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Entry version 125 (17 Jun 2020)
Sequence version 2 (14 Apr 2009)
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Protein

Dynein heavy chain 12, axonemal

Gene

DNAH12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).By similarity

Caution

Was originally derived from a readthrough transcript including ASB14 and DNAH12. DNHD2 was thought to be a distinct gene.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1253 – 1260ATPSequence analysis8
Nucleotide bindingi1534 – 1541ATPSequence analysis8
Nucleotide bindingi1892 – 1899ATPSequence analysis8
Nucleotide bindingi2257 – 2264ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 12, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 12
Axonemal dynein heavy chain 12-like protein
Axonemal dynein heavy chain 7-like protein
Ciliary dynein heavy chain 12
Dynein heavy chain 7-like, axonemal
Dynein heavy chain domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH12
Synonyms:DHC3, DLP12, DNAH12L, DNAH7L, DNAHC3, DNHD2, HDHC3, HL19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174844.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2943 DNAH12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603340 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZR08

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000174844

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27397

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZR08 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNAH12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226693521

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003703241 – 3092Dynein heavy chain 12, axonemalAdd BLAST3092

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZR08

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZR08

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZR08

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZR08

PeptideAtlas

More...
PeptideAtlasi
Q6ZR08

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZR08

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68106 [Q6ZR08-1]
68107 [Q6ZR08-2]
68108 [Q6ZR08-3]
68109 [Q6ZR08-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZR08

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZR08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174844 Expressed in bronchial epithelial cell and 100 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZR08 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZR08 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000174844 Tissue enhanced (brain, fallopian tube, lung, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6ZR08

Protein interaction database and analysis system

More...
IntActi
Q6ZR08, 2 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZR08 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZR08

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1214StemBy similarityAdd BLAST1214
Regioni1215 – 1436AAA 1By similarityAdd BLAST222
Regioni1496 – 1636AAA 2By similarityAdd BLAST141
Regioni1853 – 2104AAA 3By similarityAdd BLAST252
Regioni2218 – 2660AAA 4By similarityAdd BLAST443
Regioni2661 – 2795StalkBy similarityAdd BLAST135
Regioni2874 – 3051AAA 5By similarityAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili592 – 665Sequence analysisAdd BLAST74
Coiled coili731 – 762Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1253 – 1260GPAGTGKT motif8
Motifi1303 – 1309CFDEFNR motif7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154280

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZR08

KEGG Orthology (KO)

