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Entry version 130 (08 May 2019)
Sequence version 2 (26 Apr 2005)
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Protein

DNA topoisomerase 2-binding protein 1

Gene

Topbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for DNA replication (By similarity). Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:14718568). Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity). Induces a large increase in the kinase activity of ATR (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5685938 HDR through Single Strand Annealing (SSA)
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase 2-binding protein 1
Alternative name(s):
DNA topoisomerase II-beta-binding protein 1
Short name:
TopBP1
DNA topoisomerase II-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Topbp1
Synonyms:Kiaa0259
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920018 Topbp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726321 – 1515DNA topoisomerase 2-binding protein 1Add BLAST1515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei298PhosphothreonineBy similarity1
Modified residuei782PhosphothreonineBy similarity1
Modified residuei851PhosphothreonineBy similarity1
Modified residuei862PhosphoserineCombined sources1
Modified residuei863PhosphoserineCombined sources1
Modified residuei866PhosphoserineBy similarity1
Modified residuei888PhosphoserineBy similarity1
Modified residuei890PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and threonine residues in response to X-ray irradiation.By similarity
Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZQF0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZQF0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZQF0

PeptideAtlas

More...
PeptideAtlasi
Q6ZQF0

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZQF0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZQF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZQF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Levels increase during the first 3 weeks after birth and remain high in the fourth week.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032555 Expressed in 285 organ(s), highest expression level in cochlea

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6ZQF0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZQF0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLE. Interacts with RAD9A. Interacts with UBR5. Interacts with E2F1. Interacts with PML. Interacts with SMARCA2. Interacts with SMARCA4. Interacts with RHNO1. May interact with TOP2B. Interacts with TICRR. Interacts with HELB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
231681, 9 interactors

Protein interaction database and analysis system

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IntActi
Q6ZQF0, 10 interactors

Molecular INTeraction database

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MINTi
Q6ZQF0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035164

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5U6KX-ray2.60A/B/C/D/E/F/G/H553-746[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZQF0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 189BRCT 1PROSITE-ProRule annotationAdd BLAST89
Domaini195 – 284BRCT 2PROSITE-ProRule annotationAdd BLAST90
Domaini353 – 443BRCT 3PROSITE-ProRule annotationAdd BLAST91
Domaini551 – 636BRCT 4PROSITE-ProRule annotationAdd BLAST86
Domaini644 – 741BRCT 5PROSITE-ProRule annotationAdd BLAST98
Domaini902 – 993BRCT 6PROSITE-ProRule annotationAdd BLAST92
Domaini1255 – 1347BRCT 7PROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1510 – 1513Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1207 – 1246Pro-richAdd BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1929 Eukaryota
ENOG410XPFH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157001

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZQF0

KEGG Orthology (KO)

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KOi
K10728

Identification of Orthologs from Complete Genome Data

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OMAi
HRAFRSQ

Database of Orthologous Groups

More...
OrthoDBi
557169at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZQF0

