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Entry version 136 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Calpain-12

Gene

CAPN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-regulated non-lysosomal thiol-protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei105By similarity1
Active sitei259By similarity1
Active sitei283By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi633 – 644PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZSI9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228, Degradation of the extracellular matrix

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.017

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-12 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 12
Short name:
CANP 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPN12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000182472.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13249, CAPN12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608839, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZSI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
147968

Open Targets

More...
OpenTargetsi
ENSG00000182472

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134863447

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZSI9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAPN12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
54035703

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002077301 – 719Calpain-12Add BLAST719

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZSI9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZSI9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZSI9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZSI9

PeptideAtlas

More...
PeptideAtlasi
Q6ZSI9

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZSI9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68220

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZSI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZSI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182472, Expressed in adult mammalian kidney and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZSI9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZSI9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182472, Tissue enhanced (blood, gallbladder, liver, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6ZSI9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331636

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZSI9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 341Calpain catalyticPROSITE-ProRule annotationAdd BLAST297
Domaini620 – 655EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni342 – 540Domain IIIAdd BLAST199
Regioni541 – 719Domain IVAdd BLAST179

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161901

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010982_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZSI9

KEGG Orthology (KO)

More...
KOi
K04740

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPGQDFQ

Database of Orthologous Groups

More...
OrthoDBi
704215at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZSI9

TreeFam database of animal gene trees

More...
TreeFami
TF314748

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00214, Calpain_III, 1 hit
cd00044, CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033883, C2_III
IPR022684, Calpain_cysteine_protease
IPR022682, Calpain_domain_III
IPR022683, Calpain_III
IPR036213, Calpain_III_sf
IPR029545, CAPN12
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat

The PANTHER Classification System

More...
PANTHERi
PTHR10183:SF280, PTHR10183:SF280, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01067, Calpain_III, 1 hit
PF00648, Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704, CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00720, calpain_III, 1 hit
SM00230, CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS00139, THIOL_PROTEASE_CYS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q6ZSI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSGRVTI QLVDEEAGVG AGRLQLFRGQ SYEAIRAACL DSGILFRDPY
60 70 80 90 100
FPAGPDALGY DQLGPDSEKA KGVKWMRPHE FCAEPKFICE DMSRTDVCQG
110 120 130 140 150
SLGNCWFLAA AASLTLYPRL LRRVVPPGQD FQHGYAGVFH FQLWQFGRWM
160 170 180 190 200
DVVVDDRLPV REGKLMFVRS EQRNEFWAPL LEKAYAKLHG SYEVMRGGHM
210 220 230 240 250
NEAFVDFTGG VGEVLYLRQN SMGLFSALRH ALAKESLVGA TALSDRGEYR
260 270 280 290 300
TEEGLVKGHA YSITGTHKVF LGFTKVRLLR LRNPWGCVEW TGAWSDSCPR
310 320 330 340 350
WDTLPTECRD ALLVKKEDGE FWMELRDFLL HFDTVQICSL SPEVLGPSPE
360 370 380 390 400
GGGWHVHTFQ GRWVRGFNSG GSQPNAETFW TNPQFRLTLL EPDEEDDEDE
410 420 430 440 450
EGPWGGWGAA GARGPARGGR TPKCTVLLSL IQRNRRRLRA KGLTYLTVGF
460 470 480 490 500
HVFQIPEELL GLWDSPRSHA LLPRLLRADR SPLSARRDVT RRCCLRPGHY
510 520 530 540 550
LVVPSTAHAG DEADFTLRVF SERRHTAVEI DDVISADLQS LQGPYLPLEL
560 570 580 590 600
GLEQLFQELA GEEEELNASQ LQALLSIALE PARAHTSTPR EIGLRTCEQL
610 620 630 640 650
LQCFGHGQSL ALHHFQQLWG YLLEWQAIFN KFDEDTSGTM NSYELRLALN
660 670 680 690 700
AAGFHLNNQL TQTLTSRYRD SRLRVDFERF VSCVAHLTCI FCHCSQHLDG
710
GEGVICLTHR QWMEVATFS
Length:719
Mass (Da):81,037
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEACE2E5DD5839F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R3D7M0R3D7_HUMAN
Calpain-12
CAPN12
570Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ20M0QZ20_HUMAN
Calpain-12
CAPN12
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0X4M0R0X4_HUMAN
Calpain-12
CAPN12
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZT6M0QZT6_HUMAN
Calpain-12
CAPN12
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R052M0R052_HUMAN
Calpain-12
CAPN12
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXJ6M0QXJ6_HUMAN
Calpain-12
CAPN12
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051516287C → R. Corresponds to variant dbSNP:rs12983010Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK127398 mRNA Translation: BAC86959.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12519.1

NCBI Reference Sequences

More...
RefSeqi
NP_653292.2, NM_144691.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328867; ENSP00000331636; ENSG00000182472

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
147968

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:147968

UCSC genome browser

More...
UCSCi
uc002ojd.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127398 mRNA Translation: BAC86959.1
CCDSiCCDS12519.1
RefSeqiNP_653292.2, NM_144691.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6ZSI9, 2 interactors
STRINGi9606.ENSP00000331636

Protein family/group databases

MEROPSiC02.017

PTM databases

iPTMnetiQ6ZSI9
PhosphoSitePlusiQ6ZSI9

Polymorphism and mutation databases

BioMutaiCAPN12
DMDMi54035703

Proteomic databases

EPDiQ6ZSI9
MassIVEiQ6ZSI9
MaxQBiQ6ZSI9
PaxDbiQ6ZSI9
PeptideAtlasiQ6ZSI9
PRIDEiQ6ZSI9
ProteomicsDBi68220

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48135, 98 antibodies

The DNASU plasmid repository

More...
DNASUi
147968

Genome annotation databases

EnsembliENST00000328867; ENSP00000331636; ENSG00000182472
GeneIDi147968
KEGGihsa:147968
UCSCiuc002ojd.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
147968
DisGeNETi147968
EuPathDBiHostDB:ENSG00000182472.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CAPN12
HGNCiHGNC:13249, CAPN12
HPAiENSG00000182472, Tissue enhanced (blood, gallbladder, liver, salivary gland)
MIMi608839, gene
neXtProtiNX_Q6ZSI9
OpenTargetsiENSG00000182472
PharmGKBiPA134863447

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0045, Eukaryota
GeneTreeiENSGT00940000161901
HOGENOMiCLU_010982_0_2_1
InParanoidiQ6ZSI9
KOiK04740
OMAiPPGQDFQ
OrthoDBi704215at2759
PhylomeDBiQ6ZSI9
TreeFamiTF314748

Enzyme and pathway databases

PathwayCommonsiQ6ZSI9
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
147968, 7 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CAPN12, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
147968
PharosiQ6ZSI9, Tdark

Protein Ontology

More...
PROi
PR:Q6ZSI9
RNActiQ6ZSI9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182472, Expressed in adult mammalian kidney and 155 other tissues
ExpressionAtlasiQ6ZSI9, baseline and differential
GenevisibleiQ6ZSI9, HS

Family and domain databases

CDDicd00214, Calpain_III, 1 hit
cd00044, CysPc, 1 hit
InterProiView protein in InterPro
IPR033883, C2_III
IPR022684, Calpain_cysteine_protease
IPR022682, Calpain_domain_III
IPR022683, Calpain_III
IPR036213, Calpain_III_sf
IPR029545, CAPN12
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF280, PTHR10183:SF280, 1 hit
PfamiView protein in Pfam
PF01067, Calpain_III, 1 hit
PF00648, Peptidase_C2, 1 hit
PRINTSiPR00704, CALPAIN
SMARTiView protein in SMART
SM00720, calpain_III, 1 hit
SM00230, CysPc, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS00139, THIOL_PROTEASE_CYS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAN12_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZSI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Peptidase families
    Classification of peptidase families and list of entries
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