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UniProtKB - Q6ZSJ8 (CA122_HUMAN)

Entry version 110 (10 Feb 2021)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
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Protein

Uncharacterized protein C1orf122

Gene

C1orf122

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZSJ8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C1orf122
Alternative name(s):
Protein ALAESM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C1orf122
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24789, C1orf122

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZSJ8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197982.13

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000197982

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672440

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZSJ8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C1orf122

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541931 – 110Uncharacterized protein C1orf122Add BLAST110

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZSJ8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZSJ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZSJ8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZSJ8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZSJ8

PeptideAtlas

More...PeptideAtlasi		Q6ZSJ8

PRoteomics IDEntifications database

More...PRIDEi		Q6ZSJ8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		22883
68221 [Q6ZSJ8-1]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q6ZSJ8-1 [Q6ZSJ8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZSJ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZSJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197982, Expressed in substantia nigra and 218 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZSJ8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197982, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126077, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZSJ8, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362133

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZSJ8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZSJ8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili36 – 68Sequence analysisAdd BLAST33

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TDYG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00570000079623

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_3175232_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZSJ8

Identification of Orthologs from Complete Genome Data

More...OMAi		AREARPH

Database of Orthologous Groups

More...OrthoDBi		1560404at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031714, DUF4726

The PANTHER Classification System

More...PANTHERi		PTHR41401, PTHR41401, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15855, DUF4726, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZSJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEWGPGSDWS RGEAAGVDRG KAGLGLGGRP PPQPPREERA QQLLDAVEQR 
        60         70         80         90        100
QRQLLDTIAA CEEMLRQLGR RRPEPAGGGN VSAKPGAPPQ PAVSARGGFP 
       110
KDAGDGAAEP
Length:110
Mass (Da):11,471
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC63352FB57850CFE
GO
Isoform 2 (identifier: Q6ZSJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Show »
Length:47
Mass (Da):4,650
Checksum:iB2CDF8E8200DCF93
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH57819 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAC86950 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0466481 – 63Missing in isoform 2. CuratedAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK127381 mRNA Translation: BAC86950.1 Sequence problems.
AY517499 mRNA Translation: AAS76640.1
AL929472 Genomic DNA No translation available.
BC057819 mRNA Translation: AAH57819.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS427.2 [Q6ZSJ8-1]
CCDS44112.1 [Q6ZSJ8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001136198.1, NM_001142726.1 [Q6ZSJ8-2]
NP_940848.2, NM_198446.2 [Q6ZSJ8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373042; ENSP00000362133; ENSG00000197982 [Q6ZSJ8-1]
ENST00000373043; ENSP00000362134; ENSG00000197982 [Q6ZSJ8-2]
ENST00000468084; ENSP00000434520; ENSG00000197982 [Q6ZSJ8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		127687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:127687

UCSC genome browser

More...UCSCi		uc001ccd.3, human [Q6ZSJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127381 mRNA Translation: BAC86950.1 Sequence problems.
AY517499 mRNA Translation: AAS76640.1
AL929472 Genomic DNA No translation available.
BC057819 mRNA Translation: AAH57819.1 Sequence problems.
CCDSiCCDS427.2 [Q6ZSJ8-1]
CCDS44112.1 [Q6ZSJ8-2]
RefSeqiNP_001136198.1, NM_001142726.1 [Q6ZSJ8-2]
NP_940848.2, NM_198446.2 [Q6ZSJ8-1]

3D structure databases

SMRiQ6ZSJ8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126077, 11 interactors
IntActiQ6ZSJ8, 10 interactors
STRINGi9606.ENSP00000362133

PTM databases

iPTMnetiQ6ZSJ8
PhosphoSitePlusiQ6ZSJ8

Genetic variation databases

BioMutaiC1orf122

Proteomic databases

EPDiQ6ZSJ8
jPOSTiQ6ZSJ8
MassIVEiQ6ZSJ8
MaxQBiQ6ZSJ8
PaxDbiQ6ZSJ8
PeptideAtlasiQ6ZSJ8
PRIDEiQ6ZSJ8
ProteomicsDBi22883
68221 [Q6ZSJ8-1]
TopDownProteomicsiQ6ZSJ8-1 [Q6ZSJ8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54370, 51 antibodies

Genome annotation databases

EnsembliENST00000373042; ENSP00000362133; ENSG00000197982 [Q6ZSJ8-1]
ENST00000373043; ENSP00000362134; ENSG00000197982 [Q6ZSJ8-2]
ENST00000468084; ENSP00000434520; ENSG00000197982 [Q6ZSJ8-2]
GeneIDi127687
KEGGihsa:127687
UCSCiuc001ccd.3, human [Q6ZSJ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		127687

GeneCards: human genes, protein and diseases

More...GeneCardsi		C1orf122
HGNCiHGNC:24789, C1orf122
HPAiENSG00000197982, Low tissue specificity
neXtProtiNX_Q6ZSJ8
OpenTargetsiENSG00000197982
PharmGKBiPA142672440
VEuPathDBiHostDB:ENSG00000197982.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502TDYG, Eukaryota
GeneTreeiENSGT00570000079623
HOGENOMiCLU_3175232_0_0_1
InParanoidiQ6ZSJ8
OMAiAREARPH
OrthoDBi1560404at2759

Enzyme and pathway databases

PathwayCommonsiQ6ZSJ8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		127687, 5 hits in 858 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C1orf122, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		127687
PharosiQ6ZSJ8, Tdark

Protein Ontology

More...PROi		PR:Q6ZSJ8
RNActiQ6ZSJ8, protein

Gene expression databases

BgeeiENSG00000197982, Expressed in substantia nigra and 218 other tissues
GenevisibleiQ6ZSJ8, HS

Family and domain databases

InterProiView protein in InterPro
IPR031714, DUF4726
PANTHERiPTHR41401, PTHR41401, 1 hit
PfamiView protein in Pfam
PF15855, DUF4726, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCA122_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZSJ8
Secondary accession number(s): A2RQF4, E9PQ13, Q56A71
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 22, 2009
Last modified: February 10, 2021
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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