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Entry version 133 (17 Jun 2020)
Sequence version 2 (05 Feb 2008)
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Protein

T-lymphoma invasion and metastasis-inducing protein 2

Gene

Tiam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-lymphoma invasion and metastasis-inducing protein 2Curated
Short name:
TIAM-2
Alternative name(s):
SIF and TIAM1-like exchange factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tiam2Imported
Synonyms:Kiaa2016, Stef2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1344338 Tiam2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1655S → A: No change of phosphorylation by Rho-kinase. 1 Publication1
Mutagenesisi1656T → A: No change of phosphorylation by Rho-kinase. 1 Publication1
Mutagenesisi1662T → A: Strongly decrease phosphorylation by Rho-kinase. No change in promoting neurite growth; when associated with A-1668 and A-1672. 1 Publication1
Mutagenesisi1668T → A: Slight decrease phosphorylation by Rho-kinase. No change in promoting neurite growth; when associated with A-1662 and A-1672. 1 Publication1
Mutagenesisi1672S → A: Slight decrease phosphorylation by Rho-kinase. No change in promoting neurite growth; when associated with A-1662 and A-1668. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003174682 – 1715T-lymphoma invasion and metastasis-inducing protein 2Add BLAST1714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1604PhosphoserineCombined sources1
Modified residuei1662Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1662 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZPF3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZPF3

PeptideAtlas

More...
PeptideAtlasi
Q6ZPF3

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZPF3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZPF3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZPF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal brain (at protein level). Expressed in the olfactory bulb, cortical plate of the cerebral cortex, caudate putamen, hippocampus, ependymal cells of the lateral surface of the lateral ventricles of the brain. Weakly expressed in heart, lung, liver, skeletal muscle, kidney and testis.6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in cerebral cortex, predominantly in the cortical plate and intermediate zone and weakly in the ventricular zone, in neurites and the growth cone of neurites of the hippocampus at 15 dpc (at protein level). Expressed in embryo at 7, 11, 15 and 17 dpc. Expressed in the preplate which consists of the Cajal-Retzius cells and the precursors of subplate neurons, in neurons of the telecephalon, in primordia of cerebral cortex and hippocampus at 12 dpc. Expressed in the cortical plate, striatum and fourth ventricle of the brain, in the cartilaginous tissues including Meckel, costal, vertebral and tracheal cartilage at 14.5 dpc. Expressed in cerebral cortex, hippocampus, olfactory bulbs, rostral migratory pathway and the striatum at 17 dpc.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023800 Expressed in olfactory bulb and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZPF3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZPF3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP1A, MAP1B, PARP1 and YWHAE.

Interacts with CD44, PARD3 and MAPK8IP2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6ZPF3, 9 interactors

Molecular INTeraction database

More...
MINTi
Q6ZPF3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000125842

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZPF3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6ZPF3

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6ZPF3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini504 – 618PH 1PROSITE-ProRule annotationAdd BLAST115
Domaini831 – 902RBDPROSITE-ProRule annotationAdd BLAST72
Domaini911 – 997PDZPROSITE-ProRule annotationAdd BLAST87
Domaini1120 – 1314DHPROSITE-ProRule annotationAdd BLAST195
Domaini1347 – 1478PH 2PROSITE-ProRule annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili665 – 692Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 335Ser-richAdd BLAST121
Compositional biasi1512 – 1564Ser-richAdd BLAST53

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH 1 domain and amino acids 619-780 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TIAM family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDSQ Eukaryota
ENOG410XPCM LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000494_3_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ZPF3

KEGG Orthology (KO)

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KOi
K16847

Identification of Orthologs from Complete Genome Data

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OMAi
SLLWFPG

Database of Orthologous Groups

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OrthoDBi
34437at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZPF3

TreeFam database of animal gene trees

More...
TreeFami
TF319686

Family and domain databases

Conserved Domains Database

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CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR040655 TIAM1_CC-Ex

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF18385 Tiam_CC_Ex, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZPF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNSESQYTF QGSKNHSNTV TGAKQKPCSL KIRSVHAKDE KSLHGWTHGS
60 70 80 90 100
SGAGYKSRSL ARSCLSHFKN HQPYATRLSG PTCKVSKGTT YSKHRANTPG
110 120 130 140 150
NDFQGNSGAF LPENGFHYVD RESEESHITS NGHLLTCYGR KESLASTPPG
160 170 180 190 200
EDHRSPRVLI KTLGKLDGCL RVEFHNGGNP HKGTSEDPSG PVRLLRYSPT
210 220 230 240 250
LASETCPVRE TRRHSAAGSP SSQRPSPTDS RLRSSKGSSL SSESSWYDSP
260 270 280 290 300
WGNAGEVSEV EGSFLAPSTP DPSLPSSFPP SDTKKPFNQS SSLSSLRELY
310 320 330 340 350
KDPNLGCRSP SGTCLSSNEY ISSQVSLNNR VSFASDMDVP SRVDHRDPLH
360 370 380 390 400
YSSFTLPCRK SKALTEDAAK KDTLKARMRR FSDWTGSLSR KKRKLQEPRS
410 420 430 440 450
MEGSEYFDSH SDGLNAEGQV PAQTSSLLWS GGSAQTLPHR SESTHAISVD
460 470 480 490 500
PLRQNIYENF MRELEMSRSN TEHVETSTET MESSSESVSS LEQLDLLFEK
510 520 530 540 550
EQGVVRKAGW LFFKPLVTLQ KERKLELVAR RKWKQYWVTL KGCTLLFYET
560 570 580 590 600
YGKNSTEQNS APRCALFAED SIVQSVPEHP KKEHVFCLSN SCGDVYLFQA
610 620 630 640 650
TSQTDLENWV TAIHSACASL FAKKHGKEDT VRLLKSQTRS LLQKIDMDSK
660 670 680 690 700
MKKMAELQLS VVSDPKNRKA IENQIRQWEQ NLEKFHMDLF RMRCYLASLQ
710 720 730 740 750
GGELPNPKSL LAATSRPSKL ALGRLGVLSV SSFHALVCSR DDSTLRKRTL
760 770 780 790 800
SLTQRGKSKK GIFSSLKGLD TLARKGREKR ASITQMFDSS HSHGFLGTQL
810 820 830 840 850
PQKSTNSNKA HDLHLYGSAV DSALRDSMWE VQTYVHFQDN EGVTVTIKPE
860 870 880 890 900
HRVEDVLALV CKMRQLEPTH YGLQLRKVVD KSVEWCVPAL YEYMQEQVYD
910 920 930 940 950
EIEVFPLSVY DVQLTKTGDM TDFGFAVTVQ VDEHQHLNRI FISDVLPDSL
960 970 980 990 1000
AYGGGLRKGN EITSLNGEPV SDLDIQQMEA LFSEKSVGLT LVARPVTTRR
1010 1020 1030 1040 1050
TLCASWSDSD LFSRDQKSLP PSPNQSQLLE EFLDNFRKTA TSDFSNVPEI
1060 1070 1080 1090 1100
TTGLKRSQTE GTLDQVPHRE KMEQTFLSAD QIAELCRDLN NTHTNSMEAP
1110 1120 1130 1140 1150
TESHDPPPRP LARHLSDADR LRKVIQELVD TEKSYVKDLS CLFELYLEPL
1160 1170 1180 1190 1200
QNETFLTQDE MESLFGSLPE MLEFQKVFLE TLEDAISASS DFSVLETPSQ
1210 1220 1230 1240 1250
FRKLLFSLGG SFLYYADHFK LYSGFCANHI KVQRVLERAK TDKAFKAFLD
1260 1270 1280 1290 1300
ARNPTKQHSS TLESYLIKPV QRVLKYPLLL KELVSLTDHE SEEHYHLTEA
1310 1320 1330 1340 1350
LKAMEKVASH INEMQKIYED YGMVFDQLVA EQSGTEKEVT ELSMGELLMH
1360 1370 1380 1390 1400
STVSWLNPFL SLGKARKDIE LTVFVFKRAV ILVYKENCKL KKKLPSNSRP
1410 1420 1430 1440 1450
AHNSADLDPF KFRWLIPISA LQVRLGNTAG TENNSTWELI HTKSEIEGRP
1460 1470 1480 1490 1500
ETIFQLCCSD SENKTSIVKV IRSILRENFR RHIKCELPLE KTCKDRLVPL
1510 1520 1530 1540 1550
KNRVPVSAKL ASSRSLKGLR TSSSSEWPSE PSKGNSLDSD ECSLSSGTQS
1560 1570 1580 1590 1600
SGCPVAESRR DSKSTELEKD AQEGLAEFPD GLIKESDILS DEDEDFHHPL
1610 1620 1630 1640 1650
KQGSPTKDIE IQFQRLKISE ESDVHPVGQQ PLTESGEQPK LVRGHFCPIK
1660 1670 1680 1690 1700
RKANSTKRGR GTLLKAQTRH QSLDSHPETA SIDLNLVLER EFSVQSLTSV
1710
VNEEGFYETQ SHGKS
Length:1,715
Mass (Da):192,567
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96C1E063BC6F36C0
GO
Isoform 2 (identifier: Q6ZPF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-616: Missing.

Show »
Length:1,714
Mass (Da):192,496
Checksum:i2FFD3D8FE4D53D8B
GO
Isoform 3 (identifier: Q6ZPF3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1096: Missing.

Show »
Length:619
Mass (Da):70,146
Checksum:i61EBCE09292C61A2
GO
Isoform 4 (identifier: Q6ZPF3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     786-788: MFD → VSS
     789-1715: Missing.

Show »
Length:788
Mass (Da):87,583
Checksum:i6234115FF79D5B03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRI9A0A2I3BRI9_MOUSE
T-lymphoma invasion and metastasis-...
Tiam2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRJ9A0A2I3BRJ9_MOUSE
T-lymphoma invasion and metastasis-...
Tiam2
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98284 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45G → D in BAE34377 (PubMed:16141072).Curated1
Sequence conflicti98T → A in BAC98284 (PubMed:14621295).Curated1
Sequence conflicti261E → D in BAC98284 (PubMed:14621295).Curated1
Sequence conflicti803K → Q in BAA81823 (PubMed:10364228).Curated1
Sequence conflicti856V → I in BAA81823 (PubMed:10364228).Curated1
Sequence conflicti860V → A in BAA81823 (PubMed:10364228).Curated1
Sequence conflicti860V → A in BAC98284 (PubMed:14621295).Curated1
Sequence conflicti1077L → P in BAA81823 (PubMed:10364228).Curated1
Sequence conflicti1234R → K in AAF28865 (PubMed:10512681).Curated1
Sequence conflicti1248F → C in AAF28865 (PubMed:10512681).Curated1
Sequence conflicti1397N → D in AAF28865 (PubMed:10512681).Curated1
Sequence conflicti1446I → V in AAF28865 (PubMed:10512681).Curated1
Sequence conflicti1611I → L in BAC98284 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0309761 – 1096Missing in isoform 3. 1 PublicationAdd BLAST1096
Alternative sequenceiVSP_030977616Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_030978786 – 788MFD → VSS in isoform 4. 1 Publication3
Alternative sequenceiVSP_030979789 – 1715Missing in isoform 4. 1 PublicationAdd BLAST927

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB022915 mRNA Translation: BAA81823.1
AK129474 mRNA Translation: BAC98284.1 Different initiation.
AK158137 mRNA Translation: BAE34377.1
AK161947 mRNA Translation: BAE36649.1
BC067048 mRNA Translation: AAH67048.1
BC079600 mRNA Translation: AAH79600.1
AF121102 mRNA Translation: AAF28865.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37421.1 [Q6ZPF3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001116470.1, NM_001122998.1 [Q6ZPF3-1]
NP_001273686.1, NM_001286757.1 [Q6ZPF3-3]
NP_001273687.1, NM_001286758.1
NP_036008.2, NM_011878.2 [Q6ZPF3-1]
XP_006523288.1, XM_006523225.3 [Q6ZPF3-1]
XP_006523289.1, XM_006523226.1 [Q6ZPF3-1]
XP_006523296.1, XM_006523233.1 [Q6ZPF3-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000072156; ENSMUSP00000072020; ENSMUSG00000023800 [Q6ZPF3-1]
ENSMUST00000169838; ENSMUSP00000125842; ENSMUSG00000023800 [Q6ZPF3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
24001

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:24001

UCSC genome browser

More...
UCSCi
uc008aeo.1 mouse [Q6ZPF3-1]
uc008aep.1 mouse [Q6ZPF3-4]
uc008aer.1 mouse [Q6ZPF3-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022915 mRNA Translation: BAA81823.1
AK129474 mRNA Translation: BAC98284.1 Different initiation.
AK158137 mRNA Translation: BAE34377.1
AK161947 mRNA Translation: BAE36649.1
BC067048 mRNA Translation: AAH67048.1
BC079600 mRNA Translation: AAH79600.1
AF121102 mRNA Translation: AAF28865.1
CCDSiCCDS37421.1 [Q6ZPF3-1]
RefSeqiNP_001116470.1, NM_001122998.1 [Q6ZPF3-1]
NP_001273686.1, NM_001286757.1 [Q6ZPF3-3]
NP_001273687.1, NM_001286758.1
NP_036008.2, NM_011878.2 [Q6ZPF3-1]
XP_006523288.1, XM_006523225.3 [Q6ZPF3-1]
XP_006523289.1, XM_006523226.1 [Q6ZPF3-1]
XP_006523296.1, XM_006523233.1 [Q6ZPF3-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A8PX-ray2.10A/B/C/D500-757[»]
3A8QX-ray3.20A/B/C/D500-757[»]
SMRiQ6ZPF3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ6ZPF3, 9 interactors
MINTiQ6ZPF3
STRINGi10090.ENSMUSP00000125842

PTM databases

iPTMnetiQ6ZPF3
PhosphoSitePlusiQ6ZPF3

Proteomic databases

jPOSTiQ6ZPF3
PaxDbiQ6ZPF3
PeptideAtlasiQ6ZPF3
PRIDEiQ6ZPF3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2773 174 antibodies

Genome annotation databases

EnsembliENSMUST00000072156; ENSMUSP00000072020; ENSMUSG00000023800 [Q6ZPF3-1]
ENSMUST00000169838; ENSMUSP00000125842; ENSMUSG00000023800 [Q6ZPF3-1]
GeneIDi24001
KEGGimmu:24001
UCSCiuc008aeo.1 mouse [Q6ZPF3-1]
uc008aep.1 mouse [Q6ZPF3-4]
uc008aer.1 mouse [Q6ZPF3-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26230
MGIiMGI:1344338 Tiam2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410KDSQ Eukaryota
ENOG410XPCM LUCA
GeneTreeiENSGT00940000157012
HOGENOMiCLU_000494_3_1_1
InParanoidiQ6ZPF3
KOiK16847
OMAiSLLWFPG
OrthoDBi34437at2759
PhylomeDBiQ6ZPF3
TreeFamiTF319686

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
24001 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tiam2 mouse
EvolutionaryTraceiQ6ZPF3

Protein Ontology

More...
PROi
PR:Q6ZPF3
RNActiQ6ZPF3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000023800 Expressed in olfactory bulb and 181 other tissues
ExpressionAtlasiQ6ZPF3 baseline and differential
GenevisibleiQ6ZPF3 MM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR040655 TIAM1_CC-Ex
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF18385 Tiam_CC_Ex, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIAM2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZPF3
Secondary accession number(s): Q3TSM6
, Q3TZ33, Q6AXF2, Q6NXJ2, Q9JLY2, Q9WVS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 17, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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