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Entry version 136 (08 May 2019)
Sequence version 2 (26 Nov 2014)
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Protein

Coiled-coil domain-containing protein 141

Gene

CCDC141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in radial migration and centrosomal function.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 141
Alternative name(s):
Coiled-coil protein associated with myosin II and DISC11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC141
Synonyms:CAMDI1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26821 CCDC141

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616031 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZP82

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
285025

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CCDC141

MalaCards human disease database

More...
MalaCardsi
CCDC141

Open Targets

More...
OpenTargetsi
ENSG00000163492

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
478 Kallmann syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381449

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC141

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758754

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172961 – 1450Coiled-coil domain-containing protein 141Add BLAST1450

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZP82

PeptideAtlas

More...
PeptideAtlasi
Q6ZP82

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZP82

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68066
68067 [Q6ZP82-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZP82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZP82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163492 Expressed in 97 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZP82 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZP82 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012718

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DISC1. Interacts preferentially with phosphorylated forms of myosin regulatory light chain (MRLC).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI55EBI-928795,EBI-529989

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130000, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZP82, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000395995

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZP82

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1409 – 1450Ig-likeAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili642 – 706Sequence analysisAdd BLAST65
Coiled coili758 – 783Sequence analysisAdd BLAST26
Coiled coili861 – 970Sequence analysisAdd BLAST110

Keywords - Domaini

Coiled coil, Immunoglobulin domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFKI Eukaryota
ENOG410XSUV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000038972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111390

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZP82

Database of Orthologous Groups

More...
OrthoDBi
54602at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331580

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZP82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSQGSPSVA LSTTTVSSVA VQAGDSKIVI AVIKCGKWVQ LQLAESQPNL
60 70 80 90 100
LEIGSSQDET KKLLHDHELL LAKLKALEDR VWELLQEADK TAEENKDQSQ
110 120 130 140 150
VYDAMAETLG EAWAALVSML ERRTELLRLT SEFFENALEF AIKIDQAEDF
160 170 180 190 200
LQNTHEFESA ESLKSLLQLH EHHTKELLER SLALLNKSQQ LTDFIEKFKC
210 220 230 240 250
EGPNVNPELT QGAHSSCLKV DRLLELLQDR RRQLDKYLKQ QWQELSQVLQ
260 270 280 290 300
ICQWDQQENQ VTCWFQKTIR NLQEQSLGSS LSDNEDRIHK QEELIIKAKE
310 320 330 340 350
WNSAVEKLKS EALRILLSKD YVEKEHLQLS HQKLSQLQEE FGQLMVERNT
360 370 380 390 400
WLKKANEFFN SANKAFDVLG RVEAYLKLLK SEGLSLAVLA VRHEELHRKI
410 420 430 440 450
KDCTTDALQK GQTLISQVDS CSSQVSGIHE MMGCIKRRVD HLTEQCSAHK
460 470 480 490 500
EYALKKQQLT ASVEGYLRKV EMSIQKISPV LSNAMDVGST RSESEKILNK
510 520 530 540 550
YLELDIQAKE TSHELEAAAK TMMEKNEFVS DEMVSLSSKA RWLAEELNLF
560 570 580 590 600
GQSIDYRSQV LQTYVAFLKS SEEVEMQFQS LKEFYETEIP QKEQDDAKAK
610 620 630 640 650
HCSDSAEKQW QLFLKKSFIT QDLGLEFLNL INMAKENEIL DVKNEVYLMK
660 670 680 690 700
NTMENQKAER EELSLLRLAW QLKATESKPG KQQWAAFKEQ LKKTSHNLKL
710 720 730 740 750
LQEALMPVSA LDLGGSLQFI LDLRQKWNDM KPQFQQLNDE VQYIMKESEE
760 770 780 790 800
LTGRGAPVKE KSQQLKDLIH FHQKQKERIQ DYEDILYKVV QFHQVKEELG
810 820 830 840 850
RLIKSRELEF VEQPKELGDA HDVQIHLRCS QEKQARVDHL HRLALSLGVD
860 870 880 890 900
IISSVQRPHC SNVSAKNLQQ QLELLEEDSM KWRAKAEEYG RTLSRSVEYC
910 920 930 940 950
AMRDEINELK DSFKDIKKKF NNLKFNYTKK NEKSRNLKAL KYQIQQVDMY
960 970 980 990 1000
AEKMQALKRK MEKVSNKTSD SFLNYPSDKV NVLLEVMKDL QKHVDDFDKV
1010 1020 1030 1040 1050
VTDYKKNLDL TEHFQEVIEE CHFWYEDASA TVVRVGKYST ECKTKEAVKI
1060 1070 1080 1090 1100
LHQQFNKFIA PSVPQQEERI QEATDLAQHL YGLEEGQKYI EKIVTKHKEV
1110 1120 1130 1140 1150
LESVTELCES LTELEEKLKQ GDVLKMNPNL EDFHYDYIDL LKEPAKNKQT
1160 1170 1180 1190 1200
IFNEERNKGQ VQVADLLGIN GTGEERLPQD LKVSTDKEGG VQDLLLPEDM
1210 1220 1230 1240 1250
LSGEEYECVS PDDISLPPLP GSPESPLAPS DMEVEEPVSS SLSLHISSYG
1260 1270 1280 1290 1300
VQAGTSSPGD AQESVLPPPV AFADACNDKR ETFSSHFERP YLQFKAEPPL
1310 1320 1330 1340 1350
TSRGFVEKST ALHRISAEHP ESMMSEVHER ALQQHPQAQG GLLETREKMH
1360 1370 1380 1390 1400
ADNNFTKTQD RLHASSDAFS GLRFQSGTSR GYQRQMVPRE EIKSTSAKSS
1410 1420 1430 1440 1450
VVSLADQAPN FSRLLSNVTV MEGSPVTLEV EVTGFPEPTL TWWVAYNDKP
Note: No experimental confirmation available. Gene prediction based on EST data.
Length:1,450
Mass (Da):166,261
Last modified:November 26, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2C38E3A4B16FA86
GO
Isoform 2 (identifier: Q6ZP82-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1443-1450: WVAYNDKP → YKKGQKLSAD...VSLMYWLLTQ

Show »
Length:1,530
Mass (Da):175,067
Checksum:iF2F1CA3F2791A40B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZB3B8ZZB3_HUMAN
Coiled-coil domain-containing prote...
CCDC141 FLJ39502, hCG_22663
652Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYF7A0A0A6YYF7_HUMAN
Coiled-coil domain-containing prote...
CCDC141
894Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JR62C9JR62_HUMAN
Coiled-coil domain-containing prote...
CCDC141
628Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERF0E7ERF0_HUMAN
Coiled-coil domain-containing prote...
CCDC141
955Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI15379 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAX88845 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC04869 differs from that shown. Contaminating sequence.Curated
The sequence BAC04869 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85242 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047904828R → W Polymorphism; reduced affinity for MRLC and impairs cortical migration. Corresponds to variant dbSNP:rs12988301Ensembl.1
Natural variantiVAR_047905935R → W. Corresponds to variant dbSNP:rs17362588Ensembl.1
Natural variantiVAR_0479061170N → S. Corresponds to variant dbSNP:rs13419085Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0359681443 – 1450WVAYNDKP → YKKGQKLSADGHLQVLHKET RHSVFIPKVCKADAGLYVAR AQNSSGALSSNVILHVTGNC RLPITRVNWITLCVVYVSVS LMYWLLTQ in isoform 2. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC023270 Genomic DNA Translation: AAX88845.1 Sequence problems.
AC093792 Genomic DNA No translation available.
AC092640 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11011.1
AK096821 mRNA Translation: BAC04869.1 Sequence problems.
AK129847 mRNA Translation: BAC85242.1 Different initiation.
BC115378 mRNA Translation: AAI15379.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_775919.3, NM_173648.3 [Q6ZP82-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000443758; ENSP00000390190; ENSG00000163492 [Q6ZP82-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
285025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:285025

UCSC genome browser

More...
UCSCi
uc002une.2 human [Q6ZP82-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023270 Genomic DNA Translation: AAX88845.1 Sequence problems.
AC093792 Genomic DNA No translation available.
AC092640 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11011.1
AK096821 mRNA Translation: BAC04869.1 Sequence problems.
AK129847 mRNA Translation: BAC85242.1 Different initiation.
BC115378 mRNA Translation: AAI15379.1 Different initiation.
RefSeqiNP_775919.3, NM_173648.3 [Q6ZP82-2]

3D structure databases

SMRiQ6ZP82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130000, 4 interactors
IntActiQ6ZP82, 4 interactors
STRINGi9606.ENSP00000395995

PTM databases

iPTMnetiQ6ZP82
PhosphoSitePlusiQ6ZP82

Polymorphism and mutation databases

BioMutaiCCDC141
DMDMi74758754

Proteomic databases

PaxDbiQ6ZP82
PeptideAtlasiQ6ZP82
PRIDEiQ6ZP82
ProteomicsDBi68066
68067 [Q6ZP82-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000443758; ENSP00000390190; ENSG00000163492 [Q6ZP82-2]
GeneIDi285025
KEGGihsa:285025
UCSCiuc002une.2 human [Q6ZP82-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285025
DisGeNETi285025

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC141
GeneReviewsiCCDC141
HGNCiHGNC:26821 CCDC141
HPAiHPA012718
MalaCardsiCCDC141
MIMi616031 gene
neXtProtiNX_Q6ZP82
OpenTargetsiENSG00000163492
Orphaneti478 Kallmann syndrome
PharmGKBiPA162381449

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFKI Eukaryota
ENOG410XSUV LUCA
GeneTreeiENSGT00440000038972
HOGENOMiHOG000111390
InParanoidiQ6ZP82
OrthoDBi54602at2759
TreeFamiTF331580

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCDC141 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
285025

Protein Ontology

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PROi
PR:Q6ZP82

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163492 Expressed in 97 organ(s), highest expression level in heart
ExpressionAtlasiQ6ZP82 baseline and differential
GenevisibleiQ6ZP82 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC141_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZP82
Secondary accession number(s): H7C0P1, J3KNW6, Q8N8H3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 26, 2014
Last modified: May 8, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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