Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of G-protein signaling 9-binding protein

Gene

RGS9BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processSensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 9-binding protein
Alternative name(s):
RGS9-anchoring protein
Gene namesi
Name:RGS9BP
Synonyms:R9AP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000186326.3
HGNCiHGNC:30304 RGS9BP
MIMi607814 gene
neXtProtiNX_Q6ZS82

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 210CytoplasmicSequence analysisAdd BLAST210
Transmembranei211 – 231Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini232 – 235ExtracellularSequence analysis4

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Prolonged electroretinal response suppression (PERRS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.
See also OMIM:608415

Organism-specific databases

DisGeNETi388531
MalaCardsiRGS9BP
MIMi608415 phenotype
OpenTargetsiENSG00000186326
Orphaneti75374 Bradyopsia
PharmGKBiPA162401280

Polymorphism and mutation databases

BioMutaiRGS9BP
DMDMi74711357

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875861 – 235Regulator of G-protein signaling 9-binding proteinAdd BLAST235

Proteomic databases

EPDiQ6ZS82
PaxDbiQ6ZS82
PeptideAtlasiQ6ZS82
PRIDEiQ6ZS82
ProteomicsDBi68201

PTM databases

iPTMnetiQ6ZS82
PhosphoSitePlusiQ6ZS82

Expressioni

Gene expression databases

BgeeiENSG00000186326 Expressed in 51 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_RGS9BP
GenevisibleiQ6ZS82 HS

Organism-specific databases

HPAiHPA049791

Interactioni

Subunit structurei

Specifically interacts with isoform RGS9-1 of RGS9. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP (By similarity).By similarity

Protein-protein interaction databases

BioGridi132727, 1 interactor
STRINGi9606.ENSP00000334134

Structurei

3D structure databases

ProteinModelPortaliQ6ZS82
SMRiQ6ZS82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 200SNARE-likeBy similarityAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 54Sequence analysisAdd BLAST26
Coiled coili144 – 169Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the RGS7BP/RGS9BP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG6Z Eukaryota
ENOG4111F7N LUCA
GeneTreeiENSGT00390000002155
HOGENOMiHOG000136373
HOVERGENiHBG059498
InParanoidiQ6ZS82
OMAiACYRHLV
OrthoDBiEOG091G0PAA
PhylomeDBiQ6ZS82
TreeFamiTF331562

Family and domain databases

InterProiView protein in InterPro
IPR026512 RGS7BP/RGS9BP
IPR026513 RGS9BP
PANTHERiPTHR21029 PTHR21029, 1 hit
PTHR21029:SF1 PTHR21029:SF1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZS82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAREECKALL DGLNKTTACY HHLVLTVGGS ADSQNLRQEL QKTRQKAQEL
60 70 80 90 100
AVSTCARLTA VLRDRGLAAD ERAEFERLWV AFSGCLDLLE ADMRRALELG
110 120 130 140 150
AAFPLHAPRR PLVRTGVAGA SSGVAARALS TRSLRLEAEG DFDVADLREL
160 170 180 190 200
EREVLQVGEM IDNMEMKVNV PRWTVQARQA AGAELLSTVS AGPSSVVSLQ
210 220 230
ERGGGCDPRK ALAAILFGAV LLAAVALAVC VAKLS
Length:235
Mass (Da):25,148
Last modified:July 5, 2004 - v1
Checksum:i54A3CC6CBACAC014
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03233396A → S1 PublicationCorresponds to variant dbSNP:rs259290EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124499 mRNA Translation: BAC85865.1
AK127646 mRNA Translation: BAC87072.1
CCDSiCCDS12424.1
RefSeqiNP_997274.2, NM_207391.2
UniGeneiHs.528491

Genome annotation databases

EnsembliENST00000334176; ENSP00000334134; ENSG00000186326
GeneIDi388531
KEGGihsa:388531
UCSCiuc002ntp.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124499 mRNA Translation: BAC85865.1
AK127646 mRNA Translation: BAC87072.1
CCDSiCCDS12424.1
RefSeqiNP_997274.2, NM_207391.2
UniGeneiHs.528491

3D structure databases

ProteinModelPortaliQ6ZS82
SMRiQ6ZS82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132727, 1 interactor
STRINGi9606.ENSP00000334134

PTM databases

iPTMnetiQ6ZS82
PhosphoSitePlusiQ6ZS82

Polymorphism and mutation databases

BioMutaiRGS9BP
DMDMi74711357

Proteomic databases

EPDiQ6ZS82
PaxDbiQ6ZS82
PeptideAtlasiQ6ZS82
PRIDEiQ6ZS82
ProteomicsDBi68201

Protocols and materials databases

DNASUi388531
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334176; ENSP00000334134; ENSG00000186326
GeneIDi388531
KEGGihsa:388531
UCSCiuc002ntp.1 human

Organism-specific databases

CTDi388531
DisGeNETi388531
EuPathDBiHostDB:ENSG00000186326.3
GeneCardsiRGS9BP
HGNCiHGNC:30304 RGS9BP
HPAiHPA049791
MalaCardsiRGS9BP
MIMi607814 gene
608415 phenotype
neXtProtiNX_Q6ZS82
OpenTargetsiENSG00000186326
Orphaneti75374 Bradyopsia
PharmGKBiPA162401280
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6Z Eukaryota
ENOG4111F7N LUCA
GeneTreeiENSGT00390000002155
HOGENOMiHOG000136373
HOVERGENiHBG059498
InParanoidiQ6ZS82
OMAiACYRHLV
OrthoDBiEOG091G0PAA
PhylomeDBiQ6ZS82
TreeFamiTF331562

Enzyme and pathway databases

ReactomeiR-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Miscellaneous databases

GenomeRNAii388531
PROiPR:Q6ZS82
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186326 Expressed in 51 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_RGS9BP
GenevisibleiQ6ZS82 HS

Family and domain databases

InterProiView protein in InterPro
IPR026512 RGS7BP/RGS9BP
IPR026513 RGS9BP
PANTHERiPTHR21029 PTHR21029, 1 hit
PTHR21029:SF1 PTHR21029:SF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiR9BP_HUMAN
AccessioniPrimary (citable) accession number: Q6ZS82
Secondary accession number(s): Q6ZVJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again