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UniProtKB - Q6ZSS7 (MFSD6_HUMAN)

Entry version 130 (02 Jun 2021)
Sequence version 2 (26 Feb 2008)
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Protein

Major facilitator superfamily domain-containing protein 6

Gene

MFSD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZSS7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 6
Alternative name(s):
Macrophage MHC class I receptor 2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MFSD6
Synonyms:MMR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24711, MFSD6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613476, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZSS7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151690.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Transmembranei579 – 599HelicalSequence analysisAdd BLAST21
Transmembranei605 – 625HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54842

Open Targets

More...OpenTargetsi		ENSG00000151690

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164722278

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZSS7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MFSD6

Domain mapping of disease mutations (DMDM)

More...DMDMi		187610244

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003219402 – 791Major facilitator superfamily domain-containing protein 6Add BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZSS7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZSS7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZSS7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZSS7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZSS7

PeptideAtlas

More...PeptideAtlasi		Q6ZSS7

PRoteomics IDEntifications database

More...PRIDEi		Q6ZSS7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68237

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1484, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6ZSS7, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZSS7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZSS7

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6ZSS7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expression levels in peripheral blood mononuclear cells are highly variable between individuals, including no expression at all.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151690, Expressed in middle temporal gyrus and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZSS7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZSS7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151690, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with HLA-B62.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q6ZSS7
With#Exp.IntAct
ADIPOQ [Q15848]3EBI-2858252,EBI-10827839
ALG8 [Q9BVK2]3EBI-2858252,EBI-3921603
APH1A [Q96BI3]3EBI-2858252,EBI-2606935
APOL3 - isoform 2 [O95236-2]3EBI-2858252,EBI-11976321
AQP7 [Q6P5T0]3EBI-2858252,EBI-10489564
C19orf18 [Q8NEA5]3EBI-2858252,EBI-18323646
CD79A [P11912]3EBI-2858252,EBI-7797864
CYB5R3 [P00387]3EBI-2858252,EBI-1046040
EBP [Q15125]3EBI-2858252,EBI-3915253
ERGIC3 [Q9Y282]3EBI-2858252,EBI-781551
GJA8 [P48165]3EBI-2858252,EBI-17458373
GJB2 [P29033]3EBI-2858252,EBI-3905204
GPR152 [Q8TDT2]3EBI-2858252,EBI-13345167
GPR42 [O15529]3EBI-2858252,EBI-18076404
GPX8 [Q8TED1]3EBI-2858252,EBI-11721746
LY6E [Q16553]3EBI-2858252,EBI-18234679
MFSD4B [Q5TF39]3EBI-2858252,EBI-11922631
NKG7 [Q16617]3EBI-2858252,EBI-3919611
PDCD1LG2 [Q9BQ51]3EBI-2858252,EBI-16427978
SDC3 [A0A0S2Z4U3]3EBI-2858252,EBI-10204280
SELENOK [Q9Y6D0]3EBI-2858252,EBI-9679163
SGPL1 [O95470]3EBI-2858252,EBI-1046170
SHISAL1 [Q3SXP7]3EBI-2858252,EBI-18037857
SLC10A1 [Q14973]3EBI-2858252,EBI-3923031
SLC10A6 [Q3KNW5]3EBI-2858252,EBI-18159983
SLC18A1 - isoform 3 [P54219-3]3EBI-2858252,EBI-17595455
SLC39A2 [Q9NP94]3EBI-2858252,EBI-12898013
SMIM1 [B2RUZ4]3EBI-2858252,EBI-12188413
SSMEM1 [Q8WWF3]3EBI-2858252,EBI-17280858
STX12 [Q86Y82]3EBI-2858252,EBI-2691717
SYNDIG1 [Q9H7V2]3EBI-2858252,EBI-726331
TMEM179B [Q7Z7N9]3EBI-2858252,EBI-11724423
TMEM237 - isoform 2 [Q96Q45-2]3EBI-2858252,EBI-10982110
TMEM242 [Q9NWH2]3EBI-2858252,EBI-10315004
TMEM258 [P61165]3EBI-2858252,EBI-12019210
TMPRSS2 - isoform 2 [O15393-2]3EBI-2858252,EBI-12345267
TSPO2 [Q5TGU0]3EBI-2858252,EBI-12195249

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120193, 37 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZSS7, 41 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376141

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZSS7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 47DisorderedSequence analysisAdd BLAST26
Regioni407 – 427DisorderedSequence analysisAdd BLAST21
Regioni662 – 687DisorderedSequence analysisAdd BLAST26
Regioni723 – 791DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 47Polar residuesSequence analysisAdd BLAST15
Compositional biasi412 – 427Polar residuesSequence analysisAdd BLAST16
Compositional biasi665 – 683Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi745 – 783Polar residuesSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. MFSD6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3762, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063599

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013133_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZSS7

Identification of Orthologs from Complete Genome Data

More...OMAi		HSTRVYR

Database of Orthologous Groups

More...OrthoDBi		628784at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZSS7

TreeFam database of animal gene trees

More...TreeFami		TF314366

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024989, MFS_assoc_dom
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12832, MFS_1_like, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q6ZSS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDKVAILT DDEEEQKRKY VLADPFNGIS REPEPPSNET PSSTETSAIP 
        60         70         80         90        100
EEEIDWIEKH CVKINNDLLI SKVFYFFFYS AYGSLYPLLP VYYKQLGMSP 
       110        120        130        140        150
SQSGLLVGIR YFIEFCSAPF WGVVADRFKK GKIVLLFSLL CWVLFNLGIG 
       160        170        180        190        200
FVKPATLRCV PKIRPTTHPT NASHQLTILP TNSSFTSFLT ISPKMREKRN 
       210        220        230        240        250
LLETRLNVSD TVTLPTAPNM NSEPTLQPQT GEITNRMMDL TLNSSTATPV 
       260        270        280        290        300
SPGSVTKETT TVIVTTTKSL PSDQVMLVYD QQEVEAIFLV ILVVVIIGEF 
       310        320        330        340        350
FSASSVTIVD TVTLQYLGKH RDRYGLQRMW GSLGWGLAML SVGIGIDYTH 
       360        370        380        390        400
IEVLIDGKGC KPPEYRNYQI VFIVFGVLMT MALIVATQFR FRYNHFKNDD 
       410        420        430        440        450
SKGKEVEIPQ VERNNSTESS EETPTTTSHS QAFNFWDLIK LLCSVQYGSV 
       460        470        480        490        500
LFVAWFMGFG YGFVFTFLYW HLEDLNGTTT LFGVCSVLSH VSELTAYFFS 
       510        520        530        540        550
HKLIELIGHI RVLYIGLACN TARYIYISYL ENAWTVLPME VLQGVTHAAI 
       560        570        580        590        600
WAACISYLSA AVPPELRTSA QGILQGLHLG LGRGCGAMIG GVLVNYFGAA 
       610        620        630        640        650
ATFRGIGMAC LVILLLFALI QWLAVPDEEE DKTMLAERIP VPSSPVPIAT 
       660        670        680        690        700
IDLVQQQTED VMPRIEPRLP PKKTKHQEEQ EDVNKPAWGV SSSPWVTFVY 
       710        720        730        740        750
ALYQIKEMMQ LTRDNRASEI QPLQGTNENR ENSPAGRAQP VPCETHSDPS 
       760        770        780        790 
RNQPSPDAAA SQTQTSPAHP SVDPCTEESE EQQAQLAAGG H
Length:791
Mass (Da):88,088
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC623C7660D7BC73A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYL1C9IYL1_HUMAN
Major facilitator superfamily domai...
MFSD6
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJH2C9JJH2_HUMAN
Major facilitator superfamily domai...
MFSD6
156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0X2H7C0X2_HUMAN
Major facilitator superfamily domai...
MFSD6
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J134C9J134_HUMAN
Major facilitator superfamily domai...
MFSD6
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C284H7C284_HUMAN
Major facilitator superfamily domai...
MFSD6
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAZ7C9JAZ7_HUMAN
Major facilitator superfamily domai...
MFSD6
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY24173 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA90987 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAX10868 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti728E → G in BAA90987 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039388205R → G3 PublicationsCorresponds to variant dbSNP:rs9646748Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB472299 mRNA Translation: BAI82196.1
AK000167 mRNA Translation: BAA90987.1 Different initiation.
AK127176 mRNA Translation: BAC86869.1
AC093388 Genomic DNA Translation: AAY24173.1 Different initiation.
CH471058 Genomic DNA Translation: EAX10868.1 Different initiation.
CH471058 Genomic DNA Translation: EAX10867.1
BC050537 mRNA Translation: AAH50537.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2306.1

NCBI Reference Sequences

More...RefSeqi		NP_060164.3, NM_017694.3
XP_005246711.1, XM_005246654.2
XP_011509670.1, XM_011511368.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000281416; ENSP00000281416; ENSG00000151690
ENST00000392328; ENSP00000376141; ENSG00000151690

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54842

UCSC genome browser

More...UCSCi		uc002urz.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB472299 mRNA Translation: BAI82196.1
AK000167 mRNA Translation: BAA90987.1 Different initiation.
AK127176 mRNA Translation: BAC86869.1
AC093388 Genomic DNA Translation: AAY24173.1 Different initiation.
CH471058 Genomic DNA Translation: EAX10868.1 Different initiation.
CH471058 Genomic DNA Translation: EAX10867.1
BC050537 mRNA Translation: AAH50537.2
CCDSiCCDS2306.1
RefSeqiNP_060164.3, NM_017694.3
XP_005246711.1, XM_005246654.2
XP_011509670.1, XM_011511368.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120193, 37 interactors
IntActiQ6ZSS7, 41 interactors
STRINGi9606.ENSP00000376141

PTM databases

GlyConnecti1484, 1 N-Linked glycan (1 site)
GlyGeniQ6ZSS7, 1 site
iPTMnetiQ6ZSS7
PhosphoSitePlusiQ6ZSS7
SwissPalmiQ6ZSS7

Genetic variation databases

BioMutaiMFSD6
DMDMi187610244

Proteomic databases

EPDiQ6ZSS7
jPOSTiQ6ZSS7
MassIVEiQ6ZSS7
MaxQBiQ6ZSS7
PaxDbiQ6ZSS7
PeptideAtlasiQ6ZSS7
PRIDEiQ6ZSS7
ProteomicsDBi68237

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19836, 107 antibodies

The DNASU plasmid repository

More...DNASUi		54842

Genome annotation databases

EnsembliENST00000281416; ENSP00000281416; ENSG00000151690
ENST00000392328; ENSP00000376141; ENSG00000151690
GeneIDi54842
KEGGihsa:54842
UCSCiuc002urz.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54842
DisGeNETi54842

GeneCards: human genes, protein and diseases

More...GeneCardsi		MFSD6
HGNCiHGNC:24711, MFSD6
HPAiENSG00000151690, Low tissue specificity
MIMi613476, gene
neXtProtiNX_Q6ZSS7
OpenTargetsiENSG00000151690
PharmGKBiPA164722278
VEuPathDBiHostDB:ENSG00000151690.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3762, Eukaryota
GeneTreeiENSGT00530000063599
HOGENOMiCLU_013133_2_0_1
InParanoidiQ6ZSS7
OMAiHSTRVYR
OrthoDBi628784at2759
PhylomeDBiQ6ZSS7
TreeFamiTF314366

Enzyme and pathway databases

PathwayCommonsiQ6ZSS7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54842, 5 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MFSD6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54842
PharosiQ6ZSS7, Tbio

Protein Ontology

More...PROi		PR:Q6ZSS7
RNActiQ6ZSS7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151690, Expressed in middle temporal gyrus and 219 other tissues
ExpressionAtlasiQ6ZSS7, baseline and differential
GenevisibleiQ6ZSS7, HS

Family and domain databases

InterProiView protein in InterPro
IPR024989, MFS_assoc_dom
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF12832, MFS_1_like, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMFSD6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZSS7
Secondary accession number(s): D3KSZ4, Q86TH2, Q9NXM3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 2, 2021
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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