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Entry version 123 (02 Jun 2021)
Sequence version 3 (14 Apr 2009)
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Protein

Protein phosphatase 1 regulatory subunit 3F

Gene

PPP1R3F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycogen-targeting subunit for protein phosphatase 1 (PP1).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glycogen binding Source: MGI
  • protein phosphatase 1 binding Source: GO_Central
  • protein phosphatase binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZSY5

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM21, Carbohydrate-Binding Module Family 21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3F
Short name:
R3F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R3F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14944, PPP1R3F

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZSY5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000049769.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 768CytoplasmicSequence analysisAdd BLAST768
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei769 – 789HelicalSequence analysisAdd BLAST21
Topological domaini790 – 799ExtracellularSequence analysis10

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89801

Open Targets

More...
OpenTargetsi
ENSG00000049769

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33656

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZSY5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R3F

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226694145

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002574961 – 799Protein phosphatase 1 regulatory subunit 3FAdd BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14Phosphoserine1 Publication1
Modified residuei18Phosphoserine1 Publication1
Modified residuei420Phosphoserine1 Publication1
Modified residuei421Phosphoserine1 Publication1
Modified residuei547PhosphoserineCombined sources1
Modified residuei589PhosphoserineBy similarity1
Modified residuei594PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZSY5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZSY5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZSY5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZSY5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZSY5

PeptideAtlas

More...
PeptideAtlasi
Q6ZSY5

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZSY5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19470
68245 [Q6ZSY5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZSY5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZSY5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, skeletal muscle and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000049769, Expressed in prefrontal cortex and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZSY5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZSY5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000049769, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124607, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZSY5, 8 interactors

Molecular INTeraction database

More...
MINTi
Q6ZSY5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000055335

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZSY5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZSY5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 284CBM21PROSITE-ProRule annotationAdd BLAST157

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni53 – 104DisorderedSequence analysisAdd BLAST52
Regioni205 – 241DisorderedSequence analysisAdd BLAST37
Regioni420 – 471DisorderedSequence analysisAdd BLAST52
Regioni569 – 602DisorderedSequence analysisAdd BLAST34
Regioni723 – 742DisorderedSequence analysisAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi36 – 39PP1-binding motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi77 – 99Acidic residuesSequence analysisAdd BLAST23
Compositional biasi446 – 461Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3986, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_563304_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZSY5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMDDNTP

Database of Orthologous Groups

More...
OrthoDBi
1232750at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZSY5

TreeFam database of animal gene trees

More...
TreeFami
TF352142

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005036, CBM21_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03370, CBM_21, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51159, CBM21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZSY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARTAPVEPP LRHSAPPSPA AGEPRTSVEA AVAPRRVLFA DEALGLPLAQ
60 70 80 90 100
LRRYRPWGGP GAGKMAAAAG QDGGGGGGAD EDDDGEDGDE GEEEEEACPE
110 120 130 140 150
PSPLCPVPAG GGFYLVPTFS LPPAPGRLER LGRVMVELEA LLPPPGAVPG
160 170 180 190 200
GAGVWVPGGR PPVLRGLVRV LNRSFEKAVH VRASHDGWAS FCDHPARYVP
210 220 230 240 250
RSPPWAGAGG TGAGDPILDP GLGLGPGQAS ASSPDDGGRT DRFAFQLPFA
260 270 280 290 300
EGAGDGARLD FVVRYETPEG TFWANNHGRN YTVLLRIAPA PTPTDAEGLP
310 320 330 340 350
QQQQLPQLEP QPECQGPVEA EARQLKSCMK PVRRRPAEEE LKTKNMDDNT
360 370 380 390 400
FAMAEHPDVQ ESVGPLVAPT PLRPWPQMTL QVSDVPMTGN PAEEGDVPRS
410 420 430 440 450
SPPVAFTEVL QAPAIRIPPS SPLCGLGGSP RDQASGPDAS EGATGPFLEP
460 470 480 490 500
SQQQAEATWG VSSENGGGLE AVSGSEELLG EDTIDQELEQ LYLSHLSRLR
510 520 530 540 550
AAVAAGGAGG GGEGSTDGGM SPSHPLGILT DRDLILKWPG PERALNSALA
560 570 580 590 600
EEITLHYARL GRGVELIKDT EDPDDEGEGE EGLSVTPSSP EGDSPKESPP
610 620 630 640 650
EILSGARSVV ATMGDVWLPW AEGSGCDGPV VLGTEGQFIG DPEKGMGKDT
660 670 680 690 700
SSLHMNRVIA GVTESLGEAG TEAQIEVTSE WAGSLDPISG KEPASPVLLQ
710 720 730 740 750
GQNPTLLSPL GAEVCLSSVA RPHVSSQDEK DAGPSLEPPK KSPTLAVPAE
760 770 780 790
CVCALPPQLR GPLTQTLGVL AGLVVVPVAL NSGVSLLVLA LCLSLAWFS
Length:799
Mass (Da):82,798
Last modified:April 14, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E9EDD5515DE245D
GO
Isoform 2 (identifier: Q6ZSY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-345: Missing.
     354-354: Missing.

