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Entry version 96 (12 Aug 2020)
Sequence version 2 (24 Jul 2007)
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Protein

Centrosomal protein of 162 kDa

Gene

Cep162

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5620912, Anchoring of the basal body to the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 162 kDa
Short name:
Cep162
Alternative name(s):
Protein QN1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cep162
Synonyms:Kiaa1009, Qn1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1925343, Cep162

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002956291 – 1403Centrosomal protein of 162 kDaAdd BLAST1403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei160PhosphoserineCombined sources1
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZQ06

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZQ06

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZQ06

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZQ06

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZQ06

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZQ06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000056919, Expressed in undifferentiated genital tubercle and 238 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZQ06, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE4 (PubMed:12522145).

Interacts with alpha-tubulin.

Interacts with CEP290 (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
238234, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091319

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZQ06, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZQ06

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili614 – 1124Sequence analysisAdd BLAST511
Coiled coili1174 – 1386Sequence analysisAdd BLAST213

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP162 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSPF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009631

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005179_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZQ06

KEGG Orthology (KO)

More...
KOi
K16809

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRNQSFT

Database of Orthologous Groups

More...
OrthoDBi
520583at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZQ06

TreeFam database of animal gene trees

More...
TreeFami
TF330884

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038774, CEP162-like

The PANTHER Classification System

More...
PANTHERi
PTHR34031, PTHR34031, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ZQ06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHYFKVDLD EEFERFMKEL SDDSFENSNK TPRQPNEDNK EMKKKDPVPW
60 70 80 90 100
WIAEDDFEDD GLLGTNVSYL KTKKTYQPVM DTEEESAEKV QFLKSSGTSI
110 120 130 140 150
LSVDSLEANE LVVSEPHHST LGLGLDTLEE QEEKEQFFAR LEKGLTSSID
160 170 180 190 200
YSKLNQELDS DDSAQLKALH RYPRNTEPAE DGCENESEQE ELPETYSDDF
210 220 230 240 250
EDAEDADDPL ITKDEETHPK ENSESGKDSF PKQEEEKTGM LANVVLLDSF
260 270 280 290 300
DSVEDVGLSS QEKATPKAKA PPEITDDGPA ETGVPYGQSS GDTEALHQAY
310 320 330 340 350
CHVAHSLGDT GEPRIEASTV QTVRSSIKDG LQENEESSKN VSTTESDLPT
360 370 380 390 400
VEELMQPIRI DSYGIRAFDL QPISLKKATD SKEAESVGSL PLKTNTNTVS
410 420 430 440 450
QDTRHAIQFP HKHDESVVLH RTADEGMGSS CPATEEHLDK MYLEILKKKT
460 470 480 490 500
SVNPSLLPQD DKMNQTSRSQ LGAGEEVPVI GKQVPCKKAR STPSLPKRKP
510 520 530 540 550
QSGLYASARS SGYGKPSSPL QLFSALEKKT SKDNTKTKSV RSIPTSNQFR
560 570 580 590 600
KREILSGTKL IKPAASNKPS PHREGSPATP KRPEDPSDDS FVQLQTEPLG
610 620 630 640 650
SYGGNREKEL LMLKRAQDAE EKWTGAQALM EQMKMTFCEK EKELENTVES
660 670 680 690 700
LKRQQERELF RLNQENYILQ AKLSSFEETS RKQRWLQFGE TSDPLTGEKL
710 720 730 740 750
KQIQKEIQEQ ETLLQGYQQE NERLYNQVKD LQEQNKKNEE RMFKENQNLF
760 770 780 790 800
SELASLKEQM HKNHFLSQAV ENTEPTKNQS FTDLLAELRA AQKEKNHLME
810 820 830 840 850
DIKRLKQDKQ ALEVDLEKVK RERDQAKDQI AYATGEKLYE IKILEETHKQ
860 870 880 890 900
EVSRLQKRLQ WYAENQELLD RDAARLREAN EETEKLRLEI EKLKTESGSP
910 920 930 940 950
ATQQRLRSKE RALDAKRIQD LERQVKEMEG ILKRRYPNSL PALILAASAA
960 970 980 990 1000
GDSVDRNTVE FMERRIKKLE ADLEGKDEEA KKSLRTMEQQ FQKMKIQYEQ
1010 1020 1030 1040 1050
RLEEQEQLLA HRQKEAPQSQ RNSSSRLKAL ETELGDIKEA HQITVRKLEA
1060 1070 1080 1090 1100
EIDVLKHQNA DLEHKKNDKG DQGLQSIEFQ VEQAQARAKL ARLNEELAAK
1110 1120 1130 1140 1150
GREIQDLTKT VERLQKERRM MLSRQIPRSR EETAAKRLKK DPNRGHGNAF
1160 1170 1180 1190 1200
PETLDGKLYH PHTFTDSHIS EVLEENYRLR SELEGLILER SKLKMESEAA
1210 1220 1230 1240 1250
VCQLENSMKR VKDDAAAHIA SLKASHEREI EKLLCQNAIE NSSSKVAELN
1260 1270 1280 1290 1300
RKIATQEVLL KHFQGQVNEL QGKQESLAVS QVREEILQKQ ITKLLEELKE
1310 1320 1330 1340 1350
AKENHTPEMK HFMGLERKIK QMEMRHRQRE QELQQIIQQT RQVVETEQNK
1360 1370 1380 1390 1400
EVEKWKRLAQ LKNRELDKFR TELDSILDVL RELHRQGVVV PMALAGEENT

