UniProtKB - Q6ZR52 (ZN493_HUMAN)
Protein
Zinc finger protein 493
Gene
ZNF493
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 26 – 48 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 54 – 76 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 82 – 104 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 109 – 131 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 137 – 159 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 187 | C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 193 – 215 | C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 221 – 243 | C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 249 – 271 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 277 – 299 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 361 – 383 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 389 – 411 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 417 – 439 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 445 – 467 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 473 – 495 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 501 – 523 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 529 – 551 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 557 – 579 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 585 – 607 | C2H2-type 21PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 613 – 635 | C2H2-type 22PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6ZR52 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 493 |
Gene namesi | Name:ZNF493 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196268.11 |
HGNCi | HGNC:23708, ZNF493 |
neXtProti | NX_Q6ZR52 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 284443 |
OpenTargetsi | ENSG00000196268 |
PharmGKBi | PA134932599 |
Miscellaneous databases
Pharosi | Q6ZR52, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF493 |
DMDMi | 145559547 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047616 | 1 – 646 | Zinc finger protein 493Add BLAST | 646 |
Proteomic databases
jPOSTi | Q6ZR52 |
MassIVEi | Q6ZR52 |
MaxQBi | Q6ZR52 |
PaxDbi | Q6ZR52 |
PeptideAtlasi | Q6ZR52 |
PRIDEi | Q6ZR52 |
ProteomicsDBi | 33854 68112 [Q6ZR52-1] 68113 [Q6ZR52-2] |
PTM databases
iPTMneti | Q6ZR52 |
PhosphoSitePlusi | Q6ZR52 |
SwissPalmi | Q6ZR52 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196268, Expressed in female gonad and 217 other tissues |
ExpressionAtlasi | Q6ZR52, baseline and differential |
Genevisiblei | Q6ZR52, HS |
Organism-specific databases
HPAi | ENSG00000196268, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsIsoform 3 [Q6ZR52-3]
With | #Exp. | IntAct |
---|---|---|
CENPH [Q9H3R5] | 3 | EBI-12856290,EBI-1003700 |
MESD [Q14696] | 3 | EBI-12856290,EBI-6165891 |
Protein-protein interaction databases
BioGRIDi | 129880, 3 interactors |
IntActi | Q6ZR52, 2 interactors |
STRINGi | 9606.ENSP00000376110 |
Miscellaneous databases
RNActi | Q6ZR52, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 26 – 48 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 54 – 76 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 82 – 104 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 109 – 131 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 137 – 159 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 187 | C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 193 – 215 | C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 221 – 243 | C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 249 – 271 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 277 – 299 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 361 – 383 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 389 – 411 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 417 – 439 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 445 – 467 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 473 – 495 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 501 – 523 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 529 – 551 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 557 – 579 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 585 – 607 | C2H2-type 21PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 613 – 635 | C2H2-type 22PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161765 |
HOGENOMi | CLU_002678_17_1_1 |
InParanoidi | Q6ZR52 |
OMAi | GHKQIHS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6ZR52 |
TreeFami | TF343410 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 16 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 21 hits |
SUPFAMi | SSF57667, SSF57667, 11 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 18 hits PS50157, ZINC_FINGER_C2H2_2, 22 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZR52-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNECNVHKEG YNELNQYLTT TQSKIFQCDK YVKVFHKLLN SNRHNTKHTG
60 70 80 90 100
KKPFKCKKCG KSFCMLLHLC QHKRIHIREN SYRCEECGKA FIWFSTLTRH
110 120 130 140 150
RRVHTGEKSY KYECGKSFNQ DSNLTTHKRI HTGQKPYKCE ECGTSFYQFS
160 170 180 190 200
YLTRHKLIHT REKPYKCEQY GKTFNQSSTL TGHKIIHNGE KPYKCEECGK
210 220 230 240 250
AFSIFSTPTK HKIIHTEEKS HRCEEYCKAY KESSHLTTHK RIHTGEKPYK
260 270 280 290 300
CEECGKAFSI FSTLTKHKII HTEEKSHRCE ECGKAYKESS HLTTHKRIHT
310 320 330 340 350
GEKPYKCEEC GKTFSVFSIL TKHKIIHTEE KPYKCEECGK AFKRSSTLTK
360 370 380 390 400
HRIIHTEEKP YKCEECGKAF NQSSTLSIHK IIHTGEKPYK CEECGKAFKR
410 420 430 440 450
SSTLTIHKMI HTGEKPYKCE ECGKAFNRSS HLTTHKRIHT GHKPYKCKEC
460 470 480 490 500
GKSFSVFSTL TKHKIIHTDK KPYKCEECGK AFNRSSILSI HKKIHTGEKP
510 520 530 540 550
YKCEECGKAF KRSSHLAGHK QIHSVQKPYK CEECGKAFSI FSTLTKHKII
560 570 580 590 600
HTEEKPYKCE KCGKTFYRFS NLNTHKIIHT GEKPCKCEEC GKAFNHSSNL
610 620 630 640
IKHKLIHTGD KPYKCEACGK AFRRSSHLSR HKIIHIGIHT EETVQK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R1U0 | M0R1U0_HUMAN | Zinc finger protein 493 | ZNF493 | 48 | Annotation score: | ||
M0QXT4 | M0QXT4_HUMAN | Zinc finger protein 493 | ZNF493 LOC115648, hCG_1780065 | 95 | Annotation score: | ||
M0QY95 | M0QY95_HUMAN | Zinc finger protein 493 | ZNF493 | 94 | Annotation score: |
Sequence cautioni
The sequence BAC04591 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86997 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92323 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 181 | T → I in BAC87465 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 202 | F → L in BAC87465 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 335 | C → R in BAC04591 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 448 | K → E in BAD92323 (Ref. 2) Curated | 1 | ||
Sequence conflicti | 547 | H → Y in BAC86997 (PubMed:14702039).Curated | 1 | ||
Isoform 3 (identifier: Q6ZR52-3) | |||||
Sequence conflicti | 94 | S → G in AAH06408 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052846 | 195 | C → F3 PublicationsCorresponds to variant dbSNP:rs4621113Ensembl. | 1 | |
Natural variantiVAR_052847 | 292 | L → V1 PublicationCorresponds to variant dbSNP:rs10414834Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038298 | 1 | M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLGIAVSKPD LVTCLEQGKDPWNMKGHSTV VKPPVICSHFAEDFCPGPGI KDSFQKVILREYVKCGHKDL QLRKGCKSM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_046656 | 1 | M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLAGIAVSKP DLVTCLEQGKDPWNMKGHST VVKPPVETGFHRFSQDGLYL LTS in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_046657 | 2 – 646 | Missing in isoform 3. 1 PublicationAdd BLAST | 645 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095616 mRNA Translation: BAC04591.1 Different initiation. AK127476 mRNA Translation: BAC86997.1 Different initiation. AK128494 mRNA Translation: BAC87465.1 AB209086 mRNA Translation: BAD92323.1 Different initiation. BX648842 mRNA No translation available. AC010615 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84898.1 BC006408 mRNA Translation: AAH06408.1 |
CCDSi | CCDS12411.1 [Q6ZR52-3] CCDS12412.1 [Q6ZR52-1] CCDS42536.1 [Q6ZR52-2] |
RefSeqi | NP_001070146.1, NM_001076678.2 [Q6ZR52-2] NP_663299.2, NM_145326.2 [Q6ZR52-3] NP_787106.4, NM_175910.6 [Q6ZR52-1] |
Genome annotation databases
Ensembli | ENST00000339914; ENSP00000340651; ENSG00000196268 [Q6ZR52-3] ENST00000355504; ENSP00000347691; ENSG00000196268 [Q6ZR52-1] ENST00000392288; ENSP00000376110; ENSG00000196268 [Q6ZR52-2] |
GeneIDi | 284443 |
KEGGi | hsa:284443 |
UCSCi | uc002npu.4, human [Q6ZR52-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095616 mRNA Translation: BAC04591.1 Different initiation. AK127476 mRNA Translation: BAC86997.1 Different initiation. AK128494 mRNA Translation: BAC87465.1 AB209086 mRNA Translation: BAD92323.1 Different initiation. BX648842 mRNA No translation available. AC010615 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84898.1 BC006408 mRNA Translation: AAH06408.1 |
CCDSi | CCDS12411.1 [Q6ZR52-3] CCDS12412.1 [Q6ZR52-1] CCDS42536.1 [Q6ZR52-2] |
RefSeqi | NP_001070146.1, NM_001076678.2 [Q6ZR52-2] NP_663299.2, NM_145326.2 [Q6ZR52-3] NP_787106.4, NM_175910.6 [Q6ZR52-1] |
3D structure databases
SMRi | Q6ZR52 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129880, 3 interactors |
IntActi | Q6ZR52, 2 interactors |
STRINGi | 9606.ENSP00000376110 |
PTM databases
iPTMneti | Q6ZR52 |
PhosphoSitePlusi | Q6ZR52 |
SwissPalmi | Q6ZR52 |
Polymorphism and mutation databases
BioMutai | ZNF493 |
DMDMi | 145559547 |
Proteomic databases
jPOSTi | Q6ZR52 |
MassIVEi | Q6ZR52 |
MaxQBi | Q6ZR52 |
PaxDbi | Q6ZR52 |
PeptideAtlasi | Q6ZR52 |
PRIDEi | Q6ZR52 |
ProteomicsDBi | 33854 68112 [Q6ZR52-1] 68113 [Q6ZR52-2] |
Protocols and materials databases
Antibodypediai | 55042, 59 antibodies |
DNASUi | 284443 |
Genome annotation databases
Ensembli | ENST00000339914; ENSP00000340651; ENSG00000196268 [Q6ZR52-3] ENST00000355504; ENSP00000347691; ENSG00000196268 [Q6ZR52-1] ENST00000392288; ENSP00000376110; ENSG00000196268 [Q6ZR52-2] |
GeneIDi | 284443 |
KEGGi | hsa:284443 |
UCSCi | uc002npu.4, human [Q6ZR52-1] |
Organism-specific databases
CTDi | 284443 |
DisGeNETi | 284443 |
EuPathDBi | HostDB:ENSG00000196268.11 |
GeneCardsi | ZNF493 |
HGNCi | HGNC:23708, ZNF493 |
HPAi | ENSG00000196268, Low tissue specificity |
neXtProti | NX_Q6ZR52 |
OpenTargetsi | ENSG00000196268 |
PharmGKBi | PA134932599 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161765 |
HOGENOMi | CLU_002678_17_1_1 |
InParanoidi | Q6ZR52 |
OMAi | GHKQIHS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6ZR52 |
TreeFami | TF343410 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZR52 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 284443, 4 hits in 866 CRISPR screens |
ChiTaRSi | ZNF493, human |
GenomeRNAii | 284443 |
Pharosi | Q6ZR52, Tdark |
PROi | PR:Q6ZR52 |
RNActi | Q6ZR52, protein |
Gene expression databases
Bgeei | ENSG00000196268, Expressed in female gonad and 217 other tissues |
ExpressionAtlasi | Q6ZR52, baseline and differential |
Genevisiblei | Q6ZR52, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 16 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 21 hits |
SUPFAMi | SSF57667, SSF57667, 11 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 18 hits PS50157, ZINC_FINGER_C2H2_2, 22 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN493_HUMAN | |
Accessioni | Q6ZR52Primary (citable) accession number: Q6ZR52 Secondary accession number(s): G5E974 Q9BR99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | April 17, 2007 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations