ZSZ5-2]

3D structure databases

SMRiQ6ZSZ5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116950, 11 interactors
CORUMiQ6ZSZ5
IntActiQ6ZSZ5, 6 interactors
STRINGi9606.ENSP00000352995

PTM databases

iPTMnetiQ6ZSZ5
PhosphoSitePlusiQ6ZSZ5

Genetic variation databases

BioMutai-
ARHGEF18
DMDMi296439444

Proteomic databases

EPDiQ6ZSZ5
jPOSTiQ6ZSZ5
MassIVEiQ6ZSZ5
PaxDbiQ6ZSZ5
PeptideAtlasiQ6ZSZ5
PRIDEiQ6ZSZ5
ProteomicsDBi46652
68246 [Q6ZSZ5-1]
68247 [Q6ZSZ5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24427, 265 antibodies

Genome annotation databases

EnsembliENST00000319670; ENSP00000319200; ENSG00000104880 [Q6ZSZ5-2]
GeneIDi23370
KEGGihsa:23370
UCSCiuc002mgh.4, human [Q6ZSZ5-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23370
DisGeNETi23370

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARHGEF18
HGNCiHGNC:17090, ARHGEF18
HPAiENSG00000104880, Low tissue specificity
MalaCardsiARHGEF18
MIMi616432, gene
617433, phenotype
neXtProtiNX_Q6ZSZ5
OpenTargetsiENSG00000104880
Orphaneti791, Retinitis pigmentosa
PharmGKBiPA128394630
VEuPathDBiHostDB:ENSG00000104880.17
HostDB:ENSG00000263264.1

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SGX7, Eukaryota
KOG3520, Eukaryota
GeneTreeiENSGT00940000157375
HOGENOMiCLU_002466_0_0_1
InParanoidiQ6ZSZ5
OrthoDBi69816at2759
PhylomeDBiQ6ZSZ5
TreeFamiTF325887

Enzyme and pathway databases

PathwayCommonsiQ6ZSZ5
ReactomeiR-HSA-193648, NRAGE signals death through JNK
R-HSA-194840, Rho GTPase cycle
R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-416482, G alpha (12/13) signalling events
SIGNORiQ6ZSZ5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23370, 6 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARHGEF18, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23370
PharosiQ6ZSZ5, Tbio

Protein Ontology

More...PROi		PR:Q6ZSZ5
RNActiQ6ZSZ5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000263264, Expressed in blood and 91 other tissues
ExpressionAtlasiQ6ZSZ5, baseline and differential
GenevisibleiQ6ZSZ5, HS

Family and domain databases

CDDicd15794, PH_ARHGEF18, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037744, ARHGEF18_PH
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF17838, PH_16, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHGI_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZSZ5
Secondary accession number(s): A8MV62
, B5ME81, I3L1I5, O60274, Q6DD92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 10, 2018
Last modified: February 10, 2021
This is version 153 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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