UniProtKB - Q6ZPD8 (DG2L6_HUMAN)
Protein
Diacylglycerol O-acyltransferase 2-like protein 6
Gene
DGAT2L6
Organism
Homo sapiens (Human)
Status
Functioni
Diglyceride acyltransferase that uses fatty acyl-CoA as substrate (PubMed:15671038). Particularly active with oleate as a substrate (PubMed:15671038). Has no wax synthase activity to produce wax esters (PubMed:15671038). Able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).2 Publications
Catalytic activityi
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA1 PublicationThis reaction proceeds in the forwardCurated direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
GO - Molecular functioni
- O-acyltransferase activity Source: GO_Central
GO - Biological processi
- acylglycerol acyl-chain remodeling Source: Reactome
- lipid metabolic process Source: GO_Central
- monoacylglycerol biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.3.1.20, 2681 2.3.1.75, 2681 |
PathwayCommonsi | Q6ZPD8 |
Reactomei | R-HSA-1482883, Acyl chain remodeling of DAG and TAG |
Chemistry databases
SwissLipidsi | SLP:000000305 |
Names & Taxonomyi
Protein namesi | Recommended name: Diacylglycerol O-acyltransferase 2-like protein 6 (EC:2.3.1.-1 Publication)Alternative name(s): Diacylglycerol O-acyltransferase candidate 3 Short name: hDC3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23250, DGAT2L6 |
MIMi | 300926, gene |
neXtProti | NX_Q6ZPD8 |
VEuPathDBi | HostDB:ENSG00000184210.5 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 102 – 122 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 347516 |
OpenTargetsi | ENSG00000184210 |
PharmGKBi | PA143485448 |
Miscellaneous databases
Pharosi | Q6ZPD8, Tbio |
Genetic variation databases
BioMutai | DGAT2L6 |
DMDMi | 74749597 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249054 | 1 – 337 | Diacylglycerol O-acyltransferase 2-like protein 6Add BLAST | 337 |
Proteomic databases
PaxDbi | Q6ZPD8 |
PRIDEi | Q6ZPD8 |
ProteomicsDBi | 68076 |
PTM databases
PhosphoSitePlusi | Q6ZPD8 |
Expressioni
Tissue specificityi
Expressed in all tissues tested except pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000184210, Expressed in sural nerve and 8 other tissues |
Organism-specific databases
HPAi | ENSG00000184210, Group enriched (breast, skin) |
Interactioni
Binary interactionsi
Hide detailsQ6ZPD8
Protein-protein interaction databases
BioGRIDi | 131445, 45 interactors |
IntActi | Q6ZPD8, 43 interactors |
STRINGi | 9606.ENSP00000328036 |
Miscellaneous databases
RNActi | Q6ZPD8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the diacylglycerol acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0831, Eukaryota |
GeneTreei | ENSGT01010000222418 |
HOGENOMi | CLU_023995_0_0_1 |
InParanoidi | Q6ZPD8 |
OMAi | FPEGTWI |
OrthoDBi | 1347007at2759 |
PhylomeDBi | Q6ZPD8 |
TreeFami | TF314707 |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6ZPD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFFSRLNLQ EGLQTFFVLQ WIPVYIFLGA IPILLIPYFL LFSKFWPLAV
60 70 80 90 100
LSLAWLTYDW NTHSQGGRRS AWVRNWTLWK YFRNYFPVKL VKTHDLSPKH
110 120 130 140 150
NYIIANHPHG ILSFGVFINF ATEATGIARI FPSITPFVGT LERIFWIPIV
160 170 180 190 200
REYVMSMGVC PVSSSALKYL LTQKGSGNAV VIVVGGAAEA LLCRPGASTL
210 220 230 240 250
FLKQRKGFVK MALQTGAYLV PSYSFGENEV FNQETFPEGT WLRLFQKTFQ
260 270 280 290 300
DTFKKILGLN FCTFHGRGFT RGSWGFLPFN RPITTVVGEP LPIPRIKRPN
310 320 330
QKTVDKYHAL YISALRKLFD QHKVEYGLPE TQELTIT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK129500 mRNA Translation: BAC85167.1 AL139111 Genomic DNA No translation available. AL357752 Genomic DNA No translation available. BN000157 mRNA Translation: CAD89268.1 |
CCDSi | CCDS14397.1 |
RefSeqi | NP_940914.1, NM_198512.2 |
Genome annotation databases
Ensembli | ENST00000333026; ENSP00000328036; ENSG00000184210 |
GeneIDi | 347516 |
KEGGi | hsa:347516 |
UCSCi | uc004dxx.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK129500 mRNA Translation: BAC85167.1 AL139111 Genomic DNA No translation available. AL357752 Genomic DNA No translation available. BN000157 mRNA Translation: CAD89268.1 |
CCDSi | CCDS14397.1 |
RefSeqi | NP_940914.1, NM_198512.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 131445, 45 interactors |
IntActi | Q6ZPD8, 43 interactors |
STRINGi | 9606.ENSP00000328036 |
Chemistry databases
SwissLipidsi | SLP:000000305 |
PTM databases
PhosphoSitePlusi | Q6ZPD8 |
Genetic variation databases
BioMutai | DGAT2L6 |
DMDMi | 74749597 |
Proteomic databases
PaxDbi | Q6ZPD8 |
PRIDEi | Q6ZPD8 |
ProteomicsDBi | 68076 |
Protocols and materials databases
Antibodypediai | 13248, 40 antibodies |
DNASUi | 347516 |
Genome annotation databases
Ensembli | ENST00000333026; ENSP00000328036; ENSG00000184210 |
GeneIDi | 347516 |
KEGGi | hsa:347516 |
UCSCi | uc004dxx.2, human |
Organism-specific databases
CTDi | 347516 |
DisGeNETi | 347516 |
GeneCardsi | DGAT2L6 |
HGNCi | HGNC:23250, DGAT2L6 |
HPAi | ENSG00000184210, Group enriched (breast, skin) |
MIMi | 300926, gene |
neXtProti | NX_Q6ZPD8 |
OpenTargetsi | ENSG00000184210 |
PharmGKBi | PA143485448 |
VEuPathDBi | HostDB:ENSG00000184210.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0831, Eukaryota |
GeneTreei | ENSGT01010000222418 |
HOGENOMi | CLU_023995_0_0_1 |
InParanoidi | Q6ZPD8 |
OMAi | FPEGTWI |
OrthoDBi | 1347007at2759 |
PhylomeDBi | Q6ZPD8 |
TreeFami | TF314707 |
Enzyme and pathway databases
BRENDAi | 2.3.1.20, 2681 2.3.1.75, 2681 |
PathwayCommonsi | Q6ZPD8 |
Reactomei | R-HSA-1482883, Acyl chain remodeling of DAG and TAG |
Miscellaneous databases
BioGRID-ORCSi | 347516, 3 hits in 500 CRISPR screens |
GenomeRNAii | 347516 |
Pharosi | Q6ZPD8, Tbio |
PROi | PR:Q6ZPD8 |
RNActi | Q6ZPD8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184210, Expressed in sural nerve and 8 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DG2L6_HUMAN | |
Accessioni | Q6ZPD8Primary (citable) accession number: Q6ZPD8 Secondary accession number(s): Q6IEE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families