AEF
Length:1,403
Mass (Da):160,855
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA1363D5407D7FFF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC125370 Genomic DNA No translation available.
BC150998 mRNA Translation: AAI50999.1
BC151006 mRNA Translation: AAI51007.1
AK129260 mRNA Translation: BAC98070.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52879.1

NCBI Reference Sequences

More...
RefSeqi
NP_955020.2, NM_199316.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093802; ENSMUSP00000091319; ENSMUSG00000056919

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
382090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:382090

UCSC genome browser

More...
UCSCi
uc009qyg.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125370 Genomic DNA No translation available.
BC150998 mRNA Translation: AAI50999.1
BC151006 mRNA Translation: AAI51007.1
AK129260 mRNA Translation: BAC98070.1
CCDSiCCDS52879.1
RefSeqiNP_955020.2, NM_199316.2

3D structure databases

SMRiQ6ZQ06
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi238234, 6 interactors
STRINGi10090.ENSMUSP00000091319

PTM databases

iPTMnetiQ6ZQ06
PhosphoSitePlusiQ6ZQ06

Proteomic databases

EPDiQ6ZQ06
MaxQBiQ6ZQ06
PaxDbiQ6ZQ06
PRIDEiQ6ZQ06

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31712, 31 antibodies

Genome annotation databases

EnsembliENSMUST00000093802; ENSMUSP00000091319; ENSMUSG00000056919
GeneIDi382090
KEGGimmu:382090
UCSCiuc009qyg.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22832
MGIiMGI:1925343, Cep162

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QSPF, Eukaryota
GeneTreeiENSGT00390000009631
HOGENOMiCLU_005179_0_0_1
InParanoidiQ6ZQ06
KOiK16809
OMAiTRNQSFT
OrthoDBi520583at2759
PhylomeDBiQ6ZQ06
TreeFamiTF330884

Enzyme and pathway databases

ReactomeiR-MMU-5620912, Anchoring of the basal body to the plasma membrane

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
382090, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cep162, mouse

Protein Ontology

More...
PROi
PR:Q6ZQ06
RNActiQ6ZQ06, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000056919, Expressed in undifferentiated genital tubercle and 238 other tissues
GenevisibleiQ6ZQ06, MM

Family and domain databases

InterProiView protein in InterPro
IPR038774, CEP162-like
PANTHERiPTHR34031, PTHR34031, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE162_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZQ06
Secondary accession number(s): B9EKN3, Q6P262
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: August 12, 2020
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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