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UniProtKB - Q6ZPR6 (IBTK_MOUSE)

Entry version 133 (07 Apr 2021)
Sequence version 3 (27 Jul 2011)
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Protein

Inhibitor of Bruton tyrosine kinase

Gene

Ibtk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inhibitor of Bruton tyrosine kinase
Short name:
IBtk
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ibtk
Synonyms:Kiaa1417
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1918677, Ibtk

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002802771 – 1352Inhibitor of Bruton tyrosine kinaseAdd BLAST1352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei991PhosphoserineBy similarity1
Modified residuei1005PhosphoserineCombined sources1
Modified residuei1031PhosphoserineBy similarity1
Modified residuei1034PhosphoserineBy similarity1
Modified residuei1040PhosphoserineBy similarity1
Modified residuei1046PhosphoserineCombined sources1
Modified residuei1055PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1
Modified residuei1111PhosphoserineCombined sources1
Modified residuei1113PhosphoserineCombined sources1
Modified residuei1116PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZPR6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZPR6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZPR6

PeptideAtlas

More...PeptideAtlasi		Q6ZPR6

PRoteomics IDEntifications database

More...PRIDEi		Q6ZPR6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		267207 [Q6ZPR6-1]
267208 [Q6ZPR6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZPR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZPR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000035941, Expressed in cumulus cell and 304 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZPR6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZPR6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the PH domain of BTK.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		224442, 4 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000041145

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZPR6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 80ANK 1Add BLAST30
Repeati85 – 114ANK 2Add BLAST30
Repeati141 – 194RCC1 1Add BLAST54
Repeati195 – 246RCC1 2Add BLAST52
Repeati248 – 301RCC1 3Add BLAST54
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini565 – 645BTB 1PROSITE-ProRule annotationAdd BLAST81
Domaini769 – 837BTB 2PROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0783, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156277

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005713_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZPR6

Identification of Orthologs from Complete Genome Data

More...OMAi		PWIEATS

Database of Orthologous Groups

More...OrthoDBi		94875at2759

TreeFam database of animal gene trees

More...TreeFami		TF323747

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit
2.130.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR000210, BTB/POZ_dom
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR011333, SKP1/BTB/POZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit
PF00651, BTB, 2 hits
PF00415, RCC1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 2 hits
SM00225, BTB, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit
SSF50985, SSF50985, 1 hit
SSF54695, SSF54695, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50097, BTB, 2 hits
PS50012, RCC1_3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZPR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAATPDCTS KCRSLKHALD VLSVVTKGSE SQIKSFLARY CYNAATVKDA 
        60         70         80         90        100
FGRNAGHLAS SCGKKGVLDW LIEKGVDLLV KDKESGWTAL HRSVFYGHID 
       110        120        130        140        150
CVWSLLKHGV SLYMQDKEGL SPLDLLMKDR PTHVVFKDTD PTEVYTWGDN 
       160        170        180        190        200
TNFTLGHGSQ NSKHHPELLD LFSRSGVYVK QVVLCKFHSV FLSQKGQVYT 
       210        220        230        240        250
CGHGRGGRLG HGDEQTCLVP RLVEGLSGHN CSQVAAAKDH TVVLTDDGCV 
       260        270        280        290        300
YTFGLNMFHQ LGIIPPPASC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 
       310        320        330        340        350
REAVYTLGLN GGQLGHLLDP NGEKCVTTPR QVSALHHKDI AVSLVAASDG 
       360        370        380        390        400
ATVCVTTRGD IYLLADYQCK KMATKQLNLK KVLVSGGCME YKVDPEHLTE 
       410        420        430        440        450
NGGQKICVLA MDGAGRVFCW RSISSSLKQC RWAYPRQVSI SDIALNRNEI 
       460        470        480        490        500
LFVTQDGEGF KGKWFEDKRK NSEKKADILP NLHHSSSDVS CVPDTNSVYE 
       510        520        530        540        550
RIRLEKLPFA HRAVSVSTDP SGCNFAILQS DPKTSLYEIP VVSSSSFFEE 
       560        570        580        590        600
FGKLLRETDE MDSFHDVTFQ VGNRHFPAHK YILAVRSDFF QKLFLSDGSS 
       610        620        630        640        650
LELTDVYQKD EDAAGCHLFV VEKVHPDLFE YLLQFMYTDT CDLLTHGFKP 
       660        670        680        690        700
RMIVKRKAED CEGSPDSHLH TVNCHVDDKQ KSAFEVYRSN QAHTLSERQK 
       710        720        730        740        750
SKPKSSKKGK GVGDDDPVRM LQSVAKKFGL SNLSSRLEGV RLENEKINVI 
       760        770        780        790        800
AKKTGNKLKL SQKKCSFLYD VTMKSVDGKE FSCHKCVLCA RLEYFHSMLS 
       810        820        830        840        850
RSWIEASSCA ALEMPIQSEI LKVILDYLYT DEAVVIKESQ NVDFVCSVLV 
       860        870        880        890        900
VADQLLITRL KEICEVALTE NLTLKNAAML LEFAALYNAG QLKLSCLQFI 
       910        920        930        940        950
GLNMAALLEA RSLDVLSEDV LKDLSIFYRK MIPAMERRVI TPYQDGPDIS 
       960        970        980        990       1000
SMQVEDGEVF FKEEINMEPN YSETMFKKAK TRAKKKPRKR SDSSGGYTLS 
      1010       1020       1030       1040       1050
DVIQSPPSAG LLKSAKTNSV ESLPELLTSD SEGSYAGVAS PRDLQSPDFT 
      1060       1070       1080       1090       1100
AGFHSDKVEG KAKPYVNGIP PPCTREDVKP WEKSPTTKSA PQFIPSNRVD 
      1110       1120       1130       1140       1150
TAASSSWLAG SCSPVSPPVV DLRTIMETEE NRQKYGAAPK SNLGKIISHG 
      1160       1170       1180       1190       1200
IKLSQKQRKM IALTTKENNS GTNSMEAILT APSKSPKPAN AWAPLHSPLS 
      1210       1220       1230       1240       1250
RSFRDFLLEE KKPVPGYGSG DHVKKVCFKG TENSPALNVA RCSTHGTPGL 
      1260       1270       1280       1290       1300
ESNHVSDFPL LDSPNPWQSS SLAASPAVAP VTFASIVEEE RQQEAALIRS 
      1310       1320       1330       1340       1350
REKPLALIQV EEHAIQDLLV FYEAFGNPEE FVVVERAPQG PLAVPMWNKH 

GC
Length:1,352
Mass (Da):149,569
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FA4BC368281D734
GO
Isoform 2 (identifier: Q6ZPR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-237: Missing.

Show »
Length:1,251
Mass (Da):138,576
Checksum:iCAB5A6660438838A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WNN3A0A087WNN3_MOUSE
Inhibitor of Bruton tyrosine kinase
Ibtk
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC36779 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti282K → E in BAE20460 (PubMed:16141072).Curated1
Sequence conflicti1189A → V in BAC98163 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023605137 – 237Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH466522 Genomic DNA Translation: EDL26483.1
BC137798 mRNA Translation: AAI37799.1
AK030895 mRNA Translation: BAE20460.1
AK077387 mRNA Translation: BAC36779.1 Frameshift.
AK129353 mRNA Translation: BAC98163.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS40712.1 [Q6ZPR6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001074751.1, NM_001081282.2 [Q6ZPR6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000039213; ENSMUSP00000041145; ENSMUSG00000035941 [Q6ZPR6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		108837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:108837

UCSC genome browser

More...UCSCi		uc009qww.2, mouse [Q6ZPR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466522 Genomic DNA Translation: EDL26483.1
BC137798 mRNA Translation: AAI37799.1
AK030895 mRNA Translation: BAE20460.1
AK077387 mRNA Translation: BAC36779.1 Frameshift.
AK129353 mRNA Translation: BAC98163.1
CCDSiCCDS40712.1 [Q6ZPR6-1]
RefSeqiNP_001074751.1, NM_001081282.2 [Q6ZPR6-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi224442, 4 interactors
STRINGi10090.ENSMUSP00000041145

PTM databases

iPTMnetiQ6ZPR6
PhosphoSitePlusiQ6ZPR6

Proteomic databases

EPDiQ6ZPR6
jPOSTiQ6ZPR6
PaxDbiQ6ZPR6
PeptideAtlasiQ6ZPR6
PRIDEiQ6ZPR6
ProteomicsDBi267207 [Q6ZPR6-1]
267208 [Q6ZPR6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18465, 128 antibodies

Genome annotation databases

EnsembliENSMUST00000039213; ENSMUSP00000041145; ENSMUSG00000035941 [Q6ZPR6-1]
GeneIDi108837
KEGGimmu:108837
UCSCiuc009qww.2, mouse [Q6ZPR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25998
MGIiMGI:1918677, Ibtk

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG0783, Eukaryota
GeneTreeiENSGT00940000156277
HOGENOMiCLU_005713_0_0_1
InParanoidiQ6ZPR6
OMAiPWIEATS
OrthoDBi94875at2759
TreeFamiTF323747

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		108837, 0 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ibtk, mouse

Protein Ontology

More...PROi		PR:Q6ZPR6
RNActiQ6ZPR6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000035941, Expressed in cumulus cell and 304 other tissues
ExpressionAtlasiQ6ZPR6, baseline and differential
GenevisibleiQ6ZPR6, MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR000210, BTB/POZ_dom
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR011333, SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00651, BTB, 2 hits
PF00415, RCC1, 3 hits
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00225, BTB, 2 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF50985, SSF50985, 1 hit
SSF54695, SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50097, BTB, 2 hits
PS50012, RCC1_3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIBTK_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZPR6
Secondary accession number(s): B9EHE9, Q3V3X0, Q8BVL7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 27, 2011
Last modified: April 7, 2021
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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