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Entry version 119 (16 Oct 2019)
Sequence version 2 (15 Jan 2008)
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Protein

CCR4-NOT transcription complex subunit 1

Gene

Cnot1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-429947 Deadenylation of mRNA
R-MMU-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 1
Alternative name(s):
CCR4-associated factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cnot1
Synonyms:Kiaa1007
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442402 Cnot1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003155421 – 2375CCR4-NOT transcription complex subunit 1Add BLAST2375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei318PhosphoserineBy similarity1
Modified residuei1060PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZQ08

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZQ08

PeptideAtlas

More...
PeptideAtlasi
Q6ZQ08

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZQ08

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q6ZQ08

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZQ08

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZQ08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryonic stem (ES) cells and in inner cell mass (ICM) of the blastocyst.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036550 Expressed in 83 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZQ08 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZQ08 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits (By similarity). In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8 (By similarity).

Interacts in a ligand-dependent fashion with ESR1 and RXRA (By similarity).

Interacts with NANOS2, TOB1 and ZFP36 (PubMed:20133598).

Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct (By similarity).

Interacts with YTHDF2; the interaction is direct and promotes recruitment of the CCR4-NOT complex to N6-methyladenosine (m6A)-containing mRNAs, leading to their deadenylation and subsequent degradation (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P603223EBI-682479,EBI-6507212

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
231545, 9 interactors

Database of interacting proteins

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DIPi
DIP-46845N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6ZQ08

Protein interaction database and analysis system

More...
IntActi
Q6ZQ08, 18 interactors

Molecular INTeraction database

More...
MINTi
Q6ZQ08

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000096073

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZQ08

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni799 – 1014Interaction with ZFP36By similarityAdd BLAST216
Regioni1089 – 1604Interaction with CNOT6, CNOT6L, CNOT7 and CNOT8By similarityAdd BLAST516

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi153 – 157LXXLL5
Motifi181 – 185LXXLL5
Motifi223 – 227LXXLL5
Motifi570 – 574LXXLL5
Motifi1638 – 1642LXXLL5
Motifi1941 – 1945LXXLL5
Motifi2095 – 2099LXXLL5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1332 – 1349Thr-richAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNOT1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1831 Eukaryota
COG5103 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014869

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ZQ08

KEGG Orthology (KO)

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KOi
K12604

Identification of Orthologs from Complete Genome Data

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OMAi
FNQRVFF

Database of Orthologous Groups

More...
OrthoDBi
42530at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZQ08

TreeFam database of animal gene trees

More...
TreeFami
TF105630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 1 hit
1.25.40.840, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007196 CCR4-Not_Not1_C
IPR024557 CCR4-Not_Not1su_DUF3819
IPR040398 CNOT1
IPR032191 CNOT1_CAF1_bind
IPR032194 CNOT1_HEAT
IPR032193 CNOT1_TTP_bind
IPR038535 CNOT1_TTP_bind_sf
IPR016021 MIF4-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13162 PTHR13162, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16415 CNOT1_CAF1_bind, 1 hit
PF16418 CNOT1_HEAT, 1 hit
PF16417 CNOT1_TTP_bind, 1 hit
PF12842 DUF3819, 1 hit
PF04054 Not1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZQ08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC
60 70 80 90 100
LFSHVDFSGD GKSSGKDFHQ TQFLIQECAS LITKPNFIST LSYAIDNPLH
110 120 130 140 150
YQKSLKPAPH LFAQLSKVLK LSKVQEVIFG LALLNSSSPD LRGFAAQFIK
160 170 180 190 200
QKLPDLLRSY IDADVSGNQE GGFQDIAIEV LHLLLSHLLF GQKGAFGVGQ
210 220 230 240 250
EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL PDSGGVAKTM
260 270 280 290 300
MESSLADFMQ EVGYGFCASI EECRNIIMQF GVREVTAAQV ARVLGMMART
310 320 330 340 350
HSGLTDGIPL QSISAPGSGI WSDGKDKSEG AQAHTWNVEV LIDVLKELNP
360 370 380 390 400
SLNFKEVTYE LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDFIYRPWK
410 420 430 440 450
HAEGQLSFIQ HSLINPEVFC FADYPCHTVA TDILKAPPED DNREIATWKS
460 470 480 490 500
LDLIESLLRL AEVGQYEQVK QLFSFPIKHC PDMLVLALLQ INTSWHTLRH
510 520 530 540 550
ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH AMAEWYMRGE
560 570 580 590 600
QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW
610 620 630 640 650
LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPAETLAT
660 670 680 690 700
MLACLQACAG SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA
710 720 730 740 750
SSLDAISPVQ IDPLAGMASL SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP
760 770 780 790 800
AKAFPPLSTP NQTTAFSGIG GLSSQLPGGL GTGSLTGIGT GALGLPAVNN
810 820 830 840 850
DPFVQRKLGT SGLNQPTFQQ SKMKPSDLSQ VWPEANQHFS KEIDDEANSY
860 870 880 890 900
FQRIYNHPPH PTMSVDEVLE MLQRFKDSTI KREREVFNCM LRNLFEEYRF
910 920 930 940 950
FPQYPDKELH ITACLFGGII EKGLVTYMAL GLALRYVLEA LRKPFGSKMY
960 970 980 990 1000
YFGIAALDRF KNRLKDYPQY CQHLASISHF MQFPHHLQEY IEYGQQSRDP
1010 1020 1030 1040 1050
PVKMQGSITT PGSIALAQAQ AQAQVPAKAP LAGQVNTMVT TSTTTTVAKT
1060 1070 1080 1090 1100
VTVTKPTGVS FKKDVPPSIN TTNIDTLLVA TDQTERIVEP PENIQEKIAF
1110 1120 1130 1140 1150
IFNNLSQSNM TQKVEELKET VKEEFMPWVS QYLVMKRVSI EPNFHSLYSN
1160 1170 1180 1190 1200
FLDTLKNPEF NKMVLNETYR NIKVLLTSDK AAANFSDRSL LKNLGHWLGM
1210 1220 1230 1240 1250
ITLAKNKPIL HTDLDVKSLL LEAYVKGQQE LLYVVPFVAK VLESSIRSLV
1260 1270 1280 1290 1300
FRPPNPWTMA IMNVLAELHQ EHDLKLNLKF EIEVLCKNLA LDINELKPGN
1310 1320 1330 1340 1350
LLKDKDRLKN LDEQLSAPKK DVKQPEELPA ITTTTTSTTP ATSTTCTATV
1360 1370 1380 1390 1400
PPQPQYSYHD INVYSLAGLA PHITLNPTIP LFQAHPQLKQ CVRQAIERAV
1410 1420 1430 1440 1450
QELVHPVVDR SIKIAMTTCE QIVRKDFALD SEESRMRIAA HHMMRNLTAG
1460 1470 1480 1490 1500
MAMITCREPL LMSISTNLKN SFASALRTAS PQQREMMDQA AAQLAQDNCE
1510 1520 1530 1540 1550
LACCFIQKTA VEKAGPEMDK RLATEFELRK HARQEGRRYC DPVVLTYQAE
1560 1570 1580 1590 1600
RMPEQIRLKV GGVDPKQLAV YEEFARNVPG FLPTNDLSQP TGFLAQPMKQ
1610 1620 1630 1640 1650
AWATDDVAQI YDKCITELEQ HLHAIPPTLA MNPQAQALRS LLEVVVLSRN
1660 1670 1680 1690 1700
SRDAIAALGL LQKAVEGLLD ATSGADADLL LRYRECHLLV LKALQDGRAY
1710 1720 1730 1740 1750
GSPWCNKQIT RCLIECRDEY KYNVEAVELL IRNHLVNMQQ YDLHLAQSME
1760 1770 1780 1790 1800
NGLNYMAVAF AMQLVKILLV DERSVAHITE ADLFHTIETL MRINAHSRGN
1810 1820 1830 1840 1850
APEGLPQLME VVRSNYEAMI DRAHGGPNFM MHSGISQASE YDDPPGLREK
1860 1870 1880 1890 1900
AEYLLREWVN LYHSAAAGRD STKAFSAFVG QMHQQGILKT DDLITRFFRL
1910 1920 1930 1940 1950
CTEMCVEISY RAQAEQQHNP AANPTMIRAK CYHNLDAFVR LIALLVKHSG
1960 1970 1980 1990 2000
EATNTVTKIN LLNKVLGIVV GVLLQDHDVR QSEFQQLPYH RIFIMLLLEL
2010 2020 2030 2040 2050
NAPEHVLETI NFQTLTAFCN TFHILRPTKA PGFVYAWLEL ISHRIFIARM
2060 2070 2080 2090 2100
LAHTPQQKGW PMYAQLLIDL FKYLAPFLRN VELTKPMQIL YKGTLRVLLV
2110 2120 2130 2140 2150
LLHDFPEFLC DYHYGFCDVI PPNCIQLRNL ILSAFPRNMR LPDPFTPNLK
2160 2170 2180 2190 2200
VDMLSEINIA PRILTNFTGV MPPQFKKDLD SYLKTRSPVT FLSDLRSNLQ
2210 2220 2230 2240 2250
VSNEPGNRYN LQLINALVLY VGTQAIAHIH NKGSTPSMST ITHSAHMDIF
2260 2270 2280 2290 2300
QNLAVDLDTE GRYLFLNAIA NQLRYPNSHT HYFSCTMLYL FAEANTEAIQ
2310 2320 2330 2340 2350
EQITRVLLER LIVNRPHPWG LLITFIELIK NPAFKFWNHE FVHCAPEIEK
2360 2370
LFQSVAQCCM GQKQAQQVME GTGAS
Length:2,375
Mass (Da):266,808
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7771515027BA4B60
GO
Isoform 2 (identifier: Q6ZQ08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     777-777: P → PV
     821-826: SKMKPS → T

Show »
Length:2,371
Mass (Da):266,349
Checksum:iA7F33BDEF22E68D5
GO
Isoform 3 (identifier: Q6ZQ08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1881: Missing.

Show »
Length:494
Mass (Da):56,802
Checksum:i647E40938B0BE420
GO
Isoform 4 (identifier: Q6ZQ08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     777-777: P → PV

Show »
Length:2,376
Mass (Da):266,907
Checksum:i6122235C002F3CE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RMJ8A0A1D5RMJ8_MOUSE
CCR4-NOT transcription complex subu...
Cnot1
2,369Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZWL1B7ZWL1_MOUSE
CCR4-NOT transcription complex subu...
Cnot1
2,326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMD8A0A1D5RMD8_MOUSE
CCR4-NOT transcription complex subu...
Cnot1
1,614Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RML9A0A1D5RML9_MOUSE
CCR4-NOT transcription complex subu...
Cnot1
823Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMB6A0A1D5RMB6_MOUSE
CCR4-NOT transcription complex subu...
Cnot1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM03A0A1D5RM03_MOUSE
CCR4-NOT transcription complex subu...
Cnot1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM04A0A1D5RM04_MOUSE
CCR4-NOT transcription complex subu...
Cnot1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC27364 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC28830 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAE25479 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2089I → F in AAH18281 (PubMed:15489334).Curated1
Sequence conflicti2203N → S in BAC33267 (PubMed:16141072).Curated1
Sequence conflicti2233G → D in BAC27364 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0305641 – 1881Missing in isoform 3. 1 PublicationAdd BLAST1881
Alternative sequenceiVSP_030565777P → PV in isoform 2 and isoform 4. 2 Publications1
Alternative sequenceiVSP_030566821 – 826SKMKPS → T in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC113951 Genomic DNA No translation available.
AC127300 Genomic DNA No translation available.
AK031357 mRNA Translation: BAC27364.1 Different initiation.
AK034776 mRNA Translation: BAC28830.1 Different initiation.
AK048177 mRNA Translation: BAC33267.1
AK143651 mRNA Translation: BAE25479.1 Different initiation.
BC018281 mRNA Translation: AAH18281.2
BC158073 mRNA Translation: AAI58074.1
AK129258 Transcribed RNA Translation: BAC98068.2

NCBI Reference Sequences

More...
RefSeqi
NP_835179.1, NM_178078.2 [Q6ZQ08-2]
XP_006530937.1, XM_006530874.2 [Q6ZQ08-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000098473; ENSMUSP00000096073; ENSMUSG00000036550 [Q6ZQ08-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
234594

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:234594

UCSC genome browser

More...
UCSCi
uc009myy.1 mouse [Q6ZQ08-3]
uc009myz.3 mouse [Q6ZQ08-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113951 Genomic DNA No translation available.
AC127300 Genomic DNA No translation available.
AK031357 mRNA Translation: BAC27364.1 Different initiation.
AK034776 mRNA Translation: BAC28830.1 Different initiation.
AK048177 mRNA Translation: BAC33267.1
AK143651 mRNA Translation: BAE25479.1 Different initiation.
BC018281 mRNA Translation: AAH18281.2
BC158073 mRNA Translation: AAI58074.1
AK129258 Transcribed RNA Translation: BAC98068.2
RefSeqiNP_835179.1, NM_178078.2 [Q6ZQ08-2]
XP_006530937.1, XM_006530874.2 [Q6ZQ08-4]

3D structure databases

SMRiQ6ZQ08
ModBaseiSearch...

Protein-protein interaction databases

BioGridi231545, 9 interactors
DIPiDIP-46845N
ELMiQ6ZQ08
IntActiQ6ZQ08, 18 interactors
MINTiQ6ZQ08
STRINGi10090.ENSMUSP00000096073

PTM databases

CarbonylDBiQ6ZQ08
iPTMnetiQ6ZQ08
PhosphoSitePlusiQ6ZQ08

Proteomic databases

EPDiQ6ZQ08
PaxDbiQ6ZQ08
PeptideAtlasiQ6ZQ08
PRIDEiQ6ZQ08

Genome annotation databases

EnsembliENSMUST00000098473; ENSMUSP00000096073; ENSMUSG00000036550 [Q6ZQ08-4]
GeneIDi234594
KEGGimmu:234594
UCSCiuc009myy.1 mouse [Q6ZQ08-3]
uc009myz.3 mouse [Q6ZQ08-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23019
MGIiMGI:2442402 Cnot1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1831 Eukaryota
COG5103 LUCA
GeneTreeiENSGT00390000014869
InParanoidiQ6ZQ08
KOiK12604
OMAiFNQRVFF
OrthoDBi42530at2759
PhylomeDBiQ6ZQ08
TreeFamiTF105630

Enzyme and pathway databases

ReactomeiR-MMU-429947 Deadenylation of mRNA
R-MMU-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cnot1 mouse

Protein Ontology

More...
PROi
PR:Q6ZQ08

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036550 Expressed in 83 organ(s), highest expression level in thymus
ExpressionAtlasiQ6ZQ08 baseline and differential
GenevisibleiQ6ZQ08 MM

Family and domain databases

Gene3Di1.25.40.180, 1 hit
1.25.40.840, 1 hit
InterProiView protein in InterPro
IPR007196 CCR4-Not_Not1_C
IPR024557 CCR4-Not_Not1su_DUF3819
IPR040398 CNOT1
IPR032191 CNOT1_CAF1_bind
IPR032194 CNOT1_HEAT
IPR032193 CNOT1_TTP_bind
IPR038535 CNOT1_TTP_bind_sf
IPR016021 MIF4-like_sf
PANTHERiPTHR13162 PTHR13162, 1 hit
PfamiView protein in Pfam
PF16415 CNOT1_CAF1_bind, 1 hit
PF16418 CNOT1_HEAT, 1 hit
PF16417 CNOT1_TTP_bind, 1 hit
PF12842 DUF3819, 1 hit
PF04054 Not1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNOT1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZQ08
Secondary accession number(s): B2RY28
, Q3UPB7, Q8BSB4, Q8BXB2, Q8C0H2, Q8K3D8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 16, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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