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Protein

Potassium channel subfamily T member 1

Gene

Kcnt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandCalcium, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily T member 1
Gene namesi
Name:Kcnt1
Synonyms:Kiaa1422
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924627 Kcnt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Transmembranei84 – 104Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini105 – 141ExtracellularSequence analysisAdd BLAST37
Transmembranei142 – 162Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini163 – 173CytoplasmicSequence analysisAdd BLAST11
Transmembranei174 – 194Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini195 – 199ExtracellularSequence analysis5
Transmembranei200 – 212Helical; Name=Segment S4Sequence analysisAdd BLAST13
Topological domaini213 – 237CytoplasmicSequence analysisAdd BLAST25
Transmembranei238 – 258Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini259 – 267ExtracellularSequence analysis9
Intramembranei268 – 288Pore-formingSequence analysisAdd BLAST21
Topological domaini289 – 290ExtracellularSequence analysis2
Transmembranei291 – 311Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini312 – 1224CytoplasmicSequence analysisAdd BLAST913

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540911 – 1224Potassium channel subfamily T member 1Add BLAST1224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6ZPR4
PRIDEiQ6ZPR4

PTM databases

iPTMnetiQ6ZPR4
PhosphoSitePlusiQ6ZPR4

Expressioni

Gene expression databases

BgeeiENSMUSG00000058740 Expressed in 112 organ(s), highest expression level in cerebellum
CleanExiMM_KCNT1
ExpressionAtlasiQ6ZPR4 baseline and differential
GenevisibleiQ6ZPR4 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (By similarity). Interacts with CRBN via its cytoplasmic C-terminus (By similarity).By similarity

Protein-protein interaction databases

BioGridi230652, 1 interactor
IntActiQ6ZPR4, 1 interactor
STRINGi10090.ENSMUSP00000039058

Structurei

3D structure databases

ProteinModelPortaliQ6ZPR4
SMRiQ6ZPR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini461 – 582RCK N-terminalAdd BLAST122

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00530000063026
HOGENOMiHOG000231460
HOVERGENiHBG055190
InParanoidiQ6ZPR4
KOiK04946

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q6ZPR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARAKLPRSP SEGKAGPGDT PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG
60 70 80 90 100
QRVQVEFYVN ENTFKERLKL FFIKNQRSSL RIRLFNFSLK LLTCLLYIVR
110 120 130 140 150
VLLDNPDQGI GCWGCTKYNY TFNGSSSEFH WAPILWVERK MALWVIQVIV
160 170 180 190 200
ATISFLETML IIYLSYKGNI WEQIFHVSFV LEMINTLPFI ITVFWPPLRN
210 220 230 240 250
LFIPVFLNCW LAKHALENMI NDFHRAILRT QSAMFNQVLI LFCTLLCLVF
260 270 280 290 300
TGTCGIQHLE RAGGNLNLLT SFYFCIVTFS TVGFGDVTPK IWPSQLLVVI
310 320 330 340 350
LICVTLVVLP LQFEELVYLW MERQKSGGNY SRHRARTEKH VVLCVSSLKI
360 370 380 390 400
DLLMDFLNEF YAHPRLQDYY VVILCPSEMD VQVRRVLQIP LWSQRVIYLQ
410 420 430 440 450
GSALKDQDLM RAKMDNGEAC FILSSRNEVD RTAADHQTIL RAWAVKDFAP
460 470 480 490 500
NCPLYVQILK PENKFHVKFA DHVVCEEECK YAMLALNCIC PATSTLITLL
510 520 530 540 550
VHTSRGQEGQ ESPEQWQRTY GRCSGNEVYH IRMGDSKFFR EYEGKSFTYA
560 570 580 590 600
AFHAHKKYGV CLIGLKREEN KSILLNPGPR HILAASDTCF YINITKEENS
610 620 630 640 650
AFIFKQEEKQ KRRGLAGQAL YEGPSRLPVH SIIASMGTVA MDLQNTDCRP
660 670 680 690 700
SQGGSGGDGT KLTLPTENGS GSRRPSIAPV LELADSSALL PCDLLSDQSE
710 720 730 740 750
DEVTPSDDEG LSVVEYVKGY PPNSPYIGSS PTLCHLLPVK APFCCLRLDK
760 770 780 790 800
GCKHNSYEDA KAYGFKNKLI IVSAETAGNG LYNFIVPLRA YYRSRRELNP
810 820 830 840 850
IVLLLDNKPD HHFLEAICCF PMVYYMEGSV DNLDSLLQCG IIYADNLVVV
860 870 880 890 900
DKESTMSAEE DYMADAKTIV NVQTMFRLFP SLSITTELTH PSNMRFMQFR
910 920 930 940 950
AKDSYSLALS KLEKQERENG SNLAFMFRLP FAAGRVFSIS MLDTLLYQSF
960 970 980 990 1000
VKDYMITITR LLLGLDTTPG SGYLCAMKVT EDDLWIRTYG RLFQKLCSSS
1010 1020 1030 1040 1050
AEIPIGIYRT ECHVFSEPHD VRAQSQISVN MEDCEDTREA KGPWGTRAAS
1060 1070 1080 1090 1100
GSGSTHGRHG GSADPVEHPL LRRKSLQWAR KLSRKSTKQA GKAPVATDWI
1110 1120 1130 1140 1150
TQQRLSLYRR SERQELSELV KNRMKHLGLP TTGYEDVANL TASDVMNRVN
1160 1170 1180 1190 1200
LGYLQDEMND HHQNTLSYVL INPPPDTRLE PNDIVYLIRS DPLAHVASSS
1210 1220
QSRKSSCSNK LSSCNPETRD ETQL
Length:1,224
Mass (Da):138,106
Last modified:August 30, 2005 - v2
Checksum:i7F343893D70E506B
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AHB8A2AHB8_MOUSE
Potassium channel subfamily T membe...
Kcnt1
1,238Annotation score:
A2AHB7A2AHB7_MOUSE
Potassium channel subfamily T membe...
Kcnt1
1,217Annotation score:
A2AHB9A2AHB9_MOUSE
Potassium channel subfamily T membe...
Kcnt1
1,236Annotation score:
C0KTP6C0KTP6_MOUSE
Potassium channel subfamily T membe...
Kcnt1
1,218Annotation score:
A0A0G2JER3A0A0G2JER3_MOUSE
Potassium channel subfamily T membe...
Kcnt1
1,183Annotation score:
A0A0G2JG99A0A0G2JG99_MOUSE
Potassium channel subfamily T membe...
Kcnt1
1,202Annotation score:
A0A0G2JG91A0A0G2JG91_MOUSE
Potassium channel subfamily T membe...
Kcnt1
36Annotation score:
A0A0G2JDW4A0A0G2JDW4_MOUSE
Potassium channel subfamily T membe...
Kcnt1
330Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141190 mRNA Translation: AAI41191.1
BC171963 mRNA Translation: AAI71963.1
AK086119 mRNA Translation: BAC39614.1
AK129355 mRNA Translation: BAC98165.1
CCDSiCCDS79757.1
RefSeqiNP_001289280.1, NM_001302351.1
NP_780671.2, NM_175462.4
UniGeneiMm.119462

Genome annotation databases

EnsembliENSMUST00000114172; ENSMUSP00000109809; ENSMUSG00000058740
GeneIDi227632
KEGGimmu:227632
UCSCiuc008itq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141190 mRNA Translation: AAI41191.1
BC171963 mRNA Translation: AAI71963.1
AK086119 mRNA Translation: BAC39614.1
AK129355 mRNA Translation: BAC98165.1
CCDSiCCDS79757.1
RefSeqiNP_001289280.1, NM_001302351.1
NP_780671.2, NM_175462.4
UniGeneiMm.119462

3D structure databases

ProteinModelPortaliQ6ZPR4
SMRiQ6ZPR4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230652, 1 interactor
IntActiQ6ZPR4, 1 interactor
STRINGi10090.ENSMUSP00000039058

Chemistry databases

GuidetoPHARMACOLOGYi385

PTM databases

iPTMnetiQ6ZPR4
PhosphoSitePlusiQ6ZPR4

Proteomic databases

PaxDbiQ6ZPR4
PRIDEiQ6ZPR4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114172; ENSMUSP00000109809; ENSMUSG00000058740
GeneIDi227632
KEGGimmu:227632
UCSCiuc008itq.2 mouse

Organism-specific databases

CTDi57582
MGIiMGI:1924627 Kcnt1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00530000063026
HOGENOMiHOG000231460
HOVERGENiHBG055190
InParanoidiQ6ZPR4
KOiK04946

Miscellaneous databases

PROiPR:Q6ZPR4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058740 Expressed in 112 organ(s), highest expression level in cerebellum
CleanExiMM_KCNT1
ExpressionAtlasiQ6ZPR4 baseline and differential
GenevisibleiQ6ZPR4 MM

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNT1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPR4
Secondary accession number(s): B2RUK3, Q8C3E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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