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UniProtKB - Q6ZP82 (CC141_HUMAN)

Entry version 150 (02 Jun 2021)
Sequence version 2 (26 Nov 2014)
Previous versions | rss
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Protein

Coiled-coil domain-containing protein 141

Gene

CCDC141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in radial migration and centrosomal function.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZP82

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 141
Alternative name(s):
Coiled-coil protein associated with myosin II and DISC11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC141
Synonyms:CAMDI1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26821, CCDC141

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616031, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZP82

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163492.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		285025

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CCDC141

MalaCards human disease database

More...MalaCardsi		CCDC141

Open Targets

More...OpenTargetsi		ENSG00000163492

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		478, Kallmann syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162381449

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZP82, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC141

Domain mapping of disease mutations (DMDM)

More...DMDMi		74758754

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172961 – 1450Coiled-coil domain-containing protein 141Add BLAST1450

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZP82

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZP82

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZP82

PeptideAtlas

More...PeptideAtlasi		Q6ZP82

PRoteomics IDEntifications database

More...PRIDEi		Q6ZP82

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		44366
68066 [Q6ZP82-1]
68067 [Q6ZP82-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZP82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZP82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163492, Expressed in heart and 123 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZP82, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZP82, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DISC1.

Interacts preferentially with phosphorylated forms of myosin regulatory light chain (MRLC).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		130000, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZP82, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000395995

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZP82, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZP82

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1409 – 1450Ig-likeAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1210 – 1241DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili642 – 706Sequence analysisAdd BLAST65
Coiled coili758 – 783Sequence analysisAdd BLAST26
Coiled coili861 – 970Sequence analysisAdd BLAST110

Keywords - Domaini

Coiled coil, Immunoglobulin domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4240, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00440000038972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_251402_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZP82

Identification of Orthologs from Complete Genome Data

More...OMAi		LSSKAKW

Database of Orthologous Groups

More...OrthoDBi		54602at2759

TreeFam database of animal gene trees

More...TreeFami		TF331580

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZP82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSQGSPSVA LSTTTVSSVA VQAGDSKIVI AVIKCGKWVQ LQLAESQPNL 
        60         70         80         90        100
LEIGSSQDET KKLLHDHELL LAKLKALEDR VWELLQEADK TAEENKDQSQ 
       110        120        130        140        150
VYDAMAETLG EAWAALVSML ERRTELLRLT SEFFENALEF AIKIDQAEDF 
       160        170        180        190        200
LQNTHEFESA ESLKSLLQLH EHHTKELLER SLALLNKSQQ LTDFIEKFKC 
       210        220        230        240        250
EGPNVNPELT QGAHSSCLKV DRLLELLQDR RRQLDKYLKQ QWQELSQVLQ 
       260        270        280        290        300
ICQWDQQENQ VTCWFQKTIR NLQEQSLGSS LSDNEDRIHK QEELIIKAKE 
       310        320        330        340        350
WNSAVEKLKS EALRILLSKD YVEKEHLQLS HQKLSQLQEE FGQLMVERNT 
       360        370        380        390        400
WLKKANEFFN SANKAFDVLG RVEAYLKLLK SEGLSLAVLA VRHEELHRKI 
       410        420        430        440        450
KDCTTDALQK GQTLISQVDS CSSQVSGIHE MMGCIKRRVD HLTEQCSAHK 
       460        470        480        490        500
EYALKKQQLT ASVEGYLRKV EMSIQKISPV LSNAMDVGST RSESEKILNK 
       510        520        530        540        550
YLELDIQAKE TSHELEAAAK TMMEKNEFVS DEMVSLSSKA RWLAEELNLF 
       560        570        580        590        600
GQSIDYRSQV LQTYVAFLKS SEEVEMQFQS LKEFYETEIP QKEQDDAKAK 
       610        620        630        640        650
HCSDSAEKQW QLFLKKSFIT QDLGLEFLNL INMAKENEIL DVKNEVYLMK 
       660        670        680        690        700
NTMENQKAER EELSLLRLAW QLKATESKPG KQQWAAFKEQ LKKTSHNLKL 
       710        720        730        740        750
LQEALMPVSA LDLGGSLQFI LDLRQKWNDM KPQFQQLNDE VQYIMKESEE 
       760        770        780        790        800
LTGRGAPVKE KSQQLKDLIH FHQKQKERIQ DYEDILYKVV QFHQVKEELG 
       810        820        830        840        850
RLIKSRELEF VEQPKELGDA HDVQIHLRCS QEKQARVDHL HRLALSLGVD 
       860        870        880        890        900
IISSVQRPHC SNVSAKNLQQ QLELLEEDSM KWRAKAEEYG RTLSRSVEYC 
       910        920        930        940        950
AMRDEINELK DSFKDIKKKF NNLKFNYTKK NEKSRNLKAL KYQIQQVDMY 
       960        970        980        990       1000
AEKMQALKRK MEKVSNKTSD SFLNYPSDKV NVLLEVMKDL QKHVDDFDKV 
      1010       1020       1030       1040       1050
VTDYKKNLDL TEHFQEVIEE CHFWYEDASA TVVRVGKYST ECKTKEAVKI 
      1060       1070       1080       1090       1100
LHQQFNKFIA PSVPQQEERI QEATDLAQHL YGLEEGQKYI EKIVTKHKEV 
      1110       1120       1130       1140       1150
LESVTELCES LTELEEKLKQ GDVLKMNPNL EDFHYDYIDL LKEPAKNKQT 
      1160       1170       1180       1190       1200
IFNEERNKGQ VQVADLLGIN GTGEERLPQD LKVSTDKEGG VQDLLLPEDM 
      1210       1220       1230       1240       1250
LSGEEYECVS PDDISLPPLP GSPESPLAPS DMEVEEPVSS SLSLHISSYG 
      1260       1270       1280       1290       1300
VQAGTSSPGD AQESVLPPPV AFADACNDKR ETFSSHFERP YLQFKAEPPL 
      1310       1320       1330       1340       1350
TSRGFVEKST ALHRISAEHP ESMMSEVHER ALQQHPQAQG GLLETREKMH 
      1360       1370       1380       1390       1400
ADNNFTKTQD RLHASSDAFS GLRFQSGTSR GYQRQMVPRE EIKSTSAKSS 
      1410       1420       1430       1440       1450
VVSLADQAPN FSRLLSNVTV MEGSPVTLEV EVTGFPEPTL TWWVAYNDKP
Length:1,450
Mass (Da):166,261
Last modified:November 26, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2C38E3A4B16FA86
GO
Isoform 2 (identifier: Q6ZP82-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1443-1450: WVAYNDKP → YKKGQKLSAD...VSLMYWLLTQ

Show »
Length:1,530
Mass (Da):175,067
Checksum:iF2F1CA3F2791A40B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZB3B8ZZB3_HUMAN
Coiled-coil domain-containing prote...
CCDC141 FLJ39502, hCG_22663
652Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JR62C9JR62_HUMAN
Coiled-coil domain-containing prote...
CCDC141
628Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYF7A0A0A6YYF7_HUMAN
Coiled-coil domain-containing prote...
CCDC141
894Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI15379 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAX88845 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC04869 differs from that shown. Contaminating sequence.Curated
The sequence BAC04869 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85242 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047904828R → W Reduced affinity for MRLC and impairs cortical migration. Corresponds to variant dbSNP:rs12988301Ensembl.1
Natural variantiVAR_047905935R → W. Corresponds to variant dbSNP:rs17362588Ensembl.1
Natural variantiVAR_0479061170N → S. Corresponds to variant dbSNP:rs13419085Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0359681443 – 1450WVAYNDKP → YKKGQKLSADGHLQVLHKET RHSVFIPKVCKADAGLYVAR AQNSSGALSSNVILHVTGNC RLPITRVNWITLCVVYVSVS LMYWLLTQ in isoform 2. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC023270 Genomic DNA Translation: AAX88845.1 Sequence problems.
AC093792 Genomic DNA No translation available.
AC092640 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11011.1
AK096821 mRNA Translation: BAC04869.1 Sequence problems.
AK129847 mRNA Translation: BAC85242.1 Different initiation.
BC115378 mRNA Translation: AAI15379.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_775919.3, NM_173648.3 [Q6ZP82-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000443758; ENSP00000390190; ENSG00000163492 [Q6ZP82-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		285025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:285025

UCSC genome browser

More...UCSCi		uc002une.2, human [Q6ZP82-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023270 Genomic DNA Translation: AAX88845.1 Sequence problems.
AC093792 Genomic DNA No translation available.
AC092640 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11011.1
AK096821 mRNA Translation: BAC04869.1 Sequence problems.
AK129847 mRNA Translation: BAC85242.1 Different initiation.
BC115378 mRNA Translation: AAI15379.1 Different initiation.
RefSeqiNP_775919.3, NM_173648.3 [Q6ZP82-2]

3D structure databases

SMRiQ6ZP82
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130000, 7 interactors
IntActiQ6ZP82, 14 interactors
STRINGi9606.ENSP00000395995

PTM databases

iPTMnetiQ6ZP82
PhosphoSitePlusiQ6ZP82

Genetic variation databases

BioMutaiCCDC141
DMDMi74758754

Proteomic databases

EPDiQ6ZP82
MassIVEiQ6ZP82
PaxDbiQ6ZP82
PeptideAtlasiQ6ZP82
PRIDEiQ6ZP82
ProteomicsDBi44366
68066 [Q6ZP82-1]
68067 [Q6ZP82-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2560, 98 antibodies

The DNASU plasmid repository

More...DNASUi		285025

Genome annotation databases

EnsembliENST00000443758; ENSP00000390190; ENSG00000163492 [Q6ZP82-2]
GeneIDi285025
KEGGihsa:285025
UCSCiuc002une.2, human [Q6ZP82-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		285025
DisGeNETi285025

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC141
GeneReviewsiCCDC141
HGNCiHGNC:26821, CCDC141
MalaCardsiCCDC141
MIMi616031, gene
neXtProtiNX_Q6ZP82
OpenTargetsiENSG00000163492
Orphaneti478, Kallmann syndrome
PharmGKBiPA162381449
VEuPathDBiHostDB:ENSG00000163492.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4240, Eukaryota
GeneTreeiENSGT00440000038972
HOGENOMiCLU_251402_0_0_1
InParanoidiQ6ZP82
OMAiLSSKAKW
OrthoDBi54602at2759
TreeFamiTF331580

Enzyme and pathway databases

PathwayCommonsiQ6ZP82

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		285025, 4 hits in 164 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCDC141, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		285025
PharosiQ6ZP82, Tbio

Protein Ontology

More...PROi		PR:Q6ZP82
RNActiQ6ZP82, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163492, Expressed in heart and 123 other tissues
ExpressionAtlasiQ6ZP82, baseline and differential
GenevisibleiQ6ZP82, HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC141_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZP82
Secondary accession number(s): H7C0P1, J3KNW6, Q8N8H3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 26, 2014
Last modified: June 2, 2021
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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