Show »
Length:453
Mass (Da):46,609
Checksum:i16EAC69D6811DFCF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C178A0A494C178_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R3F
685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C546H7C546_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R3F
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI31589 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG51824 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti377Q → H in BAG51824 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028918351F → S. Corresponds to variant dbSNP:rs17148347Ensembl.1
Natural variantiVAR_076266441E → K1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450031 – 345Missing in isoform 2. 1 PublicationAdd BLAST345
Alternative sequenceiVSP_045004354Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF235097 Genomic DNA No translation available.
BC131588 mRNA Translation: AAI31589.1 Different initiation.
AK056909 mRNA Translation: BAG51824.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35254.1 [Q6ZSY5-1]
CCDS55415.1 [Q6ZSY5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001171674.1, NM_001184745.1 [Q6ZSY5-2]
NP_149992.3, NM_033215.4 [Q6ZSY5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000055335; ENSP00000055335; ENSG00000049769 [Q6ZSY5-1]
ENST00000376188; ENSP00000365359; ENSG00000049769 [Q6ZSY5-2]
ENST00000466508; ENSP00000420687; ENSG00000049769 [Q6ZSY5-2]
ENST00000495799; ENSP00000417535; ENSG00000049769 [Q6ZSY5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89801

UCSC genome browser

More...
UCSCi
uc004dnh.3, human [Q6ZSY5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235097 Genomic DNA No translation available.
BC131588 mRNA Translation: AAI31589.1 Different initiation.
AK056909 mRNA Translation: BAG51824.1 Different initiation.
CCDSiCCDS35254.1 [Q6ZSY5-1]
CCDS55415.1 [Q6ZSY5-2]
RefSeqiNP_001171674.1, NM_001184745.1 [Q6ZSY5-2]
NP_149992.3, NM_033215.4 [Q6ZSY5-1]

3D structure databases

SMRiQ6ZSY5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124607, 11 interactors
IntActiQ6ZSY5, 8 interactors
MINTiQ6ZSY5
STRINGi9606.ENSP00000055335

Protein family/group databases

CAZyiCBM21, Carbohydrate-Binding Module Family 21

PTM databases

iPTMnetiQ6ZSY5
PhosphoSitePlusiQ6ZSY5

Genetic variation databases

BioMutaiPPP1R3F
DMDMi226694145

Proteomic databases

EPDiQ6ZSY5
jPOSTiQ6ZSY5
MassIVEiQ6ZSY5
MaxQBiQ6ZSY5
PaxDbiQ6ZSY5
PeptideAtlasiQ6ZSY5
PRIDEiQ6ZSY5
ProteomicsDBi19470
68245 [Q6ZSY5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
338, 68 antibodies

The DNASU plasmid repository

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DNASUi
89801

Genome annotation databases

EnsembliENST00000055335; ENSP00000055335; ENSG00000049769 [Q6ZSY5-1]
ENST00000376188; ENSP00000365359; ENSG00000049769 [Q6ZSY5-2]
ENST00000466508; ENSP00000420687; ENSG00000049769 [Q6ZSY5-2]
ENST00000495799; ENSP00000417535; ENSG00000049769 [Q6ZSY5-2]
GeneIDi89801
KEGGihsa:89801
UCSCiuc004dnh.3, human [Q6ZSY5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
89801
DisGeNETi89801

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP1R3F
HGNCiHGNC:14944, PPP1R3F
HPAiENSG00000049769, Low tissue specificity
neXtProtiNX_Q6ZSY5
OpenTargetsiENSG00000049769
PharmGKBiPA33656
VEuPathDBiHostDB:ENSG00000049769.12

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3986, Eukaryota
GeneTreeiENSGT00390000013859
HOGENOMiCLU_563304_0_0_1
InParanoidiQ6ZSY5
OMAiNMDDNTP
OrthoDBi1232750at2759
PhylomeDBiQ6ZSY5
TreeFamiTF352142

Enzyme and pathway databases

PathwayCommonsiQ6ZSY5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
89801, 4 hits in 611 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP1R3F, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
89801
PharosiQ6ZSY5, Tbio

Protein Ontology

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PROi
PR:Q6ZSY5
RNActiQ6ZSY5, protein

Gene expression databases

BgeeiENSG00000049769, Expressed in prefrontal cortex and 196 other tissues
ExpressionAtlasiQ6ZSY5, baseline and differential
GenevisibleiQ6ZSY5, HS

Family and domain databases

InterProiView protein in InterPro
IPR005036, CBM21_dom
PfamiView protein in Pfam
PF03370, CBM_21, 1 hit
PROSITEiView protein in PROSITE
PS51159, CBM21, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPR3F_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZSY5
Secondary accession number(s): A2VDJ8, B3KPW2, E9PCM3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 14, 2009
Last modified: June 2, 2021
This is version 123 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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