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UniProtKB - Q6ZQ58 (LARP1_MOUSE)

Entry version 132 (02 Jun 2021)
Sequence version 3 (16 Apr 2014)
Previous versions | rss
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Protein

La-related protein 1

Gene

Larp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.

By similarity

Caution

Conflicting results are reported regarding the interaction with PABPC1. Some studies found that the interaction depends on the presence of mRNA; others found that the interaction is direct and does not depend on the presence of mRNA.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
Biological processTranslation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
La ribonucleoprotein domain family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Larp1
Synonyms:Kiaa0731, Larp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1890165, Larp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076102 – 1072La-related protein 1Add BLAST1071

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei68PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei138PhosphoserineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei213Omega-N-methylarginineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei299PhosphoserineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei351PhosphothreonineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei498PhosphoserineBy similarity1
Modified residuei503PhosphothreonineCombined sources1
Cross-linki508Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei525PhosphoserineCombined sources1
Modified residuei568PhosphoserineBy similarity1
Modified residuei604PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei626PhosphothreonineCombined sources1
Cross-linki680Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei701PhosphothreonineBy similarity1
Modified residuei743PhosphoserineCombined sources1
Modified residuei746PhosphothreonineBy similarity1
Modified residuei747PhosphothreonineBy similarity1
Modified residuei751PhosphoserineCombined sources1
Modified residuei754PhosphotyrosineBy similarity1
Modified residuei759PhosphothreonineBy similarity1
Modified residuei762PhosphothreonineBy similarity1
Modified residuei765PhosphothreonineBy similarity1
Modified residuei774PhosphothreonineBy similarity1
Modified residuei801PhosphoserineBy similarity1
Modified residuei822PhosphothreonineBy similarity1
Modified residuei824PhosphoserineBy similarity1
Modified residuei828PhosphoserineBy similarity1
Modified residuei830PhosphoserineCombined sources1
Modified residuei838PhosphoserineBy similarity1
Modified residuei842PhosphothreonineCombined sources1
Modified residuei845PhosphoserineCombined sources1
Modified residuei869N6-acetyllysineBy similarity1
Modified residuei994N6-acetyllysineBy similarity1
Modified residuei1034PhosphoserineBy similarity1
Modified residuei1065PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZQ58

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZQ58

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZQ58

PeptideAtlas

More...PeptideAtlasi		Q6ZQ58

PRoteomics IDEntifications database

More...PRIDEi		Q6ZQ58

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		264836 [Q6ZQ58-1]
264837 [Q6ZQ58-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZQ58

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZQ58

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6ZQ58

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 10.5 dpc, expressed in dorsal root ganglia, spinal cord, and branchial arches. At 14.5 dpc, expressed in olfactory epithelium and cranial sensory ganglia. Also expressed in salivary glands, lungs, gut, kidney, teeth and vibrissae.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000037331, Expressed in pancreas and 334 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZQ58, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZQ58, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PABPC1/PABP.

Interacts with EIF4A1.

Interacts with RPTOR. Recruited to the active mTORC1 complex via interaction with RPTOR. Inhibition of mTORC1 activity strongly reduces interaction with RPTOR and the mTORC1 complex.

Identified in a complex with mRNA, PABPC1, EIF4E and EIF4G1.

Found in a complex with PABPC1 and SHFL.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		215803, 30 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZQ58, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000136673

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZQ58, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZQ58

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini372 – 462HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 268DisorderedSequence analysisAdd BLAST268
Regioni70 – 550Required for interaction with PABPC1By similarityAdd BLAST481
Regioni289 – 331DisorderedSequence analysisAdd BLAST43
Regioni488 – 578DisorderedSequence analysisAdd BLAST91
Regioni551 – 1072Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motifBy similarityAdd BLAST522
Regioni737 – 773DisorderedSequence analysisAdd BLAST37
Regioni790 – 837DisorderedSequence analysisAdd BLAST48
Regioni850 – 1000Interaction with mRNABy similarityAdd BLAST151
Regioni933 – 976Interaction with 7-methylguanosine mRNA cap structureBy similarityAdd BLAST44
Regioni1003 – 1072DisorderedSequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 69Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi100 – 123Pro residuesSequence analysisAdd BLAST24
Compositional biasi171 – 216Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi224 – 259Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi532 – 556Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi740 – 773Polar residuesSequence analysisAdd BLAST34
Compositional biasi822 – 837Polar residuesSequence analysisAdd BLAST16
Compositional biasi1003 – 1022Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1028 – 1072Polar residuesSequence analysisAdd BLAST45

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region mediates interaction with the mRNA and polysomes. It is required for translational repression of mRNAs with a 5'TOP motif.By similarity
The N-terminal region mediates interaction with PABPC1.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LARP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2590, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159577

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZQ58

Identification of Orthologs from Complete Genome Data

More...OMAi		PGWHPDN

Database of Orthologous Groups

More...OrthoDBi		258488at2759

TreeFam database of animal gene trees

More...TreeFami		TF314516

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006607, DM15
IPR006630, La_HTH
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05383, La, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00684, DM15, 3 hits
SM00715, LA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50961, HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZQ58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATQVEPLLP AGAPLLQAEE HGLARKKPAP DAQAESGPGD GGGEPDGGVR 
        60         70         80         90        100
RPRPACARPG RDGAERESPR PPAAAEAPAG SDGEDGGRRD FVEAPPPKVN 
       110        120        130        140        150
PWTKHAPPPA AVNGQPPPEP SAPAKVVRAA APKPRKGSKV GDFGDAVNWP 
       160        170        180        190        200
TPGEIAHKSV QPQSHKPQPA RKLPPKKDMK EQEKGDGSDS KESPKTKSDE 
       210        220        230        240        250
SGEEKNGDED CQRGGQKKKG SKHKWVPLQI DMKPEVPREK LASRPTRPQE 
       260        270        280        290        300
PRHTPAVRGE MKGSEPATYM PVSVAPPTPA WQPETKVEPA WHDQDETSSV 
       310        320        330        340        350
KSDGAGGARA SFRGRGRGRG RGRGRGRGGT RTHFDYQFGY RKFDGTEGPR 
       360        370        380        390        400
THKYMNNITY YFDNVSSNEI YSMDQELLKD YIKRQIEYYF SVDNLERDFF 
       410        420        430        440        450
LRRKMDADGF LPITLIASFH RVQALTTDIS LIFAALKDSK VVEMVEEKVR 
       460        470        480        490        500
RREEPEKWPL PGPPIVDYSQ TDFSQLLNCP EFVPRQHYQK ETESAPGSPR 
       510        520        530        540        550
AVTPVPTKTE EVSNLKTLPK GLSASLPDLD SESWIEVKKR PRPSPARPKK 
       560        570        580        590        600
PEEPRFSHPT ALPQQLPSQQ LMSKDQDEQE ELDFLFDEEM EQMDGRKNTF 
       610        620        630        640        650
TAWSEEDSDY EIDDRDVNKI LIVTQTPPYM RRHPGGDRTG NHTSRAKMSA 
       660        670        680        690        700
ELAKVINDGL FYYEQDLWTE KFEPEYSQIK QEVENFKKVN MISREQFDTL 
       710        720        730        740        750
TPEPPVDPNQ EVPPGPPRFQ QVPTDALANK LFGAPEPSTI ARSLPTTVPE 
       760        770        780        790        800
SPNYRNARTP RTPRTPQLKD SSQTPRFYPV VKEGRTLDAK MPRKRKTRHS 
       810        820        830        840        850
SNPPLESHVG WVMDSREHRP RTASISSSPS EGTPAVGSYG CTPQSLPKFQ 
       860        870        880        890        900
HPSHELLKEN GFTQHVYHKY RRRCLNERKR LGIGQSQEMN TLFRFWSFFL 
       910        920        930        940        950
RDHFNKKMYE EFKQLALEDA KEGYRYGLEC LFRYYSYGLE KKFRLDIFKD 
       960        970        980        990       1000
FQEETVKDYE AGQLYGLEKF WAFLKYSKAK NLDIDPKLQE YLGKFRRLED 
      1010       1020       1030       1040       1050
FRVDPPMGEE GNHKRHPVVA GGSGEGRKRC PSQSSSRPAT GISQPPTTPT 
      1060       1070 
GQATREDAKW TSQHSDTLTL RK
Length:1,072
Mass (Da):121,125
Last modified:April 16, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAFCE019DF683870
GO
Isoform 2 (identifier: Q6ZQ58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1006: Missing.

Show »
Length:66
Mass (Da):7,040
Checksum:i9134EA00889FA520
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YJT3Z4YJT3_MOUSE
La-related protein 1
Larp1
1,072Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0151161 – 1006Missing in isoform 2. 1 PublicationAdd BLAST1006

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL672182 Genomic DNA No translation available.
BC053449 mRNA Translation: AAH53449.1
AK129202 mRNA Translation: BAC98012.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56771.1 [Q6ZQ58-1]

NCBI Reference Sequences

More...RefSeqi		NP_082727.1, NM_028451.1 [Q6ZQ58-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331 [Q6ZQ58-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		73158

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:73158

UCSC genome browser

More...UCSCi		uc007jah.2, mouse [Q6ZQ58-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672182 Genomic DNA No translation available.
BC053449 mRNA Translation: AAH53449.1
AK129202 mRNA Translation: BAC98012.1
CCDSiCCDS56771.1 [Q6ZQ58-1]
RefSeqiNP_082727.1, NM_028451.1 [Q6ZQ58-1]

3D structure databases

SMRiQ6ZQ58
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi215803, 30 interactors
IntActiQ6ZQ58, 3 interactors
STRINGi10090.ENSMUSP00000136673

PTM databases

iPTMnetiQ6ZQ58
PhosphoSitePlusiQ6ZQ58
SwissPalmiQ6ZQ58

Proteomic databases

EPDiQ6ZQ58
jPOSTiQ6ZQ58
PaxDbiQ6ZQ58
PeptideAtlasiQ6ZQ58
PRIDEiQ6ZQ58
ProteomicsDBi264836 [Q6ZQ58-1]
264837 [Q6ZQ58-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28316, 128 antibodies

Genome annotation databases

EnsembliENSMUST00000178636; ENSMUSP00000136673; ENSMUSG00000037331 [Q6ZQ58-1]
GeneIDi73158
KEGGimmu:73158
UCSCiuc007jah.2, mouse [Q6ZQ58-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23367
MGIiMGI:1890165, Larp1

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG2590, Eukaryota
GeneTreeiENSGT00940000159577
InParanoidiQ6ZQ58
OMAiPGWHPDN
OrthoDBi258488at2759
TreeFamiTF314516

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		73158, 6 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Larp1, mouse

Protein Ontology

More...PROi		PR:Q6ZQ58
RNActiQ6ZQ58, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000037331, Expressed in pancreas and 334 other tissues
ExpressionAtlasiQ6ZQ58, baseline and differential
GenevisibleiQ6ZQ58, MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607, DM15
IPR006630, La_HTH
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383, La, 1 hit
SMARTiView protein in SMART
SM00684, DM15, 3 hits
SM00715, LA, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961, HTH_LA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZQ58
Secondary accession number(s): A2AFQ8, J3QNB1, Q7TSF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: April 16, 2014
Last modified: June 2, 2021
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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