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UniProtKB - Q6ZQX7 (LIAT1_HUMAN)
Protein
Protein LIAT1
Gene
LIAT1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in ATE1-mediated N-terminal arginylation.
By similarityGO - Biological processi
- protein arginylation Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q6ZQX7 |
SignaLinki | Q6ZQX7 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein LIAT1CuratedAlternative name(s): Ligand of ATE1 proteinCurated |
Gene namesi | Name:LIAT1Curated Synonyms:C17orf97Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33800, C17orf97 |
neXtProti | NX_Q6ZQX7 |
VEuPathDBi | HostDB:ENSG00000187624 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 400566 |
OpenTargetsi | ENSG00000187624 |
PharmGKBi | PA162378582 |
Miscellaneous databases
Pharosi | Q6ZQX7, Tdark |
Genetic variation databases
BioMutai | C17orf97 |
DMDMi | 327478504 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000340233 | 1 – 453 | Protein LIAT1Add BLAST | 453 |
Proteomic databases
EPDi | Q6ZQX7 |
MassIVEi | Q6ZQX7 |
MaxQBi | Q6ZQX7 |
PeptideAtlasi | Q6ZQX7 |
PRIDEi | Q6ZQX7 |
ProteomicsDBi | 68096 [Q6ZQX7-1] 68097 [Q6ZQX7-2] 68098 [Q6ZQX7-3] 68099 [Q6ZQX7-4] |
PTM databases
iPTMneti | Q6ZQX7 |
PhosphoSitePlusi | Q6ZQX7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187624, Expressed in testis and 176 other tissues |
ExpressionAtlasi | Q6ZQX7, baseline and differential |
Genevisiblei | Q6ZQX7, HS |
Organism-specific databases
HPAi | ENSG00000187624, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with ATE1; it is not a substrate of LIAT1.
Interacts with JMJD6 and MRPS14 (By similarity).
By similarityBinary interactionsi
Isoform 4 [Q6ZQX7-4]
Protein-protein interaction databases
BioGRIDi | 134634, 3 interactors |
IntActi | Q6ZQX7, 12 interactors |
MINTi | Q6ZQX7 |
STRINGi | 9606.ENSP00000353245 |
Miscellaneous databases
RNActi | Q6ZQX7, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q6ZQX7 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 201 – 210 | 1 | 10 | |
Repeati | 211 – 220 | 2 | 10 | |
Repeati | 221 – 230 | 3 | 10 | |
Repeati | 231 – 240 | 4 | 10 | |
Repeati | 241 – 250 | 5 | 10 | |
Repeati | 251 – 260 | 6 | 10 | |
Repeati | 261 – 270 | 7 | 10 | |
Repeati | 271 – 280 | 8 | 10 | |
Repeati | 281 – 290 | 9 | 10 | |
Repeati | 291 – 300 | 10 | 10 | |
Repeati | 301 – 310 | 11 | 10 | |
Repeati | 311 – 320 | 12 | 10 | |
Repeati | 321 – 330 | 13 | 10 | |
Repeati | 331 – 340 | 14 | 10 | |
Repeati | 341 – 350 | 15 | 10 | |
Repeati | 351 – 360 | 16 | 10 | |
Repeati | 361 – 370 | 17 | 10 | |
Repeati | 371 – 380 | 18 | 10 | |
Repeati | 381 – 390 | 19 | 10 | |
Repeati | 391 – 400 | 20 | 10 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 152 | DisorderedSequence analysisAdd BLAST | 152 | |
Regioni | 145 – 197 | Interaction with ATE1By similarityAdd BLAST | 53 | |
Regioni | 201 – 400 | 20 X 10 AA approximate tandem repeat of A-L-K-G-F-H-P-D-P-EAdd BLAST | 200 | |
Regioni | 225 – 306 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 320 – 432 | DisorderedSequence analysisAdd BLAST | 113 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 63 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 82 – 97 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 124 – 145 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 320 – 400 | Basic and acidic residuesSequence analysisAdd BLAST | 81 | |
Compositional biasi | 412 – 426 | Polar residuesSequence analysisAdd BLAST | 15 |
Domaini
LIAT1 proteins of some primates, from macaques to humans, contain tandem repeats of a 10-residue sequence, whereas LIAT1 proteins of other mammals contain a single copy of this motif. Quantities of these repeats are, in general, different in LIAT1 of different primates. For example, there are 1, 4, 13, 13, 17, and 17 repeats in the gibbon, gorilla, orangutan, bonobo, neanderthal, and human LIAT1, respectively.1 Publication
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502SC86, Eukaryota |
GeneTreei | ENSGT00440000038370 |
HOGENOMi | CLU_049741_0_0_1 |
InParanoidi | Q6ZQX7 |
OMAi | LKGFHTD |
PhylomeDBi | Q6ZQX7 |
TreeFami | TF337007 |
Family and domain databases
InterProi | View protein in InterPro IPR038794, LIAT1 |
PANTHERi | PTHR36474, PTHR36474, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZQX7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METRGPGLAV RAESRRLVGI GPRAPPGRVG LQPSGRLDRR GGAGTMGYKD
60 70 80 90 100
NDGEEEEREG GAAGPRGSRL PPITGGASEL AKRKVKKKKR KKKTKGSGKG
110 120 130 140 150
DDKHQSQSLK SQPLSSSFHD ILSPCKERGP KPEHRQSKVE KKHLPSDSST
160 170 180 190 200
VSLPDFAEIE NLANRINESL RWDGILADPE AEKERIRIYK LNRRKRYRCL
210 220 230 240 250
ALKGFHPDPE ALKGFHPDPD ALKGFHPDPE ALKGFHPDPE ALKGFHPDPE
260 270 280 290 300
ALKGFHPDPE ALKGIHPDPE ALKGIHPDPE ALKGFHPDPE ALKGFHPDPE
310 320 330 340 350
ALKGFHTDPE ALKGFHIDPE ALKGFHPDPK ALKGFHPDPK ALKGFHTDPE
360 370 380 390 400
ALKGFHPDPK ALKGFHPDPE ALKGFHPDPE ALKGFHPDPE ALKGFHTDPN
410 420 430 440 450
AEEAPENLPY LSDKDGSSSH RQPTSKAECP NLCFEGNLTP KLLHSDLAPT
LLE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C5B9 | H7C5B9_HUMAN | Chromosome 17 open reading frame 97 | C17orf97 | 209 | Annotation score: | ||
I3L0T0 | I3L0T0_HUMAN | Chromosome 17 open reading frame 97 | C17orf97 | 153 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 105 | Q → L in AAI41807 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 114 | L → P in AAH57385 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 240 | E → D in AAH57385 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044008 | 56 | E → K1 PublicationCorresponds to variant dbSNP:rs4581766Ensembl. | 1 | |
Natural variantiVAR_044009 | 220 | D → E2 PublicationsCorresponds to variant dbSNP:rs35229416Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034195 | 201 – 220 | Missing in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_034196 | 236 – 265 | Missing in isoform 4. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_034197 | 256 – 265 | Missing in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_034198 | 348 – 367 | Missing in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128660 mRNA Translation: BAC87555.1 AC141424 Genomic DNA No translation available. BC057385 mRNA Translation: AAH57385.1 BC070116 mRNA Translation: AAH70116.2 BC141806 mRNA Translation: AAI41807.1 |
CCDSi | CCDS32519.2 [Q6ZQX7-4] |
RefSeqi | NP_001013694.4, NM_001013672.4 [Q6ZQX7-4] |
Genome annotation databases
Ensembli | ENST00000360127.7; ENSP00000353245.6; ENSG00000187624.9 [Q6ZQX7-4] ENST00000639297.2; ENSP00000491943.1; ENSG00000283985.2 [Q6ZQX7-4] |
GeneIDi | 400566 |
KEGGi | hsa:400566 |
MANE-Selecti | ENST00000360127.7; ENSP00000353245.6; NM_001013672.5; NP_001013694.4 [Q6ZQX7-4] |
UCSCi | uc021tna.1, human [Q6ZQX7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128660 mRNA Translation: BAC87555.1 AC141424 Genomic DNA No translation available. BC057385 mRNA Translation: AAH57385.1 BC070116 mRNA Translation: AAH70116.2 BC141806 mRNA Translation: AAI41807.1 |
CCDSi | CCDS32519.2 [Q6ZQX7-4] |
RefSeqi | NP_001013694.4, NM_001013672.4 [Q6ZQX7-4] |
3D structure databases
AlphaFoldDBi | Q6ZQX7 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 134634, 3 interactors |
IntActi | Q6ZQX7, 12 interactors |
MINTi | Q6ZQX7 |
STRINGi | 9606.ENSP00000353245 |
PTM databases
iPTMneti | Q6ZQX7 |
PhosphoSitePlusi | Q6ZQX7 |
Genetic variation databases
BioMutai | C17orf97 |
DMDMi | 327478504 |
Proteomic databases
EPDi | Q6ZQX7 |
MassIVEi | Q6ZQX7 |
MaxQBi | Q6ZQX7 |
PeptideAtlasi | Q6ZQX7 |
PRIDEi | Q6ZQX7 |
ProteomicsDBi | 68096 [Q6ZQX7-1] 68097 [Q6ZQX7-2] 68098 [Q6ZQX7-3] 68099 [Q6ZQX7-4] |
Protocols and materials databases
Antibodypediai | 10251, 46 antibodies from 12 providers |
DNASUi | 400566 |
Genome annotation databases
Ensembli | ENST00000360127.7; ENSP00000353245.6; ENSG00000187624.9 [Q6ZQX7-4] ENST00000639297.2; ENSP00000491943.1; ENSG00000283985.2 [Q6ZQX7-4] |
GeneIDi | 400566 |
KEGGi | hsa:400566 |
MANE-Selecti | ENST00000360127.7; ENSP00000353245.6; NM_001013672.5; NP_001013694.4 [Q6ZQX7-4] |
UCSCi | uc021tna.1, human [Q6ZQX7-1] |
Organism-specific databases
CTDi | 400566 |
DisGeNETi | 400566 |
GeneCardsi | C17orf97 |
HGNCi | HGNC:33800, C17orf97 |
HPAi | ENSG00000187624, Tissue enriched (testis) |
neXtProti | NX_Q6ZQX7 |
OpenTargetsi | ENSG00000187624 |
PharmGKBi | PA162378582 |
VEuPathDBi | HostDB:ENSG00000187624 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SC86, Eukaryota |
GeneTreei | ENSGT00440000038370 |
HOGENOMi | CLU_049741_0_0_1 |
InParanoidi | Q6ZQX7 |
OMAi | LKGFHTD |
PhylomeDBi | Q6ZQX7 |
TreeFami | TF337007 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZQX7 |
SignaLinki | Q6ZQX7 |
Miscellaneous databases
BioGRID-ORCSi | 400566, 14 hits in 1042 CRISPR screens |
GenomeRNAii | 400566 |
Pharosi | Q6ZQX7, Tdark |
PROi | PR:Q6ZQX7 |
RNActi | Q6ZQX7, protein |
Gene expression databases
Bgeei | ENSG00000187624, Expressed in testis and 176 other tissues |
ExpressionAtlasi | Q6ZQX7, baseline and differential |
Genevisiblei | Q6ZQX7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038794, LIAT1 |
PANTHERi | PTHR36474, PTHR36474, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LIAT1_HUMAN | |
Accessioni | Q6ZQX7Primary (citable) accession number: Q6ZQX7 Secondary accession number(s): A5D8T6, Q6NSI2, Q6PFW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports