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UniProtKB - Q6ZR52 (ZN493_HUMAN)

Entry version 159 (25 May 2022)
Sequence version 3 (17 Apr 2007)
Previous versions | rss
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Protein

Zinc finger protein 493

Gene

ZNF493

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri26 – 48C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri54 – 76C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri82 – 104C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri109 – 131C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZR52

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6ZR52

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 493
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF493
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23708, ZNF493

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZR52

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196268

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		284443

Open Targets

More...OpenTargetsi		ENSG00000196268

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134932599

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZR52, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF493

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559547

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476161 – 646Zinc finger protein 493Add BLAST646

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZR52

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZR52

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZR52

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZR52

PeptideAtlas

More...PeptideAtlasi		Q6ZR52

PRoteomics IDEntifications database

More...PRIDEi		Q6ZR52

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68112 [Q6ZR52-1]
68113 [Q6ZR52-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZR52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZR52

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6ZR52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196268, Expressed in female gonad and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZR52, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZR52, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196268, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129880, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZR52, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376110

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZR52, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6ZR52

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZR52

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 48C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri54 – 76C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri82 – 104C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri109 – 131C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161765

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZR52

Identification of Orthologs from Complete Genome Data

More...OMAi		ASHKHFH

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZR52

TreeFam database of animal gene trees

More...TreeFami		TF343410

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 21 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 11 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 22 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZR52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNECNVHKEG YNELNQYLTT TQSKIFQCDK YVKVFHKLLN SNRHNTKHTG 
        60         70         80         90        100
KKPFKCKKCG KSFCMLLHLC QHKRIHIREN SYRCEECGKA FIWFSTLTRH 
       110        120        130        140        150
RRVHTGEKSY KYECGKSFNQ DSNLTTHKRI HTGQKPYKCE ECGTSFYQFS 
       160        170        180        190        200
YLTRHKLIHT REKPYKCEQY GKTFNQSSTL TGHKIIHNGE KPYKCEECGK 
       210        220        230        240        250
AFSIFSTPTK HKIIHTEEKS HRCEEYCKAY KESSHLTTHK RIHTGEKPYK 
       260        270        280        290        300
CEECGKAFSI FSTLTKHKII HTEEKSHRCE ECGKAYKESS HLTTHKRIHT 
       310        320        330        340        350
GEKPYKCEEC GKTFSVFSIL TKHKIIHTEE KPYKCEECGK AFKRSSTLTK 
       360        370        380        390        400
HRIIHTEEKP YKCEECGKAF NQSSTLSIHK IIHTGEKPYK CEECGKAFKR 
       410        420        430        440        450
SSTLTIHKMI HTGEKPYKCE ECGKAFNRSS HLTTHKRIHT GHKPYKCKEC 
       460        470        480        490        500
GKSFSVFSTL TKHKIIHTDK KPYKCEECGK AFNRSSILSI HKKIHTGEKP 
       510        520        530        540        550
YKCEECGKAF KRSSHLAGHK QIHSVQKPYK CEECGKAFSI FSTLTKHKII 
       560        570        580        590        600
HTEEKPYKCE KCGKTFYRFS NLNTHKIIHT GEKPCKCEEC GKAFNHSSNL 
       610        620        630        640 
IKHKLIHTGD KPYKCEACGK AFRRSSHLSR HKIIHIGIHT EETVQK
Length:646
Mass (Da):75,342
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6F677DF4F48FF55
GO
Isoform 2 (identifier: Q6ZR52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPPESLDM...LQLRKGCKSM

Show »
Length:774
Mass (Da):89,824
Checksum:i35D56882C2BF4DC3
GO
Isoform 3 (identifier: Q6ZR52-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPPESLDM...SQDGLYLLTS
     2-646: Missing.

Show »
Length:103
Mass (Da):11,659
Checksum:iBB6060D29B1DA22F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1U0M0R1U0_HUMAN
Zinc finger protein 493
ZNF493
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXT4M0QXT4_HUMAN
Zinc finger protein 493
ZNF493 LOC115648, hCG_1780065
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY95M0QY95_HUMAN
Zinc finger protein 493
ZNF493
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04591 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86997 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92323 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti181T → I in BAC87465 (PubMed:14702039).Curated1
Sequence conflicti202F → L in BAC87465 (PubMed:14702039).Curated1
Sequence conflicti335C → R in BAC04591 (PubMed:14702039).Curated1
Sequence conflicti448K → E in BAD92323 (Ref. 2) Curated1
Sequence conflicti547H → Y in BAC86997 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q6ZR52-3)
Sequence conflicti94S → G in AAH06408 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052846195C → F3 PublicationsCorresponds to variant dbSNP:rs4621113Ensembl.1
Natural variantiVAR_052847292L → V1 PublicationCorresponds to variant dbSNP:rs10414834Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0382981M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLGIAVSKPD LVTCLEQGKDPWNMKGHSTV VKPPVICSHFAEDFCPGPGI KDSFQKVILREYVKCGHKDL QLRKGCKSM in isoform 2. 1 Publication1
Alternative sequenceiVSP_0466561M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLAGIAVSKP DLVTCLEQGKDPWNMKGHST VVKPPVETGFHRFSQDGLYL LTS in isoform 3. 1 Publication1
Alternative sequenceiVSP_0466572 – 646Missing in isoform 3. 1 PublicationAdd BLAST645

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK095616 mRNA Translation: BAC04591.1 Different initiation.
AK127476 mRNA Translation: BAC86997.1 Different initiation.
AK128494 mRNA Translation: BAC87465.1
AB209086 mRNA Translation: BAD92323.1 Different initiation.
BX648842 mRNA No translation available.
AC010615 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84898.1
BC006408 mRNA Translation: AAH06408.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12411.1 [Q6ZR52-3]
CCDS12412.1 [Q6ZR52-1]
CCDS42536.1 [Q6ZR52-2]

NCBI Reference Sequences

More...RefSeqi		NP_001070146.1, NM_001076678.2 [Q6ZR52-2]
NP_663299.2, NM_145326.2 [Q6ZR52-3]
NP_787106.4, NM_175910.6 [Q6ZR52-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339914.6; ENSP00000340651.6; ENSG00000196268.12 [Q6ZR52-3]
ENST00000355504.4; ENSP00000347691.4; ENSG00000196268.12
ENST00000392288.7; ENSP00000376110.2; ENSG00000196268.12 [Q6ZR52-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		284443

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:284443

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000392288.7; ENSP00000376110.2; NM_001076678.3; NP_001070146.1 [Q6ZR52-2]

UCSC genome browser

More...UCSCi		uc002npu.4, human [Q6ZR52-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095616 mRNA Translation: BAC04591.1 Different initiation.
AK127476 mRNA Translation: BAC86997.1 Different initiation.
AK128494 mRNA Translation: BAC87465.1
AB209086 mRNA Translation: BAD92323.1 Different initiation.
BX648842 mRNA No translation available.
AC010615 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84898.1
BC006408 mRNA Translation: AAH06408.1
CCDSiCCDS12411.1 [Q6ZR52-3]
CCDS12412.1 [Q6ZR52-1]
CCDS42536.1 [Q6ZR52-2]
RefSeqiNP_001070146.1, NM_001076678.2 [Q6ZR52-2]
NP_663299.2, NM_145326.2 [Q6ZR52-3]
NP_787106.4, NM_175910.6 [Q6ZR52-1]

3D structure databases

AlphaFoldDBiQ6ZR52
SMRiQ6ZR52
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129880, 4 interactors
IntActiQ6ZR52, 2 interactors
STRINGi9606.ENSP00000376110

PTM databases

iPTMnetiQ6ZR52
PhosphoSitePlusiQ6ZR52
SwissPalmiQ6ZR52

Genetic variation databases

BioMutaiZNF493
DMDMi145559547

Proteomic databases

jPOSTiQ6ZR52
MassIVEiQ6ZR52
MaxQBiQ6ZR52
PaxDbiQ6ZR52
PeptideAtlasiQ6ZR52
PRIDEiQ6ZR52
ProteomicsDBi68112 [Q6ZR52-1]
68113 [Q6ZR52-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		55042, 60 antibodies from 12 providers

The DNASU plasmid repository

More...DNASUi		284443

Genome annotation databases

EnsembliENST00000339914.6; ENSP00000340651.6; ENSG00000196268.12 [Q6ZR52-3]
ENST00000355504.4; ENSP00000347691.4; ENSG00000196268.12
ENST00000392288.7; ENSP00000376110.2; ENSG00000196268.12 [Q6ZR52-2]
GeneIDi284443
KEGGihsa:284443
MANE-SelectiENST00000392288.7; ENSP00000376110.2; NM_001076678.3; NP_001070146.1 [Q6ZR52-2]
UCSCiuc002npu.4, human [Q6ZR52-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		284443
DisGeNETi284443

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF493
HGNCiHGNC:23708, ZNF493
HPAiENSG00000196268, Low tissue specificity
neXtProtiNX_Q6ZR52
OpenTargetsiENSG00000196268
PharmGKBiPA134932599
VEuPathDBiHostDB:ENSG00000196268

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161765
HOGENOMiCLU_002678_17_1_1
InParanoidiQ6ZR52
OMAiASHKHFH
OrthoDBi1318335at2759
PhylomeDBiQ6ZR52
TreeFamiTF343410

Enzyme and pathway databases

PathwayCommonsiQ6ZR52
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiQ6ZR52

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		284443, 11 hits in 1065 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF493, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		284443
PharosiQ6ZR52, Tdark

Protein Ontology

More...PROi		PR:Q6ZR52
RNActiQ6ZR52, protein

Gene expression databases

BgeeiENSG00000196268, Expressed in female gonad and 217 other tissues
ExpressionAtlasiQ6ZR52, baseline and differential
GenevisibleiQ6ZR52, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 21 hits
SUPFAMiSSF57667, SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 22 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN493_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZR52
Secondary accession number(s): G5E974
, Q59GM3, Q6ZSF6, Q8N1Z6, Q8N965, Q9BR99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: April 17, 2007
Last modified: May 25, 2022
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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