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Entry version 120 (08 May 2019)
Sequence version 3 (16 Apr 2014)
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Protein

La-related protein 1

Gene

Larp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.By similarity

Caution

Conflicting results are reported regarding the interaction with PABPC1. Some studies found that the interaction depends on the presence of mRNA; others found that the interaction is direct and does not depend on the presence of mRNA.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
Biological processTranslation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
La ribonucleoprotein domain family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Larp1
Synonyms:Kiaa0731, Larp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1890165 Larp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076102 – 1072La-related protein 1Add BLAST1071

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei68PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei138PhosphoserineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei213Omega-N-methylarginineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei299PhosphoserineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei351PhosphothreonineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei498PhosphoserineBy similarity1
Modified residuei503PhosphothreonineCombined sources1
Cross-linki508Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei525PhosphoserineCombined sources1
Modified residuei568PhosphoserineBy similarity1
Modified residuei604PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei626PhosphothreonineCombined sources1
Cross-linki680Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei701PhosphothreonineBy similarity1
Modified residuei743PhosphoserineCombined sources1
Modified residuei746PhosphothreonineBy similarity1
Modified residuei747PhosphothreonineBy similarity1
Modified residuei751PhosphoserineCombined sources1
Modified residuei754PhosphotyrosineBy similarity1
Modified residuei759PhosphothreonineBy similarity1
Modified residuei762PhosphothreonineBy similarity1
Modified residuei765PhosphothreonineBy similarity1
Modified residuei774PhosphothreonineBy similarity1
Modified residuei801PhosphoserineBy similarity1
Modified residuei822PhosphothreonineBy similarity1
Modified residuei824PhosphoserineBy similarity1
Modified residuei828PhosphoserineBy similarity1
Modified residuei830PhosphoserineCombined sources1
Modified residuei838PhosphoserineBy similarity1
Modified residuei842PhosphothreonineCombined sources1
Modified residuei845PhosphoserineCombined sources1
Modified residuei869N6-acetyllysineBy similarity1
Modified residuei994N6-acetyllysineBy similarity1
Modified residuei1034PhosphoserineBy similarity1
Modified residuei1065PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6ZQ58

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6ZQ58

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6ZQ58

PeptideAtlas

More...
PeptideAtlasi
Q6ZQ58

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZQ58

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZQ58

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZQ58

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6ZQ58

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 10.5 dpc, expressed in dorsal root ganglia, spinal cord, and branchial arches. At 14.5 dpc, expressed in olfactory epithelium and cranial sensory ganglia. Also expressed in salivary glands, lungs, gut, kidney, teeth and vibrissae.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037331 Expressed in 311 organ(s), highest expression level in pancreas

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6ZQ58 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6ZQ58 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PABPC1/PABP. Interacts with EIF4A1. Interacts with RPTOR. Recruited to the active mTORC1 complex via interaction with RPTOR. Inhibition of mTORC1 activity strongly reduces interaction with RPTOR and the mTORC1 complex. Identified in a complex with mRNA, PABPC1, EIF4E and EIF4G1. Found in a complex with PABPC1 and RYDEN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
215803, 1 interactor

Protein interaction database and analysis system

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IntActi
Q6ZQ58, 2 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000136673

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZQ58

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini372 – 462HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni70 – 550Required for interaction with PABPC1By similarityAdd BLAST481
Regioni551 – 1072Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motifBy similarityAdd BLAST522
Regioni850 – 1000Interaction with mRNABy similarityAdd BLAST151
Regioni933 – 976Interaction with 7-methylguanosine mRNA cap structureBy similarityAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi95 – 175Pro-richAdd BLAST81

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region mediates interaction with the mRNA and polysomes. It is required for translational repression of mRNAs with a 5'TOP motif.By similarity
The N-terminal region mediates interaction with PABPC1.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LARP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2590 Eukaryota
COG5193 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159577

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113283

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZQ58

KEGG Orthology (KO)

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KOi
K18757

Identification of Orthologs from Complete Genome Data

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OMAi
ETMKDYE

Database of Orthologous Groups

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OrthoDBi
258488at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314516

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006607 DM15
IPR006630 La_HTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05383 La, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00684 DM15, 3 hits
SM00715 LA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50961 HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZQ58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATQVEPLLP AGAPLLQAEE HGLARKKPAP DAQAESGPGD GGGEPDGGVR
60 70 80 90 100
RPRPACARPG RDGAERESPR PPAAAEAPAG SDGEDGGRRD FVEAPPPKVN
110 120 130 140 150
PWTKHAPPPA AVNGQPPPEP SAPAKVVRAA APKPRKGSKV GDFGDAVNWP
160 170 180 190 200
TPGEIAHKSV QPQSHKPQPA RKLPPKKDMK EQEKGDGSDS KESPKTKSDE
210 220 230 240 250
SGEEKNGDED CQRGGQKKKG SKHKWVPLQI DMKPEVPREK LASRPTRPQE
260 270 280 290 300
PRHTPAVRGE MKGSEPATYM PVSVAPPTPA WQPETKVEPA WHDQDETSSV
310 320 330 340 350
KSDGAGGARA SFRGRGRGRG RGRGRGRGGT RTHFDYQFGY RKFDGTEGPR
360 370 380 390 400
THKYMNNITY YFDNVSSNEI YSMDQELLKD YIKRQIEYYF SVDNLERDFF
410 420 430 440 450
LRRKMDADGF LPITLIASFH RVQALTTDIS LIFAALKDSK VVEMVEEKVR
460 470 480 490 500
RREEPEKWPL PGPPIVDYSQ TDFSQLLNCP EFVPRQHYQK ETESAPGSPR
510 520 530 540 550
AVTPVPTKTE EVSNLKTLPK GLSASLPDLD SESWIEVKKR PRPSPARPKK
560 570 580 590 600
PEEPRFSHPT ALPQQLPSQQ LMSKDQDEQE ELDFLFDEEM EQMDGRKNTF
610 620 630 640 650
TAWSEEDSDY EIDDRDVNKI LIVTQTPPYM RRHPGGDRTG NHTSRAKMSA
660 670 680 690 700
ELAKVINDGL FYYEQDLWTE KFEPEYSQIK QEVENFKKVN MISREQFDTL
710 720 730 740 750
TPEPPVDPNQ EVPPGPPRFQ QVPTDALANK LFGAPEPSTI ARSLPTTVPE
760 770 780 790 800
SPNYRNARTP RTPRTPQLKD SSQTPRFYPV VKEGRTLDAK MPRKRKTRHS
810 820 830 840 850
SNPPLESHVG WVMDSREHRP RTASISSSPS EGTPAVGSYG CTPQSLPKFQ
860 870 880 890 900
HPSHELLKEN GFTQHVYHKY RRRCLNERKR LGIGQSQEMN TLFRFWSFFL
910 920 930 940 950
RDHFNKKMYE EFKQLALEDA KEGYRYGLEC LFRYYSYGLE KKFRLDIFKD
960 970 980 990 1000
FQEETVKDYE AGQLYGLEKF WAFLKYSKAK NLDIDPKLQE YLGKFRRLED
1010 1020 1030 1040 1050
FRVDPPMGEE GNHKRHPVVA GGSGEGRKRC PSQSSSRPAT GISQPPTTPT
1060 1070
GQATREDAKW TSQHSDTLTL RK
Length:1,072
Mass (Da):121,125
Last modified:April 16, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAFCE019DF683870
GO
Isoform 2 (identifier: Q6ZQ58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1006: Missing.

Note: No experimental confirmation available.
Show »
Length:66
Mass (Da):7,040
Checksum:i9134EA00889FA520
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YJT3Z4YJT3_MOUSE
La-related protein 1
Larp1
1,072Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0151161 – 1006Missing in isoform 2. 1 PublicationAdd BLAST1006

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL672182 Genomic DNA No translation available.
BC053449 mRNA Translation: AAH53449.1
AK129202 mRNA Translation: BAC98012.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS56771.1 [Q6ZQ58-1]

NCBI Reference Sequences

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RefSeqi
NP_082727.1, NM_028451.1 [Q6ZQ58-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331 [Q6ZQ58-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
73158

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:73158

UCSC genome browser

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UCSCi
uc007jah.2 mouse [Q6ZQ58-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672182 Genomic DNA No translation available.
BC053449 mRNA Translation: AAH53449.1
AK129202 mRNA Translation: BAC98012.1
CCDSiCCDS56771.1 [Q6ZQ58-1]
RefSeqiNP_082727.1, NM_028451.1 [Q6ZQ58-1]

3D structure databases

SMRiQ6ZQ58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215803, 1 interactor
IntActiQ6ZQ58, 2 interactors
STRINGi10090.ENSMUSP00000136673

PTM databases

iPTMnetiQ6ZQ58
PhosphoSitePlusiQ6ZQ58
SwissPalmiQ6ZQ58

Proteomic databases

EPDiQ6ZQ58
jPOSTiQ6ZQ58
PaxDbiQ6ZQ58
PeptideAtlasiQ6ZQ58
PRIDEiQ6ZQ58

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331 [Q6ZQ58-1]
GeneIDi73158
KEGGimmu:73158
UCSCiuc007jah.2 mouse [Q6ZQ58-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23367
MGIiMGI:1890165 Larp1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG2590 Eukaryota
COG5193 LUCA
GeneTreeiENSGT00940000159577
HOGENOMiHOG000113283
InParanoidiQ6ZQ58
KOiK18757
OMAiETMKDYE
OrthoDBi258488at2759
TreeFamiTF314516

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Larp1 mouse

Protein Ontology

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PROi
PR:Q6ZQ58

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037331 Expressed in 311 organ(s), highest expression level in pancreas
ExpressionAtlasiQ6ZQ58 baseline and differential
GenevisibleiQ6ZQ58 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607 DM15
IPR006630 La_HTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
SMARTiView protein in SMART
SM00684 DM15, 3 hits
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZQ58
Secondary accession number(s): A2AFQ8, J3QNB1, Q7TSF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: April 16, 2014
Last modified: May 8, 2019
This is version 120 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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