UniProtKB - Q6ZRQ5 (MMS22_HUMAN)
Protein
Protein MMS22-like
Gene
MMS22L
Organism
Homo sapiens (Human)
Status
Functioni
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.3 Publications
GO - Biological processi
- double-strand break repair via homologous recombination Source: UniProtKB
- replication fork processing Source: UniProtKB
Keywordsi
Biological process | DNA damage, DNA repair |
Names & Taxonomyi
Protein namesi | Recommended name: Protein MMS22-likeAlternative name(s): Methyl methanesulfonate-sensitivity protein 22-like |
Gene namesi | Name:MMS22L Synonyms:C6orf167 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21475 MMS22L |
MIMi | 615614 gene |
neXtProti | NX_Q6ZRQ5 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Note: Localizes to DNA damage sites, accumulates at stressed replication forks.
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear replication fork Source: UniProtKB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 253714 |
OpenTargetsi | ENSG00000146263 |
PharmGKBi | PA134878007 |
Miscellaneous databases
Pharosi | Q6ZRQ5 |
Polymorphism and mutation databases
BioMutai | MMS22L |
DMDMi | 281185507 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260216 | 1 – 1243 | Protein MMS22-likeAdd BLAST | 1243 |
Proteomic databases
EPDi | Q6ZRQ5 |
jPOSTi | Q6ZRQ5 |
MassIVEi | Q6ZRQ5 |
MaxQBi | Q6ZRQ5 |
PaxDbi | Q6ZRQ5 |
PeptideAtlasi | Q6ZRQ5 |
PRIDEi | Q6ZRQ5 |
ProteomicsDBi | 68153 |
PTM databases
iPTMneti | Q6ZRQ5 |
PhosphoSitePlusi | Q6ZRQ5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146263 Expressed in 93 organ(s), highest expression level in kidney |
ExpressionAtlasi | Q6ZRQ5 baseline and differential |
Organism-specific databases
HPAi | HPA067042 |
Interactioni
Subunit structurei
Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2.
3 PublicationsBinary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Q96HA7 | 5 | EBI-718662,EBI-1052467 |
Protein-protein interaction databases
BioGridi | 128982, 29 interactors |
IntActi | Q6ZRQ5, 16 interactors |
MINTi | Q6ZRQ5 |
STRINGi | 9606.ENSP00000275053 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG410IEVD Eukaryota ENOG410ZSY3 LUCA |
GeneTreei | ENSGT00390000011769 |
InParanoidi | Q6ZRQ5 |
OMAi | CTKELWV |
OrthoDBi | 523276at2759 |
PhylomeDBi | Q6ZRQ5 |
TreeFami | TF353832 |
Family and domain databases
InterProi | View protein in InterPro IPR042320 MMS22-like IPR029424 MMS22L_C IPR029425 MMS22L_N |
PANTHERi | PTHR28547 PTHR28547, 1 hit |
Pfami | View protein in Pfam PF14911 MMS22L_C, 1 hit PF14910 MMS22L_N, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q6ZRQ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENCSAASTF LTDSLELELG TEWCKPPYFS CAVDNRGGGK HFSGESYLCS
60 70 80 90 100
GALKRLILNL DPLPTNFEED TLEIFGIQWV TETALVNSSR ELFHLFRQQL
110 120 130 140 150
YNLETLLQSS CDFGKVSTLH CKADNIRQQC VLFLHYVKVF IFRYLKVQNA
160 170 180 190 200
ESHVPVHPYE ALEAQLPSVL IDELHGLLLY IGHLSELPSV NIGAFVNQNQ
210 220 230 240 250
IKLFPPSWHL LHLHLDIHWL VLEILYMLGE KLKQVVYGHQ FMNLASDNLT
260 270 280 290 300
NISLFEEHCE TLLCDLISLS LNRYDKVRSS ESLMSDQCPC LCIKELWVLL
310 320 330 340 350
IHLLDHRSKW FVSESFWNWL NKLLKTLLEK SSDRRRSSMP VIQSRDPLGF
360 370 380 390 400
SWWIITHVAS FYKFDRHGVP DEMRKVESNW NFVEELLKKS ISVQGVILEE
410 420 430 440 450
QLRMYLHCCL TLCDFWEPNI AIVTILWEYY SKNLNSSFSI SWLPFKGLAN
460 470 480 490 500
TMKSPLSMLE MVKTCCCDKQ DQELYKSSSS YTIFLCILAK VVKKAMKSNG
510 520 530 540 550
PHPWKQVKGR IYSKFHQKRM EELTEVGLQN FFSLFLLLAA VAEVEDVASH
560 570 580 590 600
VLDLLNFLKP AFVTSQRALI WKGHMAFLLM YAQKNLDIGV LAEKFSCAFR
610 620 630 640 650
EKAKEFLVSK NEEMVQRQTI WTLLSIYIDG VQEVFETSYC LYPSHEKLLN
660 670 680 690 700
DGFSMLLRAC RESELRTVLS FLQAVLARIR SMHQQLCQEL QRDNVDLFVQ
710 720 730 740 750
SSLSAKERHL AAVASALWRH FFSFLKSQRM SQVVPFSQLA DAAADFTLLA
760 770 780 790 800
MDMPSTAPSD FQPQPVISII QLFGWDDIIC PQVVARYLSH VLQNSTLCEA
810 820 830 840 850
LSHSGYVSFQ ALTVRSWIRC VLQMYIKNLS GPDDLLIDKN LEEAVEKEYM
860 870 880 890 900
KQLVKLTRLL FNLSEVKSIF SKAQVEYLSI SEDPKKALVR FFEAVGVTYG
910 920 930 940 950
NVQTLSDKSA MVTKSLEYLG EVLKYIKPYL GKKVFSAGLQ LTYGMMGILV
960 970 980 990 1000
KSWAQIFATS KAQKLLFRII DCLLLPHAVL QQEKELPAPM LSAIQKSLPL
1010 1020 1030 1040 1050
YLQGMCIVCC QSQNPNAYLN QLLGNVIEQY IGRFLPASPY VSDLGQHPVL
1060 1070 1080 1090 1100
LALRNTATIP PISSLKKCIV QVIRKSYLEY KGSSPPPRLA SILAFILQLF
1110 1120 1130 1140 1150
KETNTDIYEV ELLLPGILKC LVLVSEPQVK RLATENLQYM VKACQVGSEE
1160 1170 1180 1190 1200
EPSSQLTSVF RQFIQDYGMR YYYQVYSILE TVATLDQQVV IHLISTLTQS
1210 1220 1230 1240
LKDSEQKWGL GRNIAQREAY SKLLSHLGQM GQDEMQRLEN DNT
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE2QRD4 | E2QRD4_HUMAN | Protein MMS22-like | MMS22L | 1,203 | Annotation score: | ||
H9KVD8 | H9KVD8_HUMAN | Protein MMS22-like | MMS22L | 203 | Annotation score: | ||
H0Y8J1 | H0Y8J1_HUMAN | Protein MMS22-like | MMS22L | 88 | Annotation score: | ||
H0YAJ2 | H0YAJ2_HUMAN | Protein MMS22-like | MMS22L | 322 | Annotation score: | ||
H9KVD7 | H9KVD7_HUMAN | Protein MMS22-like | MMS22L | 140 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 292 | C → R in BAC87254 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029013 | 419 | N → D. Corresponds to variant dbSNP:rs9374435Ensembl. | 1 | |
Natural variantiVAR_029014 | 564 | T → M1 PublicationCorresponds to variant dbSNP:rs9481410Ensembl. | 1 | |
Natural variantiVAR_029015 | 875 | V → A1 PublicationCorresponds to variant dbSNP:rs1737145Ensembl. | 1 | |
Natural variantiVAR_029016 | 1015 | P → L. Corresponds to variant dbSNP:rs10484830Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128060 mRNA Translation: BAC87254.1 AL023656 Genomic DNA No translation available. AL353679 Genomic DNA No translation available. AL590484 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48494.1 CH471051 Genomic DNA Translation: EAW48496.1 CR749603 mRNA Translation: CAH18398.1 CR749822 mRNA Translation: CAH18682.1 |
CCDSi | CCDS5039.1 |
RefSeqi | NP_940870.2, NM_198468.2 XP_006715493.1, XM_006715430.1 |
Genome annotation databases
Ensembli | ENST00000275053; ENSP00000275053; ENSG00000146263 |
GeneIDi | 253714 |
KEGGi | hsa:253714 |
UCSCi | uc003ppb.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128060 mRNA Translation: BAC87254.1 AL023656 Genomic DNA No translation available. AL353679 Genomic DNA No translation available. AL590484 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48494.1 CH471051 Genomic DNA Translation: EAW48496.1 CR749603 mRNA Translation: CAH18398.1 CR749822 mRNA Translation: CAH18682.1 |
CCDSi | CCDS5039.1 |
RefSeqi | NP_940870.2, NM_198468.2 XP_006715493.1, XM_006715430.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 128982, 29 interactors |
IntActi | Q6ZRQ5, 16 interactors |
MINTi | Q6ZRQ5 |
STRINGi | 9606.ENSP00000275053 |
PTM databases
iPTMneti | Q6ZRQ5 |
PhosphoSitePlusi | Q6ZRQ5 |
Polymorphism and mutation databases
BioMutai | MMS22L |
DMDMi | 281185507 |
Proteomic databases
EPDi | Q6ZRQ5 |
jPOSTi | Q6ZRQ5 |
MassIVEi | Q6ZRQ5 |
MaxQBi | Q6ZRQ5 |
PaxDbi | Q6ZRQ5 |
PeptideAtlasi | Q6ZRQ5 |
PRIDEi | Q6ZRQ5 |
ProteomicsDBi | 68153 |
Protocols and materials databases
DNASUi | 253714 |
Genome annotation databases
Ensembli | ENST00000275053; ENSP00000275053; ENSG00000146263 |
GeneIDi | 253714 |
KEGGi | hsa:253714 |
UCSCi | uc003ppb.3 human |
Organism-specific databases
CTDi | 253714 |
DisGeNETi | 253714 |
GeneCardsi | MMS22L |
HGNCi | HGNC:21475 MMS22L |
HPAi | HPA067042 |
MIMi | 615614 gene |
neXtProti | NX_Q6ZRQ5 |
OpenTargetsi | ENSG00000146263 |
PharmGKBi | PA134878007 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IEVD Eukaryota ENOG410ZSY3 LUCA |
GeneTreei | ENSGT00390000011769 |
InParanoidi | Q6ZRQ5 |
OMAi | CTKELWV |
OrthoDBi | 523276at2759 |
PhylomeDBi | Q6ZRQ5 |
TreeFami | TF353832 |
Miscellaneous databases
ChiTaRSi | MMS22L human |
GeneWikii | MMS22L |
GenomeRNAii | 253714 |
Pharosi | Q6ZRQ5 |
PROi | PR:Q6ZRQ5 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146263 Expressed in 93 organ(s), highest expression level in kidney |
ExpressionAtlasi | Q6ZRQ5 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR042320 MMS22-like IPR029424 MMS22L_C IPR029425 MMS22L_N |
PANTHERi | PTHR28547 PTHR28547, 1 hit |
Pfami | View protein in Pfam PF14911 MMS22L_C, 1 hit PF14910 MMS22L_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MMS22_HUMAN | |
Accessioni | Q6ZRQ5Primary (citable) accession number: Q6ZRQ5 Secondary accession number(s): D6R9Y8 Q68D32 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | December 15, 2009 | |
Last modified: | October 16, 2019 | |
This is version 120 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot