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Protein
Submitted name:

cDNA FLJ46245 fis, clone TESTI4020596, highly similar to Homo sapiens calpain 5 (CAPN5)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei121PROSITE-ProRule annotation1
Active sitei292PROSITE-ProRule annotation1
Active sitei324PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ46245 fis, clone TESTI4020596, highly similar to Homo sapiens calpain 5 (CAPN5)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiQ6ZRM8
PeptideAtlasiQ6ZRM8
PRIDEiQ6ZRM8

Structurei

3D structure databases

ProteinModelPortaliQ6ZRM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 383Calpain catalyticInterPro annotationAdd BLAST318

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
HOGENOMiHOG000232036
HOVERGENiHBG001095

Family and domain databases

CDDicd04046 C2_Calpain, 1 hit
cd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR033884 C2_Calpain
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZRM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCTGTPSCI YLLSALSLRD LVLDWEPRGV PPPLPGAAAT MFSCVKPYED
60 70 80 90 100
QNYSALRRDC RRRKVLFEDP LFPATDDSLY YKGTPGPAVR WKRPKGICED
110 120 130 140 150
PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV IPDWKEQEWD
160 170 180 190 200
PEKPNAYAGI FHFHFWRFGE WVDVVIDDRL PTVNNQLIYC HSNSRNEFWC
210 220 230 240 250
ALVEKAYAKL AGCYQALDGG NTADALVDFA GGVSEPIDLT EGDFANDETK
260 270 280 290 300
RNQLFERMLK VHSRGGLISA SIKAVTAADM EARLACGLVK GHAYAVTDVR
310 320 330 340 350
KVRLGHGLLA FFKSEKMDMI RLRNPWGERE WNGPWSDTSE EWQKVSKSER
360 370 380 390 400
EKMGVTVQDD GEFWMTFEDV CRYFTDIIKC RVINTSHLSI HKTWEEARLH
410 420 430 440 450
GAWTLHEDPR QNRGGGCINH KDTFFQNPQY IFEVKKPEDE VLICIQQRPK
460 470 480 490 500
RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI YINSRSVFLR
510 520 530 540 550
TDQPEGRYVI IPTTFEPGHT GEFLLRVFTD VPSNCRELRL DEPPHTCWSS
560 570 580 590 600
LCGYPQLVTQ VHVLGAAGLK DSPTGANSYV IIKCEGDKVR SAVQKGTSTP
610 620 630 640 650
EYNVKGIFYR KKLSQPITVQ VWNHRVLKDE FLGQVHLKAD PDNLQALHTL
660 670 680
HLRDRNSRQP SNLPGTVAVH ILSSTSLMAV
Length:680
Mass (Da):77,309
Last modified:July 5, 2004 - v1
Checksum:iD6D470897ED15FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128124 mRNA Translation: BAC87282.1
UniGeneiHs.248153

Similar proteinsi

Entry informationi

Entry nameiQ6ZRM8_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRM8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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