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Entry version 118 (18 Sep 2019)
Sequence version 3 (04 Nov 2008)
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Protein

Ubiquitin carboxyl-terminal hydrolase 34

Gene

Usp34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1940NucleophilePROSITE-ProRule annotation1
Active sitei2201Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-201681 TCF dependent signaling in response to WNT
R-MMU-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.067

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 34 (EC:3.4.19.12By similarity)
Alternative name(s):
Deubiquitinating enzyme 34
Ubiquitin thioesterase 34
Ubiquitin-specific-processing protease 34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp34
Synonyms:Kiaa0570, Murr2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109473 Usp34

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495201 – 3582Ubiquitin carboxyl-terminal hydrolase 34Add BLAST3582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei352PhosphoserineBy similarity1
Modified residuei486PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei490PhosphoserineCombined sources1
Modified residuei1506PhosphoserineCombined sources1
Modified residuei2525PhosphoserineCombined sources1
Modified residuei3395PhosphoserineCombined sources1
Modified residuei3396PhosphoserineCombined sources1
Modified residuei3418PhosphothreonineCombined sources1
Modified residuei3423PhosphoserineBy similarity1
Modified residuei3443PhosphoserineCombined sources1
Modified residuei3539PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZQ93

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZQ93

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZQ93

PeptideAtlas

More...
PeptideAtlasi
Q6ZQ93

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZQ93

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZQ93

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZQ93

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000056342 Expressed in 287 organ(s), highest expression level in primary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZQ93 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZQ93 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AXIN1 and AXIN2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201621, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000120747

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZQ93

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1931 – 2276USPAdd BLAST346

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1866 Eukaryota
COG5077 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158659

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZQ93

KEGG Orthology (KO)

More...
KOi
K11853

Database of Orthologous Groups

More...
OrthoDBi
625455at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZQ93

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZQ93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCENCADLVE VLNEISDIEG GDGLQLRKEH TLKIFAYINS WTQRQCLCCF
60 70 80 90 100
KEYKHLEIFN QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ
110 120 130 140 150
AEEPLSIDRE CNEGNTERQK SIEKKSNSTR TCNLTEEESS KSSDPFSLWN
160 170 180 190 200
TDEKEKLLLC VAKIFQIQFP LYTAYKHNTH PTIEDISTQE SNILGAFCDM
210 220 230 240 250
NDVEVPLHLL RYVCLFCGKN GLSLMKDCFE YGTPETLPFL IAHAFITVVS
260 270 280 290 300
NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS DQELRQSAAR NMADLMWSTV
310 320 330 340 350
KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ LHTFNDVCNN
360 370 380 390 400
ESLVSDTETS IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA
410 420 430 440 450
EGRLSTQHID CIWAAAQLKH CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA
460 470 480 490 500
LEPGVHTEQT LYLASMLIKA LWNNALAAKA QLSKQSSFAS LLNTNMPIGN
510 520 530 540 550
KKEEEELRRA APSPWSPAAS PQSSDNSDTH QSGASDIEMD EQLINRNKHV
560 570 580 590 600
QQRLSDTEES MQGSSDETAN SGEDGSSGPG SSSGHSDGSS NEVNSSHASQ
610 620 630 640 650
SAGSPGSEVQ SEDIADIEAL KEEEEEEEEE EEEEEEEDDE EEEDEEEDDD
660 670 680 690 700
DDDDHGHNPA KNTCGTELRN RKLENPAGIC LGESQGTSER NGTNSGTGKD
710 720 730 740 750
LVFNTEPLPS VDNRIRMLDA CAHSEDPEHG ISGEVSSAHL AQGSQEACIT
760 770 780 790 800
RSGDFLGETI GNELFNCRQF IGPQHHHHHH HHHHHHHHHH HHHHHHHDGH
810 820 830 840 850
MVDDMLSADD VSCSSSQVSA KSEKNMADFD GEESGCEEEL VQINSHAELT
860 870 880 890 900
SHLQQHLPNL ASIYHEHLSQ GPAVHKHQFS SNAVTDINLD NVCKKGNTLL
910 920 930 940 950
WDIVQDDDAI NLSEGLINEA EKLLCSLVCW FTDRQIRMRF IEGCLENLGN
960 970 980 990 1000
NRSVVISLRL LPKLFGTFQQ FGSSYDTHWI TMWAEKELNM MKLFFDNLVY
1010 1020 1030 1040 1050
YIQGIREGRQ KHALYSHSAE VQVRLQFLTC VFSTLGSPDH FRLSLEQVDI
1060 1070 1080 1090 1100
LWHCLVEDSE CYDDALHWFL NQVRSKDQHA MGMETYKHLF LEKMPQLKPE
1110 1120 1130 1140 1150
TISMTGLNLF QHLCNLARLA TSAYDGGSNS ELCGMDQFWG IALRAQSGDV
1160 1170 1180 1190 1200
SRAAIQYINS YYINGKTGLE KEQEFISKCM ESLMIASSSL EQESHSSLTV
1210 1220 1230 1240 1250
IERGLLMLKT HLEAFRRRFA YHLRQWQIEG TGISSHLKAL SDKQSLPLRV
1260 1270 1280 1290 1300
VCQPAGLPDK MTIEMYPSDQ VADLRAEVTH WYENLQKEQI NQQAQLQEFG
1310 1320 1330 1340 1350
QSSRKGEFPG GLMGPVRMIS SGHELTTDYD EKALHELGFK DMQMVFVSLG
1360 1370 1380 1390 1400
APRRERKGEG VQLPASCLPP PQKDNIPMLL LLQEPHLTTL FDLLEMLASF
1410 1420 1430 1440 1450
KPPSGKVAVD DSESLKCEEL HLHAENLSRR VWELLMLLPT CPNMLTAFQN
1460 1470 1480 1490 1500
VSDEQSNDGL NWKELLKIKS AHKLLYALEI IEALGKPNRR IRRESTGSYS
1510 1520 1530 1540 1550
DLYPDSDDSS EDQVENSKNS WTCKFVAAGG LQQLLEIFNS AILEPKEQES
1560 1570 1580 1590 1600
WTVWQLDCLA CLLKLICQFA VDPSDLDLAY HDVFAWSGIA ESHRKRTWPG
1610 1620 1630 1640 1650
KSRKAAGDHA KSLHIPRLTE VFLVLVQGTS LIQRLMSVAY TYDNLAPRVL
1660 1670 1680 1690 1700
KAQSDHRSRH EVSHYSMWLL VSWAHCCSLV KSSLADSDHL QDWLKQLTLL
1710 1720 1730 1740 1750
IPETAVRHES CNGLYKLSLS GLDGGDSIHR SFLLLAASTL LKFLPDAQAL
1760 1770 1780 1790 1800
KPPRIDDYEE EPLLKPGCKE YFWLLCKLVD NIHIKDASQT TLLDLDALAR
1810 1820 1830 1840 1850
HLADCIRSRE ILDHLDGSIE DDGLSGLLRL ATSVIKHKPP FKFSREGQEF
1860 1870 1880 1890 1900
LRDIFNLLFL LPSLKDRRQP KCKSHSCRAA AYDLLVEMVK GSVENYRLIH
1910 1920 1930 1940 1950
NWVMAQHMQS HAPYKWDYWP HEDVRAECRF VGLTNLGATC YLASTIQQLY
1960 1970 1980 1990 2000
MIPEARQAVF TAKYSEDMKH KTTLLELQKM FTYLMESECK AYNPRPFCKT
2010 2020 2030 2040 2050
YTMDKQPLNT GEQKDMTEFF TDLITKVEEM SPELKNTVKS LFGGVITNNV
2060 2070 2080 2090 2100
VSLDCEHVSQ TAEEFYTVRC QVADMKNIYE SLDEVTIKDT LEGDNMYTCS
2110 2120 2130 2140 2150
HCGKKVRAEK RACFKKLPRI LSFNTMRYTF NMVTMMKEKV NTHFSFPLRL
2160 2170 2180 2190 2200
DMTPYTEDFL MGKSDRKEGF KDVGDRSKDT ESYEYDLIGV TVHTGTADGG
2210 2220 2230 2240 2250
HYYSFIRDIV NPHAYKNNKW YLFNDAEVKP FDSAQLASEC FGGEMTTKTY
2260 2270 2280 2290 2300
DSVTDKFMDF SFEKTHSAYM LFYKRMEPEE ENGREYKFDV SSELLEWIWH
2310 2320 2330 2340 2350
DNMQFLQDKN IFEHTYFGFM WQLCSCIPST LPDPKAVSLM TAKLSTSFVL
2360 2370 2380 2390 2400
ETFIHSKEKP TMLQWIELLT KQFNNSQAAC EWFLDRMADD DWWPMQILIK
2410 2420 2430 2440 2450
CPNQIVRQMF QRLCIHVIQR LRPVHAHLYL QPGMEDGSDD MDASVEDIGG
2460 2470 2480 2490 2500
RSCVTRFVRT LLLIMEHGVK PHSKHLTEYF AFLYEFAKMG EEESQFLLSL
2510 2520 2530 2540 2550
QAISTMVHFY MGTKGPENPQ VEVLSEEEGE EEEEEEDILS LAEEKYRPAA
2560 2570 2580 2590 2600
LEKMIALVAL LVEQSRSERH LTLSQTDMAA LTGGKGFPFL FQHIRDGINI
2610 2620 2630 2640 2650
RQTCNLIFSL CRYNNRLAEH IVSMLFTSIA KLTPEAANPF FKLLTMLMEF
2660 2670 2680 2690 2700
AGGPPGMPPF ASYILQRIWE VIEYNPSQCL DWLAVQTPRN KLAHSWVLQN
2710 2720 2730 2740 2750
MENWVERFLL AHNYPRVRTS AAYLLVSLIP SNSFRQMFRS TRSLHIPTRD
2760 2770 2780 2790 2800
LPLSPDTTVV LHQVYNVLLG LLSRAKLYVD AAVHGTTKLV PYLSFMTYCL
2810 2820 2830 2840 2850
ISKTEKLMFS TYFMDLWNLF QPKLSEPAIA TNHNKQALLS FWYNVCADCP
2860 2870 2880 2890 2900
ENIRLIVQNP VVTKNIAFNY ILADHDDQDV VLFNRGMLPA YYGILRLCCE
2910 2920 2930 2940 2950
QSPAFTRQLA SHQNIQWAFK NLTPHASQYP GAVEELFNLM QLFIAQRPDM
2960 2970 2980 2990 3000
REEELEDIKQ FKKTTISCYL RCLDGRSCWT TLISAFRILL ESDEDRLLVV
3010 3020 3030 3040 3050
FNRGLILMTE SFNTLHMMYH EATACHVTGD LVELLSIFLS VLKSTRPYLQ
3060 3070 3080 3090 3100
RKDVKQALIQ WQERIEFAHK LLTLLNSYSP PELRNACIDV LKELVLLSPH
3110 3120 3130 3140 3150
DFLHTLVPFL QHNHCTYHHS NIPMSLGPYF PCRENIKLIG GKSNIRPPRP
3160 3170 3180 3190 3200
ELNMCLLPTM VETSKGKDDV YDRMLLDYFF SYHQFIHLLC RVAINCEKFT
3210 3220 3230 3240 3250
ETLVKLSVLV AYEGLPLHLA LFPKLWTELC QTQSAMSKNC IKLLCEDPVF
3260 3270 3280 3290 3300
AEYIKCILMD ERTFLNNNIV YTFMTHFLLK VQSQVFSEAN CASLISTLIT
3310 3320 3330 3340 3350
NLINQYQNLQ SDFTNRVEIS KASAALNGDL RALALLLSVH TPKQLNPALI
3360 3370 3380 3390 3400
PTLQELLNKC RTCLQQRNSL QEQEAKERKT KDDEGATPVK RRRVSSDEEH
3410 3420 3430 3440 3450
TVDSCIGDIK TETREVLTPT STSDNETRDS SIIDPGTEQD LPSPENSSVK
3460 3470 3480 3490 3500
EYRMEGPSSF SEDGSHIRSQ HAEEQSNNGR FDDCKEFKDH CSKDTTLAED
3510 3520 3530 3540 3550
ESEFPSTSIS AVLSDLADLR SCDGQALSSQ DPEAAVSLSC GHSRGLISHM
3560 3570 3580
QQHDILDTLC RTIESTIHVV TRISGKGNQA AS
Length:3,582
Mass (Da):408,214
Last modified:November 4, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27BA0032ED7E06A2
GO
Isoform 2 (identifier: Q6ZQ93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-160: DEKEKLLLC → MRRKNYYYV

Show »
Length:3,431
Mass (Da):391,068
Checksum:iE7D7BECDEA86331D
GO
Isoform 3 (identifier: Q6ZQ93-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-160: DEKEKLLLC → MRRKNYYYV
     3124-3206: Missing.

Note: No experimental confirmation available.
Show »
Length:3,348
Mass (Da):381,386
Checksum:iB03CEBA62999D4CE
GO
Isoform 4 (identifier: Q6ZQ93-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-160: DEKEKLLLC → MRRKNYYYV
     2569-3582: Missing.

Note: No experimental confirmation available.
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Length:2,417
Mass (Da):275,543
Checksum:i3C4C2FC2CB1FDB6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YLQ1Z4YLQ1_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp34
810Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WJB7F6WJB7_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp34
3,602Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YN11Z4YN11_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp34
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH55938 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAM20294 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2163K → Q in BAE25365 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0356411 – 151Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST151
Alternative sequenceiVSP_035642152 – 160DEKEKLLLC → MRRKNYYYV in isoform 2, isoform 3 and isoform 4. 2 Publications9
Alternative sequenceiVSP_0204642569 – 3582Missing in isoform 4. 1 PublicationAdd BLAST1014
Alternative sequenceiVSP_0204653124 – 3206Missing in isoform 3. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL672049 Genomic DNA Translation: CAM16931.1
AL672049
, AL672004, AL772359, AL928722 Genomic DNA Translation: CAM16940.1
AL672004 Genomic DNA Translation: CAM17339.1
AL672004
, AL672049, AL772359, AL928722 Genomic DNA Translation: CAM17340.1
AL772359
, AL672004, AL672049, AL928722 Genomic DNA Translation: CAM20294.1 Different initiation.
AL928722
, AL672004, AL672049, AL772359 Genomic DNA Translation: CAO77877.1
AK033182 mRNA Translation: BAC28186.1
AK143407 mRNA Translation: BAE25365.1
AK148805 mRNA Translation: BAE28668.1
AK129165 mRNA Translation: BAC97975.1
BC055938 mRNA Translation: AAH55938.1 Sequence problems.
BC063062 mRNA Translation: AAH63062.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS56763.1 [Q6ZQ93-1]

NCBI Reference Sequences

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RefSeqi
NP_001177330.2, NM_001190401.2 [Q6ZQ93-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000180046; ENSMUSP00000137430; ENSMUSG00000056342 [Q6ZQ93-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17847

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17847

UCSC genome browser

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UCSCi
uc029rkw.1 mouse [Q6ZQ93-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672049 Genomic DNA Translation: CAM16931.1
AL672049
, AL672004, AL772359, AL928722 Genomic DNA Translation: CAM16940.1
AL672004 Genomic DNA Translation: CAM17339.1
AL672004
, AL672049, AL772359, AL928722 Genomic DNA Translation: CAM17340.1
AL772359
, AL672004, AL672049, AL928722 Genomic DNA Translation: CAM20294.1 Different initiation.
AL928722
, AL672004, AL672049, AL772359 Genomic DNA Translation: CAO77877.1
AK033182 mRNA Translation: BAC28186.1
AK143407 mRNA Translation: BAE25365.1
AK148805 mRNA Translation: BAE28668.1
AK129165 mRNA Translation: BAC97975.1
BC055938 mRNA Translation: AAH55938.1 Sequence problems.
BC063062 mRNA Translation: AAH63062.1
CCDSiCCDS56763.1 [Q6ZQ93-1]
RefSeqiNP_001177330.2, NM_001190401.2 [Q6ZQ93-1]

3D structure databases

SMRiQ6ZQ93
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201621, 1 interactor
STRINGi10090.ENSMUSP00000120747

Protein family/group databases

MEROPSiC19.067

PTM databases

iPTMnetiQ6ZQ93
PhosphoSitePlusiQ6ZQ93

Proteomic databases

EPDiQ6ZQ93
jPOSTiQ6ZQ93
PaxDbiQ6ZQ93
PeptideAtlasiQ6ZQ93
PRIDEiQ6ZQ93

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180046; ENSMUSP00000137430; ENSMUSG00000056342 [Q6ZQ93-1]
GeneIDi17847
KEGGimmu:17847
UCSCiuc029rkw.1 mouse [Q6ZQ93-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9736
MGIiMGI:109473 Usp34

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1866 Eukaryota
COG5077 LUCA
GeneTreeiENSGT00940000158659
InParanoidiQ6ZQ93
KOiK11853
OrthoDBi625455at2759
PhylomeDBiQ6ZQ93

Enzyme and pathway databases

ReactomeiR-MMU-201681 TCF dependent signaling in response to WNT
R-MMU-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Usp34 mouse

Protein Ontology

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PROi
PR:Q6ZQ93

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000056342 Expressed in 287 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ6ZQ93 baseline and differential
GenevisibleiQ6ZQ93 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP34_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZQ93
Secondary accession number(s): A2AF26
, A2AF27, A2AF77, Q3UF93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 4, 2008
Last modified: September 18, 2019
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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