UniProtKB - Q6ZQ58 (LARP1_MOUSE)

BLAST

>sp|Q6ZQ58|LARP1_MOUSE La-related protein 1 OS=Mus musculus OX=10090 GN=Larp1 PE=1 SV=3
MATQVEPLLPAGAPLLQAEEHGLARKKPAPDAQAESGPGDGGGEPDGGVRRPRPACARPG
RDGAERESPRPPAAAEAPAGSDGEDGGRRDFVEAPPPKVNPWTKHAPPPAAVNGQPPPEP
SAPAKVVRAAAPKPRKGSKVGDFGDAVNWPTPGEIAHKSVQPQSHKPQPARKLPPKKDMK
EQEKGDGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGSKHKWVPLQIDMKPEVPREK
LASRPTRPQEPRHTPAVRGEMKGSEPATYMPVSVAPPTPAWQPETKVEPAWHDQDETSSV
KSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGTEGPRTHKYMNNITY
YFDNVSSNEIYSMDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFH
RVQALTTDISLIFAALKDSKVVEMVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLLNCP
EFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSESWIEVKKR
PRPSPARPKKPEEPRFSHPTALPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTF
TAWSEEDSDYEIDDRDVNKILIVTQTPPYMRRHPGGDRTGNHTSRAKMSAELAKVINDGL
FYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQ
QVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTPRFYPV
VKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPAVGSYG
CTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFL
RDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYE
AGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHPVVA
GGSGEGRKRCPSQSSSRPATGISQPPTTPTGQATREDAKWTSQHSDTLTLRK

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History
Entry version 115 (12 Sep 2018)
Sequence version 3 (16 Apr 2014)
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Protein

La-related protein 1

Gene

Larp1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus (DENV).By similarity

GO - Molecular functionⁱ

eukaryotic initiation factor 4E binding Source: UniProtKB
mRNA 3'-UTR binding Source: UniProtKB
mRNA 5'-UTR binding Source: UniProtKB
RNA cap binding Source: UniProtKB
translation activator activity Source: UniProtKB
translation initiation factor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation Source: UniProtKB
cellular response to rapamycin Source: UniProtKB
mRNA stabilization Source: UniProtKB
negative regulation of translation Source: UniProtKB
positive regulation of macroautophagy Source: MGI
positive regulation of viral genome replication Source: MGI
response to amino acid starvation Source: UniProtKB
TORC1 signaling Source: UniProtKB
TOR signaling Source: UniProtKB
translational initiation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor, RNA-binding
Biological process	Translation regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: La-related protein 1 Alternative name(s): La ribonucleoprotein domain family member 1
Gene namesⁱ	Name:Larp1 Synonyms:Kiaa0731, Larp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1890165 Larp1

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000207610	2 – 1072	La-related protein 1Add BLAST		1071

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	68	PhosphoserineCombined sources	1
Modified residueⁱ	81	PhosphoserineCombined sources	1
Modified residueⁱ	138	PhosphoserineBy similarity	1
Modified residueⁱ	188	PhosphoserineBy similarity	1
Modified residueⁱ	193	PhosphoserineBy similarity	1
Modified residueⁱ	196	PhosphothreonineCombined sources	1
Modified residueⁱ	198	PhosphoserineCombined sources	1
Modified residueⁱ	201	PhosphoserineCombined sources	1
Modified residueⁱ	213	Omega-N-methylarginineCombined sources	1
Cross-linkⁱ	233	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	286	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	299	PhosphoserineCombined sources	1
Modified residueⁱ	302	PhosphoserineCombined sources	1
Modified residueⁱ	351	PhosphothreonineBy similarity	1
Modified residueⁱ	494	PhosphoserineBy similarity	1
Modified residueⁱ	498	PhosphoserineBy similarity	1
Modified residueⁱ	503	PhosphothreonineCombined sources	1
Cross-linkⁱ	508	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	525	PhosphoserineCombined sources	1
Modified residueⁱ	568	PhosphoserineBy similarity	1
Modified residueⁱ	604	PhosphoserineCombined sources	1
Modified residueⁱ	608	PhosphoserineCombined sources	1
Modified residueⁱ	626	PhosphothreonineCombined sources	1
Cross-linkⁱ	680	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	701	PhosphothreonineBy similarity	1
Modified residueⁱ	743	PhosphoserineCombined sources	1
Modified residueⁱ	751	PhosphoserineCombined sources	1
Modified residueⁱ	754	PhosphotyrosineBy similarity	1
Modified residueⁱ	762	PhosphothreonineBy similarity	1
Modified residueⁱ	765	PhosphothreonineBy similarity	1
Modified residueⁱ	801	PhosphoserineBy similarity	1
Modified residueⁱ	822	PhosphothreonineBy similarity	1
Modified residueⁱ	828	PhosphoserineBy similarity	1
Modified residueⁱ	830	PhosphoserineCombined sources	1
Modified residueⁱ	842	PhosphothreonineCombined sources	1
Modified residueⁱ	845	PhosphoserineCombined sources	1
Modified residueⁱ	869	N6-acetyllysineBy similarity	1
Modified residueⁱ	994	N6-acetyllysineBy similarity	1
Modified residueⁱ	1065	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q6ZQ58
PaxDbⁱ	Q6ZQ58
PeptideAtlas More...PeptideAtlasⁱ	Q6ZQ58
PRIDEⁱ	Q6ZQ58

PTM databases

iPTMnetⁱ	Q6ZQ58
PhosphoSitePlusⁱ	Q6ZQ58
SwissPalmⁱ	Q6ZQ58

Expressionⁱ

Developmental stageⁱ

At E10.5, expressed in dorsal root ganglia, spinal cord, and branchial arches. At E14.5, expressed in olfactory epithelium and cranial sensory ganglia. Also expressed in salivary glands, lungs, gut, kidney, teeth and vibrissae.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000037331 Expressed in 311 organ(s), highest expression level in pancreas
CleanExⁱ	MM_LARP1
ExpressionAtlasⁱ	Q6ZQ58 baseline and differential
Genevisibleⁱ	Q6ZQ58 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PABPC1/PABP. Associates with the mTORC1 complex via interaction with RPTOR. Interacts with EIF4E. Found in a complex with PABPC1 and RYDEN.By similarity

GO - Molecular functionⁱ

eukaryotic initiation factor 4E binding Source: UniProtKB
translation initiation factor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	215803, 1 interactor
IntActⁱ	Q6ZQ58, 2 interactors
STRINGⁱ	10090.ENSMUSP00000136673

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6ZQ58
SMRⁱ	Q6ZQ58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	372 – 462	HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST		91

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	850 – 1000	Interaction with mRNABy similarityAdd BLAST		151

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	95 – 175	Pro-richAdd BLAST		81

Sequence similaritiesⁱ

Belongs to the LARP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2590 Eukaryota COG5193 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000523
HOGENOMⁱ	HOG000113283
HOVERGENⁱ	HBG054322
InParanoidⁱ	Q6ZQ58
KEGG Orthology (KO) More...KOⁱ	K18757
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02X0
TreeFamⁱ	TF314516

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR006607 DM15 IPR006630 La_HTH IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05383 La, 1 hit
SMARTⁱ	View protein in SMART SM00684 DM15, 3 hits SM00715 LA, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS50961 HTH_LA, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q6ZQ58-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATQVEPLLP AGAPLLQAEE HGLARKKPAP DAQAESGPGD GGGEPDGGVR 
        60         70         80         90        100
RPRPACARPG RDGAERESPR PPAAAEAPAG SDGEDGGRRD FVEAPPPKVN 
       110        120        130        140        150
PWTKHAPPPA AVNGQPPPEP SAPAKVVRAA APKPRKGSKV GDFGDAVNWP 
       160        170        180        190        200
TPGEIAHKSV QPQSHKPQPA RKLPPKKDMK EQEKGDGSDS KESPKTKSDE 
       210        220        230        240        250
SGEEKNGDED CQRGGQKKKG SKHKWVPLQI DMKPEVPREK LASRPTRPQE 
       260        270        280        290        300
PRHTPAVRGE MKGSEPATYM PVSVAPPTPA WQPETKVEPA WHDQDETSSV 
       310        320        330        340        350
KSDGAGGARA SFRGRGRGRG RGRGRGRGGT RTHFDYQFGY RKFDGTEGPR 
       360        370        380        390        400
THKYMNNITY YFDNVSSNEI YSMDQELLKD YIKRQIEYYF SVDNLERDFF 
       410        420        430        440        450
LRRKMDADGF LPITLIASFH RVQALTTDIS LIFAALKDSK VVEMVEEKVR 
       460        470        480        490        500
RREEPEKWPL PGPPIVDYSQ TDFSQLLNCP EFVPRQHYQK ETESAPGSPR 
       510        520        530        540        550
AVTPVPTKTE EVSNLKTLPK GLSASLPDLD SESWIEVKKR PRPSPARPKK 
       560        570        580        590        600
PEEPRFSHPT ALPQQLPSQQ LMSKDQDEQE ELDFLFDEEM EQMDGRKNTF 
       610        620        630        640        650
TAWSEEDSDY EIDDRDVNKI LIVTQTPPYM RRHPGGDRTG NHTSRAKMSA 
       660        670        680        690        700
ELAKVINDGL FYYEQDLWTE KFEPEYSQIK QEVENFKKVN MISREQFDTL 
       710        720        730        740        750
TPEPPVDPNQ EVPPGPPRFQ QVPTDALANK LFGAPEPSTI ARSLPTTVPE 
       760        770        780        790        800
SPNYRNARTP RTPRTPQLKD SSQTPRFYPV VKEGRTLDAK MPRKRKTRHS 
       810        820        830        840        850
SNPPLESHVG WVMDSREHRP RTASISSSPS EGTPAVGSYG CTPQSLPKFQ 
       860        870        880        890        900
HPSHELLKEN GFTQHVYHKY RRRCLNERKR LGIGQSQEMN TLFRFWSFFL 
       910        920        930        940        950
RDHFNKKMYE EFKQLALEDA KEGYRYGLEC LFRYYSYGLE KKFRLDIFKD 
       960        970        980        990       1000
FQEETVKDYE AGQLYGLEKF WAFLKYSKAK NLDIDPKLQE YLGKFRRLED 
      1010       1020       1030       1040       1050
FRVDPPMGEE GNHKRHPVVA GGSGEGRKRC PSQSSSRPAT GISQPPTTPT 
      1060       1070 
GQATREDAKW TSQHSDTLTL RK

Length:1,072

Mass (Da):121,125

Last modified:April 16, 2014 - v3

Checksum:ⁱBAFCE019DF683870

Isoform 2 (identifier: Q6ZQ58-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1006: Missing.

« Hide

        10         20         30         40         50
MGEEGNHKRH PVVAGGSGEG RKRCPSQSSS RPATGISQPP TTPTGQATRE 
        60 
DAKWTSQHSD TLTLRK

Note: No experimental confirmation available.

Show »

Length:66

Mass (Da):7,040

Checksum:ⁱ9134EA00889FA520

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Z4YJT3	Z4YJT3_MOUSE		La-related protein 1 La-related protein 1	Larp1	1,072	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015116	1 – 1006	Missing in isoform 2. 1 PublicationAdd BLAST		1006

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL672182 Genomic DNA No translation available. BC053449 mRNA Translation: AAH53449.1 AK129202 mRNA Translation: BAC98012.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56771.1 [Q6ZQ58-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_082727.1, NM_028451.1 [Q6ZQ58-1]
UniGeneⁱ	Mm.248843

Genome annotation databases

Ensemblⁱ	ENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331 [Q6ZQ58-1]
GeneIDⁱ	73158
KEGGⁱ	mmu:73158
UCSC genome browser More...UCSCⁱ	uc007jah.2 mouse [Q6ZQ58-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6ZQ58	La-related protein 1		MOUSE		1072	UniRef90_Q6ZQ58
La-related protein 1		CRIGR		571
Uncharacterized protein (Fragment)		Daphnia magna		132
UPI000A306075		MUSPA		1075
UPI000A31A9E1		MUSCR		1072
+6

Protein	Similar proteins		Species	Score	Length	Source
Q6ZQ58	La-related protein 1	)	HUMAN		1096	UniRef50_Q6PKG0
LARP1 isoform 6 (Fragment)		PONAB		93
la-related protein 1 isoform X1		PHYCD		1119
Putative rna-binding protein		DESRO		1116
la-related protein 1		Florida manatee		1105
+743

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL672182 Genomic DNA No translation available. BC053449 mRNA Translation: AAH53449.1 AK129202 mRNA Translation: BAC98012.1
CCDSⁱ	CCDS56771.1 [Q6ZQ58-1]
RefSeqⁱ	NP_082727.1, NM_028451.1 [Q6ZQ58-1]
UniGeneⁱ	Mm.248843

3D structure databases

ProteinModelPortalⁱ	Q6ZQ58
SMRⁱ	Q6ZQ58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	215803, 1 interactor
IntActⁱ	Q6ZQ58, 2 interactors
STRINGⁱ	10090.ENSMUSP00000136673

PTM databases

iPTMnetⁱ	Q6ZQ58
PhosphoSitePlusⁱ	Q6ZQ58
SwissPalmⁱ	Q6ZQ58

Proteomic databases

EPDⁱ	Q6ZQ58
PaxDbⁱ	Q6ZQ58
PeptideAtlasⁱ	Q6ZQ58
PRIDEⁱ	Q6ZQ58

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331 [Q6ZQ58-1]
GeneIDⁱ	73158
KEGGⁱ	mmu:73158
UCSCⁱ	uc007jah.2 mouse [Q6ZQ58-1]

Organism-specific databases

CTDⁱ	23367
MGIⁱ	MGI:1890165 Larp1
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2590 Eukaryota COG5193 LUCA
GeneTreeⁱ	ENSGT00390000000523
HOGENOMⁱ	HOG000113283
HOVERGENⁱ	HBG054322
InParanoidⁱ	Q6ZQ58
KOⁱ	K18757
OrthoDBⁱ	EOG091G02X0
TreeFamⁱ	TF314516

Miscellaneous databases

ChiTaRSⁱ	Larp1 mouse
Protein Ontology More...PROⁱ	PR:Q6ZQ58
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037331 Expressed in 311 organ(s), highest expression level in pancreas
CleanExⁱ	MM_LARP1
ExpressionAtlasⁱ	Q6ZQ58 baseline and differential
Genevisibleⁱ	Q6ZQ58 MM

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR006607 DM15 IPR006630 La_HTH IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF05383 La, 1 hit
SMARTⁱ	View protein in SMART SM00684 DM15, 3 hits SM00715 LA, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS50961 HTH_LA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LARP1_MOUSE
Accessionⁱ	Q6ZQ58Primary (citable) accession number: Q6ZQ58 Secondary accession number(s): A2AFQ8, J3QNB1, Q7TSF7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
	Last sequence update:	April 16, 2014
	Last modified:	September 12, 2018
	This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6ZQ58 (LARP1_MOUSE)

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La-related protein 1

Larp1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