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Entry version 122 (07 Apr 2021)
Sequence version 2 (17 Apr 2007)
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Protein

Retrotransposon Gag-like protein 4

Gene

RTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cognitive function in the brain, possibly via the noradrenergic system.By similarity

Miscellaneous

RTL4 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri278 – 295CCHC-typePROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZR62

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrotransposon Gag-like protein 4Imported
Alternative name(s):
Mammalian retrotransposon-derived protein 4By similarity
Zinc finger CCHC domain-containing protein 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTL4Imported
Synonyms:MAR3, MART4By similarity, ZCCHC16Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25214, RTL4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZR62

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000187823.3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
340595

Open Targets

More...
OpenTargetsi
ENSG00000187823

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670538

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZR62, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RTL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559545

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002574941 – 310Retrotransposon Gag-like protein 4Add BLAST310

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZR62

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZR62

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68115

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZR62

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZR62

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187823, Expressed in liver and 16 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187823, Group enriched (kidney, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131082, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZR62, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340590

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZR62, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri278 – 295CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502T727, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163925

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000384_20_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZR62

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCLYCSQ

Database of Orthologous Groups

More...
OrthoDBi
583605at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZR62

TreeFam database of animal gene trees

More...
TreeFami
TF335133

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032567, LDOC1-rel
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15503, PTHR15503, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756, SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ZR62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKCTKSSST MQVEPSFLQA ENLILRLQMQ HPTTENTAKR GQVMPALATT
60 70 80 90 100
VMPVPYSLEH LTQFHGDPAN CSEFLTQVTT YLTALQISNP ANDAQIKLFF
110 120 130 140 150
DYLSQQLESC GIISGPDKST LLKQYENLIL EFQQSFGKPT KQEINPLMNA
160 170 180 190 200
KFDKGDNSSQ QDPATFHLLA QNLICNETNQ SGQFEKALAD PNQDEESVTD
210 220 230 240 250
MMDNLPDLIT QCIQLDKKHS DRPELLQSET QLPLLASLIQ HQALFSPTDP
260 270 280 290 300
PPKKGPIQLR EGQLPLTPAK RARQQETQLC LYCSQSGHFT RDCLAKRSRA
310
PATTNNTAHQ
Length:310
Mass (Da):34,685
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2F4F4EDBD580EAC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02891727L → P2 PublicationsCorresponds to variant dbSNP:rs6568050Ensembl.1
Natural variantiVAR_053756162D → Y. Corresponds to variant dbSNP:rs7474140Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK128465 mRNA Translation: BAC87453.1
BX088563 Genomic DNA No translation available.
BC137430 mRNA Translation: AAI37431.1
BC137433 mRNA Translation: AAI37434.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35369.1

NCBI Reference Sequences

More...
RefSeqi
NP_001004308.2, NM_001004308.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340433; ENSP00000340590; ENSG00000187823

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340595

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340595

UCSC genome browser

More...
UCSCi
uc065atq.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128465 mRNA Translation: BAC87453.1
BX088563 Genomic DNA No translation available.
BC137430 mRNA Translation: AAI37431.1
BC137433 mRNA Translation: AAI37434.1
CCDSiCCDS35369.1
RefSeqiNP_001004308.2, NM_001004308.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131082, 2 interactors
IntActiQ6ZR62, 1 interactor
STRINGi9606.ENSP00000340590

PTM databases

iPTMnetiQ6ZR62
PhosphoSitePlusiQ6ZR62

Genetic variation databases

BioMutaiRTL4
DMDMi145559545

Proteomic databases

PaxDbiQ6ZR62
PRIDEiQ6ZR62
ProteomicsDBi68115

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
569, 13 antibodies

Genome annotation databases

EnsembliENST00000340433; ENSP00000340590; ENSG00000187823
GeneIDi340595
KEGGihsa:340595
UCSCiuc065atq.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340595
DisGeNETi340595

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RTL4
HGNCiHGNC:25214, RTL4
HPAiENSG00000187823, Group enriched (kidney, liver)
neXtProtiNX_Q6ZR62
OpenTargetsiENSG00000187823
PharmGKBiPA142670538
VEuPathDBiHostDB:ENSG00000187823.3

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502T727, Eukaryota
GeneTreeiENSGT00940000163925
HOGENOMiCLU_000384_20_1_1
InParanoidiQ6ZR62
OMAiLCLYCSQ
OrthoDBi583605at2759
PhylomeDBiQ6ZR62
TreeFamiTF335133

Enzyme and pathway databases

PathwayCommonsiQ6ZR62

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
340595, 4 hits in 603 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RTL4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340595
PharosiQ6ZR62, Tdark

Protein Ontology

More...
PROi
PR:Q6ZR62
RNActiQ6ZR62, protein

Gene expression databases

BgeeiENSG00000187823, Expressed in liver and 16 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR032567, LDOC1-rel
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
PANTHERiPTHR15503, PTHR15503, 1 hit
SUPFAMiSSF57756, SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158, ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZR62
Secondary accession number(s): B2RPG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 17, 2007
Last modified: April 7, 2021
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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