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Entry version 144 (03 Jul 2019)
Sequence version 3 (18 May 2010)
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Protein

Helicase SRCAP

Gene

SRCAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.6 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=66 µM for ATP1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi643 – 650ATPPROSITE-ProRule annotation8
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi2857 – 2869A.T hook 1Add BLAST13
    DNA bindingi2936 – 2948A.T hook 2Add BLAST13
    DNA bindingi3004 – 3016A.T hook 3Add BLAST13

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
    Biological processHost-virus interaction, Transcription, Transcription regulation
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q6ZRS2

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q6ZRS2

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Helicase SRCAP (EC:3.6.4.-)
    Alternative name(s):
    Domino homolog 2
    Snf2-related CBP activator
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SRCAP
    Synonyms:KIAA0309
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:16974 SRCAP

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    611421 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6ZRS2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Floating-Harbor syndrome (FLHS)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips.
    Related information in OMIM

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    10847

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    SRCAP

    MalaCards human disease database

    More...
    MalaCardsi
    SRCAP
    MIMi136140 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000080603

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    2044 Floating-Harbor syndrome

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162404706

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SRCAP

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296452947

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112361 – 3230Helicase SRCAPAdd BLAST3230

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1172PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q6ZRS2

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6ZRS2

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6ZRS2

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6ZRS2

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6ZRS2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6ZRS2

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    68161
    68162 [Q6ZRS2-2]
    68163 [Q6ZRS2-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6ZRS2

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6ZRS2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000080603 Expressed in 94 organ(s), highest expression level in heart left ventricle

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6ZRS2 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6ZRS2 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA028929

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1.

    Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1.

    Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41.

    6 Publications

    (Microbial infection)

    Interacts with hepatitis C virus (HCV) NS5A.

    1 Publication

    (Microbial infection)

    Interacts with human adenovirus 2 DBP.

    1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    116058, 62 interactors

    ComplexPortal: manually curated resource of macromolecular complexes

    More...
    ComplexPortali
    CPX-974 SRCAP histone exchanging complex

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q6ZRS2

    Database of interacting proteins

    More...
    DIPi
    DIP-45191N

    Protein interaction database and analysis system

    More...
    IntActi
    Q6ZRS2, 40 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q6ZRS2

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000262518

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6ZRS2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini124 – 196HSAPROSITE-ProRule annotationAdd BLAST73
    Domaini630 – 795Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
    Domaini2044 – 2197Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi275 – 278Poly-Pro4
    Compositional biasi293 – 563Glu-richAdd BLAST271
    Compositional biasi981 – 1883Pro-richAdd BLAST903
    Compositional biasi2227 – 2362Glu-richAdd BLAST136
    Compositional biasi2426 – 3023Pro-richAdd BLAST598
    Compositional biasi3179 – 3182Poly-Glu4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0391 Eukaryota
    COG0553 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157457

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000168717

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6ZRS2

    KEGG Orthology (KO)

    More...
    KOi
    K11661

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MPPTMVN

    Database of Orthologous Groups

    More...
    OrthoDBi
    188211at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6ZRS2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106424

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00079 HELICc, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.10810, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR017956 AT_hook_DNA-bd_motif
    IPR014001 Helicase_ATP-bd
    IPR001650 Helicase_C
    IPR014012 HSA_dom
    IPR027417 P-loop_NTPase
    IPR038718 SNF2-like_sf
    IPR000330 SNF2_N

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00271 Helicase_C, 1 hit
    PF07529 HSA, 1 hit
    PF00176 SNF2_N, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00929 ATHOOK

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00384 AT_hook, 3 hits
    SM00487 DEXDc, 1 hit
    SM00490 HELICc, 1 hit
    SM00573 HSA, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 3 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51192 HELICASE_ATP_BIND_1, 1 hit
    PS51194 HELICASE_CTER, 1 hit
    PS51204 HSA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6ZRS2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MQSSPSPAHP QLPVLQTQMV SDGMTGSNPV SPASSSSPAS SGAGGISPQH
    60 70 80 90 100
    IAQDSSLDGP PGPPDGATVP LEGFSLSQAA DLANKGPKWE KSHAEIAEQA
    110 120 130 140 150
    KHEAEIETRI AELRKEGFWS LKRLPKVPEP PRPKGHWDYL CEEMQWLSAD
    160 170 180 190 200
    FAQERRWKRG VARKVVRMVI RHHEEQRQKE ERARREEQAK LRRIASTMAK
    210 220 230 240 250
    DVRQFWSNVE KVVQFKQQSR LEEKRKKALD LHLDFIVGQT EKYSDLLSQS
    260 270 280 290 300
    LNQPLTSSKA GSSPCLGSSS AASSPPPPAS RLDDEDGDFQ PQEDEEEDDE
    310 320 330 340 350
    ETIEVEEQQE GNDAEAQRRE IELLRREGEL PLEELLRSLP PQLLEGPSSP
    360 370 380 390 400
    SQTPSSHDSD TRDGPEEGAE EEPPQVLEIK PPPSAVTQRN KQPWHPDEDD
    410 420 430 440 450
    EEFTANEEEA EDEEDTIAAE EQLEGEVDHA MELSELAREG ELSMEELLQQ
    460 470 480 490 500
    YAGAYAPGSG SSEDEDEDEV DANSSDCEPE GPVEAEEPPQ EDSSSQSDSV
    510 520 530 540 550
    EDRSEDEEDE HSEEEETSGS SASEESESEE SEDAQSQSQA DEEEEDDDFG
    560 570 580 590 600
    VEYLLARDEE QSEADAGSGP PTPGPTTLGP KKEITDIAAA AESLQPKGYT
    610 620 630 640 650
    LATTQVKTPI PLLLRGQLRE YQHIGLDWLV TMYEKKLNGI LADEMGLGKT
    660 670 680 690 700
    IQTISLLAHL ACEKGNWGPH LIIVPTSVML NWEMELKRWC PSFKILTYYG
    710 720 730 740 750
    AQKERKLKRQ GWTKPNAFHV CITSYKLVLQ DHQAFRRKNW RYLILDEAQN
    760 770 780 790 800
    IKNFKSQRWQ SLLNFNSQRR LLLTGTPLQN SLMELWSLMH FLMPHVFQSH
    810 820 830 840 850
    REFKEWFSNP LTGMIEGSQE YNEGLVKRLH KVLRPFLLRR VKVDVEKQMP
    860 870 880 890 900
    KKYEHVIRCR LSKRQRCLYD DFMAQTTTKE TLATGHFMSV INILMQLRKV
    910 920 930 940 950
    CNHPNLFDPR PVTSPFITPG ICFSTASLVL RATDVHPLQR IDMGRFDLIG
    960 970 980 990 1000
    LEGRVSRYEA DTFLPRHRLS RRVLLEVATA PDPPPRPKPV KMKVNRMLQP
    1010 1020 1030 1040 1050
    VPKQEGRTVV VVNNPRAPLG PVPVRPPPGP ELSAQPTPGP VPQVLPASLM
    1060 1070 1080 1090 1100
    VSASPAGPPL IPASRPPGPV LLPPLQPNSG SLPQVLPSPL GVLSGTSRPP
    1110 1120 1130 1140 1150
    TPTLSLKPTP PAPVRLSPAP PPGSSSLLKP LTVPPGYTFP PAAATTTSTT
    1160 1170 1180 1190 1200
    TATATTTAVP APTPAPQRLI LSPDMQARLP SGEVVSIGQL ASLAQRPVAN
    1210 1220 1230 1240 1250
    AGGSKPLTFQ IQGNKLTLTG AQVRQLAVGQ PRPLQRNVVH LVSAGGQHHL
    1260 1270 1280 1290 1300
    ISQPAHVALI QAVAPTPGPT PVSVLPSSTP STTPAPTGLS LPLAANQVPP
    1310 1320 1330 1340 1350
    TMVNNTGVVK IVVRQAPRDG LTPVPPLAPA PRPPSSGLPA VLNPRPTLTP
    1360 1370 1380 1390 1400
    GRLPTPTLGT ARAPMPTPTL VRPLLKLVHS PSPEVSASAP GAAPLTISSP
    1410 1420 1430 1440 1450
    LHVPSSLPGP ASSPMPIPNS SPLASPVSST VSVPLSSSLP ISVPTTLPAP
    1460 1470 1480 1490 1500
    ASAPLTIPIS APLTVSASGP ALLTSVTPPL APVVPAAPGP PSLAPSGASP
    1510 1520 1530 1540 1550
    SASALTLGLA TAPSLSSSQT PGHPLLLAPT SSHVPGLNST VAPACSPVLV
    1560 1570 1580 1590 1600
    PASALASPFP SAPNPAPAQA SLLAPASSAS QALATPLAPM AAPQTAILAP
    1610 1620 1630 1640 1650
    SPAPPLAPLP VLAPSPGAAP VLASSQTPVP VMAPSSTPGT SLASASPVPA
    1660 1670 1680 1690 1700
    PTPVLAPSST QTMLPAPVPS PLPSPASTQT LALAPALAPT LGGSSPSQTL
    1710 1720 1730 1740 1750
    SLGTGNPQGP FPTQTLSLTP ASSLVPTPAQ TLSLAPGPPL GPTQTLSLAP
    1760 1770 1780 1790 1800
    APPLAPASPV GPAPAHTLTL APASSSASLL APASVQTLTL SPAPVPTLGP
    1810 1820 1830 1840 1850
    AAAQTLALAP ASTQSPASQA SSLVVSASGA APLPVTMVSR LPVSKDEPDT
    1860 1870 1880 1890 1900
    LTLRSGPPSP PSTATSFGGP RPRRQPPPPP RSPFYLDSLE EKRKRQRSER
    1910 1920 1930 1940 1950
    LERIFQLSEA HGALAPVYGT EVLDFCTLPQ PVASPIGPRS PGPSHPTFWT
    1960 1970 1980 1990 2000
    YTEAAHRAVL FPQQRLDQLS EIIERFIFVM PPVEAPPPSL HACHPPPWLA
    2010 2020 2030 2040 2050
    PRQAAFQEQL ASELWPRARP LHRIVCNMRT QFPDLRLIQY DCGKLQTLAV
    2060 2070 2080 2090 2100
    LLRQLKAEGH RVLIFTQMTR MLDVLEQFLT YHGHLYLRLD GSTRVEQRQA
    2110 2120 2130 2140 2150
    LMERFNADKR IFCFILSTRS GGVGVNLTGA DTVVFYDSDW NPTMDAQAQD
    2160 2170 2180 2190 2200
    RCHRIGQTRD VHIYRLISER TVEENILKKA NQKRMLGDMA IEGGNFTTAY
    2210 2220 2230 2240 2250
    FKQQTIRELF DMPLEEPSSS SVPSAPEEEE ETVASKQTHI LEQALCRAED
    2260 2270 2280 2290 2300
    EEDIRAATQA KAEQVAELAE FNENDGFPAG EGEEAGRPGA EDEEMSRAEQ
    2310 2320 2330 2340 2350
    EIAALVEQLT PIERYAMKFL EASLEEVSRE ELKQAEEQVE AARKDLDQAK
    2360 2370 2380 2390 2400
    EEVFRLPQEE EEGPGAGDES SCGTGGGTHR RSKKAKAPER PGTRVSERLR
    2410 2420 2430 2440 2450
    GARAETQGAN HTPVISAHQT RSTTTPPRCS PARERVPRPA PRPRPTPASA
    2460 2470 2480 2490 2500
    PAAIPALVPV PVSAPVPISA PNPITILPVH ILPSPPPPSQ IPPCSSPACT
    2510 2520 2530 2540 2550
    PPPACTPPPA HTPPPAQTCL VTPSSPLLLG PPSVPISASV TNLPLGLRPE
    2560 2570 2580 2590 2600
    AELCAQALAS PESLELASVA SSETSSLSLV PPKDLLPVAV EILPVSEKNL
    2610 2620 2630 2640 2650
    SLTPSAPSLT LEAGSIPNGQ EQEAPDSAEG TTLTVLPEGE ELPLCVSESN
    2660 2670 2680 2690 2700
    GLELPPSAAS DEPLQEPLEA DRTSEELTEA KTPTSSPEKP QELVTAEVAA
    2710 2720 2730 2740 2750
    PSTSSSATSS PEGPSPARPP RRRTSADVEI RGQGTGRPGQ PPGPKVLRKL
    2760 2770 2780 2790 2800
    PGRLVTVVEE KELVRRRRQQ RGAASTLVPG VSETSASPGS PSVRSMSGPE
    2810 2820 2830 2840 2850
    SSPPIGGPCE AAPSSSLPTP PQQPFIARRH IELGVTGGGS PENGDGALLA
    2860 2870 2880 2890 2900
    ITPPAVKRRR GRPPKKNRSP ADAGRGVDEA PSSTLKGKTN GADPVPGPET
    2910 2920 2930 2940 2950
    LIVADPVLEP QLIPGPQPLG PQPVHRPNPL LSPVEKRRRG RPPKARDLPI
    2960 2970 2980 2990 3000
    PGTISSAGDG NSESRTQPPP HPSPLTPLPP LLVCPTATVA NTVTTVTIST
    3010 3020 3030 3040 3050
    SPPKRKRGRP PKNPPSPRPS QLPVLDRDST SVLESCGLGR RRQPQGQGES
    3060 3070 3080 3090 3100
    EGSSSDEDGS RPLTRLARLR LEAEGMRGRK SGGSMVVAVI QDDLDLADSG
    3110 3120 3130 3140 3150
    PGGLELTPPV VSLTPKLRST RLRPGSLVPP LETEKLPRKR AGAPVGGSPG
    3160 3170 3180 3190 3200
    LAKRGRLQPP SPLGPEGSVE ESEAEASGEE EEGDGTPRRR PGPRRLVGTT
    3210 3220 3230
    NQGDQRILRS SAPPSLAGPA VSHRGRKAKT
    Length:3,230
    Mass (Da):343,555
    Last modified:May 18, 2010 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CFB74C7BDFBEAD0
    GO
    Isoform 2 (identifier: Q6ZRS2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1236-1298: RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV → M

    Show »
    Length:3,168
    Mass (Da):337,445
    Checksum:iB9A0D36717389361
    GO
    Isoform 3 (identifier: Q6ZRS2-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1085-1181: VLPSPLGVLS...SPDMQARLPS → A
         1236-1298: RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV → M

    Show »
    Length:3,072
    Mass (Da):327,838
    Checksum:iEA4D60708B59DC5B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0A0MS59A0A0A0MS59_HUMAN
    Helicase SRCAP
    SRCAP
    2,971Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087X0E3A0A087X0E3_HUMAN
    Helicase SRCAP
    SRCAP
    1,610Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J4U4C9J4U4_HUMAN
    Helicase SRCAP
    SRCAP
    100Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAI59100 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1147T → A in BAC87237 (PubMed:14702039).Curated1
    Sequence conflicti1494A → Q in AAD39760 (PubMed:10347196).Curated1
    Sequence conflicti2765R → Q in AAD39760 (PubMed:10347196).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0294411085 – 1181VLPSP…ARLPS → A in isoform 3. 2 PublicationsAdd BLAST97
    Alternative sequenceiVSP_0294421236 – 1298RNVVH…AANQV → M in isoform 2 and isoform 3. 3 PublicationsAdd BLAST63

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC093249 Genomic DNA No translation available.
    AC106886 Genomic DNA No translation available.
    AK128030 mRNA Translation: BAC87237.1
    AB002307 mRNA Translation: BAA20768.2
    BC159099 mRNA Translation: AAI59100.1 Different initiation.
    AF143946 mRNA Translation: AAD39760.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS10689.2 [Q6ZRS2-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_006653.2, NM_006662.2 [Q6ZRS2-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000262518; ENSP00000262518; ENSG00000080603 [Q6ZRS2-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    10847

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:10847

    UCSC genome browser

    More...
    UCSCi
    uc002dze.2 human [Q6ZRS2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC093249 Genomic DNA No translation available.
    AC106886 Genomic DNA No translation available.
    AK128030 mRNA Translation: BAC87237.1
    AB002307 mRNA Translation: BAA20768.2
    BC159099 mRNA Translation: AAI59100.1 Different initiation.
    AF143946 mRNA Translation: AAD39760.1
    CCDSiCCDS10689.2 [Q6ZRS2-1]
    RefSeqiNP_006653.2, NM_006662.2 [Q6ZRS2-1]

    3D structure databases

    SMRiQ6ZRS2
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi116058, 62 interactors
    ComplexPortaliCPX-974 SRCAP histone exchanging complex
    CORUMiQ6ZRS2
    DIPiDIP-45191N
    IntActiQ6ZRS2, 40 interactors
    MINTiQ6ZRS2
    STRINGi9606.ENSP00000262518

    PTM databases

    iPTMnetiQ6ZRS2
    PhosphoSitePlusiQ6ZRS2

    Polymorphism and mutation databases

    BioMutaiSRCAP
    DMDMi296452947

    Proteomic databases

    EPDiQ6ZRS2
    jPOSTiQ6ZRS2
    MaxQBiQ6ZRS2
    PaxDbiQ6ZRS2
    PeptideAtlasiQ6ZRS2
    PRIDEiQ6ZRS2
    ProteomicsDBi68161
    68162 [Q6ZRS2-2]
    68163 [Q6ZRS2-3]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    10847
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000262518; ENSP00000262518; ENSG00000080603 [Q6ZRS2-1]
    GeneIDi10847
    KEGGihsa:10847
    UCSCiuc002dze.2 human [Q6ZRS2-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10847
    DisGeNETi10847

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SRCAP
    GeneReviewsiSRCAP

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0012970
    HGNCiHGNC:16974 SRCAP
    HPAiHPA028929
    MalaCardsiSRCAP
    MIMi136140 phenotype
    611421 gene
    neXtProtiNX_Q6ZRS2
    OpenTargetsiENSG00000080603
    Orphaneti2044 Floating-Harbor syndrome
    PharmGKBiPA162404706

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0391 Eukaryota
    COG0553 LUCA
    GeneTreeiENSGT00940000157457
    HOGENOMiHOG000168717
    InParanoidiQ6ZRS2
    KOiK11661
    OMAiMPPTMVN
    OrthoDBi188211at2759
    PhylomeDBiQ6ZRS2
    TreeFamiTF106424

    Enzyme and pathway databases

    SABIO-RKiQ6ZRS2
    SIGNORiQ6ZRS2

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SRCAP human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SRCAP

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    10847

    Protein Ontology

    More...
    PROi
    PR:Q6ZRS2

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000080603 Expressed in 94 organ(s), highest expression level in heart left ventricle
    ExpressionAtlasiQ6ZRS2 baseline and differential
    GenevisibleiQ6ZRS2 HS

    Family and domain databases

    CDDicd00079 HELICc, 1 hit
    Gene3Di3.40.50.10810, 1 hit
    InterProiView protein in InterPro
    IPR017956 AT_hook_DNA-bd_motif
    IPR014001 Helicase_ATP-bd
    IPR001650 Helicase_C
    IPR014012 HSA_dom
    IPR027417 P-loop_NTPase
    IPR038718 SNF2-like_sf
    IPR000330 SNF2_N
    PfamiView protein in Pfam
    PF00271 Helicase_C, 1 hit
    PF07529 HSA, 1 hit
    PF00176 SNF2_N, 1 hit
    PRINTSiPR00929 ATHOOK
    SMARTiView protein in SMART
    SM00384 AT_hook, 3 hits
    SM00487 DEXDc, 1 hit
    SM00490 HELICc, 1 hit
    SM00573 HSA, 1 hit
    SUPFAMiSSF52540 SSF52540, 3 hits
    PROSITEiView protein in PROSITE
    PS51192 HELICASE_ATP_BIND_1, 1 hit
    PS51194 HELICASE_CTER, 1 hit
    PS51204 HSA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRCAP_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZRS2
    Secondary accession number(s): B0JZA6
    , O15026, Q7Z744, Q9Y5L9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: May 18, 2010
    Last modified: July 3, 2019
    This is version 144 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
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