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Protein

Zinc finger and BTB domain-containing protein 49

Gene

ZBTB49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.1 Publication
Isoform 1: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).1 Publication
Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri395 – 417C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processCell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 49
Alternative name(s):
Zinc finger protein 509
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB49
Synonyms:ZNF509
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000168826.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19883 ZBTB49

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616238 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZSB9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000168826

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165664822

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZBTB49

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453078

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476261 – 765Zinc finger and BTB domain-containing protein 49Add BLAST765

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZSB9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZSB9

PeptideAtlas

More...
PeptideAtlasi
Q6ZSB9

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZSB9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68212
68213 [Q6ZSB9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZSB9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZSB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in normal epidermis and in other epithelial tissues, including in colon and lung. Tends to be down-regulated in colon, lung and skin cancer tissues.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by the DNA-damaging agent etoposide. This induction is mediated by TP53 at the transcriptional level.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168826 Expressed in 151 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNF509

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZSB9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZSB9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024450

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with EP300 and KAT5/Tip60. The interaction with EP300 is direct and leads to synergistic induction of CDKN1A. On the CDKN1A promoter, forms a complex with ZBTB17/Miz-1; this interaction leads to additive CDKN1A transactivation. Isoform 3 also interacts with ZBTB17; this interaction may block ZBTB17 repressor activity.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127934, 13 interactors

Protein interaction database and analysis system

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IntActi
Q6ZSB9, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338807

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6ZSB9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZSB9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 91BTBPROSITE-ProRule annotationAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri395 – 417C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158750

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000140405

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG061540

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZSB9

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKLRSMI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02EX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZSB9

TreeFam database of animal gene trees

More...
TreeFami
TF330993

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZSB9-1) [UniParc]FASTAAdd to basket
Also known as: ZNF509L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPVATHSCH LLQQLHEQRI QGLLCDCMLV VKGVCFKAHK NVLAAFSQYF
60 70 80 90 100
RSLFQNSSSQ KNDVFHLDVK NVSGIGQILD FMYTSHLDLN QDNIQVMLDT
110 120 130 140 150
AQCLQVQNVL SLCHTFLKSA TVVQPPGMPC NSTLSLQSTL TPDATCVISE
160 170 180 190 200
NYPPHLLQEC SADAQQNKTL DESHPHASPS VNRHHSAGEI SKQAPDTSDG
210 220 230 240 250
SCTELPFKQP NYYYKLRNFY SKQYHKHAAG PSQERVVEQP FAFSTSTDLT
260 270 280 290 300
TVESQPCAVS HSECILESPE HLPSNFLAQP VNDSAPHPES DATCQQPVKQ
310 320 330 340 350
MRLKKAIHLK KLNFLKSQKY AEQVSEPKSD DGLTKRLESA SKNTLEKASS
360 370 380 390 400
QSAEEKESEE VVSCENFNCI SETERPEDPA ALEDQSQTLQ SQRQYACELC
410 420 430 440 450
GKPFKHPSNL ELHKRSHTGE KPFECNICGK HFSQAGNLQT HLRRHSGEKP
460 470 480 490 500
YICEICGKRF AASGDVQRHI IIHSGEKPHL CDICGRGFSN FSNLKEHKKT
510 520 530 540 550
HTADKVFTCD ECGKSFNMQR KLVKHRIRHT GERPYSCSAC GKCFGGSGDL
560 570 580 590 600
RRHVRTHTGE KPYTCEICNK CFTRSAVLRR HKKMHCKAGD ESPDVLEELS
610 620 630 640 650
QAIETSDLEK SQSSDSFSQD TSVTLMPVSV KLPVHPVENS VAEFDSHSGG
660 670 680 690 700
SYCKLRSMIQ PHGVSDQEKL SLDPGKLAKP QMQQTQPQAY AYSDVDTPAG
710 720 730 740 750
GEPLQADGMA MIRSSLAALD NHGGDPLGSR ASSTTYRNSE GQFFSSMTLW
760
GLAMKTLQNE NELDQ
Length:765
Mass (Da):85,061
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i287EC40D48764399
GO
Isoform 2 (identifier: Q6ZSB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-540: Missing.

Note: No experimental confirmation available.
Show »
Length:643
Mass (Da):71,222
Checksum:iE79A7A702A0B4CED
GO
Isoform 3 (identifier: Q6ZSB9-3) [UniParc]FASTAAdd to basket
Also known as: ZNF509S1

The sequence of this isoform differs from the canonical sequence as follows:
     420-420: E → N
     421-765: Missing.

Show »
Length:420
Mass (Da):46,868
Checksum:i7997383296FA2F67
GO
Isoform 4 (identifier: Q6ZSB9-4) [UniParc]FASTAAdd to basket
Also known as: ZNF509S2

The sequence of this isoform differs from the canonical sequence as follows:
     420-420: E → R
     421-765: Missing.

Show »
Length:420
Mass (Da):46,911
Checksum:i69D7383296FA2F67
GO
Isoform 5 (identifier: Q6ZSB9-5) [UniParc]FASTAAdd to basket
Also known as: ZNF509S3

The sequence of this isoform differs from the canonical sequence as follows:
     460-466: FAASGDV → EMFWGIR
     467-765: Missing.

Show »
Length:466
Mass (Da):52,273
Checksum:i9ACE3214572EDD91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJ00D6RJ00_HUMAN
Zinc finger and BTB domain-containi...
ZBTB49
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC96D6RC96_HUMAN
Zinc finger and BTB domain-containi...
ZBTB49
453Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAD4H0YAD4_HUMAN
Zinc finger and BTB domain-containi...
ZBTB49
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8P2H0Y8P2_HUMAN
Zinc finger and BTB domain-containi...
ZBTB49
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB16D6RB16_HUMAN
Zinc finger and BTB domain-containi...
ZBTB49
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16477 differs from that shown. Reason: Erroneous termination at position 372. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti449K → E in BAC87035 (PubMed:14702039).Curated1
Sequence conflicti506V → I in BAC87035 (PubMed:14702039).Curated1
Sequence conflicti618S → P in BAF85240 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057422320Y → S. Corresponds to variant dbSNP:rs2920217Ensembl.1
Natural variantiVAR_057423348A → T. Corresponds to variant dbSNP:rs4689254Ensembl.1
Natural variantiVAR_073227556T → A1 PublicationCorresponds to variant dbSNP:rs146575965Ensembl.1
Natural variantiVAR_057424642A → V1 PublicationCorresponds to variant dbSNP:rs34293093Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016343419 – 540Missing in isoform 2. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_057623420E → N in isoform 3. 1 Publication1
Alternative sequenceiVSP_057624420E → R in isoform 4. 1 Publication1
Alternative sequenceiVSP_057625421 – 765Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST345
Alternative sequenceiVSP_057626460 – 466FAASGDV → EMFWGIR in isoform 5. 1 Publication7
Alternative sequenceiVSP_057627467 – 765Missing in isoform 5. 1 PublicationAdd BLAST299

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK127560 mRNA Translation: BAC87035.1
AK292551 mRNA Translation: BAF85240.1
AC011744 Genomic DNA No translation available.
AC105415 Genomic DNA No translation available.
BC016477 mRNA Translation: AAH16477.1 Sequence problems.
BC089401 mRNA Translation: AAH89401.1
BC109087 mRNA Translation: AAI09088.1
AB209466 Transcribed RNA Translation: BAD92703.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3375.1 [Q6ZSB9-1]

NCBI Reference Sequences

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RefSeqi
NP_001317554.1, NM_001330625.1 [Q6ZSB9-1]
NP_660334.3, NM_145291.3 [Q6ZSB9-1]
XP_005248008.1, XM_005247951.4 [Q6ZSB9-5]
XP_011511718.1, XM_011513416.1 [Q6ZSB9-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.419997

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000337872; ENSP00000338807; ENSG00000168826 [Q6ZSB9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
166793

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:166793

UCSC genome browser

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UCSCi
uc003ghu.4 human [Q6ZSB9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127560 mRNA Translation: BAC87035.1
AK292551 mRNA Translation: BAF85240.1
AC011744 Genomic DNA No translation available.
AC105415 Genomic DNA No translation available.
BC016477 mRNA Translation: AAH16477.1 Sequence problems.
BC089401 mRNA Translation: AAH89401.1
BC109087 mRNA Translation: AAI09088.1
AB209466 Transcribed RNA Translation: BAD92703.1
CCDSiCCDS3375.1 [Q6ZSB9-1]
RefSeqiNP_001317554.1, NM_001330625.1 [Q6ZSB9-1]
NP_660334.3, NM_145291.3 [Q6ZSB9-1]
XP_005248008.1, XM_005247951.4 [Q6ZSB9-5]
XP_011511718.1, XM_011513416.1 [Q6ZSB9-2]
UniGeneiHs.419997

3D structure databases

ProteinModelPortaliQ6ZSB9
SMRiQ6ZSB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127934, 13 interactors
IntActiQ6ZSB9, 12 interactors
STRINGi9606.ENSP00000338807

PTM databases

iPTMnetiQ6ZSB9
PhosphoSitePlusiQ6ZSB9

Polymorphism and mutation databases

BioMutaiZBTB49
DMDMi296453078

Proteomic databases

MaxQBiQ6ZSB9
PaxDbiQ6ZSB9
PeptideAtlasiQ6ZSB9
PRIDEiQ6ZSB9
ProteomicsDBi68212
68213 [Q6ZSB9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337872; ENSP00000338807; ENSG00000168826 [Q6ZSB9-1]
GeneIDi166793
KEGGihsa:166793
UCSCiuc003ghu.4 human [Q6ZSB9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
166793
EuPathDBiHostDB:ENSG00000168826.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ZBTB49
HGNCiHGNC:19883 ZBTB49
HPAiHPA024450
MIMi616238 gene
neXtProtiNX_Q6ZSB9
OpenTargetsiENSG00000168826
PharmGKBiPA165664822

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000158750
HOGENOMiHOG000140405
HOVERGENiHBG061540
InParanoidiQ6ZSB9
OMAiCKLRSMI
OrthoDBiEOG091G02EX
PhylomeDBiQ6ZSB9
TreeFamiTF330993

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
166793

Protein Ontology

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PROi
PR:Q6ZSB9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168826 Expressed in 151 organ(s), highest expression level in oocyte
CleanExiHS_ZNF509
ExpressionAtlasiQ6ZSB9 baseline and differential
GenevisibleiQ6ZSB9 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBT49_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZSB9
Secondary accession number(s): A8K936
, Q32ML0, Q59FJ4, Q5EBN0, Q8TB80
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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