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UniProtKB - Q6ZSC3 (RBM43_HUMAN)

Entry version 119 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

RNA-binding protein 43

Gene

RBM43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZSC3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 43
Alternative name(s):
RNA-binding motif protein 43
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM43
Synonyms:C2orf38
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24790, RBM43

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZSC3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000184898.6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		375287

Open Targets

More...OpenTargetsi		ENSG00000184898

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162400761

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZSC3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBM43

Domain mapping of disease mutations (DMDM)

More...DMDMi		74711383

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002642471 – 357RNA-binding protein 43Add BLAST357

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZSC3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZSC3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZSC3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZSC3

PeptideAtlas

More...PeptideAtlasi		Q6ZSC3

PRoteomics IDEntifications database

More...PRIDEi		Q6ZSC3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68214

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZSC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZSC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184898, Expressed in female gonad and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZSC3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZSC3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000184898, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131966, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZSC3, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000331211

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZSC3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZSC3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 104RRMPROSITE-ProRule annotationAdd BLAST90

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4012, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063686

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_067477_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZSC3

Identification of Orthologs from Complete Genome Data

More...OMAi		LYLKHKC

Database of Orthologous Groups

More...OrthoDBi		1476205at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZSC3

TreeFam database of animal gene trees

More...TreeFami		TF335737

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034463, RBM43
IPR000504, RRM_dom

The PANTHER Classification System

More...PANTHERi		PTHR15225:SF8, PTHR15225:SF8, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6ZSC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVLNVKES KAPERTVVVA GLPVDLFSDQ LLAVLVKSHF QDIKNEGGDV 
        60         70         80         90        100
EDVIYPTRTK GVAYVIFKEK KVAENVIRQK KHWLARKTRH AELTVSLRVS 
       110        120        130        140        150
HFGDKIFSSV NAILDLSVFG KEVTLETLVK DLKKKIPSLS FSPLKPNGRI 
       160        170        180        190        200
SVEGSFLAVK RLRESLLARA CSLLEKDRNF TSEERKWNRQ NPQRNLQRSN 
       210        220        230        240        250
NSLASVRTLV PETARSGEML VLDTDVFLYL KHKCGSYEST LKKFHILSQE 
       260        270        280        290        300
KVDGEITTIC LKSIQVGSQP NNAKHVKELI EEWSHALYLK LRKETFILEG 
       310        320        330        340        350
KENREKRMIK RACEQLSSRY LEVLINLYRT HIDIIGSSSD TYLFKKGVMK 

LIGQKVS
Length:357
Mass (Da):40,666
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0EEA2B465888036
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZQ2B8ZZQ2_HUMAN
RNA-binding protein 43
RBM43
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033722259I → V. Corresponds to variant dbSNP:rs35749426Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK127552 mRNA Translation: BAC87031.1
CH471058 Genomic DNA Translation: EAX11514.1
BC136410 mRNA Translation: AAI36411.1
BC136411 mRNA Translation: AAI36412.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2191.1

NCBI Reference Sequences

More...RefSeqi		NP_940959.1, NM_198557.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000331426; ENSP00000331211; ENSG00000184898

Database of genes from NCBI RefSeq genomes

More...GeneIDi		375287

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:375287

UCSC genome browser

More...UCSCi		uc002txh.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127552 mRNA Translation: BAC87031.1
CH471058 Genomic DNA Translation: EAX11514.1
BC136410 mRNA Translation: AAI36411.1
BC136411 mRNA Translation: AAI36412.1
CCDSiCCDS2191.1
RefSeqiNP_940959.1, NM_198557.2

3D structure databases

SMRiQ6ZSC3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131966, 8 interactors
IntActiQ6ZSC3, 3 interactors
STRINGi9606.ENSP00000331211

PTM databases

iPTMnetiQ6ZSC3
PhosphoSitePlusiQ6ZSC3

Genetic variation databases

BioMutaiRBM43
DMDMi74711383

Proteomic databases

EPDiQ6ZSC3
jPOSTiQ6ZSC3
MassIVEiQ6ZSC3
PaxDbiQ6ZSC3
PeptideAtlasiQ6ZSC3
PRIDEiQ6ZSC3
ProteomicsDBi68214

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51960, 80 antibodies

Genome annotation databases

EnsembliENST00000331426; ENSP00000331211; ENSG00000184898
GeneIDi375287
KEGGihsa:375287
UCSCiuc002txh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		375287
DisGeNETi375287

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBM43
HGNCiHGNC:24790, RBM43
HPAiENSG00000184898, Low tissue specificity
neXtProtiNX_Q6ZSC3
OpenTargetsiENSG00000184898
PharmGKBiPA162400761
VEuPathDBiHostDB:ENSG00000184898.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4012, Eukaryota
GeneTreeiENSGT00530000063686
HOGENOMiCLU_067477_0_0_1
InParanoidiQ6ZSC3
OMAiLYLKHKC
OrthoDBi1476205at2759
PhylomeDBiQ6ZSC3
TreeFamiTF335737

Enzyme and pathway databases

PathwayCommonsiQ6ZSC3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		375287, 11 hits in 992 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		375287
PharosiQ6ZSC3, Tdark

Protein Ontology

More...PROi		PR:Q6ZSC3
RNActiQ6ZSC3, protein

Gene expression databases

BgeeiENSG00000184898, Expressed in female gonad and 194 other tissues
ExpressionAtlasiQ6ZSC3, baseline and differential
GenevisibleiQ6ZSC3, HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034463, RBM43
IPR000504, RRM_dom
PANTHERiPTHR15225:SF8, PTHR15225:SF8, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM43_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZSC3
Secondary accession number(s): B2RMT5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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