UniProtKB - Q6ZPR6 (IBTK_MOUSE)
Protein
Inhibitor of Bruton tyrosine kinase
Gene
Ibtk
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity).By similarity
GO - Molecular functioni
- protein kinase binding Source: MGI
- protein tyrosine kinase inhibitor activity Source: MGI
GO - Biological processi
- negative regulation of protein phosphorylation Source: MGI
- release of sequestered calcium ion into cytosol Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Inhibitor of Bruton tyrosine kinaseShort name: IBtk |
Gene namesi | Name:Ibtk Synonyms:Kiaa1417 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918677, Ibtk |
Subcellular locationi
Other locations
- Cytoplasm By similarity
- Membrane By similarity; Peripheral membrane protein By similarity
Note: Translocates to the plasma membrane upon IgM stimulation.By similarity
Nucleus
- nucleoplasm Source: MGI
Other locations
Keywords - Cellular componenti
Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280277 | 1 – 1352 | Inhibitor of Bruton tyrosine kinaseAdd BLAST | 1352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 991 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1005 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1031 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1034 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1040 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1046 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1055 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1084 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1111 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1113 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1116 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6ZPR6 |
jPOSTi | Q6ZPR6 |
PaxDbi | Q6ZPR6 |
PeptideAtlasi | Q6ZPR6 |
PRIDEi | Q6ZPR6 |
PTM databases
iPTMneti | Q6ZPR6 |
PhosphoSitePlusi | Q6ZPR6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000035941, Expressed in cumulus cell and 304 other tissues |
ExpressionAtlasi | Q6ZPR6, baseline and differential |
Genevisiblei | Q6ZPR6, MM |
Interactioni
Subunit structurei
Interacts with the PH domain of BTK.
By similarityGO - Molecular functioni
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 224442, 4 interactors |
STRINGi | 10090.ENSMUSP00000041145 |
Miscellaneous databases
RNActi | Q6ZPR6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 51 – 80 | ANK 1Add BLAST | 30 | |
Repeati | 85 – 114 | ANK 2Add BLAST | 30 | |
Repeati | 141 – 194 | RCC1 1Add BLAST | 54 | |
Repeati | 195 – 246 | RCC1 2Add BLAST | 52 | |
Repeati | 248 – 301 | RCC1 3Add BLAST | 54 | |
Domaini | 565 – 645 | BTB 1PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 769 – 837 | BTB 2PROSITE-ProRule annotationAdd BLAST | 69 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0783, Eukaryota |
GeneTreei | ENSGT00940000156277 |
HOGENOMi | CLU_005713_0_0_1 |
InParanoidi | Q6ZPR6 |
OMAi | PWIEATS |
OrthoDBi | 94875at2759 |
TreeFami | TF323747 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.130.10.30, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR000210, BTB/POZ_dom IPR009091, RCC1/BLIP-II IPR000408, Reg_chr_condens IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00651, BTB, 2 hits PF00415, RCC1, 3 hits |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00225, BTB, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF50985, SSF50985, 1 hit SSF54695, SSF54695, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits PS50097, BTB, 2 hits PS50012, RCC1_3, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZPR6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDAATPDCTS KCRSLKHALD VLSVVTKGSE SQIKSFLARY CYNAATVKDA
60 70 80 90 100
FGRNAGHLAS SCGKKGVLDW LIEKGVDLLV KDKESGWTAL HRSVFYGHID
110 120 130 140 150
CVWSLLKHGV SLYMQDKEGL SPLDLLMKDR PTHVVFKDTD PTEVYTWGDN
160 170 180 190 200
TNFTLGHGSQ NSKHHPELLD LFSRSGVYVK QVVLCKFHSV FLSQKGQVYT
210 220 230 240 250
CGHGRGGRLG HGDEQTCLVP RLVEGLSGHN CSQVAAAKDH TVVLTDDGCV
260 270 280 290 300
YTFGLNMFHQ LGIIPPPASC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT
310 320 330 340 350
REAVYTLGLN GGQLGHLLDP NGEKCVTTPR QVSALHHKDI AVSLVAASDG
360 370 380 390 400
ATVCVTTRGD IYLLADYQCK KMATKQLNLK KVLVSGGCME YKVDPEHLTE
410 420 430 440 450
NGGQKICVLA MDGAGRVFCW RSISSSLKQC RWAYPRQVSI SDIALNRNEI
460 470 480 490 500
LFVTQDGEGF KGKWFEDKRK NSEKKADILP NLHHSSSDVS CVPDTNSVYE
510 520 530 540 550
RIRLEKLPFA HRAVSVSTDP SGCNFAILQS DPKTSLYEIP VVSSSSFFEE
560 570 580 590 600
FGKLLRETDE MDSFHDVTFQ VGNRHFPAHK YILAVRSDFF QKLFLSDGSS
610 620 630 640 650
LELTDVYQKD EDAAGCHLFV VEKVHPDLFE YLLQFMYTDT CDLLTHGFKP
660 670 680 690 700
RMIVKRKAED CEGSPDSHLH TVNCHVDDKQ KSAFEVYRSN QAHTLSERQK
710 720 730 740 750
SKPKSSKKGK GVGDDDPVRM LQSVAKKFGL SNLSSRLEGV RLENEKINVI
760 770 780 790 800
AKKTGNKLKL SQKKCSFLYD VTMKSVDGKE FSCHKCVLCA RLEYFHSMLS
810 820 830 840 850
RSWIEASSCA ALEMPIQSEI LKVILDYLYT DEAVVIKESQ NVDFVCSVLV
860 870 880 890 900
VADQLLITRL KEICEVALTE NLTLKNAAML LEFAALYNAG QLKLSCLQFI
910 920 930 940 950
GLNMAALLEA RSLDVLSEDV LKDLSIFYRK MIPAMERRVI TPYQDGPDIS
960 970 980 990 1000
SMQVEDGEVF FKEEINMEPN YSETMFKKAK TRAKKKPRKR SDSSGGYTLS
1010 1020 1030 1040 1050
DVIQSPPSAG LLKSAKTNSV ESLPELLTSD SEGSYAGVAS PRDLQSPDFT
1060 1070 1080 1090 1100
AGFHSDKVEG KAKPYVNGIP PPCTREDVKP WEKSPTTKSA PQFIPSNRVD
1110 1120 1130 1140 1150
TAASSSWLAG SCSPVSPPVV DLRTIMETEE NRQKYGAAPK SNLGKIISHG
1160 1170 1180 1190 1200
IKLSQKQRKM IALTTKENNS GTNSMEAILT APSKSPKPAN AWAPLHSPLS
1210 1220 1230 1240 1250
RSFRDFLLEE KKPVPGYGSG DHVKKVCFKG TENSPALNVA RCSTHGTPGL
1260 1270 1280 1290 1300
ESNHVSDFPL LDSPNPWQSS SLAASPAVAP VTFASIVEEE RQQEAALIRS
1310 1320 1330 1340 1350
REKPLALIQV EEHAIQDLLV FYEAFGNPEE FVVVERAPQG PLAVPMWNKH
GC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WNN3 | A0A087WNN3_MOUSE | Inhibitor of Bruton tyrosine kinase | Ibtk | 495 | Annotation score: |
Sequence cautioni
The sequence BAC36779 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 282 | K → E in BAE20460 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1189 | A → V in BAC98163 (PubMed:14621295).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023605 | 137 – 237 | Missing in isoform 2. 1 PublicationAdd BLAST | 101 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH466522 Genomic DNA Translation: EDL26483.1 BC137798 mRNA Translation: AAI37799.1 AK030895 mRNA Translation: BAE20460.1 AK077387 mRNA Translation: BAC36779.1 Frameshift. AK129353 mRNA Translation: BAC98163.1 |
CCDSi | CCDS40712.1 [Q6ZPR6-1] |
RefSeqi | NP_001074751.1, NM_001081282.2 [Q6ZPR6-1] |
Genome annotation databases
Ensembli | ENSMUST00000039213; ENSMUSP00000041145; ENSMUSG00000035941 [Q6ZPR6-1] |
GeneIDi | 108837 |
KEGGi | mmu:108837 |
UCSCi | uc009qww.2, mouse [Q6ZPR6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH466522 Genomic DNA Translation: EDL26483.1 BC137798 mRNA Translation: AAI37799.1 AK030895 mRNA Translation: BAE20460.1 AK077387 mRNA Translation: BAC36779.1 Frameshift. AK129353 mRNA Translation: BAC98163.1 |
CCDSi | CCDS40712.1 [Q6ZPR6-1] |
RefSeqi | NP_001074751.1, NM_001081282.2 [Q6ZPR6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 224442, 4 interactors |
STRINGi | 10090.ENSMUSP00000041145 |
PTM databases
iPTMneti | Q6ZPR6 |
PhosphoSitePlusi | Q6ZPR6 |
Proteomic databases
EPDi | Q6ZPR6 |
jPOSTi | Q6ZPR6 |
PaxDbi | Q6ZPR6 |
PeptideAtlasi | Q6ZPR6 |
PRIDEi | Q6ZPR6 |
Protocols and materials databases
Antibodypediai | 18465, 125 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000039213; ENSMUSP00000041145; ENSMUSG00000035941 [Q6ZPR6-1] |
GeneIDi | 108837 |
KEGGi | mmu:108837 |
UCSCi | uc009qww.2, mouse [Q6ZPR6-1] |
Organism-specific databases
CTDi | 25998 |
MGIi | MGI:1918677, Ibtk |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0783, Eukaryota |
GeneTreei | ENSGT00940000156277 |
HOGENOMi | CLU_005713_0_0_1 |
InParanoidi | Q6ZPR6 |
OMAi | PWIEATS |
OrthoDBi | 94875at2759 |
TreeFami | TF323747 |
Miscellaneous databases
BioGRID-ORCSi | 108837, 0 hits in 18 CRISPR screens |
ChiTaRSi | Ibtk, mouse |
PROi | PR:Q6ZPR6 |
RNActi | Q6ZPR6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035941, Expressed in cumulus cell and 304 other tissues |
ExpressionAtlasi | Q6ZPR6, baseline and differential |
Genevisiblei | Q6ZPR6, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.130.10.30, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR000210, BTB/POZ_dom IPR009091, RCC1/BLIP-II IPR000408, Reg_chr_condens IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00651, BTB, 2 hits PF00415, RCC1, 3 hits |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00225, BTB, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF50985, SSF50985, 1 hit SSF54695, SSF54695, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits PS50097, BTB, 2 hits PS50012, RCC1_3, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBTK_MOUSE | |
Accessioni | Q6ZPR6Primary (citable) accession number: Q6ZPR6 Secondary accession number(s): B9EHE9, Q3V3X0, Q8BVL7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot