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Entry version 129 (25 May 2022)
Sequence version 3 (25 Nov 2008)
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Protein

Cation channel sperm-associated auxiliary subunit gamma

Gene

CATSPERG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

By similarity

Caution

In mouse, Slco6c1 is an additional auxiliary subunit of the CatSper complex. It is unclear if the related SLCO6A1 protein performs the same role in non-rodent species.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZRH7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1300642, Sperm Motility And Taxes

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.19.1, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation channel sperm-associated auxiliary subunit gammaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CATSPERGImported
Synonyms:C19orf15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25243, CATSPERG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613452, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZRH7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000099338

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 1065ExtracellularBy similarityAdd BLAST1030
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1066 – 1087HelicalBy similarityAdd BLAST22
Topological domaini1088 – 1159CytoplasmicBy similarityAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000099338

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165393235

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZRH7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CATSPERG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001956536 – 1159Cation channel sperm-associated auxiliary subunit gammaAdd BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 105By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi159 ↔ 165By similarity
Disulfide bondi288 ↔ 343By similarity
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi394 ↔ 402By similarity
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi638 ↔ 860By similarity
Disulfide bondi806 ↔ 834By similarity
Disulfide bondi882 ↔ 1046By similarity
Disulfide bondi909 ↔ 918By similarity
Disulfide bondi1010 ↔ 1016By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZRH7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZRH7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZRH7

PeptideAtlas

More...
PeptideAtlasi
Q6ZRH7

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZRH7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68130

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6ZRH7, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZRH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZRH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099338, Expressed in right testis and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZRH7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZRH7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000099338, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE, CATSPERZ, TMEM249, TMEM262 and EFCAB9. HSPA1 may be an additional auxiliary complex member. The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel. The auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 AND CATSPER2 respectively. TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121787, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386962

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZRH7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q6ZRH7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZRH7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1139 – 1159DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CATSPERG family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWAR, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014139

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZRH7

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFYEDRE

Database of Orthologous Groups

More...
OrthoDBi
110808at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZRH7

TreeFam database of animal gene trees

More...
TreeFami
TF337337

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028246, CATSPERG

The PANTHER Classification System

More...
PANTHERi
PTHR14327, PTHR14327, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15064, CATSPERG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q6ZRH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL
60 70 80 90 100
NEFKRVGESG VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK
110 120 130 140 150
INYSCEEKPS EDLVRMGHLT GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA
160 170 180 190 200
APFRSKEPCM AEEVCSMSWY TPMPIKKGSV VMRVDISSNG LGTFIPDKRF
210 220 230 240 250
QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL WHTVDQSPVL
260 270 280 290 300
ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT
310 320 330 340 350
IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV
360 370 380 390 400
YFHSNGSEYI MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT
410 420 430 440 450
TCSIIWSEYI AGEYTLLLLV ESGYGNASKR FQVVSYNTAS DDLELLYHIP
460 470 480 490 500
EFIPEARGLE FLMILGTESY TSTAMAPKGI FCNPYNNLIF IWGNFLLQSS
510 520 530 540 550
NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL LEGSYRVYQL
560 570 580 590 600
FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ
610 620 630 640 650
LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS
660 670 680 690 700
PQRYTRQERY RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY
710 720 730 740 750
ADPVHDPTWR WWANNKQDQD YYFFLASNWR SAGGVSIEMD SYEKIYNLES
760 770 780 790 800
AYELPERIFL DKGTEYSFAI FLSAQGHSFR TQSELGTAFQ LHSQVDVGVV
810 820 830 840 850
LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS GHHLMETSMT
860 870 880 890 900
VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR
910 920 930 940 950
LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV
960 970 980 990 1000
VGGGPTLDSL KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS
1010 1020 1030 1040 1050
HESPGIEWLC LENAPCYDNV PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL
1060 1070 1080 1090 1100
TFLLHIHGLP LSPKRALFII MVSASVFVGL VIFYIAFCLL WPLVVKGCTM
1110 1120 1130 1140 1150
IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS RMTEDRAEPK

EAVERQLMT
Length:1,159
Mass (Da):133,032
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D11F84445A09CDF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZI7B8ZZI7_HUMAN
Cation channel sperm-associated aux...
CATSPERG
1,119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDD6F8WDD6_HUMAN
Cation channel sperm-associated aux...
CATSPERG
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KV36H9KV36_HUMAN
Cation channel sperm-associated aux...
CATSPERG
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X1WI24X1WI24_HUMAN
Cation channel sperm-associated aux...
CATSPERG
660Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQR6K7EQR6_HUMAN
Cation channel sperm-associated aux...
CATSPERG
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQY4K7EQY4_HUMAN
Cation channel sperm-associated aux...
CATSPERG
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ16M0QZ16_HUMAN
Cation channel sperm-associated aux...
CATSPERG
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC87333 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti310 – 319RQNQLVYYFT → HQLQGLLSRG in BAC87333 (PubMed:14702039).Curated10
Sequence conflicti943Q → R in BAC87333 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05963129L → P1 PublicationCorresponds to variant dbSNP:rs2302182Ensembl.1
Natural variantiVAR_059632650S → R. Corresponds to variant dbSNP:rs3745953Ensembl.1
Natural variantiVAR_0596331137M → T. Corresponds to variant dbSNP:rs2286550Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005625 Genomic DNA No translation available.
AC005789 Genomic DNA No translation available.
AC026806 Genomic DNA No translation available.
AL133023 mRNA Translation: CAH56391.1 Different termination.
AK128220 mRNA Translation: BAC87333.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12514.2

NCBI Reference Sequences

More...
RefSeqi
NP_067008.3, NM_021185.4
XP_005259171.1, XM_005259114.4
XP_005259172.1, XM_005259115.4
XP_006723371.1, XM_006723308.3
XP_006723374.1, XM_006723311.2
XP_011525476.1, XM_011527174.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409235.8; ENSP00000386962.3; ENSG00000099338.23

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57828

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000409235.8; ENSP00000386962.3; NM_021185.5; NP_067008.3

UCSC genome browser

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UCSCi
uc002oih.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005625 Genomic DNA No translation available.
AC005789 Genomic DNA No translation available.
AC026806 Genomic DNA No translation available.
AL133023 mRNA Translation: CAH56391.1 Different termination.
AK128220 mRNA Translation: BAC87333.1 Different initiation.
CCDSiCCDS12514.2
RefSeqiNP_067008.3, NM_021185.4
XP_005259171.1, XM_005259114.4
XP_005259172.1, XM_005259115.4
XP_006723371.1, XM_006723308.3
XP_006723374.1, XM_006723311.2
XP_011525476.1, XM_011527174.2

3D structure databases

AlphaFoldDBiQ6ZRH7
SMRiQ6ZRH7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121787, 3 interactors
STRINGi9606.ENSP00000386962

Protein family/group databases

TCDBi1.A.1.19.1, the voltage-gated ion channel (vic) superfamily

PTM databases

GlyGeniQ6ZRH7, 2 sites
iPTMnetiQ6ZRH7
PhosphoSitePlusiQ6ZRH7

Genetic variation databases

BioMutaiCATSPERG
DMDMi215274173

Proteomic databases

MassIVEiQ6ZRH7
MaxQBiQ6ZRH7
PaxDbiQ6ZRH7
PeptideAtlasiQ6ZRH7
PRIDEiQ6ZRH7
ProteomicsDBi68130

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30031, 23 antibodies from 12 providers

The DNASU plasmid repository

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DNASUi
57828

Genome annotation databases

EnsembliENST00000409235.8; ENSP00000386962.3; ENSG00000099338.23
GeneIDi57828
KEGGihsa:57828
MANE-SelectiENST00000409235.8; ENSP00000386962.3; NM_021185.5; NP_067008.3
UCSCiuc002oih.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57828

GeneCards: human genes, protein and diseases

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GeneCardsi
CATSPERG
HGNCiHGNC:25243, CATSPERG
HPAiENSG00000099338, Tissue enriched (testis)
MIMi613452, gene
neXtProtiNX_Q6ZRH7
OpenTargetsiENSG00000099338
PharmGKBiPA165393235
VEuPathDBiHostDB:ENSG00000099338

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QWAR, Eukaryota
GeneTreeiENSGT00390000014139
InParanoidiQ6ZRH7
OMAiFFYEDRE
OrthoDBi110808at2759
PhylomeDBiQ6ZRH7
TreeFamiTF337337

Enzyme and pathway databases

PathwayCommonsiQ6ZRH7
ReactomeiR-HSA-1300642, Sperm Motility And Taxes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57828, 15 hits in 1065 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CATSPERG, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57828
PharosiQ6ZRH7, Tdark

Protein Ontology

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PROi
PR:Q6ZRH7
RNActiQ6ZRH7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000099338, Expressed in right testis and 118 other tissues
ExpressionAtlasiQ6ZRH7, baseline and differential
GenevisibleiQ6ZRH7, HS

Family and domain databases

InterProiView protein in InterPro
IPR028246, CATSPERG
PANTHERiPTHR14327, PTHR14327, 1 hit
PfamiView protein in Pfam
PF15064, CATSPERG, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTSRG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZRH7
Secondary accession number(s): A6NEG6, Q659E1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 25, 2008
Last modified: May 25, 2022
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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