Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 5-diphosphoinositol pentakisphosphate 3-kinase activity Source: UniProtKB-EC
• ATP binding Source: UniProtKB
• diphosphoinositol-pentakisphosphate kinase activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 17690096
• inositol-1,3,4,5,6-pentakisphosphate kinase activity Source: UniProtKB
• inositol heptakisphosphate kinase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
• inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
• inositol hexakisphosphate 5-kinase activity Source: UniProtKB
• inositol hexakisphosphate kinase activity Source: MGIInferred from direct assayⁱ
  • 17690096

GO - Biological processⁱ

• inositol metabolic process Source: UniProtKB
• inositol phosphate biosynthetic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSNSRKMSEP PRFFVGPEDA EINPGNYRRF FHHAEEEEEE EDESPPERQI 
        60         70         80         90        100
VVGICSMAKK SKSKPMKEIL ERISLFKYIT VVVFEEEIIL NEPVENWPLC 
       110        120        130        140        150
DCLISFHSKG FPLDKAVAYA KLRNPFVIND LNMQYLIQDR RDVYSILQAE 
       160        170        180        190        200
GILLPRYAIL NRDPNNPKEC NLIEGEDHVE VNGEVFQKPF VEKPVSAEDH 
       210        220        230        240        250
NVYIYYPTSA GGGSQRLFRK IGSRSSVYSP ESNVRKTGSY IYEEFMPTDG 
       260        270        280        290        300
TDVKVYTVGP DYAHAEARKS PALDGKVERD SEGKEVRYPV ILNAREKLIA 
       310        320        330        340        350
WKVCLAFKQT VCGFDLLRAN GQSYVCDVNG FSFVKNSMKY YDDCAKILGN 
       360        370        380        390        400
IVMRELAPQF HIPWSIPLEA EDIPIVPTTS GTMMELRCVI AVIRHGDRTP 
       410        420        430        440        450
KQKMKMEVRH QKFFDLFEKC DGYKSGKLKL KKPKQLQEVL DIARQLLMEL 
       460        470        480        490        500
GQNNDSEIEE NKSKLEQLKT VLEMYGHFSG INRKVQLTYL PHGCPKTSSE 
       510        520        530        540        550
EEDNRREEPS LLLVLKWGGE LTPAGRVQAE ELGRAFRCMY PGGQGDYAGF 
       560        570        580        590        600
PGCGLLRLHS TYRHDLKIYA SDEGRVQMTA AAFAKGLLAL EGELTPILVQ 
       610        620        630        640        650
MVKSANMNGL LDSDSDSLSS CQQRVKARLH EILQKDRDFT AEDYEKLTPS 
       660        670        680        690        700
GSISVIKSMH LIKNPVKTCD KVYSLIQSLT SQIRYRMEDP KSADIQLYHS 
       710        720        730        740        750
ETLELMLRRW SKLEKDFKTK NGRYDISKIP DIYDCIKYDV QHNGSLKLEN 
       760        770        780        790        800
TMELYRLSKA LADIVIPQEY GITKAEKLEI AKGYCTPLVR KIRSDLQRTQ 
       810        820        830        840        850
DDDTVNKLHP VYSRGVLSPE RHVRTRLYFT SESHVHSLLS ILRYGALCDD 
       860        870        880        890        900
SKDEQWKRAM DYLNVVNELN YMTQIVIMLY EDPNKDLSSE ERFHVELHFS 
       910        920        930        940        950
PGAKGCEEDK NLPSGYGYRP ASRENEGRRS LKTDDDEPHT SKRDEVDRAV 
       960        970        980        990       1000
MLFKPLVSEP IHIHRKSPLP RSRKITANEV VSENANYLRT PRNLVEQKQN 
      1010       1020       1030       1040       1050
PTVGFELYSM VPSICPLETL HNALFLKQVD DFLASIASPS TEVLRKVPEM 
      1060       1070       1080       1090       1100
SSMATRSSPG MRRKISLNTY TPTKILPTPP AALKSSKASS KAAAGGPSQA 
      1110       1120 
MAPHTSSRKK SINSKTEGHE PKKSTGKKR                        

        10         20         30         40         50
MSNSRKMSEP PRFFVGPEDA EINPGNYRRF FHHAEEEEEE EDESPPERQI 
        60         70         80         90        100
VVGICSMAKK SKSKPMKEIL ERISLFKYIT VVVFEEEIIL NEPVENWPLC 
       110        120        130        140        150
DCLISFHSKG FPLDKAVAYA KLRNPFVIND LNMQYLIQDR RDVYSILQAE 
       160        170        180        190        200
GILLPRYAIL NRDPNNPKEC NLIEGEDHVE VNGEVFQKPF VEKPVSAEDH 
       210        220        230        240        250
NVYIYYPTSA GGGSQRLFRK IGSRSSVYSP ESNVRKTGSY IYEEFMPTDG 
       260        270        280        290        300
TDVKVYTVGP DYAHAEARKS PALDGKVERD SEGKEVRYPV ILNAREKLIA 
       310        320        330        340        350
WKVCLAFKQT VCGFDLLRAN GQSYVCDVNG FSFVKNSMKY YDDCAKILGN 
       360        370        380        390        400
IVMRELAPQF HIPWSIPLEA EDIPIVPTTS GTMMELRCVI AVIRHGDRTP 
       410        420        430        440        450
KQKMKMEVRH QKFFDLFEKC DGYKSGKLKL KKPKQLQEVL DIARQLLMEL 
       460        470        480        490        500
GQNNDSEIEE NKSKLEQLKT VLEMYGHFSG INRKVQLTYL PHGCPKTSSE 
       510        520        530        540        550
EEDNRREEPS LLLVLKWGGE LTPAGRVQAE ELGRAFRCMY PGGQDYAGFP 
       560        570        580        590        600
GCGLLRLHST YRHDLKIYAS DEGRVQMTAA AFAKGLLALE GELTPILVQM 
       610        620        630        640        650
VKSANMNGLL DSDSDSLSSC QQRVKARLHE ILQKDRDFTA EDYEKLTPSG 
       660        670        680        690        700
SISVIKSMHL IKNPVKTCDK VYSLIQSLTS QIRYRMEDPK SADIQLYHSE 
       710        720        730        740        750
TLELMLRRWS KLEKDFKTKN GRYDISKIPD IYDCIKYDVQ HNGSLKLENT 
       760        770        780        790        800
MELYRLSKAL ADIVIPQEYG ITKAEKLEIA KGYCTPLVRK IRSDLQRTQD 
       810        820        830        840        850
DDTVNKLHPV YSRGVLSPER HVRTRLYFTS ESHVHSLLSI LRYGALCDDS 
       860        870        880        890        900
KDEQWKRAMD YLNVVNELNY MTQIVIMLYE DPNKDLSSEE RFHVELHFSP 
       910        920        930        940        950
GAKGCEEDKN LPSGYGYRPA SRENEGRRSL KTDDDEPHTS KRDEVDRAVM 
       960        970        980        990       1000
LFKPLVSEPI HIHRKSPLPR SRKITANEVV SENANYLRTP RNLVEQKQNP 
      1010       1020       1030       1040       1050
TVGFELYSMV PSICPLETLH NALFLKQVDD FLASIASPST EVLRKVPEMC 

MEFTFIVT                                               

        10         20         30         40         50
MSEPPRFFVG PEDAEINPGN YRRFFHHAEE EEEEEDESPP ERQIVVGICS 
        60         70         80         90        100
MAKKSKSKPM KEILERISLF KYITVVVFEE EIILNEPVEN WPLCDCLISF 
       110        120        130        140        150
HSKGFPLDKA VAYAKLRNPF VINDLNMQYL IQDRRDVYSI LQAEGILLPR 
       160        170        180        190        200
YAILNRDPNN PKECNLIEGE DHVEVNGEVF QKPFVEKPVS AEDHNVYIYY 
       210        220        230        240        250
PTSAGGGSQR LFRKIGSRSS VYSPESNVRK TGSYIYEEFM PTDGTDVKVY 
       260        270        280        290        300
TVGPDYAHAE ARKSPALDGK VERDSEGKEV RYPVILNARE KLIAWKVCLA 
       310        320        330        340        350
FKQTVCGFDL LRANGQSYVC DVNGFSFVKN SMKYYDDCAK ILGNIVMREL 
       360        370        380        390        400
APQFHIPWSI PLEAEDIPIV PTTSGTMMEL RCVIAVIRHG DRTPKQKMKM 
       410        420        430        440        450
EVRHQKFFDL FEKCDGYKSG KLKLKKPKQL QEVLDIARQL LMELGQNNDS 
       460        470        480        490        500
EIEENKSKLE QLKTVLEMYG HFSGINRKVQ LTYLPHGCPK TSSEEEDNRR 
       510        520        530        540        550
EEPSLLLVLK WGGELTPAGR VQAEELGRAF RCMYPGGQGD YAGFPGCGLL 
       560        570        580        590        600
RLHSTYRHDL KIYASDEGRV QMTAAAFAKG LLALEGELTP ILVQMVKSAN 
       610        620        630        640        650
MNGLLDSDSD SLSSCQQRVK ARLHEILQKD RDFTAEDYEK LTPSGSISVI 
       660        670        680        690        700
KSMHLIKNPV KTCDKVYSLI QSLTSQIRYR MEDPKSADIQ LYHSETLELM 
       710        720        730        740        750
LRRWSKLEKD FKTKNGRYDI SKIPDIYDCI KYDVQHNGSL KLENTMELYR 
       760        770        780        790        800
LSKALADIVI PQEYGITKAE KLEIAKGYCT PLVRKIRSDL QRTQDDDTVN 
       810        820        830        840        850
KLHPVYSRGV LSPERHVRTR LYFTSESHVH SLLSILRYGA LCDDSKDEQW 
       860        870        880        890        900
KRAMDYLNVV NELNYMTQIV IMLYEDPNKD LSSEERFHVE LHFSPGAKGC 
       910        920        930        940        950
EEDKNLPSGY GYRPASRENE GRRSLKTDDD EPHTSKRDEV DRAVMLFKPL 
       960        970        980        990       1000
VSEPIHIHRK SPLPRSRKIT ANEVVSENAN YLRTPRNLVE QKQNPTVGFE 
      1010       1020       1030       1040       1050
LYSMVPSICP LETLHNALFL KQVDDFLASI ASPSTEVLRK VPEMSSMATR 
      1060       1070       1080       1090       1100
SSPGMRRKIS LNTYTPTKIL PTPPAALKSS KASSKAAAGG PSQAMAPHTS 
      1110       1120 
SRKKSINSKT EGHEPKKSTG KKR                              

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot