UniProtKB - Q6ZPI3 (LCOR_MOUSE)
Protein
Ligand-dependent corepressor
Gene
Lcor
Organism
Mus musculus (Mouse)
Status
Functioni
Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 368 – 388 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 21 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: UniProtKB-KW
- estrogen receptor binding Source: MGI
- histone deacetylase binding Source: MGI
- histone methyltransferase binding Source: MGI
- RNA polymerase II transcription corepressor binding Source: MGI
- transcription corepressor activity Source: MGI
- ubiquitin-specific protease binding Source: MGI
GO - Biological processi
- cellular response to estradiol stimulus Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of histone H3-K27 trimethylation Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: MGI
- transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Ligand-dependent corepressorShort name: LCoR Alternative name(s): Mblk1-related protein 2 |
Gene namesi | Name:Lcor Synonyms:Kiaa1795, Mlr2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443930, Lcor |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000236808 | 1 – 433 | Ligand-dependent corepressorAdd BLAST | 433 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 42 | PhosphoserineBy similarity | 1 | |
Modified residuei | 63 | PhosphoserineBy similarity | 1 | |
Modified residuei | 249 | PhosphoserineBy similarity | 1 | |
Cross-linki | 254 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 414 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6ZPI3 |
jPOSTi | Q6ZPI3 |
MaxQBi | Q6ZPI3 |
PaxDbi | Q6ZPI3 |
PRIDEi | Q6ZPI3 |
ProteomicsDBi | 286181 |
PTM databases
iPTMneti | Q6ZPI3 |
PhosphoSitePlusi | Q6ZPI3 |
Expressioni
Tissue specificityi
Detected in heart and kidney.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000025019, Expressed in epithelium of small intestine and 291 other tissues |
ExpressionAtlasi | Q6ZPI3, baseline and differential |
Genevisiblei | Q6ZPI3, MM |
Interactioni
Subunit structurei
Interacts with ESR1 and ESR2 in the presence of estradiol.
Interacts with CTBP1, HDAC3 and HDAC6.
Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2 (By similarity).
By similarityGO - Molecular functioni
- estrogen receptor binding Source: MGI
- histone deacetylase binding Source: MGI
- histone methyltransferase binding Source: MGI
- RNA polymerase II transcription corepressor binding Source: MGI
- ubiquitin-specific protease binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 229316, 2 interactors |
DIPi | DIP-60279N |
IntActi | Q6ZPI3, 1 interactor |
STRINGi | 10090.ENSMUSP00000067603 |
Miscellaneous databases
RNActi | Q6ZPI3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 340 – 392 | HTH psq-typePROSITE-ProRule annotationAdd BLAST | 53 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 53 – 57 | Interaction with nuclear receptorsBy similarity | 5 | |
Motifi | 339 – 345 | Nuclear localization signalSequence analysis | 7 |
Phylogenomic databases
eggNOGi | KOG4565, Eukaryota |
GeneTreei | ENSGT00940000162611 |
HOGENOMi | CLU_040042_0_0_1 |
InParanoidi | Q6ZPI3 |
OMAi | ECEDFKQ |
OrthoDBi | 134164at2759 |
PhylomeDBi | Q6ZPI3 |
TreeFami | TF319589 |
Family and domain databases
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR007889, HTH_Psq |
Pfami | View protein in Pfam PF05225, HTH_psq, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50960, HTH_PSQ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q6ZPI3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQRMIQQFAA EYTSKTSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN
60 70 80 90 100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCASSTSLSH
110 120 130 140 150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK
160 170 180 190 200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY
210 220 230 240 250
EFSLSRMKFR GNGALSNISD LPFLAENSAF PKMAHQTKQD GKRDMSHSSP
260 270 280 290 300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQN
310 320 330 340 350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN
360 370 380 390 400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK
410 420 430
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KTE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A571BF12 | A0A571BF12_MOUSE | Ligand-dependent corepressor | Lcor | 1,696 | Annotation score: | ||
A0A494B9R4 | A0A494B9R4_MOUSE | Ligand-dependent corepressor | Lcor | 396 | Annotation score: | ||
F6RGI3 | F6RGI3_MOUSE | Ligand-dependent corepressor | Lcor | 1,242 | Annotation score: | ||
A0A571BE94 | A0A571BE94_MOUSE | Ligand-dependent corepressor | Lcor | 1,563 | Annotation score: |
Sequence cautioni
The sequence BAC98252 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32988 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 311 | S → F in BAE32988 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 382 | L → P in AAH90652 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076079 mRNA Translation: BAC20955.1 AK129442 mRNA Translation: BAC98252.1 Different initiation. AK041090 mRNA Translation: BAC30816.1 AK041621 mRNA Translation: BAC31007.2 AK155007 mRNA Translation: BAE32988.1 Frameshift. BC050068 mRNA Translation: AAH50068.1 BC090652 mRNA Translation: AAH90652.1 |
CCDSi | CCDS29810.1 |
RefSeqi | NP_742166.1, NM_172154.4 XP_006526912.1, XM_006526849.3 XP_006526913.1, XM_006526850.3 |
Genome annotation databases
Ensembli | ENSMUST00000067795; ENSMUSP00000067603; ENSMUSG00000025019 ENSMUST00000163929; ENSMUSP00000126441; ENSMUSG00000025019 |
GeneIDi | 212391 |
KEGGi | mmu:212391 |
UCSCi | uc008hly.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076079 mRNA Translation: BAC20955.1 AK129442 mRNA Translation: BAC98252.1 Different initiation. AK041090 mRNA Translation: BAC30816.1 AK041621 mRNA Translation: BAC31007.2 AK155007 mRNA Translation: BAE32988.1 Frameshift. BC050068 mRNA Translation: AAH50068.1 BC090652 mRNA Translation: AAH90652.1 |
CCDSi | CCDS29810.1 |
RefSeqi | NP_742166.1, NM_172154.4 XP_006526912.1, XM_006526849.3 XP_006526913.1, XM_006526850.3 |
3D structure databases
SMRi | Q6ZPI3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229316, 2 interactors |
DIPi | DIP-60279N |
IntActi | Q6ZPI3, 1 interactor |
STRINGi | 10090.ENSMUSP00000067603 |
PTM databases
iPTMneti | Q6ZPI3 |
PhosphoSitePlusi | Q6ZPI3 |
Proteomic databases
EPDi | Q6ZPI3 |
jPOSTi | Q6ZPI3 |
MaxQBi | Q6ZPI3 |
PaxDbi | Q6ZPI3 |
PRIDEi | Q6ZPI3 |
ProteomicsDBi | 286181 |
Genome annotation databases
Ensembli | ENSMUST00000067795; ENSMUSP00000067603; ENSMUSG00000025019 ENSMUST00000163929; ENSMUSP00000126441; ENSMUSG00000025019 |
GeneIDi | 212391 |
KEGGi | mmu:212391 |
UCSCi | uc008hly.1, mouse |
Organism-specific databases
CTDi | 84458 |
MGIi | MGI:2443930, Lcor |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG4565, Eukaryota |
GeneTreei | ENSGT00940000162611 |
HOGENOMi | CLU_040042_0_0_1 |
InParanoidi | Q6ZPI3 |
OMAi | ECEDFKQ |
OrthoDBi | 134164at2759 |
PhylomeDBi | Q6ZPI3 |
TreeFami | TF319589 |
Miscellaneous databases
BioGRID-ORCSi | 212391, 0 hits in 52 CRISPR screens |
ChiTaRSi | Lcor, mouse |
PROi | PR:Q6ZPI3 |
RNActi | Q6ZPI3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025019, Expressed in epithelium of small intestine and 291 other tissues |
ExpressionAtlasi | Q6ZPI3, baseline and differential |
Genevisiblei | Q6ZPI3, MM |
Family and domain databases
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR007889, HTH_Psq |
Pfami | View protein in Pfam PF05225, HTH_psq, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50960, HTH_PSQ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LCOR_MOUSE | |
Accessioni | Q6ZPI3Primary (citable) accession number: Q6ZPI3 Secondary accession number(s): Q3U302 Q8C9Q0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | May 30, 2006 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot