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Entry version 116 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Diacylglycerol O-acyltransferase 2-like protein 6

Gene

DGAT2L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diglyceride acyltransferase that uses fatty acyl-CoA as substrate (PubMed:15671038). Particularly active with oleate as a substrate (PubMed:15671038). Has no wax synthase activity to produce wax esters (PubMed:15671038). Able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.20 2681
2.3.1.75 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1482883 Acyl chain remodeling of DAG and TAG

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000305

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol O-acyltransferase 2-like protein 6 (EC:2.3.1.-1 Publication)
Alternative name(s):
Diacylglycerol O-acyltransferase candidate 3
Short name:
hDC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGAT2L6Imported
Synonyms:DC31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184210.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23250 DGAT2L6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300926 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZPD8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000184210

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485448

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZPD8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DGAT2L6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749597

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002490541 – 337Diacylglycerol O-acyltransferase 2-like protein 6Add BLAST337

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZPD8

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZPD8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68076

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZPD8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested except pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184210 Expressed in skin of abdomen and 4 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184210 Group enriched (breast, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q6ZPD8
With#Exp.IntAct
ABHD4 [Q8TB40]3EBI-12831978,EBI-7131019
ABHD5 [Q8WTS1]3EBI-12831978,EBI-2813554
ACSF2 [Q96CM8]3EBI-12831978,EBI-2876502
AQP6 [Q13520]3EBI-12831978,EBI-13059134
ARFIP2 [P53365]3EBI-12831978,EBI-638194
BNIP2 [Q12982]3EBI-12831978,EBI-752094
C12orf10 [Q9HB07]3EBI-12831978,EBI-709754
C16orf58 [Q96GQ5]3EBI-12831978,EBI-8636004
CIAO2A [Q9H5X1]3EBI-12831978,EBI-752069
DIABLO [Q9NR28]3EBI-12831978,EBI-517508
ECPAS [Q5VYK3]3EBI-12831978,EBI-521451
FARS2 [O95363]3EBI-12831978,EBI-2513774
FBXL19 - isoform 2 [Q6PCT2-2]3EBI-12831978,EBI-11959077
GAD2 [Q05329]3EBI-12831978,EBI-9304251
GPR152 [Q8TDT2]3EBI-12831978,EBI-13345167
HSD17B11 [Q8NBQ5]3EBI-12831978,EBI-1052304
MCEMP1 [Q8IX19]3EBI-12831978,EBI-2816356
MPP1 [Q00013]3EBI-12831978,EBI-711788
MTERF4 [Q7Z6M4]3EBI-12831978,EBI-948435
NAPB [Q9H115]3EBI-12831978,EBI-3921185
NDRG4 - isoform 2 [Q9ULP0-2]3EBI-12831978,EBI-11978907
PBX3 [Q96AL5]3EBI-12831978,EBI-741171
PGRMC2 [O15173]3EBI-12831978,EBI-1050125
PITPNC1 - isoform 2 [Q9UKF7-2]3EBI-12831978,EBI-14223623
REEP4 [Q9H6H4]3EBI-12831978,EBI-7545592
RNF144A [P50876]3EBI-12831978,EBI-2340657
RNF5 [Q99942]3EBI-12831978,EBI-348482
SCAND1 [P57086]3EBI-12831978,EBI-745846
SCN3B [Q9NY72]3EBI-12831978,EBI-17247926
SLC10A1 [Q14973]3EBI-12831978,EBI-3923031
SLC10A6 [Q3KNW5]3EBI-12831978,EBI-18159983
SMG9 [Q9H0W8]3EBI-12831978,EBI-2872322
SNX4 [O95219]3EBI-12831978,EBI-724909
STAR [P49675]3EBI-12831978,EBI-722932
THAP4 [Q8WY91]3EBI-12831978,EBI-726691
TMED8 [Q6PL24]3EBI-12831978,EBI-11603430
TMEM143 [Q96AN5]3EBI-12831978,EBI-13342951
TMEM14B [Q9NUH8]3EBI-12831978,EBI-8638294
TMEM255B [Q8WV15]3EBI-12831978,EBI-2870087
TMX2 [Q9Y320]3EBI-12831978,EBI-6447886
TTPA [P49638]3EBI-12831978,EBI-10210710
TUFM [A0A384ME17]3EBI-12831978,EBI-12261790
WIPI2 - isoform 4 [Q9Y4P8-4]3EBI-12831978,EBI-12205107

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6ZPD8, 43 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328036

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZPD8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0831 Eukaryota
ENOG410XTG3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182761

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023995_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZPD8

KEGG Orthology (KO)

More...
KOi
K11172

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPEGTWI

Database of Orthologous Groups

More...
OrthoDBi
1347007at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZPD8

TreeFam database of animal gene trees

More...
TreeFami
TF314707

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007130 DAGAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03982 DAGAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ZPD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFFSRLNLQ EGLQTFFVLQ WIPVYIFLGA IPILLIPYFL LFSKFWPLAV
60 70 80 90 100
LSLAWLTYDW NTHSQGGRRS AWVRNWTLWK YFRNYFPVKL VKTHDLSPKH
110 120 130 140 150
NYIIANHPHG ILSFGVFINF ATEATGIARI FPSITPFVGT LERIFWIPIV
160 170 180 190 200
REYVMSMGVC PVSSSALKYL LTQKGSGNAV VIVVGGAAEA LLCRPGASTL
210 220 230 240 250
FLKQRKGFVK MALQTGAYLV PSYSFGENEV FNQETFPEGT WLRLFQKTFQ
260 270 280 290 300
DTFKKILGLN FCTFHGRGFT RGSWGFLPFN RPITTVVGEP LPIPRIKRPN
310 320 330
QKTVDKYHAL YISALRKLFD QHKVEYGLPE TQELTIT
Length:337
Mass (Da):38,593
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE14B50FBD01981E4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129500 mRNA Translation: BAC85167.1
AL139111 Genomic DNA No translation available.
AL357752 Genomic DNA No translation available.
BN000157 mRNA Translation: CAD89268.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14397.1

NCBI Reference Sequences

More...
RefSeqi
NP_940914.1, NM_198512.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333026; ENSP00000328036; ENSG00000184210

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
347516

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:347516

UCSC genome browser

More...
UCSCi
uc004dxx.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129500 mRNA Translation: BAC85167.1
AL139111 Genomic DNA No translation available.
AL357752 Genomic DNA No translation available.
BN000157 mRNA Translation: CAD89268.1
CCDSiCCDS14397.1
RefSeqiNP_940914.1, NM_198512.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6ZPD8, 43 interactors
STRINGi9606.ENSP00000328036

Chemistry databases

SwissLipidsiSLP:000000305

PTM databases

PhosphoSitePlusiQ6ZPD8

Polymorphism and mutation databases

BioMutaiDGAT2L6
DMDMi74749597

Proteomic databases

PaxDbiQ6ZPD8
PRIDEiQ6ZPD8
ProteomicsDBi68076

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13248 40 antibodies

The DNASU plasmid repository

More...
DNASUi
347516

Genome annotation databases

EnsembliENST00000333026; ENSP00000328036; ENSG00000184210
GeneIDi347516
KEGGihsa:347516
UCSCiuc004dxx.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
347516
EuPathDBiHostDB:ENSG00000184210.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DGAT2L6
HGNCiHGNC:23250 DGAT2L6
HPAiENSG00000184210 Group enriched (breast, skin)
MIMi300926 gene
neXtProtiNX_Q6ZPD8
OpenTargetsiENSG00000184210
PharmGKBiPA143485448

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0831 Eukaryota
ENOG410XTG3 LUCA
GeneTreeiENSGT00950000182761
HOGENOMiCLU_023995_0_0_1
InParanoidiQ6ZPD8
KOiK11172
OMAiFPEGTWI
OrthoDBi1347007at2759
PhylomeDBiQ6ZPD8
TreeFamiTF314707

Enzyme and pathway databases

BRENDAi2.3.1.20 2681
2.3.1.75 2681
ReactomeiR-HSA-1482883 Acyl chain remodeling of DAG and TAG

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
347516 2 hits in 413 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
347516
PharosiQ6ZPD8 Tbio

Protein Ontology

More...
PROi
PR:Q6ZPD8
RNActiQ6ZPD8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184210 Expressed in skin of abdomen and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR007130 DAGAT
PfamiView protein in Pfam
PF03982 DAGAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDG2L6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZPD8
Secondary accession number(s): Q6IEE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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