UniProtKB - Q6ZS10 (CL17A_HUMAN)
Protein
C-type lectin domain family 17, member A
Gene
CLEC17A
Organism
Homo sapiens (Human)
Status
Functioni
Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 341 | CalciumBy similarity | 1 | |
Metal bindingi | 343 | CalciumBy similarity | 1 | |
Metal bindingi | 348 | CalciumBy similarity | 1 | |
Metal bindingi | 360 | CalciumBy similarity | 1 | |
Metal bindingi | 361 | CalciumBy similarity | 1 |
GO - Molecular functioni
- fucose binding Source: UniProtKB
- identical protein binding Source: IntAct
- mannose binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Receptor |
Ligand | Calcium, Lectin, Mannose-binding, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6ZS10 |
Names & Taxonomyi
Protein namesi | Recommended name: C-type lectin domain family 17, member AAlternative name(s): Prolectin |
Gene namesi | Name:CLEC17A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187912.11 |
HGNCi | HGNC:34520, CLEC17A |
MIMi | 616838, gene |
neXtProti | NX_Q6ZS10 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Note: In fibroblasts, expressed on the cell surface.1 Publication
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 172 | CytoplasmicSequence analysisAdd BLAST | 172 | |
Transmembranei | 173 – 193 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 194 – 378 | ExtracellularSequence analysisAdd BLAST | 185 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 388512 |
OpenTargetsi | ENSG00000187912 |
PharmGKBi | PA164717947 |
Miscellaneous databases
Pharosi | Q6ZS10, Tbio |
Polymorphism and mutation databases
BioMutai | CLEC17A |
DMDMi | 300669632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319428 | 1 – 378 | C-type lectin domain family 17, member AAdd BLAST | 378 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 237 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 254 ↔ 265 | PROSITE-ProRule annotation | ||
Disulfide bondi | 282 ↔ 372 | PROSITE-ProRule annotation | ||
Glycosylationi | 285 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 350 ↔ 364 | PROSITE-ProRule annotation |
Post-translational modificationi
Phosphorylated on tyrosine residues.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q6ZS10 |
PaxDbi | Q6ZS10 |
PeptideAtlasi | Q6ZS10 |
PRIDEi | Q6ZS10 |
ProteomicsDBi | 68178 [Q6ZS10-1] 68179 [Q6ZS10-2] 68180 [Q6ZS10-3] |
PTM databases
GlyGeni | Q6ZS10, 3 sites |
iPTMneti | Q6ZS10 |
PhosphoSitePlusi | Q6ZS10 |
Expressioni
Tissue specificityi
Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen.1 Publication
Gene expression databases
Bgeei | ENSG00000187912, Expressed in tonsil and 79 other tissues |
ExpressionAtlasi | Q6ZS10, baseline and differential |
Organism-specific databases
HPAi | ENSG00000187912, Group enriched (blood, intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Oligomer; disulfide-linked.
1 PublicationBinary interactionsi
Hide detailsQ6ZS10
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 132718, 23 interactors |
IntActi | Q6ZS10, 21 interactors |
STRINGi | 9606.ENSP00000393719 |
Miscellaneous databases
RNActi | Q6ZS10, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 261 – 373 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 113 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 22 | Poly-Glu | 5 | |
Compositional biasi | 44 – 48 | Poly-Glu | 5 | |
Compositional biasi | 70 – 74 | Poly-Glu | 5 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000163153 |
HOGENOMi | CLU_063069_0_0_1 |
InParanoidi | Q6ZS10 |
OMAi | EEDCASM |
OrthoDBi | 985894at2759 |
PhylomeDBi | Q6ZS10 |
TreeFami | TF343491 |
Family and domain databases
CDDi | cd03590, CLECT_DC-SIGN_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033989, CD209-like_CTLD IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZS10-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHNLYSITGY PDPPGTMEEE EEDDDYENST PPYKDLPPKP GTMEEEEEDD
60 70 80 90 100
DYENSTPPYK DLPPKPGTME EEEEDDDYEN STPPYKDLPP KPGSSAPPRP
110 120 130 140 150
PRAAKETEKP PLPCKPRNMT GLDLAAVTCP PPQLAVNLEP SPLQPSLAAT
160 170 180 190 200
PVPWLNQRSG GPGCCQKRWM VYLCLLVVTS LFLGCLGLTV TLIKYQELME
210 220 230 240 250
ELRMLSFQQM TWRTNMTGMA GLAGLKHDIA RVRADTNQSL VELWGLLDCR
260 270 280 290 300
RITCPEGWLP FEGKCYYFSP STKSWDEARM FCQENYSHLV IINSFAEHNF
310 320 330 340 350
VAKAHGSPRV YWLGLNDRAQ EGDWRWLDGS PVTLSFWEPE EPNNIHDEDC
360 370
ATMNKGGTWN DLSCYKTTYW ICERKCSC
Isoform 2 (identifier: Q6ZS10-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
248-265: DCRRITCPEGWLPFEGKC → EFCGQGPWLSTGVLAGAE
266-378: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8W1T8 | F8W1T8_HUMAN | C-type lectin domain family 17, mem... | CLEC17A | 227 | Annotation score: |
Sequence cautioni
The sequence EAW84437 differs from that shown. Reason: Erroneous gene model prediction.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039405 | 248 – 265 | DCRRI…FEGKC → EFCGQGPWLSTGVLAGAE in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_039406 | 266 – 378 | Missing in isoform 2. 1 PublicationAdd BLAST | 113 | |
Alternative sequenceiVSP_039407 | 299 – 306 | NFVAKAHG → LLGARGTQ in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_039408 | 307 – 378 | Missing in isoform 3. 1 PublicationAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK127809 mRNA Translation: BAC87146.1 AC010527 Genomic DNA No translation available. AC140008 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84437.1 Sequence problems. BC140848 mRNA Translation: AAI40849.1 BC144665 mRNA Translation: AAI44666.1 |
CCDSi | CCDS46002.2 [Q6ZS10-3] CCDS56087.1 [Q6ZS10-1] |
RefSeqi | NP_001191047.1, NM_001204118.1 [Q6ZS10-1] NP_997273.3, NM_207390.3 [Q6ZS10-3] |
Genome annotation databases
Ensembli | ENST00000339847; ENSP00000341620; ENSG00000187912 [Q6ZS10-2] ENST00000417570; ENSP00000393719; ENSG00000187912 [Q6ZS10-1] ENST00000547437; ENSP00000450065; ENSG00000187912 [Q6ZS10-3] |
GeneIDi | 388512 |
KEGGi | hsa:388512 |
UCSCi | uc010dzn.3, human [Q6ZS10-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK127809 mRNA Translation: BAC87146.1 AC010527 Genomic DNA No translation available. AC140008 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84437.1 Sequence problems. BC140848 mRNA Translation: AAI40849.1 BC144665 mRNA Translation: AAI44666.1 |
CCDSi | CCDS46002.2 [Q6ZS10-3] CCDS56087.1 [Q6ZS10-1] |
RefSeqi | NP_001191047.1, NM_001204118.1 [Q6ZS10-1] NP_997273.3, NM_207390.3 [Q6ZS10-3] |
3D structure databases
SMRi | Q6ZS10 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132718, 23 interactors |
IntActi | Q6ZS10, 21 interactors |
STRINGi | 9606.ENSP00000393719 |
PTM databases
GlyGeni | Q6ZS10, 3 sites |
iPTMneti | Q6ZS10 |
PhosphoSitePlusi | Q6ZS10 |
Polymorphism and mutation databases
BioMutai | CLEC17A |
DMDMi | 300669632 |
Proteomic databases
MassIVEi | Q6ZS10 |
PaxDbi | Q6ZS10 |
PeptideAtlasi | Q6ZS10 |
PRIDEi | Q6ZS10 |
ProteomicsDBi | 68178 [Q6ZS10-1] 68179 [Q6ZS10-2] 68180 [Q6ZS10-3] |
Protocols and materials databases
Antibodypediai | 50548, 52 antibodies |
Genome annotation databases
Ensembli | ENST00000339847; ENSP00000341620; ENSG00000187912 [Q6ZS10-2] ENST00000417570; ENSP00000393719; ENSG00000187912 [Q6ZS10-1] ENST00000547437; ENSP00000450065; ENSG00000187912 [Q6ZS10-3] |
GeneIDi | 388512 |
KEGGi | hsa:388512 |
UCSCi | uc010dzn.3, human [Q6ZS10-1] |
Organism-specific databases
CTDi | 388512 |
DisGeNETi | 388512 |
EuPathDBi | HostDB:ENSG00000187912.11 |
GeneCardsi | CLEC17A |
HGNCi | HGNC:34520, CLEC17A |
HPAi | ENSG00000187912, Group enriched (blood, intestine, lymphoid tissue) |
MIMi | 616838, gene |
neXtProti | NX_Q6ZS10 |
OpenTargetsi | ENSG00000187912 |
PharmGKBi | PA164717947 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000163153 |
HOGENOMi | CLU_063069_0_0_1 |
InParanoidi | Q6ZS10 |
OMAi | EEDCASM |
OrthoDBi | 985894at2759 |
PhylomeDBi | Q6ZS10 |
TreeFami | TF343491 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZS10 |
Miscellaneous databases
BioGRID-ORCSi | 388512, 3 hits in 839 CRISPR screens |
GenomeRNAii | 388512 |
Pharosi | Q6ZS10, Tbio |
PROi | PR:Q6ZS10 |
RNActi | Q6ZS10, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187912, Expressed in tonsil and 79 other tissues |
ExpressionAtlasi | Q6ZS10, baseline and differential |
Family and domain databases
CDDi | cd03590, CLECT_DC-SIGN_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033989, CD209-like_CTLD IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CL17A_HUMAN | |
Accessioni | Q6ZS10Primary (citable) accession number: Q6ZS10 Secondary accession number(s): A8MX68, B2RTX0, B7ZMM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | July 13, 2010 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM