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UniProtKB - Q6ZRY4 (RBPS2_HUMAN)

Entry version 135 (23 Feb 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

RNA-binding protein with multiple splicing 2

Gene

RBPMS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856).

Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZRY4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6ZRY4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein with multiple splicing 2
Alternative name(s):
RNA binding protein, mRNA processing factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBPMS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19098, RBPMS2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		619034, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZRY4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166831

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49L → E: Strongly reduces homodimerization and interaction with EEF2. Strongly reduces NOG mRNA binding. Loss of function in gastrointestinal smooth muscle cell differentiation. 1 Publication1
Mutagenesisi49L → Q: No effect on homodimerization. No effect on function in gastrointestinal smooth muscle cell differentiation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		348093

Open Targets

More...OpenTargetsi		ENSG00000166831

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134871904

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZRY4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBPMS2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762401

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002749092 – 209RNA-binding protein with multiple splicing 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZRY4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZRY4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZRY4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZRY4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZRY4

PeptideAtlas

More...PeptideAtlasi		Q6ZRY4

PRoteomics IDEntifications database

More...PRIDEi		Q6ZRY4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		467
68173 [Q6ZRY4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZRY4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZRY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166831, Expressed in cardiac muscle of right atrium and 168 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZRY4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166831, Tissue enhanced (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:25064856).

Interacts with EEF2 (PubMed:25064856).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q6ZRY4
With#Exp.IntAct
AOC1 [P19801]3EBI-11987469,EBI-12826295
ARID5A [Q03989]3EBI-11987469,EBI-948603
BHLHE40 [O14503]3EBI-11987469,EBI-711810
BOLL - isoform 4 [Q8N9W6-4]3EBI-11987469,EBI-11983447
C10orf55 [Q5SWW7]3EBI-11987469,EBI-12809220
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-11987469,EBI-11976299
CAMK2A [Q9UQM7]3EBI-11987469,EBI-1383687
CBX2 - isoform 2 [Q14781-2]3EBI-11987469,EBI-11974585
CELF4 - isoform 2 [Q9BZC1-2]3EBI-11987469,EBI-12818201
DND1 [Q8IYX4]3EBI-11987469,EBI-12071340
ESRP1 [Q6NXG1]3EBI-11987469,EBI-10213520
FAM168A - isoform 2 [Q92567-2]3EBI-11987469,EBI-11978259
FOXD4L1 [Q9NU39]4EBI-11987469,EBI-11320806
FOXD4L3 [Q6VB84]3EBI-11987469,EBI-11961494
FOXH1 [O75593]3EBI-11987469,EBI-1759806
FUBP3 - isoform 2 [Q96I24-2]3EBI-11987469,EBI-12267436
HNRNPC [P07910]3EBI-11987469,EBI-357966
HNRNPK - isoform 2 [P61978-2]3EBI-11987469,EBI-7060731
HNRNPU - isoform 2 [Q00839-2]3EBI-11987469,EBI-351143
IFIT2 [Q8IZ03]3EBI-11987469,EBI-746217
KLF1 [Q13351]3EBI-11987469,EBI-8284732
KLHDC7B [Q96G42]3EBI-11987469,EBI-9478422
KRTAP11-1 [Q8IUC1]3EBI-11987469,EBI-1052037
KRTAP19-5 [Q3LI72]3EBI-11987469,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-11987469,EBI-12805508
KRTAP19-7 [Q3SYF9]3EBI-11987469,EBI-10241353
KRTAP6-1 [Q3LI64]3EBI-11987469,EBI-12111050
KRTAP6-2 [Q3LI66]3EBI-11987469,EBI-11962084
KRTAP8-1 [Q8IUC2]5EBI-11987469,EBI-10261141
LASP1 - isoform 2 [Q14847-2]3EBI-11987469,EBI-9088686
MAGED1 [Q9Y5V3]3EBI-11987469,EBI-716006
MKRN3 [Q13064]3EBI-11987469,EBI-2340269
MSX2 [P35548]3EBI-11987469,EBI-6447480
MYPOP [Q86VE0]3EBI-11987469,EBI-2858213
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-11987469,EBI-11022007
PCBP1 [Q15365]4EBI-11987469,EBI-946095
PPP1R37 [O75864]3EBI-11987469,EBI-5235692
PRR20D [P86480]3EBI-11987469,EBI-12754095
PTBP2 - isoform 2 [Q9UKA9-2]3EBI-11987469,EBI-12255608
RALY [Q53GL6]3EBI-11987469,EBI-9512693
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-11987469,EBI-12123390
RBFOX2 - isoform 10 [O43251-10]5EBI-11987469,EBI-11963050
RBM3 [P98179]3EBI-11987469,EBI-2949699
RBM41 [Q96IZ5]3EBI-11987469,EBI-740773
RBM42 [Q9BTD8]3EBI-11987469,EBI-746862
RBM46 [Q8TBY0]3EBI-11987469,EBI-12068216
RBPMS - isoform C [Q93062-3]3EBI-11987469,EBI-740343
itself3EBI-11987469,EBI-11987469
RHOXF2 [Q9BQY4]3EBI-11987469,EBI-372094
SEMA3B - isoform 2 [Q13214-2]3EBI-11987469,EBI-11017428
SNRPA [P09012]6EBI-11987469,EBI-607085
STRBP [Q96SI9]3EBI-11987469,EBI-740355
TENT5B [Q96A09]3EBI-11987469,EBI-752030
TEX37 [Q96LM6]3EBI-11987469,EBI-743976
TIAL1 - isoform 2 [Q01085-2]3EBI-11987469,EBI-11064654
UFSP1 [Q6NVU6]3EBI-11987469,EBI-12068150
UNC119 [Q13432]3EBI-11987469,EBI-711260
USP54 - isoform 6 [Q70EL1-9]3EBI-11987469,EBI-11975223
VPS37C [A5D8V6]3EBI-11987469,EBI-2559305
ZBTB32 [A0A0C4DGF1]3EBI-11987469,EBI-10188476
ZC3H10 [Q96K80]3EBI-11987469,EBI-742550
ZMAT5 [Q9UDW3]3EBI-11987469,EBI-7850213
ZNF385C - isoform 2 [Q66K41-2]3EBI-11987469,EBI-12055653

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131505, 82 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZRY4, 66 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000300069

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZRY4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q6ZRY4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZRY4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 108RRMPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni41 – 51Important for homodimerization1 PublicationAdd BLAST11

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1457, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158086

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_099973_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZRY4

Identification of Orthologs from Complete Genome Data

More...OMAi		HAQMRWF

Database of Orthologous Groups

More...OrthoDBi		1368991at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZRY4

TreeFam database of animal gene trees

More...TreeFami		TF351070

Family and domain databases

Conserved Domains Database

More...CDDi		cd12683, RRM_RBPMS2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034787, RBPMS2_RRM
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZRY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNLKPDGEH GGSTGTGSGA GSGGALEEEV RTLFVSGLPV DIKPRELYLL 
        60         70         80         90        100
FRPFKGYEGS LIKLTARQPV GFVIFDSRAG AEAAKNALNG IRFDPENPQT 
       110        120        130        140        150
LRLEFAKANT KMAKSKLMAT PNPSNVHPAL GAHFIARDPY DLMGAALIPA 
       160        170        180        190        200
SPEAWAPYPL YTTELTPAIS HAAFTYPTAT AAAAALHAQV RWYPSSDTTQ 

QGWKYRQFC
Length:209
Mass (Da):22,497
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7924D0CD3AD860C
GO
Isoform 2 (identifier: Q6ZRY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:98
Mass (Da):10,663
Checksum:i007A855887EAD5C4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0568961 – 111Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY369207 mRNA Translation: AAQ73311.1
AK127873 mRNA Translation: BAC87172.1
AC091582 Genomic DNA No translation available.
AC100830 Genomic DNA No translation available.
BC131612 mRNA Translation: AAI31613.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32271.1 [Q6ZRY4-1]

NCBI Reference Sequences

More...RefSeqi		NP_919248.1, NM_194272.2 [Q6ZRY4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000300069; ENSP00000300069; ENSG00000166831
ENST00000560606; ENSP00000456720; ENSG00000166831 [Q6ZRY4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		348093

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:348093

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000300069.5; ENSP00000300069.4; NM_194272.3; NP_919248.1

UCSC genome browser

More...UCSCi		uc002anq.4, human [Q6ZRY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY369207 mRNA Translation: AAQ73311.1
AK127873 mRNA Translation: BAC87172.1
AC091582 Genomic DNA No translation available.
AC100830 Genomic DNA No translation available.
BC131612 mRNA Translation: AAI31613.1
CCDSiCCDS32271.1 [Q6ZRY4-1]
RefSeqiNP_919248.1, NM_194272.2 [Q6ZRY4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9KNMR-A/B27-117[»]
BMRBiQ6ZRY4
SMRiQ6ZRY4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi131505, 82 interactors
IntActiQ6ZRY4, 66 interactors
STRINGi9606.ENSP00000300069

PTM databases

iPTMnetiQ6ZRY4
PhosphoSitePlusiQ6ZRY4

Genetic variation databases

BioMutaiRBPMS2
DMDMi74762401

Proteomic databases

EPDiQ6ZRY4
jPOSTiQ6ZRY4
MassIVEiQ6ZRY4
MaxQBiQ6ZRY4
PaxDbiQ6ZRY4
PeptideAtlasiQ6ZRY4
PRIDEiQ6ZRY4
ProteomicsDBi467
68173 [Q6ZRY4-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25848, 92 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		348093

Genome annotation databases

EnsembliENST00000300069; ENSP00000300069; ENSG00000166831
ENST00000560606; ENSP00000456720; ENSG00000166831 [Q6ZRY4-2]
GeneIDi348093
KEGGihsa:348093
MANE-SelectiENST00000300069.5; ENSP00000300069.4; NM_194272.3; NP_919248.1
UCSCiuc002anq.4, human [Q6ZRY4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		348093
DisGeNETi348093

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBPMS2
HGNCiHGNC:19098, RBPMS2
HPAiENSG00000166831, Tissue enhanced (heart)
MIMi619034, gene
neXtProtiNX_Q6ZRY4
OpenTargetsiENSG00000166831
PharmGKBiPA134871904
VEuPathDBiHostDB:ENSG00000166831

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1457, Eukaryota
GeneTreeiENSGT00940000158086
HOGENOMiCLU_099973_3_0_1
InParanoidiQ6ZRY4
OMAiHAQMRWF
OrthoDBi1368991at2759
PhylomeDBiQ6ZRY4
TreeFamiTF351070

Enzyme and pathway databases

PathwayCommonsiQ6ZRY4
SignaLinkiQ6ZRY4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		348093, 11 hits in 1039 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RBPMS2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		348093
PharosiQ6ZRY4, Tbio

Protein Ontology

More...PROi		PR:Q6ZRY4
RNActiQ6ZRY4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166831, Expressed in cardiac muscle of right atrium and 168 other tissues
GenevisibleiQ6ZRY4, HS

Family and domain databases

CDDicd12683, RRM_RBPMS2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034787, RBPMS2_RRM
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBPS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZRY4
Secondary accession number(s): A2RRG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: February 23, 2022
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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