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Protein

Doublecortin domain-containing protein 5

Gene

DCDC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).1 Publication

GO - Molecular functioni

  • microtubule binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • intracellular signal transduction Source: InterPro
  • regulation of mitotic cytokinesis Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 5
Gene namesi
Name:DCDC5
Synonyms:KIAA1493
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24799 DCDC5
MIMi612321 gene
neXtProtiNX_Q6ZRR9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi190359182

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386161 – 648Doublecortin domain-containing protein 5Add BLAST648

Proteomic databases

PRIDEiQ6ZRR9
ProteomicsDBi68160

Expressioni

Gene expression databases

CleanExiHS_DCDC5

Interactioni

Subunit structurei

Interacts with dynein intermediate chain, tubulin, RAB8A, RAB3IP, NUDC, PAFAH1B1 and DCTN1 (PubMed:22159412).1 Publication

GO - Molecular functioni

  • microtubule binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliQ6ZRR9
SMRiQ6ZRR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 94Doublecortin 1PROSITE-ProRule annotationAdd BLAST91
Domaini491 – 570Doublecortin 2PROSITE-ProRule annotationAdd BLAST80

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000078278
HOVERGENiHBG105685
InParanoidiQ6ZRR9
PhylomeDBiQ6ZRR9
TreeFamiTF329467

Family and domain databases

CDDicd00161 RICIN, 1 hit
InterProiView protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
SUPFAMiSSF50370 SSF50370, 1 hit
SSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZRR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKPICKTTE PYAPVRLRVL QNGEKNKNRS VTILGPDISP GRKTQCTEIL
60 70 80 90 100
NLPSAARRLY NEKGKEIFAL KDLQRDELVY VSCGELWINP DLSIAQQKKQ
110 120 130 140 150
IFLRNLESDI AKIQIFCSTH KIEALVLEVQ SDIVSGSKLA VHKPVAIFGE
160 170 180 190 200
EKQVTEPEEK QMQEDPLTTE NASSEILDSH VRAHLRMKAC HTLPRYAWQE
210 220 230 240 250
TSHDFDEDDS LPKKTEKGLF ENVEPQKKHS CSPKHSKLHK HCHQQFEYRD
260 270 280 290 300
GQIISHAAPQ LVLGVQGPNL RSGMEVVLVE KKSDGSHQRW IHQEDSRTFH
310 320 330 340 350
LVSNPDLVLA VSMTKTRNEV CGYPVIVQKY KPYNNGAANQ KWHYMKNIKA
360 370 380 390 400
LVAFHSTALD KEITSANYAG VCTSSVIKEE NIDQPGYCYL SPDGKRKTML
410 420 430 440 450
CLACGQSMRT EKGLKQLLPG VPFLCISGTK TQKPFLQGPF KVISVAEVDL
460 470 480 490 500
SCDKAEKTLS YYQARLLSLR MKTCTQAASH SGMAATHQKA VKIIAYKNGD
510 520 530 540 550
GYRNGKLIVA GTFPMLLTEC TEQLGLARAA SKVYTKDGTP IFTLRDLVLW
560 570 580 590 600
ALDESFLQRD SEKQKQDAAP VGKEQIIVEK NPRMKVKNRL FAKSVTSDSL
610 620 630 640
DGIDKSLLTL ILRNPIAIWV SCGEPFLPPN ESRKIRETEL AKKGQNFG
Length:648
Mass (Da):72,753
Last modified:June 10, 2008 - v2
Checksum:i296E9E0594D74548
GO

Sequence cautioni

The sequence BAC87240 differs from that shown.Curated
The sequence CAO03425 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72D → N in BAC87240 (PubMed:14702039).Curated1
Sequence conflicti341K → R in BAC87240 (PubMed:14702039).Curated1
Sequence conflicti631E → ALQ in BAC87240 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128035 mRNA Translation: BAC87240.1 Sequence problems.
AL135932 Genomic DNA Translation: CAO03425.1 Sequence problems.
UniGeneiHs.127405
Hs.530438
Hs.592000
Hs.729691
Hs.730375

Similar proteinsi

Entry informationi

Entry nameiDCDC5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRR9
Secondary accession number(s): B1AL47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 20, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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