Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (26 Feb 2020)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Solute carrier organic anion transporter family member 4C1

Gene

SLCO4C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.By similarity2 Publications

Miscellaneous

SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as ouabain, digitoxin and digoxigenin.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.8 µM for digoxin1 Publication
  2. KM=0.38 µM for ouabain1 Publication
  3. KM=5.9 µM for thyroxine1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDevelopmental protein
    Biological processDifferentiation, Ion transport, Spermatogenesis, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-879518 Transport of organic anions

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.60.1.11 the organo anion transporter (oat) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 4C1
    Alternative name(s):
    OATP-H
    Organic anion transporter M1
    Short name:
    OATP-M1
    Solute carrier family 21 member 20
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLCO4C1Imported
    Synonyms:OATP4C11 Publication, OATPX, SLC21A20Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:23612 SLCO4C1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609013 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6ZQN7

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 105CytoplasmicSequence analysisAdd BLAST105
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei106 – 126Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini127 – 145ExtracellularSequence analysisAdd BLAST19
    Transmembranei146 – 166Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini167 – 172CytoplasmicSequence analysis6
    Transmembranei173 – 197Helical; Name=3Sequence analysisAdd BLAST25
    Topological domaini198 – 223ExtracellularSequence analysisAdd BLAST26
    Transmembranei224 – 254Helical; Name=4Sequence analysisAdd BLAST31
    Topological domaini255 – 274CytoplasmicSequence analysisAdd BLAST20
    Transmembranei275 – 295Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini296 – 311ExtracellularSequence analysisAdd BLAST16
    Transmembranei312 – 336Helical; Name=6Sequence analysisAdd BLAST25
    Topological domaini337 – 377CytoplasmicSequence analysisAdd BLAST41
    Transmembranei378 – 399Helical; Name=7Sequence analysisAdd BLAST22
    Topological domaini400 – 419ExtracellularSequence analysisAdd BLAST20
    Transmembranei420 – 443Helical; Name=8Sequence analysisAdd BLAST24
    Topological domaini444 – 447CytoplasmicSequence analysis4
    Transmembranei448 – 471Helical; Name=9Sequence analysisAdd BLAST24
    Topological domaini472 – 580ExtracellularSequence analysisAdd BLAST109
    Transmembranei581 – 603Helical; Name=10Sequence analysisAdd BLAST23
    Topological domaini604 – 612CytoplasmicSequence analysis9
    Transmembranei613 – 638Helical; Name=11Sequence analysisAdd BLAST26
    Topological domaini639 – 672ExtracellularSequence analysisAdd BLAST34
    Transmembranei673 – 690Helical; Name=12Sequence analysisAdd BLAST18
    Topological domaini691 – 724CytoplasmicSequence analysisAdd BLAST34

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    353189

    Open Targets

    More...
    OpenTargetsi
    ENSG00000173930

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134892408

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6ZQN7 Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2073690

    Drug and drug target database

    More...
    DrugBanki
    DB00509 Dextrothyroxine
    DB01396 Digitoxin
    DB00390 Digoxin
    DB00451 Levothyroxine
    DB00279 Liothyronine
    DB01583 Liotrix
    DB00563 Methotrexate
    DB01092 Ouabain
    DB06335 Saxagliptin

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLCO4C1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74749598

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371511 – 724Solute carrier organic anion transporter family member 4C1Add BLAST724

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineBy similarity1
    Modified residuei16PhosphoserineBy similarity1
    Modified residuei24PhosphoserineBy similarity1
    Modified residuei26PhosphoserineBy similarity1
    Modified residuei28PhosphoserineBy similarity1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi501 ↔ 526PROSITE-ProRule annotation
    Disulfide bondi505 ↔ 516PROSITE-ProRule annotation
    Disulfide bondi507 ↔ 530PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q6ZQN7

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6ZQN7

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6ZQN7

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6ZQN7

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6ZQN7

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6ZQN7

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6ZQN7

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    68081

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6ZQN7

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6ZQN7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000173930 Expressed in bone marrow and 108 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6ZQN7 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA058249

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    131662, 2 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q6ZQN7, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000309741

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q6ZQN7 protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini495 – 549Kazal-likePROSITE-ProRule annotationAdd BLAST55

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3626 Eukaryota
    ENOG410XRSF LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00980000198527

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_008954_2_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6ZQN7

    KEGG Orthology (KO)

    More...
    KOi
    K14355

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VTCKVIT

    Database of Orthologous Groups

    More...
    OrthoDBi
    228564at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6ZQN7

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF317540

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002350 Kazal_dom
    IPR036058 Kazal_dom_sf
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004156 OATP

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11388 PTHR11388, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07648 Kazal_2, 1 hit
    PF03137 OATP, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF100895 SSF100895, 1 hit
    SSF103473 SSF103473, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00805 oat, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51465 KAZAL_2, 1 hit
    PS50850 MFS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q6ZQN7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKSAKGIENL AFVPSSPDIL RRLSASPSQI EVSALSSDPQ RENSQPQELQ
    60 70 80 90 100
    KPQEPQKSPE PSLPSAPPNV SEEKLRSLSL SEFEEGSYGW RNFHPQCLQR
    110 120 130 140 150
    CNTPGGFLLH YCLLAVTQGI VVNGLVNISI STVEKRYEMK SSLTGLISSS
    160 170 180 190 200
    YDISFCLLSL FVSFFGERGH KPRWLAFAAF MIGLGALVFS LPQFFSGEYK
    210 220 230 240 250
    LGSLFEDTCV TTRNSTSCTS STSSLSNYLY VFILGQLLLG AGGTPLYTLG
    260 270 280 290 300
    TAFLDDSVPT HKSSLYIGTG YAMSILGPAI GYVLGGQLLT IYIDVAMGES
    310 320 330 340 350
    TDVTEDDPRW LGAWWIGFLL SWIFAWSLII PFSCFPKHLP GTAEIQAGKT
    360 370 380 390 400
    SQAHQSNSNA DVKFGKSIKD FPAALKNLMK NAVFMCLVLS TSSEALITTG
    410 420 430 440 450
    FATFLPKFIE NQFGLTSSFA ATLGGAVLIP GAALGQILGG FLVSKFRMTC
    460 470 480 490 500
    KNTMKFALFT SGVALTLSFV FMYAKCENEP FAGVSESYNG TGELGNLIAP
    510 520 530 540 550
    CNANCNCSRS YYYPVCGDGV QYFSPCFAGC SNPVAHRKPK VYYNCSCIER
    560 570 580 590 600
    KTEITSTAET FGFEAKAGKC ETHCAKLPIF LCIFFIVIIF TFMAGTPITV
    610 620 630 640 650
    SILRCVNHRQ RSLALGIQFM VLRLLGTIPG PIIFGFTIDS TCILWDINDC
    660 670 680 690 700
    GIKGACWIYD NIKMAHMLVA ISVTCKVITM FFNGFAIFLY KPPPSATDVS
    710 720
    FHKENAVVTN VLAEQDLNKI VKEG
    Length:724
    Mass (Da):78,948
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AC275B99E20A8EC
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti672S → C in AAP33047 (Ref. 2) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF401643 mRNA Translation: AAQ03086.1
    AY273896 mRNA Translation: AAP33047.2
    AK128854 mRNA Translation: BAC87647.1
    CH471086 Genomic DNA Translation: EAW49099.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS34205.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_851322.3, NM_180991.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000310954; ENSP00000309741; ENSG00000173930

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    353189

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:353189

    UCSC genome browser

    More...
    UCSCi
    uc003knm.4 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF401643 mRNA Translation: AAQ03086.1
    AY273896 mRNA Translation: AAP33047.2
    AK128854 mRNA Translation: BAC87647.1
    CH471086 Genomic DNA Translation: EAW49099.1
    CCDSiCCDS34205.1
    RefSeqiNP_851322.3, NM_180991.4

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi131662, 2 interactors
    IntActiQ6ZQN7, 1 interactor
    STRINGi9606.ENSP00000309741

    Chemistry databases

    ChEMBLiCHEMBL2073690
    DrugBankiDB00509 Dextrothyroxine
    DB01396 Digitoxin
    DB00390 Digoxin
    DB00451 Levothyroxine
    DB00279 Liothyronine
    DB01583 Liotrix
    DB00563 Methotrexate
    DB01092 Ouabain
    DB06335 Saxagliptin

    Protein family/group databases

    TCDBi2.A.60.1.11 the organo anion transporter (oat) family

    PTM databases

    iPTMnetiQ6ZQN7
    PhosphoSitePlusiQ6ZQN7

    Polymorphism and mutation databases

    BioMutaiSLCO4C1
    DMDMi74749598

    Proteomic databases

    EPDiQ6ZQN7
    jPOSTiQ6ZQN7
    MassIVEiQ6ZQN7
    MaxQBiQ6ZQN7
    PaxDbiQ6ZQN7
    PeptideAtlasiQ6ZQN7
    PRIDEiQ6ZQN7
    ProteomicsDBi68081

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    353189

    Genome annotation databases

    EnsembliENST00000310954; ENSP00000309741; ENSG00000173930
    GeneIDi353189
    KEGGihsa:353189
    UCSCiuc003knm.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    353189
    DisGeNETi353189

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLCO4C1
    HGNCiHGNC:23612 SLCO4C1
    HPAiHPA058249
    MIMi609013 gene
    neXtProtiNX_Q6ZQN7
    OpenTargetsiENSG00000173930
    PharmGKBiPA134892408

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3626 Eukaryota
    ENOG410XRSF LUCA
    GeneTreeiENSGT00980000198527
    HOGENOMiCLU_008954_2_1_1
    InParanoidiQ6ZQN7
    KOiK14355
    OMAiVTCKVIT
    OrthoDBi228564at2759
    PhylomeDBiQ6ZQN7
    TreeFamiTF317540

    Enzyme and pathway databases

    ReactomeiR-HSA-6798695 Neutrophil degranulation
    R-HSA-879518 Transport of organic anions

    Miscellaneous databases

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    353189
    PharosiQ6ZQN7 Tbio

    Protein Ontology

    More...
    PROi
    PR:Q6ZQN7
    RNActiQ6ZQN7 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000173930 Expressed in bone marrow and 108 other tissues
    GenevisibleiQ6ZQN7 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002350 Kazal_dom
    IPR036058 Kazal_dom_sf
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004156 OATP
    PANTHERiPTHR11388 PTHR11388, 1 hit
    PfamiView protein in Pfam
    PF07648 Kazal_2, 1 hit
    PF03137 OATP, 1 hit
    SUPFAMiSSF100895 SSF100895, 1 hit
    SSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00805 oat, 1 hit
    PROSITEiView protein in PROSITE
    PS51465 KAZAL_2, 1 hit
    PS50850 MFS, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO4C1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZQN7
    Secondary accession number(s): Q86UG5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 5, 2004
    Last modified: February 26, 2020
    This is version 145 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again