TreeFam database of animal gene trees

More...
TreeFami
TF326403

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00027 BRCT, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10190, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533 BRCT, 4 hits
PF12738 PTCB-BRCT, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52113 SSF52113, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6ZQF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRNDQEPFL VKFLKSSDNS ECFFKALESI KELQSEDYLQ IITDEEALKI
60 70 80 90 100
RENDKSLYIC DRFSGTVFDH LKQLGCRIVG PQVVTFCMRH QQCVPRAEHP
110 120 130 140 150
VYNMIMSDVT VSCTSLDKDK REEVHKYVQM MGGRVYRDLN VSVTHLIAGE
160 170 180 190 200
VGSKKYLVAA NLKKPILLPS WIKTLWEKSQ EKKITKYTDV NMEDFKCPIF
210 220 230 240 250
LGCIICVTGL NGIHRKTVQQ LTAKHGGQYM GQLKMNECTH LIVQEPKGQK
260 270 280 290 300
YECARRWNVH CVTLQWFHDS IEKGFCQDES IYKAETRVEA KMVPDTSTPT
310 320 330 340 350
AQSNAESHTL ADVSHISNIN GSCVNETMFG STTSKLECSL ENLENLDISM
360 370 380 390 400
FQAPEDLLDG CRIYLCGFSG RKLDKLRRLI NSGGGVRFNQ LNEDVTHVIV
410 420 430 440 450
GDYDDDVRQF WSKSSHRPHV VGAKWLLECF TKGYILPEES YIHTNYQPAG
460 470 480 490 500
IAVSDQPGNQ TAVLDKSGSF SKSALVPAER LQQADEDLLA QYGNDDSTMV
510 520 530 540 550
EAKLSEALEP EVGPCPGSAH REPCDDSTHI SVQEENKSSV SHCILDDSTV
560 570 580 590 600
REEGLFSQKS FLVLGFSVEN KCNIVDIIRE HAGKIVSLPS RIVADYAVVP
610 620 630 640 650
LLGCEVDVTV GEVVTNTWLV TCIDNQTLVD PKSNPLFTPV SVMSGVTPLE
660 670 680 690 700
DCVISFSQCV GAERDSLVFL ANHLGASVQE FFVRKANAKK GMLASTHLIV
710 720 730 740 750
KEPTGSKYEA AKKWSLPAVN ISWLLETARI GKRADENHFL VDNAPKQEQV
760 770 780 790 800
LETKIPNGVS SNPDLPAHPD AHLEIHRKKA VTPLDMNRFQ SRAFRAVISQ
810 820 830 840 850
QRGQDPTFPP VRQPLTKEPS LHLDTPSKFL SKDKLFKPSF DVTDALAALE
860 870 880 890 900
TPNAASQKRK LSSPLSEVIV RNLTVALANS SRNTDSHSAS PQLKGAHLEE
910 920 930 940 950
EETRKPLDSV VVCVSKKLSK KQSELNGVAA SLGAEYRWSF DETVTHFIYQ
960 970 980 990 1000
GRANDSNREY KSAKERGVHI VSEHWLLECA QEYKHLPESL YPHTYNPKMS
1010 1020 1030 1040 1050
LDINTVQDGR LCNSRAPLAV SASKDDGPDH LSVEGNETNT MGTNDKESPL
1060 1070 1080 1090 1100
LNGSGRDDCK GALTQALEMR ENFQKQLQEI MSATCIVKTP AQKTCMSRSS
1110 1120 1130 1140 1150
CNSASSTPDS ARSVRSGRSR VLEALRQSRQ AVPDVNTEPS QNEQIIWDDP
1160 1170 1180 1190 1200
TAREERARLA SNLQWPSDPT QHSELQVEIK MPDDSPSRKP VYHSEIAEQA
1210 1220 1230 1240 1250
SCVTQAPGHP GSEEPEPPVA ERPLIPEPQA PAVASPLAKP PVAPQPADKI
1260 1270 1280 1290 1300
ETQEETHRKV KKQYVFQMSS LNSQERIDYC RLIKDLGGSV IEKQCSDPSC
1310 1320 1330 1340 1350
THMVVGYPLR NEKYLASMAA GKWVLHRSYL DACKTAGRFV QEEDYEWGSS
1360 1370 1380 1390 1400
SILDALPDVT EHQQKLALAA MRWRKRIQQS QESGIVEGAF SGWKAILRVD
1410 1420 1430 1440 1450
RPREAGFKRL LQAGGAKVLS GHPEPLLKDA THLFCDFNKL KPDDCRVFIA
1460 1470 1480 1490 1500
EATAQNMVCL KTEYIADYLM LESPPCADNY RVSEAALFHN KKGGPGLPQK
1510
RKTPAENVVK RPRVH
Length:1,515
Mass (Da):168,860
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2E729D2E57B6F2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WS55A0A087WS55_MOUSE
DNA topoisomerase 2-binding protein...
Topbp1
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPG9A0A087WPG9_MOUSE
DNA topoisomerase 2-binding protein...
Topbp1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WS20A0A087WS20_MOUSE
DNA topoisomerase 2-binding protein...
Topbp1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07170 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC39345 differs from that shown. Reason: Frameshift at position 183.Curated
The sequence BAC97914 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324V → I in AAH07170 (PubMed:15489334).Curated1
Sequence conflicti461T → I in AAH07170 (PubMed:15489334).Curated1
Sequence conflicti521R → L in AAH07170 (PubMed:15489334).Curated1
Sequence conflicti607D → E in AAH07170 (PubMed:15489334).Curated1
Sequence conflicti835L → P in AAH62111 (PubMed:15489334).Curated1
Sequence conflicti1041M → I in AAH07170 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1420S → P in strain: FVB/N. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129104 mRNA Translation: BAC97914.1 Different initiation.
BC006707 mRNA Translation: AAH06707.1
BC007170 mRNA Translation: AAH07170.1 Different initiation.
BC026608 mRNA Translation: AAH26608.1
BC049797 mRNA Translation: AAH49797.1
BC062111 mRNA Translation: AAH62111.1
AK084654 mRNA Translation: BAC39241.2
AK085031 mRNA Translation: BAC39345.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23453.1

