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Entry version 109 (10 Apr 2019)
Sequence version 2 (18 May 2010)
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Protein

Lipocalin-like 1 protein

Gene

LCNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipocalin-like 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LCNL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000214402.6

Human Gene Nomenclature Database

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HGNCi
HGNC:34436 LCNL1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZST4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000214402

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164722092

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LCNL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434562

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003484701 – 164Lipocalin-like 1 proteinAdd BLAST164

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6ZST4

PRoteomics IDEntifications database

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PRIDEi
Q6ZST4

ProteomicsDB human proteome resource

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ProteomicsDBi
68239

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6ZST4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6ZST4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000214402 Expressed in 87 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6ZST4 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6ZST4, 2 interactors

Molecular INTeraction database

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MINTi
Q6ZST4

STRING: functional protein association networks

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STRINGi
9606.ENSP00000386162

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6ZST4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IXK6 Eukaryota
ENOG411141C LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000208505

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ZST4

Identification of Orthologs from Complete Genome Data

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OMAi
VAFSDYQ

Database of Orthologous Groups

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OrthoDBi
1107052at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6ZST4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom

The PANTHER Classification System

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PANTHERi
PTHR11430 PTHR11430, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00061 Lipocalin, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50814 SSF50814, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ZST4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGVVSDDQD FLDSKDTMKM AVVLVTPLGN GDLALKFGYP TPHGGCQKMD
60 70 80 90 100
TTFTEGAVPG QFSNPAMALS DIRVAFSDYQ HFALLYLEMR KGGLRNQWLQ
110 120 130 140 150
LYGGRAAGRR PRHPRFGSGM SPLCLHQPFL HAEGGTAGSW CLWPRVPAPP
160
CPSLPLFAPP APSL
Length:164
Mass (Da):17,784
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0C265A527C6A0BB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04618968A → T1 PublicationCorresponds to variant dbSNP:rs17578859Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK127160 mRNA Translation: BAC86862.1
AL807752 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43908.1

NCBI Reference Sequences

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RefSeqi
NP_997393.3, NM_207510.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.695210

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000408973; ENSP00000386162; ENSG00000214402

Database of genes from NCBI RefSeq genomes

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GeneIDi
401562

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:401562

UCSC genome browser

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UCSCi
uc004ckh.2 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127160 mRNA Translation: BAC86862.1
AL807752 Genomic DNA No translation available.
CCDSiCCDS43908.1
RefSeqiNP_997393.3, NM_207510.3
UniGeneiHs.695210

3D structure databases

ProteinModelPortaliQ6ZST4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZST4, 2 interactors
MINTiQ6ZST4
STRINGi9606.ENSP00000386162

PTM databases

iPTMnetiQ6ZST4
PhosphoSitePlusiQ6ZST4

Polymorphism and mutation databases

BioMutaiLCNL1
DMDMi296434562

Proteomic databases

PaxDbiQ6ZST4
PRIDEiQ6ZST4
ProteomicsDBi68239

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408973; ENSP00000386162; ENSG00000214402
GeneIDi401562
KEGGihsa:401562
UCSCiuc004ckh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
401562
EuPathDBiHostDB:ENSG00000214402.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LCNL1
HGNCiHGNC:34436 LCNL1
neXtProtiNX_Q6ZST4
OpenTargetsiENSG00000214402
PharmGKBiPA164722092

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXK6 Eukaryota
ENOG411141C LUCA
GeneTreeiENSGT00950000182638
HOGENOMiHOG000208505
InParanoidiQ6ZST4
OMAiVAFSDYQ
OrthoDBi1107052at2759
PhylomeDBiQ6ZST4

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
401562

Protein Ontology

More...
PROi
PR:Q6ZST4

Gene expression databases

BgeeiENSG00000214402 Expressed in 87 organ(s), highest expression level in right testis
GenevisibleiQ6ZST4 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
SUPFAMiSSF50814 SSF50814, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCNL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZST4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 18, 2010
Last modified: April 10, 2019
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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