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Entry version 134 (13 Nov 2019)
Sequence version 2 (05 Sep 2006)
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Protein

Chromatin-remodeling ATPase INO80

Gene

Ino80

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated upon binding to double stranded DNA or nucleosomes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi545 – 552ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, DNA-binding, Hydrolase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin-remodeling ATPase INO80Curated (EC:3.6.4.-By similarity)
Alternative name(s):
DNA helicase-related INO80 complex homolog 1Curated
DNA helicase-related protein INO80Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ino80
Synonyms:Inoc1, Kiaa1259
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915392 Ino80

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002488301 – 1559Chromatin-remodeling ATPase INO80Add BLAST1559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118N6-acetyllysineBy similarity1
Modified residuei1515PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZPV2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZPV2

PeptideAtlas

More...
PeptideAtlasi
Q6ZPV2

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZPV2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZPV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZPV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034154 Expressed in 256 organ(s), highest expression level in stomach

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZPV2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZPV2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the chromatin remodeling INO80 complex; three different complex modules assemble on different domains of INO80.

Interacts with DDB1.

Interacts with transcriptional repressor protein YY1; the interaction recruits the INO80 complex to YY1 target genes.

Interacts with YY1AP1.

Interacts with tubulin alpha.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
212678, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-878 INO80 chromatin remodeling complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6ZPV2

Protein interaction database and analysis system

More...
IntActi
Q6ZPV2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000051845

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZPV2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini282 – 407DBINOPROSITE-ProRule annotationAdd BLAST126
Domaini532 – 703Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST172
Domaini1108 – 1263Helicase C-terminalPROSITE-ProRule annotationAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 268Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80DBy similarityAdd BLAST268
Regioni214 – 528Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1By similarityAdd BLAST315
Regioni523 – 1559Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2By similarityAdd BLAST1037

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DBINO region is involved in binding to DNA.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0388 Eukaryota
ENOG410XP0A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141110

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231795

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZPV2

KEGG Orthology (KO)

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KOi
K11665

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDAGEMK

Database of Orthologous Groups

More...
OrthoDBi
188211at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZPV2

TreeFam database of animal gene trees

More...
TreeFami
TF324408

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020838 DBINO
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR031047 Ino80
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

The PANTHER Classification System

More...
PANTHERi
PTHR45685:SF2 PTHR45685:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13892 DBINO, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51413 DBINO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZPV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASELGAGDD GSSTELAKPL YLQYLERALR LDHFLRQTSA IFNRNISSDD
60 70 80 90 100
SEDGLDDNNP LLPESGDPLI QVKEEPPNSL LGETSGASSS GLLNPYSLNG
110 120 130 140 150
VLQSESKSDK GNLYNFSKLK KSRKWLKSIL LSDESSEADS QSEDNDDEEE
160 170 180 190 200
ELSLSREELH NMLRLHKYKK LHQNKYSKDK ELQQYQYYSA GLLSTYDPFY
210 220 230 240 250
EQQRHLLGPK KKKFKEDKKL KAKLKKVKKK RRRDEEFSSE ESPRHHHHQT
260 270 280 290 300
KVFAKFSHDA PPPGTKKKHL SIEQLNARRR KVWLSIVKKE LPKANKQKSS
310 320 330 340 350
ARNLFLTNSR KLAHQCMKEV RRAALQAQKN CKETLPRARR LTKEMLLYWK
360 370 380 390 400
KYEKVEKEHR KRAEKEALEQ RKLDEEMREA KRQQRKLNFL ITQTELYAHF
410 420 430 440 450
MSRKRDMGHD GIQEEILRKL EDSSTQRQID IGGGVVVNIT QEDYDSNHFK
460 470 480 490 500
AQALKNAENA YHIHQARTRS FDEDAKESRA AALRAADKSG SGFGESYSLA
510 520 530 540 550
NPSIRAGEDI PQPTIFNGKL KGYQLKGMNW LANLYEQGIN GILADEMGLG
560 570 580 590 600
KTVQSIALLA HLAERENIWG PFLIISPAST LNNWHQEFTR FVPKFKVLPY
610 620 630 640 650
WGNPHDRKVI RRFWSQKTLY TQDAPFHVVI TSYQLVVQDV KYFQRVKWQY
660 670 680 690 700
MVLDEAQALK SSSSVRWKIL LQFQCRNRLL LTGTPIQNTM AELWALLHFI
710 720 730 740 750
MPTLFDSHEE FNEWFSKDIE SHAENKSAID ENQLSRLHMI LKPFMLRRIK
760 770 780 790 800
KDVENELSDK IEILTYCQLT SRQKLLYQAL KNKISIEDLL QSSMGSTQQA
810 820 830 840 850
QNTTSSLMNL VMQFRKVCNH PELFERQETW SPFHISLKPY EISKFIYRHG
860 870 880 890 900
QIRVFNHSRD RWLKVLLSPF APDYIQQSLF HRKGINEGSC FSFLRFIDVS
910 920 930 940 950
PAEMANLMLQ GLLARWLALF LSLKASYRLH QLRSWAEPDG TSHQSYLRNK
960 970 980 990 1000
DFLLGVDFPL SFPNLCSCPL LKSLVFSSHC KAVSGYSDHV VHQRRSATSS
1010 1020 1030 1040 1050
LRCCLLTELP SFLCVASPRV TAVPLDSYCN DRSAEYERGV LKEGGSLAAK
1060 1070 1080 1090 1100
QCLLNGAPEL ATDWLSRRSQ FFPEPAGGLL SIRPQNGWSF IRIPGKESLI
1110 1120 1130 1140 1150
TDSGKLYALD VLLTRLKSQG HRVLIYSQMT RMIDLLEEYM VYRKHTYMRL
1160 1170 1180 1190 1200
DGSSKISERR DMVADFQTRN DIFVFLLSTR AGGLGINLTA ADTVIFYDSD
1210 1220 1230 1240 1250
WNPTVDQQAM DRAHRLGQTK QVTVYRLICK GTIEERILQR AKEKSEIQRM
1260 1270 1280 1290 1300
VISGGNFKPD TLKPKEVVSL LLDDEELEKK LRLRQEEKRQ QEESNRVKER
1310 1320 1330 1340 1350
KRKREKYAEK KKKEDELDGK RRKEGVNLVI PFVPSADNSN LSADGDDSFI
1360 1370 1380 1390 1400
SVDSAMPSPF SEISISSELH TGSIPPDESS SDMLVIVDDP ASSAPQSRAT
1410 1420 1430 1440 1450
NSPASITGSV SDTVNGISIQ EVPAAGRGHS ARSRGRPKGS GSTAKGAGKG
1460 1470 1480 1490 1500
RSRKSTAGSA AAMAGAKAGA AAASAAAYAA YGYNVSKGIS ASSPLQTSIV
1510 1520 1530 1540 1550
RPAGLADFGP SSASSPLSSP LNKGNNIPGT PKSLHMTSSL ASDSLIRKQG

KGTNPSGGR
Length:1,559
Mass (Da):176,520
Last modified:September 5, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA02B780D0B13D08F
GO
Isoform 2 (identifier: Q6ZPV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-614: Missing.

Show »
Length:1,552
Mass (Da):175,533
Checksum:iC502A210B56F55AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YL66Z4YL66_MOUSE
Chromatin-remodeling ATPase INO80
Ino80
1,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020334608 – 614Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844862 Genomic DNA No translation available.
AK040612 mRNA Translation: BAC30644.1
AK129317 Transcribed RNA Translation: BAC98127.1
BC059235 mRNA Translation: AAH59235.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16602.1 [Q6ZPV2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_080850.2, NM_026574.3 [Q6ZPV2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000049920; ENSMUSP00000051845; ENSMUSG00000034154 [Q6ZPV2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
68142

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68142

UCSC genome browser

More...
UCSCi
uc008ltt.2 mouse [Q6ZPV2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844862 Genomic DNA No translation available.
AK040612 mRNA Translation: BAC30644.1
AK129317 Transcribed RNA Translation: BAC98127.1
BC059235 mRNA Translation: AAH59235.1
CCDSiCCDS16602.1 [Q6ZPV2-1]
RefSeqiNP_080850.2, NM_026574.3 [Q6ZPV2-1]

3D structure databases

SMRiQ6ZPV2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi212678, 1 interactor
ComplexPortaliCPX-878 INO80 chromatin remodeling complex
CORUMiQ6ZPV2
IntActiQ6ZPV2, 3 interactors
STRINGi10090.ENSMUSP00000051845

PTM databases

iPTMnetiQ6ZPV2
PhosphoSitePlusiQ6ZPV2

Proteomic databases

EPDiQ6ZPV2
PaxDbiQ6ZPV2
PeptideAtlasiQ6ZPV2
PRIDEiQ6ZPV2

Genome annotation databases

EnsembliENSMUST00000049920; ENSMUSP00000051845; ENSMUSG00000034154 [Q6ZPV2-1]
GeneIDi68142
KEGGimmu:68142
UCSCiuc008ltt.2 mouse [Q6ZPV2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54617
MGIiMGI:1915392 Ino80

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG0388 Eukaryota
ENOG410XP0A LUCA
GeneTreeiENSGT00900000141110
HOGENOMiHOG000231795
InParanoidiQ6ZPV2
KOiK11665
OMAiYDAGEMK
OrthoDBi188211at2759
PhylomeDBiQ6ZPV2
TreeFamiTF324408

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ino80 mouse

Protein Ontology

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PROi
PR:Q6ZPV2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000034154 Expressed in 256 organ(s), highest expression level in stomach
ExpressionAtlasiQ6ZPV2 baseline and differential
GenevisibleiQ6ZPV2 MM

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR020838 DBINO
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR031047 Ino80
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR45685:SF2 PTHR45685:SF2, 1 hit
PfamiView protein in Pfam
PF13892 DBINO, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51413 DBINO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINO80_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZPV2
Secondary accession number(s): A2AQP8
, Q6P7V0, Q6PCP1, Q8C9T7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 13, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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