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Protein

Condensin-2 complex subunit D3

Gene

Ncapd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.By similarity

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • histone binding Source: GO_Central
  • methylated histone binding Source: MGI

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome separation Source: GO_Central
  • meiotic chromosome condensation Source: GO_Central
  • meiotic chromosome separation Source: MGI
  • mitotic chromosome condensation Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin-2 complex subunit D3
Alternative name(s):
Non-SMC condensin II complex subunit D3
Gene namesi
Name:Ncapd3
Synonyms:Kiaa0056
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2142989 Ncapd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507171 – 1506Condensin-2 complex subunit D3Add BLAST1506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei562PhosphoserineBy similarity1
Modified residuei1359PhosphoserineBy similarity1
Modified residuei1368PhosphoserineBy similarity1
Modified residuei1381PhosphoserineBy similarity1
Modified residuei1393PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZQK0
MaxQBiQ6ZQK0
PaxDbiQ6ZQK0
PRIDEiQ6ZQK0

PTM databases

iPTMnetiQ6ZQK0
PhosphoSitePlusiQ6ZQK0

Expressioni

Gene expression databases

CleanExiMM_NCAPD3

Interactioni

Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219559, 1 interactor
ComplexPortaliCPX-986 Condensin II complex
STRINGi10090.ENSMUSP00000072871

Structurei

3D structure databases

ProteinModelPortaliQ6ZQK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati442 – 476HEAT 1Add BLAST35
Repeati532 – 567HEAT 2Add BLAST36
Repeati574 – 605HEAT 3Add BLAST32
Repeati968 – 1004HEAT 4Add BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1213 – 1270Sequence analysisAdd BLAST58

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0413 Eukaryota
ENOG410XSGK LUCA
HOGENOMiHOG000111840
HOVERGENiHBG061537
InParanoidiQ6ZQK0
KOiK11491

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR012371 NCAPD3
PANTHERiPTHR14222 PTHR14222, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PIRSFiPIRSF036508 Condns_HCP-6, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6ZQK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALQDLGENL QPWCPLGLSL EWVKTVWDLD FTEIEPLDPS IVGEILETGR
60 70 80 90 100
DAFTKLYGSL FPFATDESGS LESIWTFFTE NDISSNTLVA LFCHFVQEAH
110 120 130 140 150
KKSASAQYRE YGLHAAGLYF LLLEIPGIVV NQVFHPVMFD KCIQILKRSW
160 170 180 190 200
PQESNLTQKR KKDHSKSSKD NYRKSRKRGK PPRKEDYQVD ELSREEEEEE
210 220 230 240 250
EEIYFSGRDL CQIRDAIFNL LKNFLRLLPK FSLKEKPQSI QTCIEVFVAL
260 270 280 290 300
TSFEPIPHKF LISQARNLNE VKHISELAYY GLYLLCSPVH GEENKVIGSI
310 320 330 340 350
FHQMLNVILM LEVGEGSRCA PLAITSQVIN CRNQAVQFVS SLVDELQASV
360 370 380 390 400
YPVLGTLLQH ICAKVVDKAE YRTYAAQSLV QLLTKLPSEE YATFIAWLYK
410 420 430 440 450
YSRSSKIPHR VFTLDVALAL LTLPERELDD TVSLEHQKFL KHKFFVQEII
460 470 480 490 500
FDRCLDKAPT VRSKALSSFA HCLELSSSNT SESILEIFIN SNLVPGIQNL
510 520 530 540 550
SNTVLNPSPV LTSRNGYSAQ SRTHNNDEQT LPGERCFMTM LRKRIKDEKI
560 570 580 590 600
NVRKSALQVL MSILKHCDIL SMEQDLLILQ DHCRDPAISV RKQALQSLTE
610 620 630 640 650
LVMAQPTCVP VQKAWLMGVI PVVMDCESTV QEKALECLDQ LLLQNIKHHK
660 670 680 690 700
KFHSADRSQV LAWSLLALLT IENQDLRRYL NKAFHIWSKK DKFSSTFINS
710 720 730 740 750
VISHTDTERS APAWMLLSKI TCSSPKLDYT KIIESWERLS REQSPNSNTL
760 770 780 790 800
GYMLCVIGHI AKHLPKGTRD KITGVIKAKL NGFQWSPELI SSSVDALQKL
810 820 830 840 850
CRASAKTVLE EQGLLKQVCG DVLATCEQHL SNILLKEDGT GNMDEGLVVK
860 870 880 890 900
CIFTLGDIAQ LCPAIVEKRV FLLIQSILAS SAHSDHLPSS QGTTDALDSQ
910 920 930 940 950
PPFQPRSSAM PSVIRAHAII TLGKLCLQHE DLAKKSIPAL VRELEVSEDV
960 970 980 990 1000
AVRNNVIIVI CDLCIRYTVM VDNYIPNISV CLKDSDPFIR KQTLVLLTNL
1010 1020 1030 1040 1050
LQEEYVKWKG SLFFRFVSTL VDSHPDIASL GEFCLAHLLL KRNPTMFFQH
1060 1070 1080 1090 1100
FIECIFHFNS YEKHGQYNKF SQSERGKQLF LLKGKTNKEK RMRIYKFLLE
1110 1120 1130 1140 1150
HFTDEQRFNV TSKICLNILA CFTDGILPMD MEASELLSDT FDILNSKEIK
1160 1170 1180 1190 1200
LLAMRAQTSK DLLEEDDVAL ANVVMQEAQM KIISQVQKRN FIENIIPIII
1210 1220 1230 1240 1250
SLKTVLEKNK IPALRELMNY LREVMQDYRD EINDFFAVDK QLASELEYDM
1260 1270 1280 1290 1300
KKYNEQLAQE QALTEHANAT KGPEDSDRVP SAQVAPDLEA VPALAAAPMA
1310 1320 1330 1340 1350
AAAAAAPMAA AAAAAGQDNA DVPPTQSRPS APRSNFTPTL PPISENGPLK
1360 1370 1380 1390 1400
IMSSTRPMSL STIAILNSVK KAVASKNRTR SLGALPFNVE TGSPENPSSH
1410 1420 1430 1440 1450
ESSLSLEKES DRTVNHVTKR AISTPENSIS DVTFAAGVSY IGTPATFFTK
1460 1470 1480 1490 1500
EKHEAQEQGS DILCLSLLDK RPPQSPQWNV KSPARSHGST RSSRRSLRKA

PLKTAN
Length:1,506
Mass (Da):169,432
Last modified:July 27, 2011 - v3
Checksum:iD0DE95875214D3FD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K4DI67K4DI67_MOUSE
Condensin-2 complex subunit D3
Ncapd3
1,506Annotation score:
Q80W41Q80W41_MOUSE
Condensin-2 complex subunit D3
Ncapd3
1,223Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128I → S in BAB31654 (PubMed:16141072).Curated1
Sequence conflicti128I → S in BAC97856 (PubMed:14621295).Curated1
Sequence conflicti422T → E in BAC97856 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156163 Genomic DNA No translation available.
CT025660 Genomic DNA No translation available.
AK019297 mRNA Translation: BAB31654.1
AK129046 mRNA Translation: BAC97856.1
CCDSiCCDS57665.1
RefSeqiNP_835214.2, NM_178113.3
UniGeneiMm.251777

Genome annotation databases

GeneIDi78658
KEGGimmu:78658

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156163 Genomic DNA No translation available.
CT025660 Genomic DNA No translation available.
AK019297 mRNA Translation: BAB31654.1
AK129046 mRNA Translation: BAC97856.1
CCDSiCCDS57665.1
RefSeqiNP_835214.2, NM_178113.3
UniGeneiMm.251777

3D structure databases

ProteinModelPortaliQ6ZQK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219559, 1 interactor
ComplexPortaliCPX-986 Condensin II complex
STRINGi10090.ENSMUSP00000072871

PTM databases

iPTMnetiQ6ZQK0
PhosphoSitePlusiQ6ZQK0

Proteomic databases

EPDiQ6ZQK0
MaxQBiQ6ZQK0
PaxDbiQ6ZQK0
PRIDEiQ6ZQK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78658
KEGGimmu:78658

Organism-specific databases

CTDi23310
MGIiMGI:2142989 Ncapd3
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0413 Eukaryota
ENOG410XSGK LUCA
HOGENOMiHOG000111840
HOVERGENiHBG061537
InParanoidiQ6ZQK0
KOiK11491

Miscellaneous databases

ChiTaRSiNcapd3 mouse
PROiPR:Q6ZQK0
SOURCEiSearch...

Gene expression databases

CleanExiMM_NCAPD3

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR012371 NCAPD3
PANTHERiPTHR14222 PTHR14222, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PIRSFiPIRSF036508 Condns_HCP-6, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNDD3_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQK0
Secondary accession number(s): E9QPR0, Q9CS21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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