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Protein

Diacylglycerol O-acyltransferase 2-like protein 6

Gene

DGAT2L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to produce wax esters.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.20 2681
2.3.1.75 2681
ReactomeiR-HSA-1482883 Acyl chain remodeling of DAG and TAG

Chemistry databases

SwissLipidsiSLP:000000305

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol O-acyltransferase 2-like protein 6 (EC:2.3.1.-)
Alternative name(s):
Diacylglycerol O-acyltransferase candidate 3
Short name:
hDC3
Gene namesi
Name:DGAT2L6
Synonyms:DC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000184210.5
HGNCiHGNC:23250 DGAT2L6
MIMi300926 gene
neXtProtiNX_Q6ZPD8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184210
PharmGKBiPA143485448

Polymorphism and mutation databases

BioMutaiDGAT2L6
DMDMi74749597

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002490541 – 337Diacylglycerol O-acyltransferase 2-like protein 6Add BLAST337

Proteomic databases

PaxDbiQ6ZPD8
PRIDEiQ6ZPD8
ProteomicsDBi68076

PTM databases

PhosphoSitePlusiQ6ZPD8

Expressioni

Tissue specificityi

Expressed in all tissues tested except pancreas.1 Publication

Gene expression databases

BgeeiENSG00000184210
CleanExiHS_DGAT2L6

Interactioni

Protein-protein interaction databases

IntActiQ6ZPD8, 40 interactors
STRINGi9606.ENSP00000328036

Structurei

3D structure databases

ProteinModelPortaliQ6ZPD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831 Eukaryota
ENOG410XTG3 LUCA
GeneTreeiENSGT00750000117391
HOGENOMiHOG000179738
HOVERGENiHBG065791
InParanoidiQ6ZPD8
KOiK11172
OMAiREYVMSM
OrthoDBiEOG091G0BGQ
PhylomeDBiQ6ZPD8
TreeFamiTF314707

Family and domain databases

InterProiView protein in InterPro
IPR007130 DAGAT
PfamiView protein in Pfam
PF03982 DAGAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZPD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFFSRLNLQ EGLQTFFVLQ WIPVYIFLGA IPILLIPYFL LFSKFWPLAV
60 70 80 90 100
LSLAWLTYDW NTHSQGGRRS AWVRNWTLWK YFRNYFPVKL VKTHDLSPKH
110 120 130 140 150
NYIIANHPHG ILSFGVFINF ATEATGIARI FPSITPFVGT LERIFWIPIV
160 170 180 190 200
REYVMSMGVC PVSSSALKYL LTQKGSGNAV VIVVGGAAEA LLCRPGASTL
210 220 230 240 250
FLKQRKGFVK MALQTGAYLV PSYSFGENEV FNQETFPEGT WLRLFQKTFQ
260 270 280 290 300
DTFKKILGLN FCTFHGRGFT RGSWGFLPFN RPITTVVGEP LPIPRIKRPN
310 320 330
QKTVDKYHAL YISALRKLFD QHKVEYGLPE TQELTIT
Length:337
Mass (Da):38,593
Last modified:July 5, 2004 - v1
Checksum:iE14B50FBD01981E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129500 mRNA Translation: BAC85167.1
AL139111 Genomic DNA No translation available.
AL357752 Genomic DNA No translation available.
BN000157 mRNA Translation: CAD89268.1
CCDSiCCDS14397.1
RefSeqiNP_940914.1, NM_198512.2
UniGeneiHs.454355

Genome annotation databases

EnsembliENST00000333026; ENSP00000328036; ENSG00000184210
GeneIDi347516
KEGGihsa:347516
UCSCiuc004dxx.2 human

Similar proteinsi

Entry informationi

Entry nameiDG2L6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZPD8
Secondary accession number(s): Q6IEE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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