UniProtKB - Q6ZPJ0 (TEX2_MOUSE)
Protein
Testis-expressed protein 2
Gene
Tex2
Organism
Mus musculus (Mouse)
Status
Functioni
During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation.By similarity
GO - Molecular functioni
- lipid binding Source: GO_Central
GO - Biological processi
- lipid transport Source: UniProtKB-KW
Keywordsi
Biological process | Lipid transport, Transport |
Ligand | Lipid-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Testis-expressed protein 2 |
Gene namesi | Name:Tex2 Synonyms:Kiaa1738 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102465, Tex2 |
Subcellular locationi
Nucleus
- Nucleus membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Enriched at the nucleus-vacuole junction (By similarity). During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (By similarity).By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 473 – 493 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 495 – 515 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000244480 | 1 – 1128 | Testis-expressed protein 2Add BLAST | 1128 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 195 | PhosphoserineBy similarity | 1 | |
Modified residuei | 261 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 264 | PhosphoserineCombined sources | 1 | |
Modified residuei | 265 | PhosphoserineCombined sources | 1 | |
Modified residuei | 269 | PhosphoserineCombined sources | 1 | |
Modified residuei | 294 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 593 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 733 | PhosphoserineBy similarity | 1 | |
Modified residuei | 739 | PhosphoserineBy similarity | 1 | |
Modified residuei | 745 | PhosphoserineBy similarity | 1 | |
Modified residuei | 749 | PhosphoserineCombined sources | 1 | |
Modified residuei | 752 | PhosphoserineCombined sources | 1 | |
Modified residuei | 799 | PhosphoserineCombined sources | 1 | |
Modified residuei | 816 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q6ZPJ0 |
MaxQBi | Q6ZPJ0 |
PaxDbi | Q6ZPJ0 |
PeptideAtlasi | Q6ZPJ0 |
PRIDEi | Q6ZPJ0 |
ProteomicsDBi | 263108 |
PTM databases
GlyGeni | Q6ZPJ0, 1 site |
iPTMneti | Q6ZPJ0 |
PhosphoSitePlusi | Q6ZPJ0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040548, Expressed in testis and 288 other tissues |
ExpressionAtlasi | Q6ZPJ0, baseline and differential |
Genevisiblei | Q6ZPJ0, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 204128, 2 interactors |
IntActi | Q6ZPJ0, 1 interactor |
STRINGi | 10090.ENSMUSP00000041985 |
Miscellaneous databases
RNActi | Q6ZPJ0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 817 – 1102 | SMP-LTDPROSITE-ProRule annotationAdd BLAST | 286 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 51 | Poly-Glu | 9 | |
Compositional biasi | 134 – 195 | Ser-richAdd BLAST | 62 | |
Compositional biasi | 817 – 822 | Poly-Glu | 6 | |
Compositional biasi | 1040 – 1043 | Poly-Pro | 4 |
Domaini
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2238, Eukaryota |
GeneTreei | ENSGT00390000000463 |
HOGENOMi | CLU_008315_0_0_1 |
InParanoidi | Q6ZPJ0 |
OMAi | MARCVPQ |
OrthoDBi | 332149at2759 |
PhylomeDBi | Q6ZPJ0 |
TreeFami | TF314900 |
Family and domain databases
InterProi | View protein in InterPro IPR031468, SMP_LBD |
PROSITEi | View protein in PROSITE PS51847, SMP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q6ZPJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSLNGRHAE KTIDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE
60 70 80 90 100
EFRGYLEEGL DDQSIVTGLE AKEDLYLESQ GGHDPAGPVS TAPADGLSVS
110 120 130 140 150
ESPAILPVSE NTVKLLESPA PALQVLSPVP LALSPGSSSS GPLASSPSVS
160 170 180 190 200
SLSEQKTSSS SPLSSPSKSP VLSSSASSSA LSSAKPFMSL VKSLSTEVEP
210 220 230 240 250
KESPHPPRHR HLMKTLVKSL STDTSRQESD TVSYKPPDSK LNLHLFKQFT
260 270 280 290 300
QPRNTGGDSK TAPSSPLTSP SDTRSFFKVP EMEAKIEDTK RRLSEVIYEP
310 320 330 340 350
FQLLSKIIGE ESGSHRPKAL SASASELSSL SGLNGHLESN NYSIKEEEGD
360 370 380 390 400
SEGEGYGSDS NTSRSDHLKP TEDASKEVEP KGSQASSLKD LGLKTSSLVL
410 420 430 440 450
EKCSLSALVS KEDEEFCELY TEDFELETEG EGRLDKTLDL PLKPEVLASD