NCBI Reference Sequences

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RefSeqi
NP_795953.2, NM_176979.5
XP_006511770.1, XM_006511707.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035164; ENSMUSP00000035164; ENSMUSG00000032555

Database of genes from NCBI RefSeq genomes

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GeneIDi
235559

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:235559

UCSC genome browser

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UCSCi
uc009rgl.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129104 mRNA Translation: BAC97914.1 Different initiation.
BC006707 mRNA Translation: AAH06707.1
BC007170 mRNA Translation: AAH07170.1 Different initiation.
BC026608 mRNA Translation: AAH26608.1
BC049797 mRNA Translation: AAH49797.1
BC062111 mRNA Translation: AAH62111.1
AK084654 mRNA Translation: BAC39241.2
AK085031 mRNA Translation: BAC39345.1 Frameshift.
CCDSiCCDS23453.1
RefSeqiNP_795953.2, NM_176979.5
XP_006511770.1, XM_006511707.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5U6KX-ray2.60A/B/C/D/E/F/G/H553-746[»]
SMRiQ6ZQF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231681, 9 interactors
IntActiQ6ZQF0, 10 interactors
MINTiQ6ZQF0
STRINGi10090.ENSMUSP00000035164

PTM databases

iPTMnetiQ6ZQF0
PhosphoSitePlusiQ6ZQF0

Proteomic databases

EPDiQ6ZQF0
MaxQBiQ6ZQF0
PaxDbiQ6ZQF0
PeptideAtlasiQ6ZQF0
PRIDEiQ6ZQF0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035164; ENSMUSP00000035164; ENSMUSG00000032555
GeneIDi235559
KEGGimmu:235559
UCSCiuc009rgl.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11073
MGIiMGI:1920018 Topbp1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1929 Eukaryota
ENOG410XPFH LUCA
GeneTreeiENSGT00940000157001
InParanoidiQ6ZQF0
KOiK10728
OMAiHRAFRSQ
OrthoDBi557169at2759
PhylomeDBiQ6ZQF0
TreeFamiTF326403

Enzyme and pathway databases

ReactomeiR-MMU-5685938 HDR through Single Strand Annealing (SSA)
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6ZQF0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032555 Expressed in 285 organ(s), highest expression level in cochlea
ExpressionAtlasiQ6ZQF0 baseline and differential
GenevisibleiQ6ZQF0 MM

Family and domain databases

CDDicd00027 BRCT, 6 hits
Gene3Di3.40.50.10190, 9 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
PfamiView protein in Pfam
PF00533 BRCT, 4 hits
PF12738 PTCB-BRCT, 2 hits
SMARTiView protein in SMART
SM00292 BRCT, 8 hits
SUPFAMiSSF52113 SSF52113, 7 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOPB1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZQF0
Secondary accession number(s): Q6P6P0
, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 8, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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