UniProtKB - Q6ZRY4 (RBPS2_HUMAN)
RNA-binding protein with multiple splicing 2
RBPMS2
Functioni
RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856).
Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity).
By similarity1 PublicationGO - Molecular functioni
- identical protein binding Source: IntAct
- mRNA binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- embryonic digestive tract morphogenesis Source: UniProtKB
- negative regulation of BMP signaling pathway Source: UniProtKB
- negative regulation of smooth muscle cell differentiation Source: UniProtKB
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6ZRY4 |
SignaLinki | Q6ZRY4 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein with multiple splicing 2Alternative name(s): RNA binding protein, mRNA processing factor 2 |
Gene namesi | Name:RBPMS2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19098, RBPMS2 |
MIMi | 619034, gene |
neXtProti | NX_Q6ZRY4 |
VEuPathDBi | HostDB:ENSG00000166831 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 49 | L → E: Strongly reduces homodimerization and interaction with EEF2. Strongly reduces NOG mRNA binding. Loss of function in gastrointestinal smooth muscle cell differentiation. 1 Publication | 1 | |
Mutagenesisi | 49 | L → Q: No effect on homodimerization. No effect on function in gastrointestinal smooth muscle cell differentiation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 348093 |
OpenTargetsi | ENSG00000166831 |
PharmGKBi | PA134871904 |
Miscellaneous databases
Pharosi | Q6ZRY4, Tbio |
Genetic variation databases
BioMutai | RBPMS2 |
DMDMi | 74762401 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000274909 | 2 – 209 | RNA-binding protein with multiple splicing 2Add BLAST | 208 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q6ZRY4 |
jPOSTi | Q6ZRY4 |
MassIVEi | Q6ZRY4 |
MaxQBi | Q6ZRY4 |
PaxDbi | Q6ZRY4 |
PeptideAtlasi | Q6ZRY4 |
PRIDEi | Q6ZRY4 |
ProteomicsDBi | 467 68173 [Q6ZRY4-1] |
PTM databases
iPTMneti | Q6ZRY4 |
PhosphoSitePlusi | Q6ZRY4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166831, Expressed in cardiac muscle of right atrium and 168 other tissues |
Genevisiblei | Q6ZRY4, HS |
Organism-specific databases
HPAi | ENSG00000166831, Tissue enhanced (heart) |
Interactioni
Subunit structurei
Binary interactionsi
Q6ZRY4
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 131505, 82 interactors |
IntActi | Q6ZRY4, 66 interactors |
STRINGi | 9606.ENSP00000300069 |
Miscellaneous databases
RNActi | Q6ZRY4, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q6ZRY4 |
SMRi | Q6ZRY4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 108 | RRMPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 41 – 51 | Important for homodimerization1 PublicationAdd BLAST | 11 |
Phylogenomic databases
eggNOGi | KOG1457, Eukaryota |
GeneTreei | ENSGT00940000158086 |
HOGENOMi | CLU_099973_3_0_1 |
InParanoidi | Q6ZRY4 |
OMAi | HAQMRWF |
OrthoDBi | 1368991at2759 |
PhylomeDBi | Q6ZRY4 |
TreeFami | TF351070 |
Family and domain databases
CDDi | cd12683, RRM_RBPMS2, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034787, RBPMS2_RRM IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSNLKPDGEH GGSTGTGSGA GSGGALEEEV RTLFVSGLPV DIKPRELYLL
60 70 80 90 100
FRPFKGYEGS LIKLTARQPV GFVIFDSRAG AEAAKNALNG IRFDPENPQT
110 120 130 140 150
LRLEFAKANT KMAKSKLMAT PNPSNVHPAL GAHFIARDPY DLMGAALIPA
160 170 180 190 200
SPEAWAPYPL YTTELTPAIS HAAFTYPTAT AAAAALHAQV RWYPSSDTTQ
QGWKYRQFC
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056896 | 1 – 111 | Missing in isoform 2. 1 PublicationAdd BLAST | 111 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY369207 mRNA Translation: AAQ73311.1 AK127873 mRNA Translation: BAC87172.1 AC091582 Genomic DNA No translation available. AC100830 Genomic DNA No translation available. BC131612 mRNA Translation: AAI31613.1 |
CCDSi | CCDS32271.1 [Q6ZRY4-1] |
RefSeqi | NP_919248.1, NM_194272.2 [Q6ZRY4-1] |
Genome annotation databases
Ensembli | ENST00000300069; ENSP00000300069; ENSG00000166831 ENST00000560606; ENSP00000456720; ENSG00000166831 [Q6ZRY4-2] |
GeneIDi | 348093 |
KEGGi | hsa:348093 |
MANE-Selecti | ENST00000300069.5; ENSP00000300069.4; NM_194272.3; NP_919248.1 |
UCSCi | uc002anq.4, human [Q6ZRY4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY369207 mRNA Translation: AAQ73311.1 AK127873 mRNA Translation: BAC87172.1 AC091582 Genomic DNA No translation available. AC100830 Genomic DNA No translation available. BC131612 mRNA Translation: AAI31613.1 |
CCDSi | CCDS32271.1 [Q6ZRY4-1] |
RefSeqi | NP_919248.1, NM_194272.2 [Q6ZRY4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2M9K | NMR | - | A/B | 27-117 | [»] | |
BMRBi | Q6ZRY4 | |||||
SMRi | Q6ZRY4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 131505, 82 interactors |
IntActi | Q6ZRY4, 66 interactors |
STRINGi | 9606.ENSP00000300069 |
PTM databases
iPTMneti | Q6ZRY4 |
PhosphoSitePlusi | Q6ZRY4 |
Genetic variation databases
BioMutai | RBPMS2 |
DMDMi | 74762401 |
Proteomic databases
EPDi | Q6ZRY4 |
jPOSTi | Q6ZRY4 |
MassIVEi | Q6ZRY4 |
MaxQBi | Q6ZRY4 |
PaxDbi | Q6ZRY4 |
PeptideAtlasi | Q6ZRY4 |
PRIDEi | Q6ZRY4 |
ProteomicsDBi | 467 68173 [Q6ZRY4-1] |
Protocols and materials databases
Antibodypediai | 25848, 92 antibodies from 18 providers |
DNASUi | 348093 |
Genome annotation databases
Ensembli | ENST00000300069; ENSP00000300069; ENSG00000166831 ENST00000560606; ENSP00000456720; ENSG00000166831 [Q6ZRY4-2] |
GeneIDi | 348093 |
KEGGi | hsa:348093 |
MANE-Selecti | ENST00000300069.5; ENSP00000300069.4; NM_194272.3; NP_919248.1 |
UCSCi | uc002anq.4, human [Q6ZRY4-1] |
Organism-specific databases
CTDi | 348093 |
DisGeNETi | 348093 |
GeneCardsi | RBPMS2 |
HGNCi | HGNC:19098, RBPMS2 |
HPAi | ENSG00000166831, Tissue enhanced (heart) |
MIMi | 619034, gene |
neXtProti | NX_Q6ZRY4 |
OpenTargetsi | ENSG00000166831 |
PharmGKBi | PA134871904 |
VEuPathDBi | HostDB:ENSG00000166831 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1457, Eukaryota |
GeneTreei | ENSGT00940000158086 |
HOGENOMi | CLU_099973_3_0_1 |
InParanoidi | Q6ZRY4 |
OMAi | HAQMRWF |
OrthoDBi | 1368991at2759 |
PhylomeDBi | Q6ZRY4 |
TreeFami | TF351070 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZRY4 |
SignaLinki | Q6ZRY4 |
Miscellaneous databases
BioGRID-ORCSi | 348093, 11 hits in 1039 CRISPR screens |
ChiTaRSi | RBPMS2, human |
GenomeRNAii | 348093 |
Pharosi | Q6ZRY4, Tbio |
PROi | PR:Q6ZRY4 |
RNActi | Q6ZRY4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166831, Expressed in cardiac muscle of right atrium and 168 other tissues |
Genevisiblei | Q6ZRY4, HS |
Family and domain databases
CDDi | cd12683, RRM_RBPMS2, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034787, RBPMS2_RRM IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RBPS2_HUMAN | |
Accessioni | Q6ZRY4Primary (citable) accession number: Q6ZRY4 Secondary accession number(s): A2RRG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references