460 470 480 490 500
GVALESEDEE DSATEHQELP VKTLGFFIMC VYAYLILPLP YYMSGLFLGV
510 520 530 540 550
GLGFMTAVCM IWFFTPPSAH KHHKSLKALR HQSTRSLDIK EPEILKGWMN
560 570 580 590 600
EIYNYDPETY HATLTHSVFV RLEGGTLRLS KPNKNISRRA SYNETKPEVT
610 620 630 640 650
YISQKIYDLS DSKIYLVPKS LARKRIWNKK YPICIELGRQ DDFMSKAQSD
660 670 680 690 700
KEATEEKPPP EKELPSEDLK KPPQPQEGTK SSQRDPILYL FGRTGREKEE
710 720 730 740 750
WFRRFILASR LKSELRKPAG VSGSKSGLLP AHSRHSSPSG HLSHSRSSSK
760 770 780 790 800
GSVEEMMSQP KQKELVGSVR QKMLLDYSVY MGRCVPQDNR SPHRSPVQSA
810 820 830 840 850
ESSPTASKKL PEAPPSEEEE QEAWVNALLG RIFWDFLGEK YWSDVVSKKI
860 870 880 890 900
QMKLSKIKLP YFMNELTLTE LDMGVAVPKI LQAFKPYVDH QGLWIDLEMS
910 920 930 940 950
YNGSFLMTLE TKMNLTKLGK EPLVEALKVG EIGKEGCRPR AYCLADSDEE
960 970 980 990 1000
SSSAGSSEED DPPEPTAGDK QPLPGAEGYV GGHRTSKIMR FVDKITKSKY
1010 1020 1030 1040 1050
FQKATETEFI KKKIEEVSNT PLLLTVEVQE CRGTLAVNIP PPPTDRIWYG
1060 1070 1080 1090 1100
FRKPPYVELK ARPKLGEREV TLVHVTEWIE KKLEQELQKV FVMPNMDDVY
1110 1120
IPIMHSAMDP RSTSCLLKEP PVETSDQL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A140LHL8 | A0A140LHL8_MOUSE | Testis-expressed protein 2 | Tex2 | 629 | Annotation score: | ||
B1ATR2 | B1ATR2_MOUSE | Testis-expressed protein 2 | Tex2 | 844 | Annotation score: | ||
B1ATR3 | B1ATR3_MOUSE | Testis-expressed protein 2 | Tex2 | 168 | Annotation score: | ||
B1ATR4 | B1ATR4_MOUSE | Testis-expressed protein 2 | Tex2 | 40 | Annotation score: |
Sequence cautioni
The sequence BAC98244 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK129434 mRNA Translation: BAC98244.1 Different initiation. AL663053 Genomic DNA No translation available. |
CCDSi | CCDS25557.1 |
RefSeqi | NP_938034.2, NM_198292.3 XP_006533206.1, XM_006533143.3 XP_006533207.1, XM_006533144.3 XP_006533208.1, XM_006533145.1 XP_006533209.1, XM_006533146.3 XP_006533210.1, XM_006533147.3 |
Genome annotation databases
Ensembli | ENSMUST00000042780; ENSMUSP00000041985; ENSMUSG00000040548 |
GeneIDi | 21763 |
KEGGi | mmu:21763 |
UCSCi | uc007lzb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK129434 mRNA Translation: BAC98244.1 Different initiation. AL663053 Genomic DNA No translation available. |
CCDSi | CCDS25557.1 |
RefSeqi | NP_938034.2, NM_198292.3 XP_006533206.1, XM_006533143.3 XP_006533207.1, XM_006533144.3 XP_006533208.1, XM_006533145.1 XP_006533209.1, XM_006533146.3 XP_006533210.1, XM_006533147.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 204128, 2 interactors |
IntActi | Q6ZPJ0, 1 interactor |
STRINGi | 10090.ENSMUSP00000041985 |
PTM databases
GlyGeni | Q6ZPJ0, 1 site |
iPTMneti | Q6ZPJ0 |
PhosphoSitePlusi | Q6ZPJ0 |
Proteomic databases
EPDi | Q6ZPJ0 |
MaxQBi | Q6ZPJ0 |
PaxDbi | Q6ZPJ0 |
PeptideAtlasi | Q6ZPJ0 |
PRIDEi | Q6ZPJ0 |
ProteomicsDBi | 263108 |
Protocols and materials databases
Antibodypediai | 19114, 94 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042780; ENSMUSP00000041985; ENSMUSG00000040548 |
GeneIDi | 21763 |
KEGGi | mmu:21763 |
UCSCi | uc007lzb.1, mouse |
Organism-specific databases
CTDi | 55852 |
MGIi | MGI:102465, Tex2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2238, Eukaryota |
GeneTreei | ENSGT00390000000463 |
HOGENOMi | CLU_008315_0_0_1 |
InParanoidi | Q6ZPJ0 |
OMAi | MARCVPQ |
OrthoDBi | 332149at2759 |
PhylomeDBi | Q6ZPJ0 |
TreeFami | TF314900 |
Miscellaneous databases
BioGRID-ORCSi | 21763, 1 hit in 52 CRISPR screens |
ChiTaRSi | Tex2, mouse |
PROi | PR:Q6ZPJ0 |
RNActi | Q6ZPJ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040548, Expressed in testis and 288 other tissues |
ExpressionAtlasi | Q6ZPJ0, baseline and differential |
Genevisiblei | Q6ZPJ0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR031468, SMP_LBD |
PROSITEi | View protein in PROSITE PS51847, SMP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEX2_MOUSE | |
Accessioni | Q6ZPJ0Primary (citable) accession number: Q6ZPJ0 Secondary accession number(s): B1ATR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | April 7, 2021 | |
This is version 108 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot