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Entry version 112 (13 Feb 2019)
Sequence version 2 (10 Jul 2007)
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Protein

Myotubularin-related protein 5

Gene

Sbf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.By similarity

Caution

Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1422 in the dsPTPase catalytic loop and does not have phosphatase activity (By similarity). The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.By similarityCurated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • pseudophosphatase activity Source: MGI
  • Rab guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  • regulation of cell growth Source: MGI
  • regulation of GTPase activity Source: InterPro
  • spermatogenesis Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1483248 Synthesis of PIPs at the ER membrane
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 5
Alternative name(s):
Inactive phosphatidylinositol 3-phosphatase 5Curated
SET-binding factor 1
Short name:
Sbf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sbf1
Synonyms:Kiaa3020, Mtmr5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1925230 Sbf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002934761 – 1867Myotubularin-related protein 5Add BLAST1867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1120PhosphoserineBy similarity1
Modified residuei1137PhosphothreonineBy similarity1
Modified residuei1222N6-methyllysineBy similarity1
Modified residuei1746PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZPE2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZPE2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZPE2

PeptideAtlas

More...
PeptideAtlasi
Q6ZPE2

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZPE2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZPE2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZPE2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036529 Expressed in 233 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZPE2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZPE2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with lipid phosphatase MTMR2. Interacts with KMT2A/MLL1 (via SET domain). Interacts with SUV39H1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
219065, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZPE2, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000118107

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11867
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5UNMR-A1762-1865[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6ZPE2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6ZPE2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6ZPE2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 184uDENNPROSITE-ProRule annotationAdd BLAST178
Domaini203 – 336cDENNPROSITE-ProRule annotationAdd BLAST134
Domaini338 – 439dDENNPROSITE-ProRule annotationAdd BLAST102
Domaini880 – 968GRAMSequence analysisAdd BLAST89
Domaini1120 – 1596Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST477
Domaini1761 – 1865PHPROSITE-ProRule annotationAdd BLAST105

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain mediates interaction with MTMR2.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1090 Eukaryota
KOG2080 Eukaryota
ENOG410XTJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155263

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000044360

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052527

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ZPE2

KEGG Orthology (KO)

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KOi
K18061

Identification of Orthologs from Complete Genome Data

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OMAi
DQATAKM

Database of Orthologous Groups

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OrthoDBi
45015at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318583

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR004182 GRAM
IPR030574 MTMR5
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029021 Prot-tyrosine_phosphatase-like
IPR022096 SBF1/SBF2
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10807 PTHR10807, 1 hit
PTHR10807:SF43 PTHR10807:SF43, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02141 DENN, 1 hit
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
PF00169 PH, 1 hit
PF12335 SBF2, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00568 GRAM, 1 hit
SM00233 PH, 1 hit
SM00800 uDENN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS51339 PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZPE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARLADYFVL VAFGPHPRGS GEGQGQILQR FPEKDWEDNP FPQGIELFCQ
60 70 80 90 100
PSGWQLCPER NPPTFFVAVL TDINSERHYC ACLTFWEPVE STQEVVCTDN
110 120 130 140 150
ATEKEEEADG GGQARLSSTA PAQPGQLFAP KTLVLVSRLD HAEVFRNSLG
160 170 180 190 200
LIYAIHVEGL NVSLENVIGN LLTCTVPLAG GSQRTISLGA GDRQVIQTPL
210 220 230 240 250
VDSLPVSRCS VALLFRQLGI TNVLSLFCAA LTEHKVLFLS RSYQRLADAC
260 270 280 290 300
RGLLALLFPL RYSFTYVPIL PAQLLEVLST PTPFIIGVNA AFQAETQELL
310 320 330 340 350
DVIVADLDGG TVTVPECVHI PPLPEPLQSQ THNVLSMVLD PELELADLAF
360 370 380 390 400
PPPTTSASSL KMQDKELRAV FLRLFAQLLQ GYRWCLHIVR IHPEPVIRFH
410 420 430 440 450
KAAFLGQRGL VEDDFLMKVL EGMAFAGFVS ERGVPYRATD LFDELVAHEV
460 470 480 490 500
ARMRADESHP HRVLRHVQEL AEQLYKNENP YPAVAMHKVQ RPGEASHLRR
510 520 530 540 550
THRPFPRLDE GTIQWIVDQA AAKMQGAPPA VKAERRSTVP SGPPMTAILE
560 570 580 590 600
RCSGPHINSA RRLEVVRNCI SYVFEGKMLE AKKLLPAVLR ALKGRAARRC
610 620 630 640 650
LAHELHLHVQ QNRAVLDHQQ FDFVVRMMNC CLQDCTSLDE HGIASALLPL
660 670 680 690 700
VTAFCRKLSP GVTQFAYSCV QEHVVWSTPQ FWEAMFYGDV QTHIRALYLE
710 720 730 740 750
PSDGVSPTQE TGEAQSQDDE RSALDVASEQ RRLWPTLSRE KQQELVQKEE
760 770 780 790 800
STVFSQAIHY ANRMSYLLLP LDSSKSRLLR ERAGLGDLES ASNSLVTNSM
810 820 830 840 850
AGSVAESYDT ESGFEDAETC DVAGAVVRFI NRFVDKVCTE SGVTSDHLKG
860 870 880 890 900
LHVMVPDIVQ MHIETLEAVH RESKRLPPIQ KPKLLRPRLL PGEECVLDGL
910 920 930 940 950
RVYLLPDGRE EGVGGSGGGP ALLPAEGAVF LTTYRVIFTG MPTDPLVGEQ
960 970 980 990 1000
VVVRSFPVAA LTKEKRISVQ TPVDQLLQDG LQLRSCTFQL LKMAFDEEVG
1010 1020 1030 1040 1050
SDSAELFRKQ LHKLRYPPDI RATFAFTLGS AHTPGRPPRV TKDKGPSFRT
1060 1070 1080 1090 1100
LSRNLMKNAK KTIGRQYVTR KKYNPPGWEH RGQPPPEDQE DEISVSEELE
1110 1120 1130 1140 1150
PSTLTPSSAL KPSDRMTMSS LVERACCRDY QRLGLGTLSS SLSRAKSEPF
1160 1170 1180 1190 1200
RISPVNRMYA ICRSYPGLLI VPQSIQDNAL QRVSRCYRQN RFPVVCWRSG
1210 1220 1230 1240 1250
RSKAVLLRSG GLHGKGVVGL FKAQNTPSPG QAQADSSSLE QEKYLQAVVS
1260 1270 1280 1290 1300
SMPRYADSSG RNTLSSFSSA HMGGHGKWSS VRASGRSSGL GSDVGSRLAG
1310 1320 1330 1340 1350
RDLLSTPHTN GAPPDSGFLR PQRAALYIIG DKAQLKGVRP DPLQQWELVP
1360 1370 1380 1390 1400
IEVFEARQVK ASFKKLLKAC VPGCPATEPS PASFLRSLED SEWLIQIHKL
1410 1420 1430 1440 1450
LQISVLVVEL LDSGSSVLVS LEDGWDITTQ VVSLVQLLSD PFYRTLEGFR
1460 1470 1480 1490 1500
LLVEKEWLSF GHRFSHRGAH TLAGQSSGFT PVFLQFLDCV HQVHLQFPME
1510 1520 1530 1540 1550
FEFSQFYLKF LGYHHTSRRF RTFLLDSDYE RIELGLLYEE KGERRGQLAC
1560 1570 1580 1590 1600
KSVWEYVDRL SKRTPMFYNY TYAPEDTEVL RPYSNVSNLK VWDFYTEETL
1610 1620 1630 1640 1650
AEGPPYDWEL AQGPPEPPEE ERPDGGAPQS RRRVVWPCYD SRPRVQPDAI
1660 1670 1680 1690 1700
SRLLEELQRL ETELGRPSER WKDTWDRVKA AQRLESRQDG RGTPSSLLVS
1710 1720 1730 1740 1750
AVPHHRRSLG VYLQEGPVGS TLSLSLDSDQ SSGSTTSSSR QAARRSTSTL
1760 1770 1780 1790 1800
YSQFQTAESE NRSYEGILYK KGAFMKPWKA RWFVLDKTKH QLRYYDHRMD
1810 1820 1830 1840 1850
TECKGVIDLA EVEAVAPGTP TIGAPKTVDE KAFFDVKTTR RVYNFCAQDV
1860
PSAQQWVDRI QSCLSDA
Length:1,867
Mass (Da):208,693
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16C7033FAA62CB1A
GO
Isoform 2 (identifier: Q6ZPE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1275-1275: H → HVPSPRARVTTLSNPLAASASRWTASR

Show »
Length:1,893
Mass (Da):211,428
Checksum:iD4F26DD11889F5D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BKD9H3BKD9_MOUSE
Myotubularin-related protein 5
Sbf1
415Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S251F6S251_MOUSE
Myotubularin-related protein 5
Sbf1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RG52D6RG52_MOUSE
Myotubularin-related protein 5
Sbf1
403Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7AWK3F7AWK3_MOUSE
Myotubularin-related protein 5
Sbf1
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH29156 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC98295 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti317C → R in AAI72094 (PubMed:15489334).Curated1
Sequence conflicti1347E → D in AAI57936 (PubMed:15489334).Curated1
Sequence conflicti1521R → W in BAC36139 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0475231275H → HVPSPRARVTTLSNPLAASA SRWTASR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129485 mRNA Translation: BAC98295.1 Different initiation.
AC160538 Genomic DNA No translation available.
BC029156 mRNA Translation: AAH29156.1 Different initiation.
BC098209 mRNA Translation: AAH98209.1
BC157935 mRNA Translation: AAI57936.1
BC158013 mRNA Translation: AAI58014.1
BC172094 mRNA Translation: AAI72094.1
AK076039 mRNA Translation: BAC36139.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37175.2 [Q6ZPE2-1]
CCDS49699.1 [Q6ZPE2-2]

NCBI Reference Sequences

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RefSeqi
NP_001074499.2, NM_001081030.2 [Q6ZPE2-1]
NP_001164032.1, NM_001170561.1 [Q6ZPE2-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.35483

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000123791; ENSMUSP00000120725; ENSMUSG00000036529 [Q6ZPE2-1]
ENSMUST00000144585; ENSMUSP00000118107; ENSMUSG00000036529 [Q6ZPE2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
77980

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:77980

UCSC genome browser

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UCSCi
uc007xfz.1 mouse [Q6ZPE2-1]
uc011zxu.1 mouse [Q6ZPE2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129485 mRNA Translation: BAC98295.1 Different initiation.
AC160538 Genomic DNA No translation available.
BC029156 mRNA Translation: AAH29156.1 Different initiation.
BC098209 mRNA Translation: AAH98209.1
BC157935 mRNA Translation: AAI57936.1
BC158013 mRNA Translation: AAI58014.1
BC172094 mRNA Translation: AAI72094.1
AK076039 mRNA Translation: BAC36139.1
CCDSiCCDS37175.2 [Q6ZPE2-1]
CCDS49699.1 [Q6ZPE2-2]
RefSeqiNP_001074499.2, NM_001081030.2 [Q6ZPE2-1]
NP_001164032.1, NM_001170561.1 [Q6ZPE2-2]
UniGeneiMm.35483

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5UNMR-A1762-1865[»]
ProteinModelPortaliQ6ZPE2
SMRiQ6ZPE2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219065, 4 interactors
IntActiQ6ZPE2, 5 interactors
STRINGi10090.ENSMUSP00000118107

PTM databases

iPTMnetiQ6ZPE2
PhosphoSitePlusiQ6ZPE2

Proteomic databases

EPDiQ6ZPE2
jPOSTiQ6ZPE2
PaxDbiQ6ZPE2
PeptideAtlasiQ6ZPE2
PRIDEiQ6ZPE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000123791; ENSMUSP00000120725; ENSMUSG00000036529 [Q6ZPE2-1]
ENSMUST00000144585; ENSMUSP00000118107; ENSMUSG00000036529 [Q6ZPE2-2]
GeneIDi77980
KEGGimmu:77980
UCSCiuc007xfz.1 mouse [Q6ZPE2-1]
uc011zxu.1 mouse [Q6ZPE2-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6305
MGIiMGI:1925230 Sbf1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1090 Eukaryota
KOG2080 Eukaryota
ENOG410XTJ1 LUCA
GeneTreeiENSGT00940000155263
HOGENOMiHOG000044360
HOVERGENiHBG052527
InParanoidiQ6ZPE2
KOiK18061
OMAiDQATAKM
OrthoDBi45015at2759
TreeFamiTF318583

Enzyme and pathway databases

ReactomeiR-MMU-1483248 Synthesis of PIPs at the ER membrane
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sbf1 mouse
EvolutionaryTraceiQ6ZPE2

Protein Ontology

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PROi
PR:Q6ZPE2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036529 Expressed in 233 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ6ZPE2 baseline and differential
GenevisibleiQ6ZPE2 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR004182 GRAM
IPR030574 MTMR5
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029021 Prot-tyrosine_phosphatase-like
IPR022096 SBF1/SBF2
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF43 PTHR10807:SF43, 1 hit
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
PF00169 PH, 1 hit
PF12335 SBF2, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00568 GRAM, 1 hit
SM00233 PH, 1 hit
SM00800 uDENN, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS51339 PPASE_MYOTUBULARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMR5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZPE2
Secondary accession number(s): B2RXQ1
, B2RXX4, B7ZWK2, Q4QQM2, Q8BK68, Q8K2Z0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: February 13, 2019
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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