Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 124 (31 Jul 2019)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Rho family-interacting cell polarization regulator 1

Gene

RIPOR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho family-interacting cell polarization regulator 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIPOR1
Synonyms:FAM65A, KIAA1930
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25836 RIPOR1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZS17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79567

Open Targets

More...
OpenTargetsi
ENSG00000039523

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671875

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RIPOR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74711310

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891101 – 1223Rho family-interacting cell polarization regulator 1Add BLAST1223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei355PhosphothreonineCombined sources1
Modified residuei456PhosphoserineBy similarity1
Modified residuei459PhosphoserineBy similarity1
Modified residuei874PhosphoserineBy similarity1
Modified residuei875PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZS17

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZS17

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZS17

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZS17

PeptideAtlas

More...
PeptideAtlasi
Q6ZS17

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZS17

ProteomicsDB human proteome resource

More...
ProteomicsDBi
19285
68182 [Q6ZS17-1]
68183 [Q6ZS17-2]
68184 [Q6ZS17-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZS17

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZS17

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000039523 Expressed in 213 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZS17 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZS17 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005923

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with RHOA (GTP-bound form); this interaction links active RHOA to STK24 and STK26 kinases (PubMed:27807006).

Interacts with RHOB (PubMed:27807006).

Interacts with RHOC (PubMed:27807006).

Interacts (via C-terminus) with PDCD10; this interaction occurs in a Rho-independent manner (PubMed:27807006).

Interacts (via C-terminus) with STK24; this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006).

Interacts (via C-terminus) with STK26; this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006).

Interacts (via N-terminus) with 14-3-3 proteins; these interactions occur in a Rho-dependent manner (PubMed:27807006).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122715, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZS17, 5 interactors

Molecular INTeraction database

More...
MINTi
Q6ZS17

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000400099

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili89 – 114Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi481 – 767Pro-richAdd BLAST287

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIPOR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGQR Eukaryota
ENOG410ZI73 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153717

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112476

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZS17

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTVFQFW

Database of Orthologous Groups

More...
OrthoDBi
1121546at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZS17

TreeFam database of animal gene trees

More...
TreeFami
TF329332

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR031780 FAM65_N
IPR026136 RIPOR3

The PANTHER Classification System

More...
PANTHERi
PTHR15829 PTHR15829, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15903 PL48, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZS17-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSLSVRPQR RLLSARVNRS QSFAGVLGSH ERGPSLSFRS FPVFSPPGPP
60 70 80 90 100
RKPPALSRVS RMFSVAHPAA KVPQPERLDL VYTALKRGLT AYLEVHQQEQ
110 120 130 140 150
EKLQGQIRES KRNSRLGFLY DLDKQVKSIE RFLRRLEFHA SKIDELYEAY
160 170 180 190 200
CVQRRLRDGA YNMVRAYTTG SPGSREARDS LAEATRGHRE YTESMCLLES
210 220 230 240 250
ELEAQLGEFH LRMKGLAGFA RLCVGDQYEI CMKYGRQRWK LRGRIEGSGK
260 270 280 290 300
QVWDSEETIF LPLLTEFLSI KVTELKGLAN HVVVGSVSCE TKDLFAALPQ
310 320 330 340 350
VVAVDINDLG TIKLSLEVTW SPFDKDDQPS AASSVNKAST VTKRFSTYSQ
360 370 380 390 400
SPPDTPSLRE QAFYNMLRRQ EELENGTAWS LSSESSDDSS SPQLSGTARH
410 420 430 440 450
SPAPRPLVQQ PEPLPIQVAF RRPETPSSGP LDEEGAVAPV LANGHAPYSR
460 470 480 490 500
TLSHISEASV DAALAEASVE AVGPESLAWG PSPPTHPAPT HGEHPSPVPP
510 520 530 540 550
ALDPGHSATS STLGTTGSVP TSTDPAPSAH LDSVHKSTDS GPSELPGPTH
560 570 580 590 600
TTTGSTYSAI TTTHSAPSPL THTTTGSTHK PIISTLTTTG PTLNIIGPVQ
610 620 630 640 650
TTTSPTHTMP SPTHTTASPT HTSTSPTHTP TSPTHKTSMS PPTTTSPTPS
660 670 680 690 700
GMGLVQTATS PTHPTTSPTH PTTSPILINV SPSTSLELAT LSSPSKHSDP
710 720 730 740 750
TLPGTDSLPC SPPVSNSYTQ ADPMAPRTPH PSPAHSSRKP LTSPAPDPSE
760 770 780 790 800
STVQSLSPTP SPPTPAPQHS DLCLAMAVQT PVPTAAGGSG DRSLEEALGA
810 820 830 840 850
LMAALDDYRG QFPELQGLEQ EVTRLESLLM QRQGLTRSRA SSLSITVEHA
860 870 880 890 900
LESFSFLNED EDEDNDVPGD RPPSSPEAGA EDSIDSPSAR PLSTGCPALD
910 920 930 940 950
AALVRHLYHC SRLLLKLGTF GPLRCQEAWA LERLLREARV LEAVCEFSRR
960 970 980 990 1000
WEIPASSAQE VVQFSASRPG FLTFWDQCTE RLSCFLCPVE RVLLTFCNQY
1010 1020 1030 1040 1050
GARLSLRQPG LAEAVCVKFL EDALGQKLPR RPQPGPGEQL TVFQFWSFVE
1060 1070 1080 1090 1100
TLDSPTMEAY VTETAEEVLL VRNLNSDDQA VVLKALRLAP EGRLRRDGLR
1110 1120 1130 1140 1150
ALSSLLVHGN NKVMAAVSTQ LRSLSLGPTF RERALLCFLD QLEDEDVQTR
1160 1170 1180 1190 1200
VAGCLALGCI KAPEGIEPLV YLCQTDTEAV REAARQSLQQ CGEEGQSAHR
1210 1220
RLEESLDALP RIFGPGSMAS TAF
Length:1,223
Mass (Da):132,308
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C6C9A387E93DEC7
GO
Isoform 2 (identifier: Q6ZS17-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-38: Missing.

