UniProtKB - Q6ZSS7 (MFSD6_HUMAN)
Protein
Major facilitator superfamily domain-containing protein 6
Gene
MFSD6
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Major facilitator superfamily domain-containing protein 6Alternative name(s): Macrophage MHC class I receptor 2 homolog |
Gene namesi | Name:MFSD6 Synonyms:MMR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24711 MFSD6 |
MIMi | 613476 gene |
neXtProti | NX_Q6ZSS7 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 73 – 93 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 132 – 152 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 286 – 306 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 369 – 389 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 450 – 470 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 479 – 499 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 507 – 527 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 544 – 564 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 579 – 599 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 605 – 625 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000151690 |
PharmGKBi | PA164722278 |
Miscellaneous databases
Pharosi | Q6ZSS7 |
Polymorphism and mutation databases
BioMutai | MFSD6 |
DMDMi | 187610244 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000321940 | 2 – 791 | Major facilitator superfamily domain-containing protein 6Add BLAST | 790 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 10 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q6ZSS7 |
jPOSTi | Q6ZSS7 |
MassIVEi | Q6ZSS7 |
MaxQBi | Q6ZSS7 |
PaxDbi | Q6ZSS7 |
PeptideAtlasi | Q6ZSS7 |
PRIDEi | Q6ZSS7 |
ProteomicsDBi | 68237 |
PTM databases
GlyConnecti | 1484 |
iPTMneti | Q6ZSS7 |
PhosphoSitePlusi | Q6ZSS7 |
SwissPalmi | Q6ZSS7 |
Expressioni
Tissue specificityi
Widely expressed. Expression levels in peripheral blood mononuclear cells are highly variable between individuals, including no expression at all.1 Publication
Gene expression databases
Bgeei | ENSG00000151690 Expressed in 206 organ(s), highest expression level in middle temporal gyrus |
ExpressionAtlasi | Q6ZSS7 baseline and differential |
Genevisiblei | Q6ZSS7 HS |
Organism-specific databases
HPAi | HPA022274 |
Interactioni
Subunit structurei
May interact with HLA-B62.
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Q7Z7N9 | 4 | EBI-2858252,EBI-11724423 |
Protein-protein interaction databases
BioGridi | 120193, 1 interactor |
IntActi | Q6ZSS7, 38 interactors |
STRINGi | 9606.ENSP00000376141 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3762 Eukaryota ENOG410YMHR LUCA |
GeneTreei | ENSGT00530000063599 |
HOGENOMi | HOG000230724 |
InParanoidi | Q6ZSS7 |
OMAi | HSTRVYR |
OrthoDBi | 628784at2759 |
PhylomeDBi | Q6ZSS7 |
TreeFami | TF314366 |
Family and domain databases
InterProi | View protein in InterPro IPR024989 MFS_assoc_dom IPR036259 MFS_trans_sf |
Pfami | View protein in Pfam PF12832 MFS_1_like, 1 hit |
SUPFAMi | SSF103473 SSF103473, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q6ZSS7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADDKVAILT DDEEEQKRKY VLADPFNGIS REPEPPSNET PSSTETSAIP
60 70 80 90 100
EEEIDWIEKH CVKINNDLLI SKVFYFFFYS AYGSLYPLLP VYYKQLGMSP
110 120 130 140 150
SQSGLLVGIR YFIEFCSAPF WGVVADRFKK GKIVLLFSLL CWVLFNLGIG
160 170 180 190 200
FVKPATLRCV PKIRPTTHPT NASHQLTILP TNSSFTSFLT ISPKMREKRN
210 220 230 240 250
LLETRLNVSD TVTLPTAPNM NSEPTLQPQT GEITNRMMDL TLNSSTATPV
260 270 280 290 300
SPGSVTKETT TVIVTTTKSL PSDQVMLVYD QQEVEAIFLV ILVVVIIGEF
310 320 330 340 350
FSASSVTIVD TVTLQYLGKH RDRYGLQRMW GSLGWGLAML SVGIGIDYTH
360 370 380 390 400
IEVLIDGKGC KPPEYRNYQI VFIVFGVLMT MALIVATQFR FRYNHFKNDD
410 420 430 440 450
SKGKEVEIPQ VERNNSTESS EETPTTTSHS QAFNFWDLIK LLCSVQYGSV
460 470 480 490 500
LFVAWFMGFG YGFVFTFLYW HLEDLNGTTT LFGVCSVLSH VSELTAYFFS
510 520 530 540 550
HKLIELIGHI RVLYIGLACN TARYIYISYL ENAWTVLPME VLQGVTHAAI
560 570 580 590 600
WAACISYLSA AVPPELRTSA QGILQGLHLG LGRGCGAMIG GVLVNYFGAA
610 620 630 640 650
ATFRGIGMAC LVILLLFALI QWLAVPDEEE DKTMLAERIP VPSSPVPIAT
660 670 680 690 700
IDLVQQQTED VMPRIEPRLP PKKTKHQEEQ EDVNKPAWGV SSSPWVTFVY
710 720 730 740 750
ALYQIKEMMQ LTRDNRASEI QPLQGTNENR ENSPAGRAQP VPCETHSDPS
760 770 780 790
RNQPSPDAAA SQTQTSPAHP SVDPCTEESE EQQAQLAAGG H
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9IYL1 | C9IYL1_HUMAN | Major facilitator superfamily domai... | MFSD6 | 179 | Annotation score: | ||
C9JJH2 | C9JJH2_HUMAN | Major facilitator superfamily domai... | MFSD6 | 156 | Annotation score: | ||
H7C0X2 | H7C0X2_HUMAN | Major facilitator superfamily domai... | MFSD6 | 271 | Annotation score: | ||
C9J134 | C9J134_HUMAN | Major facilitator superfamily domai... | MFSD6 | 114 | Annotation score: | ||
H7C284 | H7C284_HUMAN | Major facilitator superfamily domai... | MFSD6 | 91 | Annotation score: | ||
C9JAZ7 | C9JAZ7_HUMAN | Major facilitator superfamily domai... | MFSD6 | 42 | Annotation score: |
Sequence cautioni
The sequence AAY24173 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA90987 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAX10868 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 728 | E → G in BAA90987 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039388 | 205 | R → G3 PublicationsCorresponds to variant dbSNP:rs9646748Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB472299 mRNA Translation: BAI82196.1 AK000167 mRNA Translation: BAA90987.1 Different initiation. AK127176 mRNA Translation: BAC86869.1 AC093388 Genomic DNA Translation: AAY24173.1 Different initiation. CH471058 Genomic DNA Translation: EAX10868.1 Different initiation. CH471058 Genomic DNA Translation: EAX10867.1 BC050537 mRNA Translation: AAH50537.2 |
CCDSi | CCDS2306.1 |
RefSeqi | NP_060164.3, NM_017694.3 XP_005246711.1, XM_005246654.2 XP_011509670.1, XM_011511368.1 |
Genome annotation databases
Ensembli | ENST00000281416; ENSP00000281416; ENSG00000151690 ENST00000392328; ENSP00000376141; ENSG00000151690 |
GeneIDi | 54842 |
KEGGi | hsa:54842 |
UCSCi | uc002urz.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB472299 mRNA Translation: BAI82196.1 AK000167 mRNA Translation: BAA90987.1 Different initiation. AK127176 mRNA Translation: BAC86869.1 AC093388 Genomic DNA Translation: AAY24173.1 Different initiation. CH471058 Genomic DNA Translation: EAX10868.1 Different initiation. CH471058 Genomic DNA Translation: EAX10867.1 BC050537 mRNA Translation: AAH50537.2 |
CCDSi | CCDS2306.1 |
RefSeqi | NP_060164.3, NM_017694.3 XP_005246711.1, XM_005246654.2 XP_011509670.1, XM_011511368.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 120193, 1 interactor |
IntActi | Q6ZSS7, 38 interactors |
STRINGi | 9606.ENSP00000376141 |
PTM databases
GlyConnecti | 1484 |
iPTMneti | Q6ZSS7 |
PhosphoSitePlusi | Q6ZSS7 |
SwissPalmi | Q6ZSS7 |
Polymorphism and mutation databases
BioMutai | MFSD6 |
DMDMi | 187610244 |
Proteomic databases
EPDi | Q6ZSS7 |
jPOSTi | Q6ZSS7 |
MassIVEi | Q6ZSS7 |
MaxQBi | Q6ZSS7 |
PaxDbi | Q6ZSS7 |
PeptideAtlasi | Q6ZSS7 |
PRIDEi | Q6ZSS7 |
ProteomicsDBi | 68237 |
Genome annotation databases
Ensembli | ENST00000281416; ENSP00000281416; ENSG00000151690 ENST00000392328; ENSP00000376141; ENSG00000151690 |
GeneIDi | 54842 |
KEGGi | hsa:54842 |
UCSCi | uc002urz.2 human |
Organism-specific databases
CTDi | 54842 |
GeneCardsi | MFSD6 |
HGNCi | HGNC:24711 MFSD6 |
HPAi | HPA022274 |
MIMi | 613476 gene |
neXtProti | NX_Q6ZSS7 |
OpenTargetsi | ENSG00000151690 |
PharmGKBi | PA164722278 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3762 Eukaryota ENOG410YMHR LUCA |
GeneTreei | ENSGT00530000063599 |
HOGENOMi | HOG000230724 |
InParanoidi | Q6ZSS7 |
OMAi | HSTRVYR |
OrthoDBi | 628784at2759 |
PhylomeDBi | Q6ZSS7 |
TreeFami | TF314366 |
Miscellaneous databases
ChiTaRSi | MFSD6 human |
GenomeRNAii | 54842 |
Pharosi | Q6ZSS7 |
PROi | PR:Q6ZSS7 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151690 Expressed in 206 organ(s), highest expression level in middle temporal gyrus |
ExpressionAtlasi | Q6ZSS7 baseline and differential |
Genevisiblei | Q6ZSS7 HS |
Family and domain databases
InterProi | View protein in InterPro IPR024989 MFS_assoc_dom IPR036259 MFS_trans_sf |
Pfami | View protein in Pfam PF12832 MFS_1_like, 1 hit |
SUPFAMi | SSF103473 SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFSD6_HUMAN | |
Accessioni | Q6ZSS7Primary (citable) accession number: Q6ZSS7 Secondary accession number(s): D3KSZ4, Q86TH2, Q9NXM3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | October 16, 2019 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot