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Protein

Uncharacterized protein C15orf39

Gene

C15orf39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C15orf39
Gene namesi
ORF Names:FP6578
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000167173.18
HGNCiHGNC:24497 C15orf39
neXtProtiNX_Q6ZRI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167173
PharmGKBiPA142672275

Polymorphism and mutation databases

BioMutaiC15orf39
DMDMi296439396

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443431 – 1047Uncharacterized protein C15orf39Add BLAST1047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17N6-acetyllysineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei397PhosphothreonineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei496PhosphoserineBy similarity1
Modified residuei497PhosphoserineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei956PhosphoserineCombined sources1
Modified residuei988PhosphoserineBy similarity1
Modified residuei996PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6ZRI6
MaxQBiQ6ZRI6
PaxDbiQ6ZRI6
PeptideAtlasiQ6ZRI6
PRIDEiQ6ZRI6
ProteomicsDBi68134
68135 [Q6ZRI6-2]
68136 [Q6ZRI6-3]

PTM databases

iPTMnetiQ6ZRI6
PhosphoSitePlusiQ6ZRI6

Expressioni

Gene expression databases

BgeeiENSG00000167173 Expressed in 167 organ(s), highest expression level in testis
CleanExiHS_C15orf39
ExpressionAtlasiQ6ZRI6 baseline and differential
GenevisibleiQ6ZRI6 HS

Organism-specific databases

HPAiHPA039961
HPA041907

Interactioni

Protein-protein interaction databases

BioGridi121235, 31 interactors
IntActiQ6ZRI6, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6ZRI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGI4 Eukaryota
ENOG410YQ9P LUCA
GeneTreeiENSGT00390000002672
HOVERGENiHBG081296
InParanoidiQ6ZRI6
OMAiGLQWRDC
OrthoDBiEOG091G02IX
PhylomeDBiQ6ZRI6
TreeFamiTF338672

Family and domain databases

InterProiView protein in InterPro
IPR037656 C15orf39
PANTHERiPTHR28422 PTHR28422, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZRI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEKRPLRTL GPVMYGKLPR LETDSGLEHS LPHSVGNQDP CTYKGSYFSC
60 70 80 90 100
PMAGTPKAES EQLASWTPYP PLYSTGMAGP PLQADNLLTN CLFYRSPAEG
110 120 130 140 150
PEKMQDSSPV ELLPFSPQAH SYPGPPLAAP KPVYRNPLCY GLSTCLGEGA
160 170 180 190 200
VKRPLDVDWT LATGPLLPSA DPPCSLAPAP SKGQTLDGTF LRGVPAEGSS
210 220 230 240 250
KDSSGSFSPC QPFLEKYQTI HSTGFLASRY TGPYPRNSKQ AMSEGPSSPW
260 270 280 290 300
TQLAQPLGPP CQDTGPTHYP PPHHPPPHPP QALPCPPACR HPEKQGSYSP
310 320 330 340 350
ALPLQPLGGH KGTGYQAGGL GSPYLRQQAA QAPYIPPLGL DAYPYPSAPL
360 370 380 390 400
PAPSPGLKLE PPLTPRCPLD FAPQTLSFPY ARDDLSLYGA SPGLGGTPPS
410 420 430 440 450
QNNVRAVPQP GAFQRACQPL PASQPCSEPV RPAQEAEEKT WLPSCRKEKL
460 470 480 490 500
QPRLSEHSGP PIVIRDSPVP CTPPALPPCA RECQSLPQKE GARPPSSPPM
510 520 530 540 550
PVIDNVFSLA PYRDYLDVPA PEATTEPDSA TAEPDSAPAT SEGQDKGCRG
560 570 580 590 600
TLPAQEGPSG SKPLRGSLKE EVALDLSVRK PTAEASPVKA SRSVEHAKPT
610 620 630 640 650
AAMDVPDVGN MVSDLPGLKK IDTEAPGLPG VPVTTDAMPR TNFHSSVAFM
660 670 680 690 700
FRKFKILRPA PLPAAVVPST PTSAPAPTQP APTPTSGPIG LRILAQQPLS
710 720 730 740 750
VTCFSLALPS PPAVAVASPA PAPAPSPAPA RAQAPASARD PAPAPAPVAG
760 770 780 790 800
PAPASTSAPG DSLEQHFTGL HASLCDAISG SVAHSPPEKL REWLETAGPW
810 820 830 840 850
GQAAWQDCQG VQGLLAKLLS QLQRFDRTHR CPFPHVVRAG AIFVPIHLVK
860 870 880 890 900
ERLFPRLPPA SVDHVLQEHR VELRPTTLSE ERALRELALP GCTSRMLKLL
910 920 930 940 950
ALRQLPDIYP DLLGLQWRDC VRRQLGDFDT EAGAVSSSEP TVARGEPESL
960 970 980 990 1000
ALAQKSPAPK VRKPGRKPPT PGPEKAEAAA GEESCGASPT PATSASPPGP
1010 1020 1030 1040
TLKARFRSLL ETAWLNGLAL PTWGHKSSRP DQPSPCPQLL DSQSHHL
Length:1,047
Mass (Da):110,673
Last modified:May 18, 2010 - v3
Checksum:i4D31AB94689FED5F
GO
Isoform 2 (identifier: Q6ZRI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     927-938: DFDTEAGAVSSS → EHGAAPVATGAV
     939-1047: Missing.

Note: No experimental confirmation available.
Show »
Length:938
Mass (Da):99,213
Checksum:i224E1B67D192F3ED
GO
Isoform 3 (identifier: Q6ZRI6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-910: Missing.
     911-925: DLLGLQWRDCVRRQL → MGQPQWPPELCEQVT

Show »
Length:137
Mass (Da):14,321
Checksum:iFB2A52B334FF8320
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMJ2H3BMJ2_HUMAN
Uncharacterized protein C15orf39
C15orf39
807Annotation score:
H3BT66H3BT66_HUMAN
Uncharacterized protein C15orf39
C15orf39
29Annotation score:
H3BRS2H3BRS2_HUMAN
Uncharacterized protein C15orf39
C15orf39
27Annotation score:
H3BN41H3BN41_HUMAN
Uncharacterized protein C15orf39
C15orf39
21Annotation score:

Sequence cautioni

The sequence AAQ06680 differs from that shown. Reason: Frameshift at position 267.Curated
The sequence CAB55985 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD39045 differs from that shown. Reason: Frameshift at position 900.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti592R → H in CAD39045 (PubMed:17974005).Curated1
Sequence conflicti913L → P in BAC87324 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026891119A → P1 PublicationCorresponds to variant dbSNP:rs1873379Ensembl.1
Natural variantiVAR_026892491G → DCombined sources3 PublicationsCorresponds to variant dbSNP:rs11072532Ensembl.1
Natural variantiVAR_026893536S → A1 PublicationCorresponds to variant dbSNP:rs28509789Ensembl.1
Natural variantiVAR_026894945G → DCombined sources5 PublicationsCorresponds to variant dbSNP:rs3743211Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0195381 – 910Missing in isoform 3. 3 PublicationsAdd BLAST910
Alternative sequenceiVSP_019539911 – 925DLLGL…VRRQL → MGQPQWPPELCEQVT in isoform 3. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_019540927 – 938DFDTE…AVSSS → EHGAAPVATGAV in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_019541939 – 1047Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117540 mRNA Translation: CAB55985.3 Different initiation.
AK125111 mRNA Translation: BAG54145.1
AK125604 mRNA Translation: BAC86215.1
AK128205 mRNA Translation: BAC87324.1
AF495726 mRNA Translation: AAQ06680.1 Frameshift.
CR533482 mRNA Translation: CAG38513.1
AC113208 Genomic DNA No translation available.
BC001762 mRNA Translation: AAH01762.1
BC011379 mRNA Translation: AAH11379.2
BC011905 mRNA Translation: AAH11905.1
BC051235 mRNA Translation: AAH51235.1
BC110367 mRNA Translation: AAI10368.1
AL834382 mRNA Translation: CAD39045.1 Frameshift.
CCDSiCCDS10276.1 [Q6ZRI6-1]
PIRiT17295
RefSeqiNP_056307.2, NM_015492.4
UniGeneiHs.17936

Genome annotation databases

EnsembliENST00000360639; ENSP00000353854; ENSG00000167173 [Q6ZRI6-1]
ENST00000394987; ENSP00000378438; ENSG00000167173 [Q6ZRI6-1]
ENST00000567617; ENSP00000458025; ENSG00000167173 [Q6ZRI6-2]
GeneIDi56905
KEGGihsa:56905
UCSCiuc002azp.4 human [Q6ZRI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117540 mRNA Translation: CAB55985.3 Different initiation.
AK125111 mRNA Translation: BAG54145.1
AK125604 mRNA Translation: BAC86215.1
AK128205 mRNA Translation: BAC87324.1
AF495726 mRNA Translation: AAQ06680.1 Frameshift.
CR533482 mRNA Translation: CAG38513.1
AC113208 Genomic DNA No translation available.
BC001762 mRNA Translation: AAH01762.1
BC011379 mRNA Translation: AAH11379.2
BC011905 mRNA Translation: AAH11905.1
BC051235 mRNA Translation: AAH51235.1
BC110367 mRNA Translation: AAI10368.1
AL834382 mRNA Translation: CAD39045.1 Frameshift.
CCDSiCCDS10276.1 [Q6ZRI6-1]
PIRiT17295
RefSeqiNP_056307.2, NM_015492.4
UniGeneiHs.17936

3D structure databases

ProteinModelPortaliQ6ZRI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121235, 31 interactors
IntActiQ6ZRI6, 6 interactors

PTM databases

iPTMnetiQ6ZRI6
PhosphoSitePlusiQ6ZRI6

Polymorphism and mutation databases

BioMutaiC15orf39
DMDMi296439396

Proteomic databases

EPDiQ6ZRI6
MaxQBiQ6ZRI6
PaxDbiQ6ZRI6
PeptideAtlasiQ6ZRI6
PRIDEiQ6ZRI6
ProteomicsDBi68134
68135 [Q6ZRI6-2]
68136 [Q6ZRI6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360639; ENSP00000353854; ENSG00000167173 [Q6ZRI6-1]
ENST00000394987; ENSP00000378438; ENSG00000167173 [Q6ZRI6-1]
ENST00000567617; ENSP00000458025; ENSG00000167173 [Q6ZRI6-2]
GeneIDi56905
KEGGihsa:56905
UCSCiuc002azp.4 human [Q6ZRI6-1]

Organism-specific databases

CTDi56905
EuPathDBiHostDB:ENSG00000167173.18
GeneCardsiC15orf39
H-InvDBiHIX0012438
HIX0172847
HGNCiHGNC:24497 C15orf39
HPAiHPA039961
HPA041907
neXtProtiNX_Q6ZRI6
OpenTargetsiENSG00000167173
PharmGKBiPA142672275
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGI4 Eukaryota
ENOG410YQ9P LUCA
GeneTreeiENSGT00390000002672
HOVERGENiHBG081296
InParanoidiQ6ZRI6
OMAiGLQWRDC
OrthoDBiEOG091G02IX
PhylomeDBiQ6ZRI6
TreeFamiTF338672

Miscellaneous databases

ChiTaRSiC15orf39 human
GenomeRNAii56905
PROiPR:Q6ZRI6

Gene expression databases

BgeeiENSG00000167173 Expressed in 167 organ(s), highest expression level in testis
CleanExiHS_C15orf39
ExpressionAtlasiQ6ZRI6 baseline and differential
GenevisibleiQ6ZRI6 HS

Family and domain databases

InterProiView protein in InterPro
IPR037656 C15orf39
PANTHERiPTHR28422 PTHR28422, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO039_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRI6
Secondary accession number(s): B3KWI3
, C9J888, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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