Show »
Length:1,219
Mass (Da):131,873
Checksum:i200460D45BD48AF9
GO
Isoform 3 (identifier: Q6ZS17-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNTKKRGSPARTHSM
     35-38: Missing.

Note: No experimental confirmation available.
Show »
Length:1,233
Mass (Da):133,426
Checksum:i478DD57FEC6CB7F6
GO
Isoform 4 (identifier: Q6ZS17-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTIWQMQKQAQRGSPARTHSM
     35-38: Missing.

Note: No experimental confirmation available.
Show »
Length:1,239
Mass (Da):134,198
Checksum:iB250037B6F22D2C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMG9H3BMG9_HUMAN
Rho family-interacting cell polariz...
RIPOR1
589Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTL6A0A0A0MTL6_HUMAN
Rho family-interacting cell polariz...
RIPOR1
1,238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSV5H3BSV5_HUMAN
Rho family-interacting cell polariz...
RIPOR1
627Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQI5H3BQI5_HUMAN
Rho family-interacting cell polariz...
RIPOR1
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU12H3BU12_HUMAN
Rho family-interacting cell polariz...
RIPOR1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUP6H3BUP6_HUMAN
Rho family-interacting cell polariz...
RIPOR1
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS40H3BS40_HUMAN
Rho family-interacting cell polariz...
RIPOR1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV02H3BV02_HUMAN
Rho family-interacting cell polariz...
RIPOR1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BP86H3BP86_HUMAN
Rho family-interacting cell polariz...
RIPOR1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSX9H3BSX9_HUMAN
Rho family-interacting cell polariz...
RIPOR1
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14678 differs from that shown. Reason: Erroneous termination at position 256. Translated as Glu.Curated
The sequence BAB67823 differs from that shown. Reason: Frameshift at position 579.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152V → A in BAG57170 (PubMed:14702039).Curated1
Sequence conflicti653G → S in BAB14678 (PubMed:14702039).Curated1
Sequence conflicti766A → T in BAG57170 (PubMed:14702039).Curated1
Sequence conflicti831Missing in BAB67823 (PubMed:11572484).Curated1
Sequence conflicti1012A → T in BAB14678 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0433151M → MNTKKRGSPARTHSM in isoform 3. 1 Publication1
Alternative sequenceiVSP_0450021M → MTIWQMQKQAQRGSPARTHS M in isoform 4. 1 Publication1
Alternative sequenceiVSP_02590335 – 38Missing in isoform 2, isoform 3 and isoform 4. 2 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023787 mRNA Translation: BAB14678.1 Sequence problems.
AK293748 mRNA Translation: BAG57170.1
AK295677 mRNA Translation: BAG58534.1
AC027682 Genomic DNA No translation available.
AK127792 mRNA Translation: BAC87139.1
AB067517 mRNA Translation: BAB67823.1 Frameshift.
BC001850 mRNA Translation: AAH01850.3
BC054512 mRNA Translation: AAH54512.1
BC098587 mRNA Translation: AAH98587.1
AL834312 mRNA Translation: CAD38982.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10840.1 [Q6ZS17-2]
CCDS54026.1 [Q6ZS17-4]
CCDS54027.1 [Q6ZS17-3]
CCDS54028.1 [Q6ZS17-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001180451.1, NM_001193522.1 [Q6ZS17-1]
NP_001180452.1, NM_001193523.1 [Q6ZS17-4]
NP_001180453.1, NM_001193524.1 [Q6ZS17-3]
NP_078795.2, NM_024519.3 [Q6ZS17-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000042381; ENSP00000042381; ENSG00000039523 [Q6ZS17-2]
ENST00000379312; ENSP00000368614; ENSG00000039523 [Q6ZS17-1]
ENST00000422602; ENSP00000400099; ENSG00000039523 [Q6ZS17-4]
ENST00000428437; ENSP00000389456; ENSG00000039523 [Q6ZS17-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79567

UCSC genome browser

More...
UCSCi
uc002eth.4 human [Q6ZS17-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023787 mRNA Translation: BAB14678.1 Sequence problems.
AK293748 mRNA Translation: BAG57170.1
AK295677 mRNA Translation: BAG58534.1
AC027682 Genomic DNA No translation available.
AK127792 mRNA Translation: BAC87139.1
AB067517 mRNA Translation: BAB67823.1 Frameshift.
BC001850 mRNA Translation: AAH01850.3
BC054512 mRNA Translation: AAH54512.1
BC098587 mRNA Translation: AAH98587.1
AL834312 mRNA Translation: CAD38982.1
CCDSiCCDS10840.1 [Q6ZS17-2]
CCDS54026.1 [Q6ZS17-4]
CCDS54027.1 [Q6ZS17-3]
CCDS54028.1 [Q6ZS17-1]
RefSeqiNP_001180451.1, NM_001193522.1 [Q6ZS17-1]
NP_001180452.1, NM_001193523.1 [Q6ZS17-4]
NP_001180453.1, NM_001193524.1 [Q6ZS17-3]
NP_078795.2, NM_024519.3 [Q6ZS17-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122715, 7 interactors
IntActiQ6ZS17, 5 interactors
MINTiQ6ZS17
STRINGi9606.ENSP00000400099

PTM databases

iPTMnetiQ6ZS17
PhosphoSitePlusiQ6ZS17

Polymorphism and mutation databases

BioMutaiRIPOR1
DMDMi74711310

Proteomic databases

EPDiQ6ZS17
jPOSTiQ6ZS17
MaxQBiQ6ZS17
PaxDbiQ6ZS17
PeptideAtlasiQ6ZS17
PRIDEiQ6ZS17
ProteomicsDBi19285
68182 [Q6ZS17-1]
68183 [Q6ZS17-2]
68184 [Q6ZS17-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79567
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000042381; ENSP00000042381; ENSG00000039523 [Q6ZS17-2]
ENST00000379312; ENSP00000368614; ENSG00000039523 [Q6ZS17-1]
ENST00000422602; ENSP00000400099; ENSG00000039523 [Q6ZS17-4]
ENST00000428437; ENSP00000389456; ENSG00000039523 [Q6ZS17-3]
GeneIDi79567
KEGGihsa:79567
UCSCiuc002eth.4 human [Q6ZS17-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79567
DisGeNETi79567

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RIPOR1
HGNCiHGNC:25836 RIPOR1
HPAiHPA005923
neXtProtiNX_Q6ZS17
OpenTargetsiENSG00000039523
PharmGKBiPA142671875

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGQR Eukaryota
ENOG410ZI73 LUCA
GeneTreeiENSGT00940000153717
HOGENOMiHOG000112476
InParanoidiQ6ZS17
OMAiLTVFQFW
OrthoDBi1121546at2759
PhylomeDBiQ6ZS17
TreeFamiTF329332

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM65A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79567

Protein Ontology

More...
PROi
PR:Q6ZS17

Gene expression databases

BgeeiENSG00000039523 Expressed in 213 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ6ZS17 baseline and differential
GenevisibleiQ6ZS17 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR031780 FAM65_N
IPR026136 RIPOR3
PANTHERiPTHR15829 PTHR15829, 1 hit
PfamiView protein in Pfam
PF15903 PL48, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIPR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZS17
Secondary accession number(s): B4DEQ9
, B4DIM2, E9PBS3, Q4G0A4, Q7Z5R7, Q8NDA4, Q96J39, Q96PV8, Q9H8D9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: July 31, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again