More...
KOi
K10408

Database of Orthologous Groups

More...
OrthoDBi
2079at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZR08

TreeFam database of animal gene trees

More...
TreeFami
TF333463

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR043157 Dynein_AAA1S
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR043160 Dynein_C_barrel
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR10676 PTHR10676, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZR08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDANKAAIA AEKEALNLKL PPIVHLPENI GVDTPTQSKL LKYRRSKEQQ
60 70 80 90 100
QKINQLVIDG AKRNLDRTLG KRTPLLPPPD YPQTMTSEMK KKGFNYIYMK
110 120 130 140 150
QCVESSPLVP IQQEWLDHML RLIPESLKEG KEREELLESL INEVSSDFEN
160 170 180 190 200
SMKRYLVQSV LVKPPVKSLE DEGGPLPESP VGLDYSNPWH SSYVQARNQI
210 220 230 240 250
FSNLHIIHPT MKMLLDLGYT TFADTVLLDF TGIRAKGPID CESLKTDLSI
260 270 280 290 300
QTRNAEEKIM NTWYPKVINL FTKKEALEGV KPEKLDAFYS CVSTLMSNQL
310 320 330 340 350
KDLLRRTVEG FVKLFDPKDQ QRLPIFKIEL TFDDDKMEFY PTFQDLEDNV
360 370 380 390 400
LSLVERIAEA LQNVQTIPSW LSGTSTPVNL DTELPEHVLH WAVDTLKAAV
410 420 430 440 450
HRNLEGARKH YETYVEKYNW LLDGTAVENI ETFQTEDHTF DEYTEFIEKF
460 470 480 490 500
LSLASEIMLL PQWIHYTMVR LDCEDLKTGL TNKAKAFANI LLNDIASKYR
510 520 530 540 550
KENECICSEF EAIKEHALKV PETTEEMMDL ISYVEKARTV GIEELILRIQ
560 570 580 590 600
ESKRQMSYFL DVFLFPQEDL ALNATVLMWP RKINPIFDEN DELIENAKHK
610 620 630 640 650
KENELMAKRE KLILEIEKES RRMEEFTEFA ELERMQQYVT DVRQLQKRIQ
660 670 680 690 700
ESEEAVQFIN KEEELFKWEL TKYPELDKLK VNIEPYQKFF NFVLKWQRSE
710 720 730 740 750
KRWMDGGFLD LNGESMEADV EEFSREIFKT LKFFQTKLKK ELQEKRKAAR
760 770 780 790 800
KRSLEEEKIE EEPKDNATIT MCRMRARHWK QISEIVGYDL TPDSGTTLRK
810 820 830 840 850
VLKLNLTPYL EQFEVISAGA SKEFSLEKAM NTMIGTWEDI AFHISLYRDT
860 870 880 890 900
GVCILSSVDE IQAILDDQII KTQTMRGSPF IKPFEHEIKA WEDRLIRIQE
910 920 930 940 950
TIDEWLKVQA QWLYLEPIFC SEDIMQQMPE EGRQFQTVDR HWRDIMKFCA
960 970 980 990 1000
KDPKVLAATS LTGLLEKLQN CNELLEKIMK GLNAYLEKKR LFFPRFFFLS
1010 1020 1030 1040 1050
NDEMLEILSE TKDPLRVQPH LKKCFEGIAK LEFLPNLDIK AMYSSEGERV
1060 1070 1080 1090 1100
ELIALISTSA ARGAVEKWLI QVEDLMLRSV HDVIAAARLA YPESARRDWV
1110 1120 1130 1140 1150
REWPGQVVLC ISQMFWTSET QEVISGGTEG LKKYYKELQN QLNEIVELVR
1160 1170 1180 1190 1200
GKLSKQTRTT LGALVTIDVH ARDVVMDMIK MGVSHDTDFL WLAQLRYYWE
1210 1220 1230 1240 1250
NENARVRIIN CNVKYAYEYL GNSPRLVITP LTDRCYRTLI GAFYLNLGGA
1260 1270 1280 1290 1300
PEGPAGTGKT ETTKDLAKAL AVQCVVFNCS DGLDYLAMGK FFKGLASSGA
1310 1320 1330 1340 1350
WACFDEFNRI ELEVLSVVAQ QILCIQRAIQ QKLVVFVFEG TELKLNPNCF
1360 1370 1380 1390 1400
VAITMNPGYA GRSELPDNLK VLFRTVAMMV PNYALIAEIS LYSYGFLNAR
1410 1420 1430 1440 1450
PLSVKIVMTY RLCSEQLSSQ FHYDYGMRAV KAVLVAAGNL KLKYPNENED
1460 1470 1480 1490 1500
ILLLRSIKDV NEPKFLSHDI PLFNGITSDL FPGIKLPEAD YHEFLECAHE
1510 1520 1530 1540 1550
ACNVHNLQPV KFFLEKIIQT YEMMIVRHGF MLVGEPFAAK TKVLHVLADT
1560 1570 1580 1590 1600
LTLMNEHGYG EEEKVIYRTV NPKSITMGQL FGQFDPVSHE WTDGIVANTF
1610 1620 1630 1640 1650
REFALSETPD RKWVVFDGPI DTLWIESMNT VLDDNKKLCL MSGEIIQMSP
1660 1670 1680 1690 1700
QMSLIFETMD LSQASPATVS RCGMIYLEPS QLGWEPLVSS WLNSLKGPLC
1710 1720 1730 1740 1750
EPEYQALLRG LFAWLIPPSL NQRVELFQLN YLYTTIVSKI LKILITFRIS
1760 1770 1780 1790 1800
NYFKYVPLKT QCTFIKFFLH QQACFIFSLI WSIGGSCDTD GRRVFDTFIR
1810 1820 1830 1840 1850
LIILGKDDEN PVPDSVGKWE CPFDEKGLVY DYMYELKNKG RWVHWNELIK
1860 1870 1880 1890 1900
NTNLGDKQIK IQDIIVPTMD TIRYTFLMDL SITYAKPLLF VGPTGTGKSV
1910 1920 1930 1940 1950
YVKDKLMNHL EKDQYFPFYI NLSARTSANQ VQNIIMARLD KRRKGVFGPP
1960 1970 1980 1990 2000
MGKKCIIFID DMNMPALEKY GAQPPIELLR QFFDCGHWYD LKDTSKITLV
2010 2020 2030 2040 2050
DIELIAAMGP PGGGRNPVTP RCIRHFNICS INSFSDETMV RIFSSIVAFY
2060 2070 2080 2090 2100
LRTHEFPPEY FVIGNQIVNG TMEIYKQSVE NLLPTPTKSH YTFNLRDFSR
2110 2120 2130 2140 2150
VIRGCLLIER DAVANKHTMI RLFVHEVLRV FYDRLINDDD RRWLFQLTKT
2160 2170 2180 2190 2200
VIKDHFKESF HSIFSHLRKQ NAPVTEEDLR NLMFGDYMNP DLEGDDRVYI
2210 2220 2230 2240 2250
EIPNIHHFSD VVDQCLDEYN QTHKTRMNLV IFRYVLEHLS RICRVLKQSG
2260 2270 2280 2290 2300
GNALLVGLGG SGRQSLTRLA TSMAKMHIFQ PEISKSYGMN EWREDMKSFI
2310 2320 2330 2340 2350
AVPVTNRIVD NKSKILEKRL RYLNDHFTYN LYCNICRSLF EKDKLLFSFL
2360 2370 2380 2390 2400
LCANLLLARK EIEYQELMFL LTGGVSLKSA EKNPDPTWLQ DKSWEEICRA
2410 2420 2430 2440 2450
SEFPAFRGLR QHFCEHIYEW REIYDSKEPH NAKFPAPMDK NLNELQKIII
2460 2470 2480 2490 2500
LRCLRPDKIT PAITNYVTDK LGKKFVEPPP FDLTKSYLDS NCTIPLIFVL
2510 2520 2530 2540 2550
SPGADPMASL LKFANDKSMS GNKFQAISLG QGQGPIAAKM IKAAIEEGTW
2560 2570 2580 2590 2600
VCLQNCHLAV SWMPMLEKIC EDFTSETCNS SFRLWLTSYP SSKFPVTILQ
2610 2620 2630 2640 2650
NGVKMTNEPP TGLRLNLLQS YLTDPVSDPE FFKGCRGKEL AWEKLLFGVC
2660 2670 2680 2690 2700
FFHALVQERK KFGPLGWNIP YGFNESDLRI SIRQLQLFIN EYDTIPFEAI
2710 2720 2730 2740 2750
SYLTGECNYG GRVTDDWDRR LLLTMLADFY NLYIVENPHY KFSPSGNYFA
2760 2770 2780 2790 2800
PPKGTYEDYI EFIKKLPFTQ HPEIFGLHEN VDISKDLQQT KTLFESLLLT
2810 2820 2830 2840 2850
QGGSKQTGAS GSTDQILLEI TKDILNKLPS DFDIEMALRK YPVRYEESMN
2860 2870 2880 2890 2900
TVLVQEMERF NNLIITIRNT LRDLEKAIKG VVVMDSALEA LSGSLLVGKV
2910 2920 2930 2940 2950
PEIWAKRSYP SLKPLGSYIT DFLARLNFLQ DWYNSGKPCV FWLSGFFFTQ
2960 2970 2980 2990 3000
AFLTGAMQNY ARKYTTPIDL LGYEFEVIPS DTSDTSPEDG VYIHGLYLDG
3010 3020 3030 3040 3050
ARWDRESGLL AEQYPKLLFD LMPIIWIKPT QKSRIIKSDA YVCPLYKTSE
3060 3070 3080 3090
RKGTLSTTGH STNFVIAMLL KTDQPTRHWI KRGVALLCQL DD
Length:3,092
Mass (Da):356,942
Last modified:April 14, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC40401DD227DDCD7
GO
Isoform 4 (identifier: Q6ZR08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-457: FIEKFLSLASEI → ELDCWVVWEVYF
     458-3092: Missing.

Show »
Length:457
Mass (Da):52,686
Checksum:i13F5F8392901C7B3
GO
Isoform 2 (identifier: Q6ZR08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2367: Missing.
     2641-2686: Missing.

Show »
Length:679
Mass (Da):77,343
Checksum:i18999951FE963068
GO
Isoform 3 (identifier: Q6ZR08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1985: Missing.
     1986-2296: GHWYDLKDTS...YGMNEWREDM → MLCKKKKIPC...NLYINSIHDS
     2297-2310: Missing.

Show »
Length:1,093
Mass (Da):125,223
Checksum:i3BCFD7B7F1B7C93D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PG32E9PG32_HUMAN
Dynein heavy chain 12, axonemal
DNAH12
3,960Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5N3H7C5N3_HUMAN
Dynein heavy chain 12, axonemal
DNAH12
740Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QTM1J3QTM1_HUMAN
Dynein heavy chain 12, axonemal
DNAH12
784Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5S4H7C5S4_HUMAN
Dynein heavy chain 12, axonemal
DNAH12
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB09729 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13K → R in BAC86512 (PubMed:14702039).Curated1
Sequence conflicti1125S → G in AAB09729 (PubMed:8666668).Curated1
Sequence conflicti1170H → R in AAB09729 (PubMed:8666668).Curated1
Sequence conflicti1310 – 1311IE → NS in AAB09729 (PubMed:8666668).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03482932V → A1 PublicationCorresponds to variant dbSNP:rs9311651Ensembl.1
Natural variantiVAR_034830139S → N. Corresponds to variant dbSNP:rs6778837Ensembl.1
Natural variantiVAR_034831224D → E. Corresponds to variant dbSNP:rs6445902EnsemblClinVar.1
Natural variantiVAR_034832231T → A. Corresponds to variant dbSNP:rs7629743Ensembl.1
Natural variantiVAR_060142467T → P. Corresponds to variant dbSNP:rs6806444EnsemblClinVar.1
Natural variantiVAR_0601431549D → N. Corresponds to variant dbSNP:rs6773904Ensembl.1
Natural variantiVAR_0601441704Y → H. Corresponds to variant dbSNP:rs4462937Ensembl.1
Natural variantiVAR_0601451748R → C. Corresponds to variant dbSNP:rs17050836Ensembl.1
Natural variantiVAR_0601461754K → N. Corresponds to variant dbSNP:rs17793014Ensembl.1
Natural variantiVAR_0601471763T → I. Corresponds to variant dbSNP:rs4681982Ensembl.1
Natural variantiVAR_0373902740Y → F. Corresponds to variant dbSNP:rs17057989Ensembl.1
Natural variantiVAR_0373912893G → S1 PublicationCorresponds to variant dbSNP:rs4060726Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0369201 – 2367Missing in isoform 2. 1 PublicationAdd BLAST2367
Alternative sequenceiVSP_0369211 – 1985Missing in isoform 3. 1 PublicationAdd BLAST1985
Alternative sequenceiVSP_039335446 – 457FIEKF…LASEI → ELDCWVVWEVYF in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_039336458 – 3092Missing in isoform 4. 1 PublicationAdd BLAST2635
Alternative sequenceiVSP_0369221986 – 2296GHWYD…WREDM → MLCKKKKIPCSEEFLLSKTL GDPVKIRAWNIAGLPTDTFS IDNGVIVNNCRRWPLMIDPQ GQANKWIKNSERENQLSVIK LSDSDYMRTLENCIQFGTPL LLENVGEELDPSLEPLLLRQ TFKQGGIDCIRLGEVIIEYS FDFKFYITTKLRNPHYMPEL ATKVSLLNFMITPEGLEDQL LGIVVAKERPELEEERNALI LQSAANKKQLKDIEKKILET LSSSEGNILEDESAIKVLDS AKMMSNEITKKQQIAEKTEL KIAESREGYRPIAKHSSVLF FSIADLANIDPMYQYSLTWF VNLYINSIHDS in isoform 3. 1 PublicationAdd BLAST311
Alternative sequenceiVSP_0369232297 – 2310Missing in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0369242641 – 2686Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097746 mRNA Translation: BAC05158.1
AK126276 mRNA Translation: BAC86512.1
AK128592 mRNA Translation: BAC87517.1
AC092418 Genomic DNA No translation available.
AC093928 Genomic DNA No translation available.
AC121250 Genomic DNA No translation available.
U53532 mRNA Translation: AAB09729.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33771.1 [Q6ZR08-4]

NCBI Reference Sequences

More...
RefSeqi
NP_940966.2, NM_198564.3 [Q6ZR08-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311202; ENSP00000312554; ENSG00000174844 [Q6ZR08-4]
ENST00000351747; ENSP00000295937; ENSG00000174844 [Q6ZR08-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
201625

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:201625

UCSC genome browser

More...
UCSCi
uc003dit.2 human [Q6ZR08-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097746 mRNA Translation: BAC05158.1
AK126276 mRNA Translation: BAC86512.1
AK128592 mRNA Translation: BAC87517.1
AC092418 Genomic DNA No translation available.
AC093928 Genomic DNA No translation available.
AC121250 Genomic DNA No translation available.
U53532 mRNA Translation: AAB09729.1 Frameshift.
CCDSiCCDS33771.1 [Q6ZR08-4]
RefSeqiNP_940966.2, NM_198564.3 [Q6ZR08-4]

3D structure databases

SMRiQ6ZR08
ModBaseiSearch...

Protein-protein interaction databases

ELMiQ6ZR08
IntActiQ6ZR08, 2 interactors

PTM databases

iPTMnetiQ6ZR08
PhosphoSitePlusiQ6ZR08

Polymorphism and mutation databases

BioMutaiDNAH12
DMDMi226693521

Proteomic databases

EPDiQ6ZR08
jPOSTiQ6ZR08
MassIVEiQ6ZR08
PaxDbiQ6ZR08
PeptideAtlasiQ6ZR08
PRIDEiQ6ZR08
ProteomicsDBi68106 [Q6ZR08-1]
68107 [Q6ZR08-2]
68108 [Q6ZR08-3]
68109 [Q6ZR08-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48520 65 antibodies

Genome annotation databases

EnsembliENST00000311202; ENSP00000312554; ENSG00000174844 [Q6ZR08-4]
ENST00000351747; ENSP00000295937; ENSG00000174844 [Q6ZR08-1]
GeneIDi201625
KEGGihsa:201625
UCSCiuc003dit.2 human [Q6ZR08-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
201625
EuPathDBiHostDB:ENSG00000174844.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNAH12
HGNCiHGNC:2943 DNAH12
HPAiENSG00000174844 Tissue enhanced (brain, fallopian tube, lung, testis)
MIMi603340 gene
neXtProtiNX_Q6ZR08
OpenTargetsiENSG00000174844
PharmGKBiPA27397

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154280
HOGENOMiCLU_000038_0_2_1
InParanoidiQ6ZR08
KOiK10408
OrthoDBi2079at2759
PhylomeDBiQ6ZR08
TreeFamiTF333463

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
201625 2 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNAH12 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
201625
PharosiQ6ZR08 Tbio

Protein Ontology

More...
PROi
PR:Q6ZR08
RNActiQ6ZR08 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174844 Expressed in bronchial epithelial cell and 100 other tissues
ExpressionAtlasiQ6ZR08 baseline and differential
GenevisibleiQ6ZR08 HS

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR043157 Dynein_AAA1S
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR043160 Dynein_C_barrel
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 4 hits
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH12_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZR08
Secondary accession number(s): A6NGI2
, Q6ZTR8, Q8N7R9, Q8WXK2, Q92816
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 14, 2009
Last modified: June 17, 2020
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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