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Protein

Cullin-associated NEDD8-dissociated protein 1

Gene

Cand1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8951664 Neddylation
R-MMU-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 1
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 1
p120 CAND1
Gene namesi
Name:Cand1
Synonyms:D10Ertd516e, Kiaa0829
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1261820 Cand1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000892942 – 1230Cullin-associated NEDD8-dissociated protein 1Add BLAST1229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei558PhosphoserineCombined sources1
Modified residuei971N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6ZQ38
MaxQBiQ6ZQ38
PaxDbiQ6ZQ38
PeptideAtlasiQ6ZQ38
PRIDEiQ6ZQ38

PTM databases

iPTMnetiQ6ZQ38
PhosphoSitePlusiQ6ZQ38
SwissPalmiQ6ZQ38

Expressioni

Gene expression databases

BgeeiENSMUSG00000020114 Expressed in 287 organ(s), highest expression level in blastocyst
CleanExiMM_CAND1
ExpressionAtlasiQ6ZQ38 baseline and differential
GenevisibleiQ6ZQ38 MM

Interactioni

Subunit structurei

Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins (By similarity). Interacts with DCUN1D3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215017, 8 interactors
IntActiQ6ZQ38, 12 interactors
MINTiQ6ZQ38
STRINGi10090.ENSMUSP00000020315

Structurei

3D structure databases

ProteinModelPortaliQ6ZQ38
SMRiQ6ZQ38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 39HEAT 1Add BLAST38
Repeati44 – 81HEAT 2Add BLAST38
Repeati83 – 119HEAT 3Add BLAST37
Repeati131 – 165HEAT 4Add BLAST35
Repeati171 – 208HEAT 5Add BLAST38
Repeati210 – 247HEAT 6Add BLAST38
Repeati248 – 282HEAT 7Add BLAST35
Repeati289 – 366HEAT 8Add BLAST78
Repeati370 – 407HEAT 9Add BLAST38
Repeati424 – 467HEAT 10Add BLAST44
Repeati471 – 510HEAT 11Add BLAST40
Repeati515 – 552HEAT 12Add BLAST38
Repeati563 – 602HEAT 13Add BLAST40
Repeati606 – 643HEAT 14Add BLAST38
Repeati646 – 683HEAT 15Add BLAST38
Repeati688 – 725HEAT 16Add BLAST38
Repeati729 – 768HEAT 17Add BLAST40
Repeati770 – 808HEAT 18Add BLAST39
Repeati809 – 845HEAT 19Add BLAST37
Repeati852 – 889HEAT 20Add BLAST38
Repeati890 – 927HEAT 21Add BLAST38
Repeati928 – 960HEAT 22Add BLAST33
Repeati961 – 998HEAT 23Add BLAST38
Repeati1002 – 1039HEAT 24Add BLAST38
Repeati1043 – 1097HEAT 25Add BLAST55
Repeati1099 – 1133HEAT 26Add BLAST35
Repeati1140 – 1189HEAT 27Add BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi314 – 344Asp-richAdd BLAST31

Sequence similaritiesi

Belongs to the CAND family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1824 Eukaryota
ENOG410XPK4 LUCA
GeneTreeiENSGT00390000017740
HOGENOMiHOG000264713
HOVERGENiHBG053467
InParanoidiQ6ZQ38
KOiK17263