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Entry version 115 (02 Jun 2021)
Sequence version 2 (05 Oct 2010)
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Protein

TLC domain-containing protein 5

Gene

TLCD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZRR5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TLC domain-containing protein 5Curated
Alternative name(s):
Transmembrane protein 136
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLCD5Imported
Synonyms:TMEM136
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28280, TLCD5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZRR5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000181264.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
219902

Open Targets

More...
OpenTargetsi
ENSG00000181264

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596257

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZRR5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM136

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153509

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002855831 – 245TLC domain-containing protein 5Add BLAST245

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZRR5

PeptideAtlas

More...
PeptideAtlasi
Q6ZRR5

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZRR5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68154 [Q6ZRR5-1]
68155 [Q6ZRR5-2]
68156 [Q6ZRR5-3]
68157 [Q6ZRR5-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181264, Expressed in brain and 180 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZRR5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000181264, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128593, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312672

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZRR5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 204TLCPROSITE-ProRule annotationAdd BLAST176

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TLCD5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4474, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008162

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_083447_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZRR5

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGGVAMY

Database of Orthologous Groups

More...
OrthoDBi
1353190at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZRR5

TreeFam database of animal gene trees

More...
TreeFami
TF329126

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006634, TLC-dom
IPR042512, TLCD5

The PANTHER Classification System

More...
PANTHERi
PTHR31898, PTHR31898, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03798, TRAM_LAG1_CLN8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00724, TLC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50922, TLC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZRR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALALCLQVL CSLCGWLSLY ISFCHLNKHR SYEWSCRLVT FTHGVLSIGL
60 70 80 90 100
SAYIGFIDGP WPFTHPGSPN TPLQVHVLCL TLGYFIFDLG WCVYFQSEGA
110 120 130 140 150
LMLAHHTLSI LGIIMALVLG ESGTEVNAVL FGSELTNPLL QMRWFLRETG
160 170 180 190 200
HYHSFTGDVV DFLFVALFTG VRIGVGACLL FCEMVSPTPK WFVKAGGVAM
210 220 230 240
YAVSWCFMFS IWRFAWRKSI KKYHAWRSRR SEERQLKHNG HLKIH
Length:245
Mass (Da):27,859
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18BC58C2528DDB61
GO
Isoform 2 (identifier: Q6ZRR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-210: WCVYFQSEGA...YAVSWCFMFS → C

Show »
Length:126
Mass (Da):14,687
Checksum:i0C5C37ADE6C78CE6
GO
Isoform 3 (identifier: Q6ZRR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTQCCFLRVHPLFFWFWSFHHRM

Show »
Length:267
Mass (Da):30,767
Checksum:i9B77A8BAA168D11E
GO
Isoform 4 (identifier: Q6ZRR5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTQCCFLRVHPLFFWFWSFHHRM
     91-210: WCVYFQSEGA...YAVSWCFMFS → C

Show »
Length:148
Mass (Da):17,596
Checksum:i0BC8988CE159D9ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102M → I in BAC87244 (PubMed:14702039).Curated1
Sequence conflicti130L → P in BAG64992 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0398531M → MTQCCFLRVHPLFFWFWSFH HRM in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_02487191 – 210WCVYF…CFMFS → C in isoform 2 and isoform 4. 2 PublicationsAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK128040 mRNA Translation: BAC87244.1
AK294713 mRNA Translation: BAG57865.1
AK304086 mRNA Translation: BAG64992.1
AP001150 Genomic DNA No translation available.
BC015232 mRNA Translation: AAH15232.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55792.1 [Q6ZRR5-3]
CCDS55793.1 [Q6ZRR5-1]
CCDS8432.1 [Q6ZRR5-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001185599.1, NM_001198670.1 [Q6ZRR5-3]
NP_001185600.1, NM_001198671.1 [Q6ZRR5-1]
NP_001185601.1, NM_001198672.1
NP_001185602.1, NM_001198673.1
NP_001185603.1, NM_001198674.1 [Q6ZRR5-2]
NP_001185604.1, NM_001198675.1
NP_777586.1, NM_174926.2 [Q6ZRR5-4]
XP_016872816.1, XM_017017327.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314475; ENSP00000312672; ENSG00000181264 [Q6ZRR5-3]
ENST00000375095; ENSP00000364236; ENSG00000181264 [Q6ZRR5-1]
ENST00000529187; ENSP00000434862; ENSG00000181264 [Q6ZRR5-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
219902

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:219902

UCSC genome browser

More...
UCSCi
uc001pxg.4, human [Q6ZRR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128040 mRNA Translation: BAC87244.1
AK294713 mRNA Translation: BAG57865.1
AK304086 mRNA Translation: BAG64992.1
AP001150 Genomic DNA No translation available.
BC015232 mRNA Translation: AAH15232.2
CCDSiCCDS55792.1 [Q6ZRR5-3]
CCDS55793.1 [Q6ZRR5-1]
CCDS8432.1 [Q6ZRR5-4]
RefSeqiNP_001185599.1, NM_001198670.1 [Q6ZRR5-3]
NP_001185600.1, NM_001198671.1 [Q6ZRR5-1]
NP_001185601.1, NM_001198672.1
NP_001185602.1, NM_001198673.1
NP_001185603.1, NM_001198674.1 [Q6ZRR5-2]
NP_001185604.1, NM_001198675.1
NP_777586.1, NM_174926.2 [Q6ZRR5-4]
XP_016872816.1, XM_017017327.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi128593, 1 interactor
STRINGi9606.ENSP00000312672

Genetic variation databases

BioMutaiTMEM136
DMDMi308153509

Proteomic databases

PaxDbiQ6ZRR5
PeptideAtlasiQ6ZRR5
PRIDEiQ6ZRR5
ProteomicsDBi68154 [Q6ZRR5-1]
68155 [Q6ZRR5-2]
68156 [Q6ZRR5-3]
68157 [Q6ZRR5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
71703, 17 antibodies

The DNASU plasmid repository

More...
DNASUi
219902

Genome annotation databases

EnsembliENST00000314475; ENSP00000312672; ENSG00000181264 [Q6ZRR5-3]
ENST00000375095; ENSP00000364236; ENSG00000181264 [Q6ZRR5-1]
ENST00000529187; ENSP00000434862; ENSG00000181264 [Q6ZRR5-4]
GeneIDi219902
KEGGihsa:219902
UCSCiuc001pxg.4, human [Q6ZRR5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
219902
DisGeNETi219902

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TLCD5
HGNCiHGNC:28280, TLCD5
HPAiENSG00000181264, Low tissue specificity
neXtProtiNX_Q6ZRR5
OpenTargetsiENSG00000181264
PharmGKBiPA144596257
VEuPathDBiHostDB:ENSG00000181264.8

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4474, Eukaryota
GeneTreeiENSGT00390000008162
HOGENOMiCLU_083447_0_0_1
InParanoidiQ6ZRR5
OMAiCGGVAMY
OrthoDBi1353190at2759
PhylomeDBiQ6ZRR5
TreeFamiTF329126

Enzyme and pathway databases

PathwayCommonsiQ6ZRR5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
219902, 5 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM136, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
219902
PharosiQ6ZRR5, Tdark

Protein Ontology

More...
PROi
PR:Q6ZRR5
RNActiQ6ZRR5, protein

Gene expression databases

BgeeiENSG00000181264, Expressed in brain and 180 other tissues
GenevisibleiQ6ZRR5, HS

Family and domain databases

InterProiView protein in InterPro
IPR006634, TLC-dom
IPR042512, TLCD5
PANTHERiPTHR31898, PTHR31898, 1 hit
PfamiView protein in Pfam
PF03798, TRAM_LAG1_CLN8, 1 hit
SMARTiView protein in SMART
SM00724, TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922, TLC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLCD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZRR5
Secondary accession number(s): B4DGQ4, B4E230, Q8IZ79
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 5, 2010
Last modified: June 2, 2021
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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