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UniProtKB - Q6ZQ93 (UBP34_MOUSE)

Entry version 125 (07 Oct 2020)
Sequence version 3 (04 Nov 2008)
Previous versions | rss
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Protein

Ubiquitin carboxyl-terminal hydrolase 34

Gene

Usp34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1940NucleophilePROSITE-ProRule annotation1
Active sitei2201Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-201681, TCF dependent signaling in response to WNT
R-MMU-5689880, Ub-specific processing proteases

Protein family/group databases

MEROPS protease database

More...MEROPSi		C19.067

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 34 (EC:3.4.19.12By similarity)
Alternative name(s):
Deubiquitinating enzyme 34
Ubiquitin thioesterase 34
Ubiquitin-specific-processing protease 34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp34
Synonyms:Kiaa0570, Murr2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:109473, Usp34

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495201 – 3582Ubiquitin carboxyl-terminal hydrolase 34Add BLAST3582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei352PhosphoserineBy similarity1
Modified residuei486PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei490PhosphoserineCombined sources1
Modified residuei1506PhosphoserineCombined sources1
Modified residuei2525PhosphoserineCombined sources1
Modified residuei3395PhosphoserineCombined sources1
Modified residuei3396PhosphoserineCombined sources1
Modified residuei3418PhosphothreonineCombined sources1
Modified residuei3423PhosphoserineBy similarity1
Modified residuei3443PhosphoserineCombined sources1
Modified residuei3539PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZQ93

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZQ93

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZQ93

PeptideAtlas

More...PeptideAtlasi		Q6ZQ93

PRoteomics IDEntifications database

More...PRIDEi		Q6ZQ93

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZQ93

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZQ93

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000056342, Expressed in primary oocyte and 303 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZQ93, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZQ93, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AXIN1 and AXIN2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201621, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000120747

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZQ93, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZQ93

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1931 – 2276USPAdd BLAST346

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1866, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158659

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000109_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZQ93

KEGG Orthology (KO)

More...KOi		K11853

Database of Orthologous Groups

More...OrthoDBi		625455at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZQ93

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR021905, DUF3517
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12030, DUF3517, 1 hit
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZQ93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCENCADLVE VLNEISDIEG GDGLQLRKEH TLKIFAYINS WTQRQCLCCF 
        60         70         80         90        100
KEYKHLEIFN QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ 
       110        120        130        140        150
AEEPLSIDRE CNEGNTERQK SIEKKSNSTR TCNLTEEESS KSSDPFSLWN 
       160        170        180        190        200
TDEKEKLLLC VAKIFQIQFP LYTAYKHNTH PTIEDISTQE SNILGAFCDM 
       210        220        230        240        250
NDVEVPLHLL RYVCLFCGKN GLSLMKDCFE YGTPETLPFL IAHAFITVVS 
       260        270        280        290        300
NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS DQELRQSAAR NMADLMWSTV 
       310        320        330        340        350
KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ LHTFNDVCNN 
       360        370        380        390        400
ESLVSDTETS IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA 
       410        420        430        440        450
EGRLSTQHID CIWAAAQLKH CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA 
       460        470        480        490        500
LEPGVHTEQT LYLASMLIKA LWNNALAAKA QLSKQSSFAS LLNTNMPIGN 
       510        520        530        540        550
KKEEEELRRA APSPWSPAAS PQSSDNSDTH QSGASDIEMD EQLINRNKHV 
       560        570        580        590        600
QQRLSDTEES MQGSSDETAN SGEDGSSGPG SSSGHSDGSS NEVNSSHASQ 
       610        620        630        640        650
SAGSPGSEVQ SEDIADIEAL KEEEEEEEEE EEEEEEEDDE EEEDEEEDDD 
       660        670        680        690        700
DDDDHGHNPA KNTCGTELRN RKLENPAGIC LGESQGTSER NGTNSGTGKD 
       710        720        730        740        750
LVFNTEPLPS VDNRIRMLDA CAHSEDPEHG ISGEVSSAHL AQGSQEACIT 
       760        770        780        790        800
RSGDFLGETI GNELFNCRQF IGPQHHHHHH HHHHHHHHHH HHHHHHHDGH 
       810        820        830        840        850
MVDDMLSADD VSCSSSQVSA KSEKNMADFD GEESGCEEEL VQINSHAELT 
       860        870        880        890        900
SHLQQHLPNL ASIYHEHLSQ GPAVHKHQFS SNAVTDINLD NVCKKGNTLL 
       910        920        930        940        950
WDIVQDDDAI NLSEGLINEA EKLLCSLVCW FTDRQIRMRF IEGCLENLGN 
       960        970        980        990       1000
NRSVVISLRL LPKLFGTFQQ FGSSYDTHWI TMWAEKELNM MKLFFDNLVY 
      1010       1020       1030       1040       1050
YIQGIREGRQ KHALYSHSAE VQVRLQFLTC VFSTLGSPDH FRLSLEQVDI 
      1060       1070       1080       1090       1100
LWHCLVEDSE CYDDALHWFL NQVRSKDQHA MGMETYKHLF LEKMPQLKPE 
      1110       1120       1130       1140       1150
TISMTGLNLF QHLCNLARLA TSAYDGGSNS ELCGMDQFWG IALRAQSGDV 
      1160       1170       1180       1190       1200
SRAAIQYINS YYINGKTGLE KEQEFISKCM ESLMIASSSL EQESHSSLTV 
      1210       1220       1230       1240       1250
IERGLLMLKT HLEAFRRRFA YHLRQWQIEG TGISSHLKAL SDKQSLPLRV 
      1260       1270       1280       1290       1300
VCQPAGLPDK MTIEMYPSDQ VADLRAEVTH WYENLQKEQI NQQAQLQEFG 
      1310       1320       1330       1340       1350
QSSRKGEFPG GLMGPVRMIS SGHELTTDYD EKALHELGFK DMQMVFVSLG 
      1360       1370       1380       1390       1400
APRRERKGEG VQLPASCLPP PQKDNIPMLL LLQEPHLTTL FDLLEMLASF 
      1410       1420       1430       1440       1450
KPPSGKVAVD DSESLKCEEL HLHAENLSRR VWELLMLLPT CPNMLTAFQN 
      1460       1470       1480       1490       1500
VSDEQSNDGL NWKELLKIKS AHKLLYALEI IEALGKPNRR IRRESTGSYS 
      1510       1520       1530       1540       1550
DLYPDSDDSS EDQVENSKNS WTCKFVAAGG LQQLLEIFNS AILEPKEQES 
      1560       1570       1580       1590       1600
WTVWQLDCLA CLLKLICQFA VDPSDLDLAY HDVFAWSGIA ESHRKRTWPG 
      1610       1620       1630       1640       1650
KSRKAAGDHA KSLHIPRLTE VFLVLVQGTS LIQRLMSVAY TYDNLAPRVL 
      1660       1670       1680       1690       1700
KAQSDHRSRH EVSHYSMWLL VSWAHCCSLV KSSLADSDHL QDWLKQLTLL 
      1710       1720       1730       1740       1750
IPETAVRHES CNGLYKLSLS GLDGGDSIHR SFLLLAASTL LKFLPDAQAL 
      1760       1770       1780       1790       1800
KPPRIDDYEE EPLLKPGCKE YFWLLCKLVD NIHIKDASQT TLLDLDALAR 
      1810       1820       1830       1840       1850
HLADCIRSRE ILDHLDGSIE DDGLSGLLRL ATSVIKHKPP FKFSREGQEF 
      1860       1870       1880       1890       1900
LRDIFNLLFL LPSLKDRRQP KCKSHSCRAA AYDLLVEMVK GSVENYRLIH 
      1910       1920       1930       1940       1950
NWVMAQHMQS HAPYKWDYWP HEDVRAECRF VGLTNLGATC YLASTIQQLY 
      1960       1970       1980       1990       2000
MIPEARQAVF TAKYSEDMKH KTTLLELQKM FTYLMESECK AYNPRPFCKT 
      2010       2020       2030       2040       2050
YTMDKQPLNT GEQKDMTEFF TDLITKVEEM SPELKNTVKS LFGGVITNNV 
      2060       2070       2080       2090       2100
VSLDCEHVSQ TAEEFYTVRC QVADMKNIYE SLDEVTIKDT LEGDNMYTCS 
      2110       2120       2130       2140       2150
HCGKKVRAEK RACFKKLPRI LSFNTMRYTF NMVTMMKEKV NTHFSFPLRL 
      2160       2170       2180       2190       2200
DMTPYTEDFL MGKSDRKEGF KDVGDRSKDT ESYEYDLIGV TVHTGTADGG 
      2210       2220       2230       2240       2250
HYYSFIRDIV NPHAYKNNKW YLFNDAEVKP FDSAQLASEC FGGEMTTKTY 
      2260       2270       2280       2290       2300
DSVTDKFMDF SFEKTHSAYM LFYKRMEPEE ENGREYKFDV SSELLEWIWH 
      2310       2320       2330       2340       2350
DNMQFLQDKN IFEHTYFGFM WQLCSCIPST LPDPKAVSLM TAKLSTSFVL 
      2360       2370       2380       2390       2400
ETFIHSKEKP TMLQWIELLT KQFNNSQAAC EWFLDRMADD DWWPMQILIK 
      2410       2420       2430       2440       2450
CPNQIVRQMF QRLCIHVIQR LRPVHAHLYL QPGMEDGSDD MDASVEDIGG 
      2460       2470       2480       2490       2500
RSCVTRFVRT LLLIMEHGVK PHSKHLTEYF AFLYEFAKMG EEESQFLLSL 
      2510       2520       2530       2540       2550
QAISTMVHFY MGTKGPENPQ VEVLSEEEGE EEEEEEDILS LAEEKYRPAA 
      2560       2570       2580       2590       2600
LEKMIALVAL LVEQSRSERH LTLSQTDMAA LTGGKGFPFL FQHIRDGINI 
      2610       2620       2630       2640       2650
RQTCNLIFSL CRYNNRLAEH IVSMLFTSIA KLTPEAANPF FKLLTMLMEF 
      2660       2670       2680       2690       2700
AGGPPGMPPF ASYILQRIWE VIEYNPSQCL DWLAVQTPRN KLAHSWVLQN 
      2710       2720       2730       2740       2750
MENWVERFLL AHNYPRVRTS AAYLLVSLIP SNSFRQMFRS TRSLHIPTRD 
      2760       2770       2780       2790       2800
LPLSPDTTVV LHQVYNVLLG LLSRAKLYVD AAVHGTTKLV PYLSFMTYCL 
      2810       2820       2830       2840       2850
ISKTEKLMFS TYFMDLWNLF QPKLSEPAIA TNHNKQALLS FWYNVCADCP 
      2860       2870       2880       2890       2900
ENIRLIVQNP VVTKNIAFNY ILADHDDQDV VLFNRGMLPA YYGILRLCCE 
      2910       2920       2930       2940       2950
QSPAFTRQLA SHQNIQWAFK NLTPHASQYP GAVEELFNLM QLFIAQRPDM 
      2960       2970       2980       2990       3000
REEELEDIKQ FKKTTISCYL RCLDGRSCWT TLISAFRILL ESDEDRLLVV 
      3010       3020       3030       3040       3050
FNRGLILMTE SFNTLHMMYH EATACHVTGD LVELLSIFLS VLKSTRPYLQ 
      3060       3070       3080       3090       3100
RKDVKQALIQ WQERIEFAHK LLTLLNSYSP PELRNACIDV LKELVLLSPH 
      3110       3120       3130       3140       3150
DFLHTLVPFL QHNHCTYHHS NIPMSLGPYF PCRENIKLIG GKSNIRPPRP 
      3160       3170       3180       3190       3200
ELNMCLLPTM VETSKGKDDV YDRMLLDYFF SYHQFIHLLC RVAINCEKFT 
      3210       3220       3230       3240       3250
ETLVKLSVLV AYEGLPLHLA LFPKLWTELC QTQSAMSKNC IKLLCEDPVF 
      3260       3270       3280       3290       3300
AEYIKCILMD ERTFLNNNIV YTFMTHFLLK VQSQVFSEAN CASLISTLIT 
      3310       3320       3330       3340       3350
NLINQYQNLQ SDFTNRVEIS KASAALNGDL RALALLLSVH TPKQLNPALI 
      3360       3370       3380       3390       3400
PTLQELLNKC RTCLQQRNSL QEQEAKERKT KDDEGATPVK RRRVSSDEEH 
      3410       3420       3430       3440       3450
TVDSCIGDIK TETREVLTPT STSDNETRDS SIIDPGTEQD LPSPENSSVK 
      3460       3470       3480       3490       3500
EYRMEGPSSF SEDGSHIRSQ HAEEQSNNGR FDDCKEFKDH CSKDTTLAED 
      3510       3520       3530       3540       3550
ESEFPSTSIS AVLSDLADLR SCDGQALSSQ DPEAAVSLSC GHSRGLISHM 
      3560       3570       3580 
QQHDILDTLC RTIESTIHVV TRISGKGNQA AS
Length:3,582
Mass (Da):408,214
Last modified:November 4, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27BA0032ED7E06A2
GO
Isoform 2 (identifier: Q6ZQ93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-160: DEKEKLLLC → MRRKNYYYV

Show »
Length:3,431
Mass (Da):391,068
Checksum:iE7D7BECDEA86331D
GO
Isoform 3 (identifier: Q6ZQ93-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-160: DEKEKLLLC → MRRKNYYYV
     3124-3206: Missing.

Show »
Length:3,348
Mass (Da):381,386
Checksum:iB03CEBA62999D4CE
GO
Isoform 4 (identifier: Q6ZQ93-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-160: DEKEKLLLC → MRRKNYYYV
     2569-3582: Missing.

Show »
Length:2,417
Mass (Da):275,543
Checksum:i3C4C2FC2CB1FDB6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WJB7F6WJB7_MOUSE
Ubiquitinyl hydrolase 1
Usp34
3,602Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YLQ1Z4YLQ1_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp34
810Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YN11Z4YN11_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp34
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH55938 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAM20294 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2163K → Q in BAE25365 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0356411 – 151Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST151
Alternative sequenceiVSP_035642152 – 160DEKEKLLLC → MRRKNYYYV in isoform 2, isoform 3 and isoform 4. 2 Publications9
Alternative sequenceiVSP_0204642569 – 3582Missing in isoform 4. 1 PublicationAdd BLAST1014
Alternative sequenceiVSP_0204653124 – 3206Missing in isoform 3. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL672049 Genomic DNA Translation: CAM16931.1
AL672049 AL928722 Genomic DNA Translation: CAM16940.1
AL672004 Genomic DNA Translation: CAM17339.1
AL672004 AL928722 Genomic DNA Translation: CAM17340.1
AL772359 AL928722 Genomic DNA Translation: CAM20294.1 Different initiation.
AL928722 AL772359 Genomic DNA Translation: CAO77877.1
AK033182 mRNA Translation: BAC28186.1
AK143407 mRNA Translation: BAE25365.1
AK148805 mRNA Translation: BAE28668.1
AK129165 mRNA Translation: BAC97975.1
BC055938 mRNA Translation: AAH55938.1 Sequence problems.
BC063062 mRNA Translation: AAH63062.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56763.1 [Q6ZQ93-1]

NCBI Reference Sequences

More...RefSeqi		NP_001177330.2, NM_001190401.2 [Q6ZQ93-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000180046; ENSMUSP00000137430; ENSMUSG00000056342 [Q6ZQ93-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		17847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:17847

UCSC genome browser

More...UCSCi		uc029rkw.1, mouse [Q6ZQ93-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672049 Genomic DNA Translation: CAM16931.1
AL672049 AL928722 Genomic DNA Translation: CAM16940.1
AL672004 Genomic DNA Translation: CAM17339.1
AL672004 AL928722 Genomic DNA Translation: CAM17340.1
AL772359 AL928722 Genomic DNA Translation: CAM20294.1 Different initiation.
AL928722 AL772359 Genomic DNA Translation: CAO77877.1
AK033182 mRNA Translation: BAC28186.1
AK143407 mRNA Translation: BAE25365.1
AK148805 mRNA Translation: BAE28668.1
AK129165 mRNA Translation: BAC97975.1
BC055938 mRNA Translation: AAH55938.1 Sequence problems.
BC063062 mRNA Translation: AAH63062.1
CCDSiCCDS56763.1 [Q6ZQ93-1]
RefSeqiNP_001177330.2, NM_001190401.2 [Q6ZQ93-1]

3D structure databases

SMRiQ6ZQ93
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201621, 2 interactors
STRINGi10090.ENSMUSP00000120747

Protein family/group databases

MEROPSiC19.067

PTM databases

iPTMnetiQ6ZQ93
PhosphoSitePlusiQ6ZQ93

Proteomic databases

EPDiQ6ZQ93
jPOSTiQ6ZQ93
PaxDbiQ6ZQ93
PeptideAtlasiQ6ZQ93
PRIDEiQ6ZQ93

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7689, 88 antibodies

Genome annotation databases

EnsembliENSMUST00000180046; ENSMUSP00000137430; ENSMUSG00000056342 [Q6ZQ93-1]
GeneIDi17847
KEGGimmu:17847
UCSCiuc029rkw.1, mouse [Q6ZQ93-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9736
MGIiMGI:109473, Usp34

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1866, Eukaryota
GeneTreeiENSGT00940000158659
HOGENOMiCLU_000109_0_0_1
InParanoidiQ6ZQ93
KOiK11853
OrthoDBi625455at2759
PhylomeDBiQ6ZQ93

Enzyme and pathway databases

ReactomeiR-MMU-201681, TCF dependent signaling in response to WNT
R-MMU-5689880, Ub-specific processing proteases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		17847, 6 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Usp34, mouse

Protein Ontology

More...PROi		PR:Q6ZQ93
RNActiQ6ZQ93, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000056342, Expressed in primary oocyte and 303 other tissues
ExpressionAtlasiQ6ZQ93, baseline and differential
GenevisibleiQ6ZQ93, MM

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR021905, DUF3517
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF12030, DUF3517, 1 hit
PF00443, UCH, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP34_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZQ93
Secondary accession number(s): A2AF26
, A2AF27, A2AF77, Q3UF93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 4, 2008
Last modified: October 7, 2020
This is version 125 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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