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Protein

Ligand-dependent corepressor

Gene

Lcor

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi368 – 388H-T-H motifPROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: MGI
  • transcription factor binding Source: MGI

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent corepressor
Short name:
LCoR
Alternative name(s):
Mblk1-related protein 2
Gene namesi
Name:Lcor
Synonyms:Kiaa1795, Mlr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2443930 Lcor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002368081 – 433Ligand-dependent corepressorAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei249PhosphoserineBy similarity1
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6ZPI3
MaxQBiQ6ZPI3
PaxDbiQ6ZPI3
PRIDEiQ6ZPI3

PTM databases

iPTMnetiQ6ZPI3
PhosphoSitePlusiQ6ZPI3

Expressioni

Tissue specificityi

Detected in heart and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000025019
CleanExiMM_LCOR
ExpressionAtlasiQ6ZPI3 baseline and differential
GenevisibleiQ6ZPI3 MM

Interactioni

Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2 (By similarity).By similarity

GO - Molecular functioni

  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi229316, 2 interactors
DIPiDIP-60279N
IntActiQ6ZPI3, 1 interactor
STRINGi10090.ENSMUSP00000067603

Structurei

3D structure databases

ProteinModelPortaliQ6ZPI3
SMRiQ6ZPI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 392HTH psq-typePROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi53 – 57Interaction with nuclear receptorsBy similarity5
Motifi339 – 345Nuclear localization signalSequence analysis7

Phylogenomic databases

eggNOGiKOG4565 Eukaryota
ENOG4111GCI LUCA
GeneTreeiENSGT00520000055615
HOGENOMiHOG000253915
HOVERGENiHBG079596
InParanoidiQ6ZPI3
OMAiNSAFQKM
OrthoDBiEOG091G0N6A
PhylomeDBiQ6ZPI3
TreeFamiTF319589

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF05225 HTH_psq, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50960 HTH_PSQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZPI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRMIQQFAA EYTSKTSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN
60 70 80 90 100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCASSTSLSH
110 120 130 140 150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK
160 170 180 190 200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY
210 220 230 240 250
EFSLSRMKFR GNGALSNISD LPFLAENSAF PKMAHQTKQD GKRDMSHSSP
260 270 280 290 300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQN
310 320 330 340 350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN
360 370 380 390 400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK
410 420 430
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KTE
Length:433
Mass (Da):47,125
Last modified:May 30, 2006 - v2
Checksum:i736656D1F7E9A041
GO

Sequence cautioni

The sequence BAC98252 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32988 differs from that shown. Reason: Frameshift at position 421.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311S → F in BAE32988 (PubMed:16141072).Curated1
Sequence conflicti382L → P in AAH90652 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076079 mRNA Translation: BAC20955.1
AK129442 mRNA Translation: BAC98252.1 Different initiation.
AK041090 mRNA Translation: BAC30816.1
AK041621 mRNA Translation: BAC31007.2
AK155007 mRNA Translation: BAE32988.1 Frameshift.
BC050068 mRNA Translation: AAH50068.1
BC090652 mRNA Translation: AAH90652.1
CCDSiCCDS29810.1
RefSeqiNP_742166.1, NM_172154.4
XP_006526912.1, XM_006526849.3
XP_006526913.1, XM_006526850.3
UniGeneiMm.422910
Mm.459119

Genome annotation databases

EnsembliENSMUST00000067795; ENSMUSP00000067603; ENSMUSG00000025019
ENSMUST00000163929; ENSMUSP00000126441; ENSMUSG00000025019
GeneIDi212391
KEGGimmu:212391
UCSCiuc008hly.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLCOR_MOUSE
AccessioniPrimary (citable) accession number: Q6ZPI3
Secondary accession number(s): Q3U302
, Q5CZW7, Q80VA8, Q8BGT2, Q8C9Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 23, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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