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Protein

Solute carrier organic anion transporter family member 4C1

Gene

SLCO4C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.By similarity2 Publications

Miscellaneous

SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as ouabain, digitoxin and digoxigenin.1 Publication

Kineticsi

  1. KM=7.8 µM for digoxin1 Publication
  2. KM=0.38 µM for ouabain1 Publication
  3. KM=5.9 µM for thyroxine1 Publication

    GO - Molecular functioni

    • sodium-independent organic anion transmembrane transporter activity Source: GO_Central

    GO - Biological processi

    Keywordsi

    Molecular functionDevelopmental protein
    Biological processDifferentiation, Ion transport, Spermatogenesis, Transport

    Enzyme and pathway databases

    ReactomeiR-HSA-6798695 Neutrophil degranulation
    R-HSA-879518 Transport of organic anions

    Protein family/group databases

    TCDBi2.A.60.1.11 the organo anion transporter (oat) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 4C1
    Alternative name(s):
    OATP-H
    Organic anion transporter M1
    Short name:
    OATP-M1
    Solute carrier family 21 member 20
    Gene namesi
    Name:SLCO4C1Imported
    Synonyms:OATP4C11 Publication, OATPX, SLC21A20Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 5

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000173930.8
    HGNCiHGNC:23612 SLCO4C1
    MIMi609013 gene
    neXtProtiNX_Q6ZQN7

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 105CytoplasmicSequence analysisAdd BLAST105
    Transmembranei106 – 126Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini127 – 145ExtracellularSequence analysisAdd BLAST19
    Transmembranei146 – 166Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini167 – 172CytoplasmicSequence analysis6
    Transmembranei173 – 197Helical; Name=3Sequence analysisAdd BLAST25
    Topological domaini198 – 223ExtracellularSequence analysisAdd BLAST26
    Transmembranei224 – 254Helical; Name=4Sequence analysisAdd BLAST31
    Topological domaini255 – 274CytoplasmicSequence analysisAdd BLAST20
    Transmembranei275 – 295Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini296 – 311ExtracellularSequence analysisAdd BLAST16
    Transmembranei312 – 336Helical; Name=6Sequence analysisAdd BLAST25
    Topological domaini337 – 377CytoplasmicSequence analysisAdd BLAST41
    Transmembranei378 – 399Helical; Name=7Sequence analysisAdd BLAST22
    Topological domaini400 – 419ExtracellularSequence analysisAdd BLAST20
    Transmembranei420 – 443Helical; Name=8Sequence analysisAdd BLAST24
    Topological domaini444 – 447CytoplasmicSequence analysis4
    Transmembranei448 – 471Helical; Name=9Sequence analysisAdd BLAST24
    Topological domaini472 – 580ExtracellularSequence analysisAdd BLAST109
    Transmembranei581 – 603Helical; Name=10Sequence analysisAdd BLAST23
    Topological domaini604 – 612CytoplasmicSequence analysis9
    Transmembranei613 – 638Helical; Name=11Sequence analysisAdd BLAST26
    Topological domaini639 – 672ExtracellularSequence analysisAdd BLAST34
    Transmembranei673 – 690Helical; Name=12Sequence analysisAdd BLAST18
    Topological domaini691 – 724CytoplasmicSequence analysisAdd BLAST34

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi353189
    OpenTargetsiENSG00000173930
    PharmGKBiPA134892408

    Chemistry databases

    ChEMBLiCHEMBL2073690
    DrugBankiDB00509 Dextrothyroxine
    DB01396 Digitoxin
    DB00390 Digoxin
    DB00451 Levothyroxine
    DB00279 Liothyronine
    DB01583 Liotrix
    DB00563 Methotrexate
    DB01092 Ouabain
    DB06335 Saxagliptin

    Polymorphism and mutation databases

    BioMutaiSLCO4C1
    DMDMi74749598

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003371511 – 724Solute carrier organic anion transporter family member 4C1Add BLAST724

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei15PhosphoserineBy similarity1
    Modified residuei16PhosphoserineBy similarity1
    Modified residuei24PhosphoserineBy similarity1
    Modified residuei26PhosphoserineBy similarity1
    Modified residuei28PhosphoserineBy similarity1
    Disulfide bondi501 ↔ 526PROSITE-ProRule annotation
    Disulfide bondi505 ↔ 516PROSITE-ProRule annotation
    Disulfide bondi507 ↔ 530PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    EPDiQ6ZQN7
    MaxQBiQ6ZQN7
    PaxDbiQ6ZQN7
    PeptideAtlasiQ6ZQN7
    PRIDEiQ6ZQN7
    ProteomicsDBi68081

    PTM databases

    iPTMnetiQ6ZQN7
    PhosphoSitePlusiQ6ZQN7

    Expressioni

    Tissue specificityi

    Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.1 Publication

    Gene expression databases

    BgeeiENSG00000173930 Expressed in 109 organ(s), highest expression level in bone marrow
    CleanExiHS_SLCO4C1
    GenevisibleiQ6ZQN7 HS

    Interactioni

    Protein-protein interaction databases

    BioGridi131662, 2 interactors
    IntActiQ6ZQN7, 1 interactor
    STRINGi9606.ENSP00000309741

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZQN7
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini495 – 549Kazal-likePROSITE-ProRule annotationAdd BLAST55

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3626 Eukaryota
    ENOG410XRSF LUCA
    GeneTreeiENSGT00760000119014
    HOGENOMiHOG000231270
    HOVERGENiHBG100565
    InParanoidiQ6ZQN7
    KOiK14355
    OMAiCSCIERK
    OrthoDBiEOG091G02FX
    PhylomeDBiQ6ZQN7
    TreeFamiTF317540

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR002350 Kazal_dom
    IPR036058 Kazal_dom_sf
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004156 OATP
    PANTHERiPTHR11388 PTHR11388, 1 hit
    PfamiView protein in Pfam
    PF07648 Kazal_2, 1 hit
    PF03137 OATP, 1 hit
    SUPFAMiSSF100895 SSF100895, 1 hit
    SSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00805 oat, 1 hit
    PROSITEiView protein in PROSITE
    PS51465 KAZAL_2, 1 hit
    PS50850 MFS, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q6ZQN7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKSAKGIENL AFVPSSPDIL RRLSASPSQI EVSALSSDPQ RENSQPQELQ
    60 70 80 90 100
    KPQEPQKSPE PSLPSAPPNV SEEKLRSLSL SEFEEGSYGW RNFHPQCLQR
    110 120 130 140 150
    CNTPGGFLLH YCLLAVTQGI VVNGLVNISI STVEKRYEMK SSLTGLISSS
    160 170 180 190 200
    YDISFCLLSL FVSFFGERGH KPRWLAFAAF MIGLGALVFS LPQFFSGEYK
    210 220 230 240 250
    LGSLFEDTCV TTRNSTSCTS STSSLSNYLY VFILGQLLLG AGGTPLYTLG
    260 270 280 290 300
    TAFLDDSVPT HKSSLYIGTG YAMSILGPAI GYVLGGQLLT IYIDVAMGES
    310 320 330 340 350
    TDVTEDDPRW LGAWWIGFLL SWIFAWSLII PFSCFPKHLP GTAEIQAGKT
    360 370 380 390 400
    SQAHQSNSNA DVKFGKSIKD FPAALKNLMK NAVFMCLVLS TSSEALITTG
    410 420 430 440 450
    FATFLPKFIE NQFGLTSSFA ATLGGAVLIP GAALGQILGG FLVSKFRMTC
    460 470 480 490 500
    KNTMKFALFT SGVALTLSFV FMYAKCENEP FAGVSESYNG TGELGNLIAP
    510 520 530 540 550
    CNANCNCSRS YYYPVCGDGV QYFSPCFAGC SNPVAHRKPK VYYNCSCIER
    560 570 580 590 600
    KTEITSTAET FGFEAKAGKC ETHCAKLPIF LCIFFIVIIF TFMAGTPITV
    610 620 630 640 650
    SILRCVNHRQ RSLALGIQFM VLRLLGTIPG PIIFGFTIDS TCILWDINDC
    660 670 680 690 700
    GIKGACWIYD NIKMAHMLVA ISVTCKVITM FFNGFAIFLY KPPPSATDVS
    710 720
    FHKENAVVTN VLAEQDLNKI VKEG
    Length:724
    Mass (Da):78,948
    Last modified:July 5, 2004 - v1
    Checksum:i7AC275B99E20A8EC
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti672S → C in AAP33047 (Ref. 2) Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF401643 mRNA Translation: AAQ03086.1
    AY273896 mRNA Translation: AAP33047.2
    AK128854 mRNA Translation: BAC87647.1
    CH471086 Genomic DNA Translation: EAW49099.1
    CCDSiCCDS34205.1
    RefSeqiNP_851322.3, NM_180991.4
    UniGeneiHs.127648

    Genome annotation databases

    EnsembliENST00000310954; ENSP00000309741; ENSG00000173930
    GeneIDi353189
    KEGGihsa:353189
    UCSCiuc003knm.4 human

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF401643 mRNA Translation: AAQ03086.1
    AY273896 mRNA Translation: AAP33047.2
    AK128854 mRNA Translation: BAC87647.1
    CH471086 Genomic DNA Translation: EAW49099.1
    CCDSiCCDS34205.1
    RefSeqiNP_851322.3, NM_180991.4
    UniGeneiHs.127648

    3D structure databases

    ProteinModelPortaliQ6ZQN7
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi131662, 2 interactors
    IntActiQ6ZQN7, 1 interactor
    STRINGi9606.ENSP00000309741

    Chemistry databases

    ChEMBLiCHEMBL2073690
    DrugBankiDB00509 Dextrothyroxine
    DB01396 Digitoxin
    DB00390 Digoxin
    DB00451 Levothyroxine
    DB00279 Liothyronine
    DB01583 Liotrix
    DB00563 Methotrexate
    DB01092 Ouabain
    DB06335 Saxagliptin

    Protein family/group databases

    TCDBi2.A.60.1.11 the organo anion transporter (oat) family

    PTM databases

    iPTMnetiQ6ZQN7
    PhosphoSitePlusiQ6ZQN7

    Polymorphism and mutation databases

    BioMutaiSLCO4C1
    DMDMi74749598

    Proteomic databases

    EPDiQ6ZQN7
    MaxQBiQ6ZQN7
    PaxDbiQ6ZQN7
    PeptideAtlasiQ6ZQN7
    PRIDEiQ6ZQN7
    ProteomicsDBi68081

    Protocols and materials databases

    DNASUi353189
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000310954; ENSP00000309741; ENSG00000173930
    GeneIDi353189
    KEGGihsa:353189
    UCSCiuc003knm.4 human

    Organism-specific databases

    CTDi353189
    DisGeNETi353189
    EuPathDBiHostDB:ENSG00000173930.8
    GeneCardsiSLCO4C1
    H-InvDBiHIX0024798
    HGNCiHGNC:23612 SLCO4C1
    MIMi609013 gene
    neXtProtiNX_Q6ZQN7
    OpenTargetsiENSG00000173930
    PharmGKBiPA134892408
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG3626 Eukaryota
    ENOG410XRSF LUCA
    GeneTreeiENSGT00760000119014
    HOGENOMiHOG000231270
    HOVERGENiHBG100565
    InParanoidiQ6ZQN7
    KOiK14355
    OMAiCSCIERK
    OrthoDBiEOG091G02FX
    PhylomeDBiQ6ZQN7
    TreeFamiTF317540

    Enzyme and pathway databases

    ReactomeiR-HSA-6798695 Neutrophil degranulation
    R-HSA-879518 Transport of organic anions

    Miscellaneous databases

    GenomeRNAii353189
    PROiPR:Q6ZQN7
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000173930 Expressed in 109 organ(s), highest expression level in bone marrow
    CleanExiHS_SLCO4C1
    GenevisibleiQ6ZQN7 HS

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR002350 Kazal_dom
    IPR036058 Kazal_dom_sf
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004156 OATP
    PANTHERiPTHR11388 PTHR11388, 1 hit
    PfamiView protein in Pfam
    PF07648 Kazal_2, 1 hit
    PF03137 OATP, 1 hit
    SUPFAMiSSF100895 SSF100895, 1 hit
    SSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00805 oat, 1 hit
    PROSITEiView protein in PROSITE
    PS51465 KAZAL_2, 1 hit
    PS50850 MFS, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSO4C1_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZQN7
    Secondary accession number(s): Q86UG5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 5, 2004
    Last modified: November 7, 2018
    This is version 135 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
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