UniProtKB - Q6ZQ58 (LARP1_MOUSE)
La-related protein 1
Larp1
Functioni
Caution
GO - Molecular functioni
- eukaryotic initiation factor 4E binding Source: UniProtKB
- mRNA 3'-UTR binding Source: UniProtKB
- mRNA 5'-UTR binding Source: UniProtKB
- ribosomal small subunit binding Source: UniProtKB
- RNA 7-methylguanosine cap binding Source: UniProtKB
- RNA cap binding Source: UniProtKB
- translation activator activity Source: UniProtKB
- translation initiation factor binding Source: UniProtKB
GO - Biological processi
- cell population proliferation Source: UniProtKB
- cellular response to rapamycin Source: UniProtKB
- mRNA stabilization Source: UniProtKB
- negative regulation of translation Source: UniProtKB
- negative regulation of translational initiation Source: UniProtKB
- positive regulation of macroautophagy Source: MGI
- positive regulation of translational initiation Source: MGI
- positive regulation of viral genome replication Source: MGI
- posttranscriptional regulation of gene expression Source: MGI
- response to amino acid starvation Source: UniProtKB
- TORC1 signaling Source: UniProtKB
- TOR signaling Source: UniProtKB
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Repressor, RNA-binding |
Biological process | Translation regulation |
Names & Taxonomyi
Protein namesi | Recommended name: La-related protein 1Alternative name(s): La ribonucleoprotein domain family member 1 |
Gene namesi | Name:Larp1 Synonyms:Kiaa0731, Larp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1890165, Larp1 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
- Cytoplasmic granule By similarity
Note: Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.By similarity
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic stress granule Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000207610 | 2 – 1072 | La-related protein 1Add BLAST | 1071 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 68 | PhosphoserineCombined sources | 1 | |
Modified residuei | 81 | PhosphoserineCombined sources | 1 | |
Modified residuei | 138 | PhosphoserineBy similarity | 1 | |
Modified residuei | 188 | PhosphoserineBy similarity | 1 | |
Modified residuei | 193 | PhosphoserineBy similarity | 1 | |
Modified residuei | 196 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 198 | PhosphoserineCombined sources | 1 | |
Modified residuei | 201 | PhosphoserineCombined sources | 1 | |
Modified residuei | 213 | Omega-N-methylarginineCombined sources | 1 | |
Cross-linki | 233 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 286 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 299 | PhosphoserineCombined sources | 1 | |
Modified residuei | 302 | PhosphoserineCombined sources | 1 | |
Modified residuei | 351 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 494 | PhosphoserineBy similarity | 1 | |
Modified residuei | 498 | PhosphoserineBy similarity | 1 | |
Modified residuei | 503 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 508 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 525 | PhosphoserineCombined sources | 1 | |
Modified residuei | 568 | PhosphoserineBy similarity | 1 | |
Modified residuei | 604 | PhosphoserineCombined sources | 1 | |
Modified residuei | 608 | PhosphoserineCombined sources | 1 | |
Modified residuei | 626 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 680 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 701 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 743 | PhosphoserineCombined sources | 1 | |
Modified residuei | 746 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 747 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 751 | PhosphoserineCombined sources | 1 | |
Modified residuei | 754 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 759 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 762 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 765 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 774 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 801 | PhosphoserineBy similarity | 1 | |
Modified residuei | 822 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 824 | PhosphoserineBy similarity | 1 | |
Modified residuei | 828 | PhosphoserineBy similarity | 1 | |
Modified residuei | 830 | PhosphoserineCombined sources | 1 | |
Modified residuei | 838 | PhosphoserineBy similarity | 1 | |
Modified residuei | 842 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 845 | PhosphoserineCombined sources | 1 | |
Modified residuei | 869 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 994 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1034 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1065 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6ZQ58 |
jPOSTi | Q6ZQ58 |
PaxDbi | Q6ZQ58 |
PeptideAtlasi | Q6ZQ58 |
PRIDEi | Q6ZQ58 |
PTM databases
iPTMneti | Q6ZQ58 |
PhosphoSitePlusi | Q6ZQ58 |
SwissPalmi | Q6ZQ58 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000037331, Expressed in pancreas and 328 other tissues |
ExpressionAtlasi | Q6ZQ58, baseline and differential |
Genevisiblei | Q6ZQ58, MM |
Interactioni
Subunit structurei
Interacts with PABPC1/PABP.
Interacts with EIF4A1.
Interacts with RPTOR. Recruited to the active mTORC1 complex via interaction with RPTOR. Inhibition of mTORC1 activity strongly reduces interaction with RPTOR and the mTORC1 complex.
Identified in a complex with mRNA, PABPC1, EIF4E and EIF4G1.
Found in a complex with PABPC1 and SHFL.
By similarityGO - Molecular functioni
- eukaryotic initiation factor 4E binding Source: UniProtKB
- translation initiation factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 215803, 29 interactors |
IntActi | Q6ZQ58, 3 interactors |
STRINGi | 10090.ENSMUSP00000136673 |
Miscellaneous databases
RNActi | Q6ZQ58, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 372 – 462 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 550 | Required for interaction with PABPC1By similarityAdd BLAST | 481 | |
Regioni | 551 – 1072 | Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motifBy similarityAdd BLAST | 522 | |
Regioni | 850 – 1000 | Interaction with mRNABy similarityAdd BLAST | 151 | |
Regioni | 933 – 976 | Interaction with 7-methylguanosine mRNA cap structureBy similarityAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 95 – 175 | Pro-richAdd BLAST | 81 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota |
GeneTreei | ENSGT00940000159577 |
InParanoidi | Q6ZQ58 |
OMAi | PGWHPDN |
OrthoDBi | 258488at2759 |
TreeFami | TF314516 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006607, DM15 IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00684, DM15, 3 hits SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATQVEPLLP AGAPLLQAEE HGLARKKPAP DAQAESGPGD GGGEPDGGVR
60 70 80 90 100
RPRPACARPG RDGAERESPR PPAAAEAPAG SDGEDGGRRD FVEAPPPKVN
110 120 130 140 150
PWTKHAPPPA AVNGQPPPEP SAPAKVVRAA APKPRKGSKV GDFGDAVNWP
160 170 180 190 200
TPGEIAHKSV QPQSHKPQPA RKLPPKKDMK EQEKGDGSDS KESPKTKSDE
210 220 230 240 250
SGEEKNGDED CQRGGQKKKG SKHKWVPLQI DMKPEVPREK LASRPTRPQE
260 270 280 290 300
PRHTPAVRGE MKGSEPATYM PVSVAPPTPA WQPETKVEPA WHDQDETSSV
310 320 330 340 350
KSDGAGGARA SFRGRGRGRG RGRGRGRGGT RTHFDYQFGY RKFDGTEGPR
360 370 380 390 400
THKYMNNITY YFDNVSSNEI YSMDQELLKD YIKRQIEYYF SVDNLERDFF
410 420 430 440 450
LRRKMDADGF LPITLIASFH RVQALTTDIS LIFAALKDSK VVEMVEEKVR
460 470 480 490 500
RREEPEKWPL PGPPIVDYSQ TDFSQLLNCP EFVPRQHYQK ETESAPGSPR
510 520 530 540 550
AVTPVPTKTE EVSNLKTLPK GLSASLPDLD SESWIEVKKR PRPSPARPKK
560 570 580 590 600
PEEPRFSHPT ALPQQLPSQQ LMSKDQDEQE ELDFLFDEEM EQMDGRKNTF
610 620 630 640 650
TAWSEEDSDY EIDDRDVNKI LIVTQTPPYM RRHPGGDRTG NHTSRAKMSA
660 670 680 690 700
ELAKVINDGL FYYEQDLWTE KFEPEYSQIK QEVENFKKVN MISREQFDTL
710 720 730 740 750
TPEPPVDPNQ EVPPGPPRFQ QVPTDALANK LFGAPEPSTI ARSLPTTVPE
760 770 780 790 800
SPNYRNARTP RTPRTPQLKD SSQTPRFYPV VKEGRTLDAK MPRKRKTRHS
810 820 830 840 850
SNPPLESHVG WVMDSREHRP RTASISSSPS EGTPAVGSYG CTPQSLPKFQ
860 870 880 890 900
HPSHELLKEN GFTQHVYHKY RRRCLNERKR LGIGQSQEMN TLFRFWSFFL
910 920 930 940 950
RDHFNKKMYE EFKQLALEDA KEGYRYGLEC LFRYYSYGLE KKFRLDIFKD
960 970 980 990 1000
FQEETVKDYE AGQLYGLEKF WAFLKYSKAK NLDIDPKLQE YLGKFRRLED
1010 1020 1030 1040 1050
FRVDPPMGEE GNHKRHPVVA GGSGEGRKRC PSQSSSRPAT GISQPPTTPT
1060 1070
GQATREDAKW TSQHSDTLTL RK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketZ4YJT3 | Z4YJT3_MOUSE | La-related protein 1 | Larp1 | 1,072 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015116 | 1 – 1006 | Missing in isoform 2. 1 PublicationAdd BLAST | 1006 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672182 Genomic DNA No translation available. BC053449 mRNA Translation: AAH53449.1 AK129202 mRNA Translation: BAC98012.1 |
CCDSi | CCDS56771.1 [Q6ZQ58-1] |
RefSeqi | NP_082727.1, NM_028451.1 [Q6ZQ58-1] |
Genome annotation databases
Ensembli | ENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331 [Q6ZQ58-1] |
GeneIDi | 73158 |
KEGGi | mmu:73158 |
UCSCi | uc007jah.2, mouse [Q6ZQ58-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672182 Genomic DNA No translation available. BC053449 mRNA Translation: AAH53449.1 AK129202 mRNA Translation: BAC98012.1 |
CCDSi | CCDS56771.1 [Q6ZQ58-1] |
RefSeqi | NP_082727.1, NM_028451.1 [Q6ZQ58-1] |
3D structure databases
SMRi | Q6ZQ58 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 215803, 29 interactors |
IntActi | Q6ZQ58, 3 interactors |
STRINGi | 10090.ENSMUSP00000136673 |
PTM databases
iPTMneti | Q6ZQ58 |
PhosphoSitePlusi | Q6ZQ58 |
SwissPalmi | Q6ZQ58 |
Proteomic databases
EPDi | Q6ZQ58 |
jPOSTi | Q6ZQ58 |
PaxDbi | Q6ZQ58 |
PeptideAtlasi | Q6ZQ58 |
PRIDEi | Q6ZQ58 |
Protocols and materials databases
Antibodypediai | 28316, 125 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331 [Q6ZQ58-1] |
GeneIDi | 73158 |
KEGGi | mmu:73158 |
UCSCi | uc007jah.2, mouse [Q6ZQ58-1] |
Organism-specific databases
CTDi | 23367 |
MGIi | MGI:1890165, Larp1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota |
GeneTreei | ENSGT00940000159577 |
InParanoidi | Q6ZQ58 |
OMAi | PGWHPDN |
OrthoDBi | 258488at2759 |
TreeFami | TF314516 |
Miscellaneous databases
BioGRID-ORCSi | 73158, 3 hits in 17 CRISPR screens |
ChiTaRSi | Larp1, mouse |
PROi | PR:Q6ZQ58 |
RNActi | Q6ZQ58, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037331, Expressed in pancreas and 328 other tissues |
ExpressionAtlasi | Q6ZQ58, baseline and differential |
Genevisiblei | Q6ZQ58, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006607, DM15 IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00684, DM15, 3 hits SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LARP1_MOUSE | |
Accessioni | Q6ZQ58Primary (citable) accession number: Q6ZQ58 Secondary accession number(s): A2AFQ8, J3QNB1, Q7TSF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families