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Entry version 141 (02 Jun 2021)
Sequence version 2 (24 Jul 2007)
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Protein

Ankyrin repeat and IBR domain-containing protein 1

Gene

Ankib1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

By similarity

Caution

Lacks one Cys residue in the IBR-type zinc finger domain that is one of the conserved features of the family.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.By similarity EC:2.3.2.31

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi334Zinc 1PROSITE-ProRule annotation1
Metal bindingi337Zinc 1PROSITE-ProRule annotation1
Metal bindingi352Zinc 2PROSITE-ProRule annotation1
Metal bindingi354Zinc 2; via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi357Zinc 1PROSITE-ProRule annotation1
Metal bindingi360Zinc 1PROSITE-ProRule annotation1
Metal bindingi379Zinc 2PROSITE-ProRule annotation1
Metal bindingi384Zinc 2PROSITE-ProRule annotation1
Metal bindingi466Zinc 3PROSITE-ProRule annotation1
Metal bindingi469Zinc 3PROSITE-ProRule annotation1
Metal bindingi474Zinc 3; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi479Zinc 3PROSITE-ProRule annotation1
Metal bindingi520Zinc 4PROSITE-ProRule annotation1
Metal bindingi523Zinc 4PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei533PROSITE-ProRule annotation1
Metal bindingi538Zinc 4PROSITE-ProRule annotation1
Metal bindingi541Zinc 4PROSITE-ProRule annotation1
Metal bindingi546Zinc 5PROSITE-ProRule annotation1
Metal bindingi549Zinc 5PROSITE-ProRule annotation1
Metal bindingi556Zinc 5; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi566Zinc 5PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri334 – 384RING-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri402 – 479IBR-typePROSITE-ProRule annotationAdd BLAST78
Zinc fingeri520 – 549RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and IBR domain-containing protein 1 (EC:2.3.2.31By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankib1
Synonyms:Kiaa1386
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918047, Ankib1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000668932 – 1085Ankyrin repeat and IBR domain-containing protein 1Add BLAST1084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei738PhosphoserineCombined sources1
Modified residuei879PhosphoserineBy similarity1
Modified residuei906PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZPS6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZPS6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZPS6

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZPS6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
285801

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZPS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZPS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040351, Expressed in cumulus cell and 306 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZPS6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
214259, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000040946

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZPS6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZPS6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 75ANK 1Add BLAST31
Repeati145 – 174ANK 2Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini846 – 865UIMPROSITE-ProRule annotationAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni282 – 322DisorderedSequence analysisAdd BLAST41
Regioni330 – 570TRIAD supradomainPROSITE-ProRule annotationAdd BLAST241
Regioni764 – 808DisorderedSequence analysisAdd BLAST45
Regioni884 – 907DisorderedSequence analysisAdd BLAST24
Regioni921 – 959DisorderedSequence analysisAdd BLAST39
Regioni1014 – 1085DisorderedSequence analysisAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili576 – 641Sequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi301 – 322Polar residuesSequence analysisAdd BLAST22
Compositional biasi783 – 797Polar residuesSequence analysisAdd BLAST15
Compositional biasi884 – 905Polar residuesSequence analysisAdd BLAST22
Compositional biasi926 – 959Polar residuesSequence analysisAdd BLAST34
Compositional biasi1014 – 1042Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi1067 – 1085Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RBR family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri334 – 384RING-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri402 – 479IBR-typePROSITE-ProRule annotationAdd BLAST78
Zinc fingeri520 – 549RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1815, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157621

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZPS6

Database of Orthologous Groups

More...
OrthoDBi
469819at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZPS6

TreeFam database of animal gene trees

More...
TreeFami
TF331104

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR031127, E3_UB_ligase_RBR
IPR002867, IBR_dom
IPR044066, TRIAD_supradom
IPR003903, UIM_dom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR11685, PTHR11685, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF01485, IBR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00647, IBR, 2 hits
SM00184, RING, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS51873, TRIAD, 1 hit
PS50330, UIM, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6ZPS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNTTTKFRK ALINGDENLA CQIYENNPQL KESLDPNISY GEPYQHNTPL
60 70 80 90 100
HYAARHGMNR ILGTFLFGRD GNPNKRNVHN ETSMHLLCMG PQIMISEGTL
110 120 130 140 150
HPRLARPVED DFRRADCLQM ILQWKGAKLD QGEYERAAID AVDNKKNTPL
160 170 180 190 200
HYAAASGMKA CVELLVKHGG DLFAENENRD TPCDCAEKQQ HKDLALSLES
210 220 230 240 250
QMVFSRDPEA EEIEAEYAAL DKREPYEGLR PQDLRRLKDM LIVETADMLQ
260 270 280 290 300
APLFTAEALL RAHDWDREKL LEAWMSNPEN CCQRSGVQMP TPPPSGYNAW
310 320 330 340 350
DTLPSPRTPR TTRSSVTSPD EISLSPGDLD TSLCDICMCS ISVFEDPVDM
360 370 380 390 400
PCGHDFCRGC WEAFLNLKIQ EGEAHNIFCP AYECFQLVPV DVIESVVSKE
410 420 430 440 450
MDKRYLQFDI KAFVENNPAI KWCPTAGCER AVRLTKQGSN PSGSDTLSFP
460 470 480 490 500
LLRAPAVDCG KGHLFCWECL GEAHEPCDCQ TWKNWLQKIT EMKPEELVGV
510 520 530 540 550
SEAYEDAANC LWLLTNSKPC ANCKSPIQKN EGCNHMQCAK CKYDFCWICL
560 570 580 590 600
EEWKKHSSST GGYYRCTRYE VIQHVEEQSK EMTVEAEKKH KRFQELDRFM
610 620 630 640 650
HYYTRYKNHE HSYQLEQRLL KTAKEKMEQL SRALKETEGG CPDTTFIEDA
660 670 680 690 700
VHVLLKTRRI LKCSYPYGFF LEPKSTKKEI FELMQTDLEM VTEDLAQKVN
710 720 730 740 750
RPYLRTPRHK IIRAACLVQQ KRQEFLASVA RGVAPADSPD APRRSFAGGT
760 770 780 790 800
WDWEYLGFAS PEYRRRHRQQ RRRGDVHSLL SNPTDLDEPS ESTFDLPEGS
810 820 830 840 850
SGRRPGASVV SSASMSVLHS SSLRDYSPAS RSANQDSLQA LSSLDEDDPN
860 870 880 890 900
ILLAIQLSLQ ESGLDMDEET RDFLSNETSL GAIGSSLPSR LDSVPRSTES
910 920 930 940 950
PRAALSSSEL LELGDSLMRL GADSDPFSTD TLSSRPLSET RSDFCPSSSD
960 970 980 990 1000
LDSAGQDPSA NDNLLGNIMA WFHDMNPQSI ALIPPAATTE ISAEPQLPCI
1010 1020 1030 1040 1050
RDGSEGVRDM ELVPPEDSVS KDTGVHEGER AQMEENPLEE NILAREELSQ
1060 1070 1080
AGDSSNEAVG RGDRPDAASQ TPQTSSDWLE QVHSV
Length:1,085
Mass (Da):121,876
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAB5F58A624F3972
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JEA0A0A0G2JEA0_MOUSE
RBR-type E3 ubiquitin transferase
Ankib1
809Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH79620 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129343 mRNA Translation: BAC98153.1
BC079620 mRNA Translation: AAH79620.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51408.1

NCBI Reference Sequences

More...
RefSeqi
NP_001003909.2, NM_001003909.4
NP_001276457.1, NM_001289528.1
NP_001276458.1, NM_001289529.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043551; ENSMUSP00000040946; ENSMUSG00000040351

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:70797

UCSC genome browser

More...
UCSCi
uc008who.3, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129343 mRNA Translation: BAC98153.1
BC079620 mRNA Translation: AAH79620.1 Sequence problems.
CCDSiCCDS51408.1
RefSeqiNP_001003909.2, NM_001003909.4
NP_001276457.1, NM_001289528.1
NP_001276458.1, NM_001289529.1

3D structure databases

SMRiQ6ZPS6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi214259, 2 interactors
STRINGi10090.ENSMUSP00000040946

PTM databases

iPTMnetiQ6ZPS6
PhosphoSitePlusiQ6ZPS6

Proteomic databases

EPDiQ6ZPS6
MaxQBiQ6ZPS6
PaxDbiQ6ZPS6
PRIDEiQ6ZPS6
ProteomicsDBi285801

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
8661, 24 antibodies

The DNASU plasmid repository

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DNASUi
70797

Genome annotation databases

EnsembliENSMUST00000043551; ENSMUSP00000040946; ENSMUSG00000040351
GeneIDi70797
KEGGimmu:70797
UCSCiuc008who.3, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54467
MGIiMGI:1918047, Ankib1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1815, Eukaryota
GeneTreeiENSGT00940000157621
InParanoidiQ6ZPS6
OrthoDBi469819at2759
PhylomeDBiQ6ZPS6
TreeFamiTF331104

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
70797, 3 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ankib1, mouse

Protein Ontology

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PROi
PR:Q6ZPS6
RNActiQ6ZPS6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000040351, Expressed in cumulus cell and 306 other tissues
GenevisibleiQ6ZPS6, MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR031127, E3_UB_ligase_RBR
IPR002867, IBR_dom
IPR044066, TRIAD_supradom
IPR003903, UIM_dom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR11685, PTHR11685, 1 hit
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF01485, IBR, 2 hits
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00647, IBR, 2 hits
SM00184, RING, 2 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS51873, TRIAD, 1 hit
PS50330, UIM, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKIB1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZPS6
Secondary accession number(s): Q6AXE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 24, 2007
Last modified: June 2, 2021
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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