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Protein

Rho GTPase-activating protein 26

Gene

Arhgap26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RHOA and CDC42.By similarity

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • phospholipid binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 26
Alternative name(s):
Rho-type GTPase-activating protein 26
Gene namesi
Name:Arhgap26
Synonyms:Kiaa0621
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1918552 Arhgap26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003555531 – 814Rho GTPase-activating protein 26Add BLAST814

Proteomic databases

EPDiQ6ZQ82
MaxQBiQ6ZQ82
PaxDbiQ6ZQ82
PRIDEiQ6ZQ82

PTM databases

iPTMnetiQ6ZQ82
PhosphoSitePlusiQ6ZQ82

Expressioni

Gene expression databases

BgeeiENSMUSG00000036452 Expressed in 222 organ(s), highest expression level in visual cortex
ExpressionAtlasiQ6ZQ82 baseline and differential
GenevisibleiQ6ZQ82 MM

Interactioni

Subunit structurei

Binds to the C-terminus of PTK2/FAK1 (By similarity). Interacts with NYAP1, NYAP2 and MYO16.By similarity1 Publication

Protein-protein interaction databases

BioGridi214619, 1 interactor
IntActiQ6ZQ82, 2 interactors
MINTiQ6ZQ82
STRINGi10090.ENSMUSP00000095200

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ82
SMRiQ6ZQ82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 369PHPROSITE-ProRule annotationAdd BLAST105
Domaini383 – 568Rho-GAPPROSITE-ProRule annotationAdd BLAST186
Domaini756 – 814SH3PROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi584 – 701Ser-richAdd BLAST118

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1451 Eukaryota
ENOG410YJPS LUCA
GeneTreeiENSGT00930000150818
HOGENOMiHOG000018767
HOVERGENiHBG067993
InParanoidiQ6ZQ82
KOiK20071
OrthoDBiEOG091G01TT
TreeFamiTF316851

Family and domain databases

CDDicd07636 BAR_GRAF, 1 hit
cd12064 SH3_GRAF, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR030061 GRAF
IPR035483 GRAF_BAR
IPR035481 GRAF_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR12552:SF4 PTHR12552:SF4, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q6ZQ82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL
60 70 80 90 100
KNLSSAKRKF ADSLNEFKFQ CIGDAETDDE MCIARSLQEF AAVLRNLEDE
110 120 130 140 150
RSRMIENASE VLITPLEKFR KEQIGAAREA KKKYDKETEK YCGTLEKHLN
160 170 180 190 200
LSSKKKESQL QEADSQVDLV RQHFYEVSLE YVFKVQEVQE RKMFEFVEPL
210 220 230 240 250
LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE GTRSEVESLM
260 270 280 290 300
KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM
310 320 330 340 350
VPFDQKSGGK GGEDESVTLK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ
360 370 380 390 400
ALSEEDRRLW MEAMDGREPV YNSNRDSQSE GTAQLDSIGF SIIRKCIHAV
410 420 430 440 450
ETRGINEQGL YRIVGVNSRV QKLLSVLMDP KAASETETDI CAEWEIKTVT
460 470 480 490 500
SALKTYLRML PGPLMMYQFQ RSFIKAAKLE NQETRVSEIH SLVHRLPEKN
510 520 530 540 550
RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ EETVAAIMDI
560 570 580 590 600
KFQNIVIEIL IENHEKIFNT VPDVPLTNAQ LHLSRKKSSD SKPPSCSKRP
610 620 630 640 650
LTLFHAVPST EKQEQRNSII NSSLESVSSS ANSILNSSSS LQPNLNSSDS
660 670 680 690 700
NLDVVKPSRP SSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPIR
710 720 730 740 750
SVAGFVWFSV AAVVLSLAWS SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV
760 770 780 790 800
REDSSTPFRK AKALYACQAE HDSELSFTAG TVFDNVHPSQ EPGWLEGTLN
810
GKTGLIPENY VEFL
Length:814
Mass (Da):92,071
Last modified:July 27, 2011 - v3
Checksum:iB1BA51634549C891
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAQ3E9QAQ3_MOUSE
Rho GTPase-activating protein 26
Arhgap26
759Annotation score:
D3Z1X5D3Z1X5_MOUSE
Rho GTPase-activating protein 26
Arhgap26
170Annotation score:
F6XTB7F6XTB7_MOUSE
Rho GTPase-activating protein 26
Arhgap26
388Annotation score:
Q3U860Q3U860_MOUSE
Rho GTPase-activating protein 26
Arhgap26
171Annotation score:
F6Q7M1F6Q7M1_MOUSE
Rho GTPase-activating protein 26
Arhgap26
144Annotation score:
F7D661F7D661_MOUSE
Rho GTPase-activating protein 26
Arhgap26
115Annotation score:
A0A087WSU1A0A087WSU1_MOUSE
Rho GTPase-activating protein 26
Arhgap26
104Annotation score:

Sequence cautioni

The sequence BAC97986 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti598K → E in BAC97986 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129176 mRNA Translation: BAC97986.1 Different initiation.
AC110730 Genomic DNA No translation available.
AC129603 Genomic DNA No translation available.
AC132098 Genomic DNA No translation available.
AC132450 Genomic DNA No translation available.
AC133601 Genomic DNA No translation available.
AC151409 Genomic DNA No translation available.
AC151580 Genomic DNA No translation available.
CCDSiCCDS29205.1
RefSeqiNP_780373.3, NM_175164.4
UniGeneiMm.329396

Genome annotation databases

EnsembliENSMUST00000097593; ENSMUSP00000095200; ENSMUSG00000036452
GeneIDi71302
KEGGimmu:71302
UCSCiuc008esr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129176 mRNA Translation: BAC97986.1 Different initiation.
AC110730 Genomic DNA No translation available.
AC129603 Genomic DNA No translation available.
AC132098 Genomic DNA No translation available.
AC132450 Genomic DNA No translation available.
AC133601 Genomic DNA No translation available.
AC151409 Genomic DNA No translation available.
AC151580 Genomic DNA No translation available.
CCDSiCCDS29205.1
RefSeqiNP_780373.3, NM_175164.4
UniGeneiMm.329396

3D structure databases

ProteinModelPortaliQ6ZQ82
SMRiQ6ZQ82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214619, 1 interactor
IntActiQ6ZQ82, 2 interactors
MINTiQ6ZQ82
STRINGi10090.ENSMUSP00000095200

PTM databases

iPTMnetiQ6ZQ82
PhosphoSitePlusiQ6ZQ82

Proteomic databases

EPDiQ6ZQ82
MaxQBiQ6ZQ82
PaxDbiQ6ZQ82
PRIDEiQ6ZQ82

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097593; ENSMUSP00000095200; ENSMUSG00000036452
GeneIDi71302
KEGGimmu:71302
UCSCiuc008esr.1 mouse

Organism-specific databases

CTDi23092
MGIiMGI:1918552 Arhgap26
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1451 Eukaryota
ENOG410YJPS LUCA
GeneTreeiENSGT00930000150818
HOGENOMiHOG000018767
HOVERGENiHBG067993
InParanoidiQ6ZQ82
KOiK20071
OrthoDBiEOG091G01TT
TreeFamiTF316851

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiArhgap26 mouse
PROiPR:Q6ZQ82
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036452 Expressed in 222 organ(s), highest expression level in visual cortex
ExpressionAtlasiQ6ZQ82 baseline and differential
GenevisibleiQ6ZQ82 MM

Family and domain databases

CDDicd07636 BAR_GRAF, 1 hit
cd12064 SH3_GRAF, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR030061 GRAF
IPR035483 GRAF_BAR
IPR035481 GRAF_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR12552:SF4 PTHR12552:SF4, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHG26_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQ82
Secondary accession number(s): E9QLL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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