UniProtKB - Q6ZP82 (CC141_HUMAN)
Protein
Coiled-coil domain-containing protein 141
Gene
CCDC141
Organism
Homo sapiens (Human)
Status
Functioni
Plays a critical role in radial migration and centrosomal function.By similarity
GO - Biological processi
- centrosome localization Source: Ensembl
- cerebral cortex radially oriented cell migration Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q6ZP82 |
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 141Alternative name(s): Coiled-coil protein associated with myosin II and DISC11 Publication |
Gene namesi | Name:CCDC141 Synonyms:CAMDI1 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26821, CCDC141 |
MIMi | 616031, gene |
neXtProti | NX_Q6ZP82 |
VEuPathDBi | HostDB:ENSG00000163492.13 |
Subcellular locationi
Cytoskeleton
- centrosome By similarity
Other locations
- Cytoplasm By similarity
Note: Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner.By similarity
Cytoskeleton
- centrosome Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-SubCell
- neuron projection Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 285025 |
GeneReviewsi | CCDC141 |
MalaCardsi | CCDC141 |
OpenTargetsi | ENSG00000163492 |
Orphaneti | 478, Kallmann syndrome |
PharmGKBi | PA162381449 |
Miscellaneous databases
Pharosi | Q6ZP82, Tbio |
Genetic variation databases
BioMutai | CCDC141 |
DMDMi | 74758754 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317296 | 1 – 1450 | Coiled-coil domain-containing protein 141Add BLAST | 1450 |
Proteomic databases
EPDi | Q6ZP82 |
MassIVEi | Q6ZP82 |
PaxDbi | Q6ZP82 |
PeptideAtlasi | Q6ZP82 |
PRIDEi | Q6ZP82 |
ProteomicsDBi | 44366 68066 [Q6ZP82-1] 68067 [Q6ZP82-2] |
PTM databases
iPTMneti | Q6ZP82 |
PhosphoSitePlusi | Q6ZP82 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163492, Expressed in heart and 121 other tissues |
ExpressionAtlasi | Q6ZP82, baseline and differential |
Genevisiblei | Q6ZP82, HS |
Interactioni
Subunit structurei
Interacts with DISC1.
Interacts preferentially with phosphorylated forms of myosin regulatory light chain (MRLC).
By similarityBinary interactionsi
Hide detailsQ6ZP82
Protein-protein interaction databases
BioGRIDi | 130000, 6 interactors |
IntActi | Q6ZP82, 14 interactors |
STRINGi | 9606.ENSP00000395995 |
Miscellaneous databases
RNActi | Q6ZP82, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1409 – 1450 | Ig-likeAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 642 – 706 | Sequence analysisAdd BLAST | 65 | |
Coiled coili | 758 – 783 | Sequence analysisAdd BLAST | 26 | |
Coiled coili | 861 – 970 | Sequence analysisAdd BLAST | 110 |
Keywords - Domaini
Coiled coil, Immunoglobulin domainPhylogenomic databases
eggNOGi | KOG4240, Eukaryota |
GeneTreei | ENSGT00440000038972 |
HOGENOMi | CLU_251402_0_0_1 |
InParanoidi | Q6ZP82 |
OrthoDBi | 54602at2759 |
TreeFami | TF331580 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZP82-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSQGSPSVA LSTTTVSSVA VQAGDSKIVI AVIKCGKWVQ LQLAESQPNL
60 70 80 90 100
LEIGSSQDET KKLLHDHELL LAKLKALEDR VWELLQEADK TAEENKDQSQ
110 120 130 140 150
VYDAMAETLG EAWAALVSML ERRTELLRLT SEFFENALEF AIKIDQAEDF
160 170 180 190 200
LQNTHEFESA ESLKSLLQLH EHHTKELLER SLALLNKSQQ LTDFIEKFKC
210 220 230 240 250
EGPNVNPELT QGAHSSCLKV DRLLELLQDR RRQLDKYLKQ QWQELSQVLQ
260 270 280 290 300
ICQWDQQENQ VTCWFQKTIR NLQEQSLGSS LSDNEDRIHK QEELIIKAKE
310 320 330 340 350
WNSAVEKLKS EALRILLSKD YVEKEHLQLS HQKLSQLQEE FGQLMVERNT
360 370 380 390 400
WLKKANEFFN SANKAFDVLG RVEAYLKLLK SEGLSLAVLA VRHEELHRKI
410 420 430 440 450
KDCTTDALQK GQTLISQVDS CSSQVSGIHE MMGCIKRRVD HLTEQCSAHK
460 470 480 490 500
EYALKKQQLT ASVEGYLRKV EMSIQKISPV LSNAMDVGST RSESEKILNK
510 520 530 540 550
YLELDIQAKE TSHELEAAAK TMMEKNEFVS DEMVSLSSKA RWLAEELNLF
560 570 580 590 600
GQSIDYRSQV LQTYVAFLKS SEEVEMQFQS LKEFYETEIP QKEQDDAKAK
610 620 630 640 650
HCSDSAEKQW QLFLKKSFIT QDLGLEFLNL INMAKENEIL DVKNEVYLMK
660 670 680 690 700
NTMENQKAER EELSLLRLAW QLKATESKPG KQQWAAFKEQ LKKTSHNLKL
710 720 730 740 750
LQEALMPVSA LDLGGSLQFI LDLRQKWNDM KPQFQQLNDE VQYIMKESEE
760 770 780 790 800
LTGRGAPVKE KSQQLKDLIH FHQKQKERIQ DYEDILYKVV QFHQVKEELG
810 820 830 840 850
RLIKSRELEF VEQPKELGDA HDVQIHLRCS QEKQARVDHL HRLALSLGVD
860 870 880 890 900
IISSVQRPHC SNVSAKNLQQ QLELLEEDSM KWRAKAEEYG RTLSRSVEYC
910 920 930 940 950
AMRDEINELK DSFKDIKKKF NNLKFNYTKK NEKSRNLKAL KYQIQQVDMY
960 970 980 990 1000
AEKMQALKRK MEKVSNKTSD SFLNYPSDKV NVLLEVMKDL QKHVDDFDKV
1010 1020 1030 1040 1050
VTDYKKNLDL TEHFQEVIEE CHFWYEDASA TVVRVGKYST ECKTKEAVKI
1060 1070 1080 1090 1100
LHQQFNKFIA PSVPQQEERI QEATDLAQHL YGLEEGQKYI EKIVTKHKEV
1110 1120 1130 1140 1150
LESVTELCES LTELEEKLKQ GDVLKMNPNL EDFHYDYIDL LKEPAKNKQT
1160 1170 1180 1190 1200
IFNEERNKGQ VQVADLLGIN GTGEERLPQD LKVSTDKEGG VQDLLLPEDM
1210 1220 1230 1240 1250
LSGEEYECVS PDDISLPPLP GSPESPLAPS DMEVEEPVSS SLSLHISSYG
1260 1270 1280 1290 1300
VQAGTSSPGD AQESVLPPPV AFADACNDKR ETFSSHFERP YLQFKAEPPL
1310 1320 1330 1340 1350
TSRGFVEKST ALHRISAEHP ESMMSEVHER ALQQHPQAQG GLLETREKMH
1360 1370 1380 1390 1400
ADNNFTKTQD RLHASSDAFS GLRFQSGTSR GYQRQMVPRE EIKSTSAKSS
1410 1420 1430 1440 1450
VVSLADQAPN FSRLLSNVTV MEGSPVTLEV EVTGFPEPTL TWWVAYNDKP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB8ZZB3 | B8ZZB3_HUMAN | Coiled-coil domain-containing prote... | CCDC141 FLJ39502, hCG_22663 | 652 | Annotation score: | ||
C9JR62 | C9JR62_HUMAN | Coiled-coil domain-containing prote... | CCDC141 | 628 | Annotation score: | ||
A0A0A6YYF7 | A0A0A6YYF7_HUMAN | Coiled-coil domain-containing prote... | CCDC141 | 894 | Annotation score: |
Sequence cautioni
The sequence AAI15379 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAX88845 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC04869 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85242 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047904 | 828 | R → W Reduced affinity for MRLC and impairs cortical migration. Corresponds to variant dbSNP:rs12988301Ensembl. | 1 | |
Natural variantiVAR_047905 | 935 | R → W. Corresponds to variant dbSNP:rs17362588Ensembl. | 1 | |
Natural variantiVAR_047906 | 1170 | N → S. Corresponds to variant dbSNP:rs13419085Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035968 | 1443 – 1450 | WVAYNDKP → YKKGQKLSADGHLQVLHKET RHSVFIPKVCKADAGLYVAR AQNSSGALSSNVILHVTGNC RLPITRVNWITLCVVYVSVS LMYWLLTQ in isoform 2. 2 Publications | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC023270 Genomic DNA Translation: AAX88845.1 Sequence problems. AC093792 Genomic DNA No translation available. AC092640 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX11011.1 AK096821 mRNA Translation: BAC04869.1 Sequence problems. AK129847 mRNA Translation: BAC85242.1 Different initiation. BC115378 mRNA Translation: AAI15379.1 Different initiation. |
RefSeqi | NP_775919.3, NM_173648.3 [Q6ZP82-2] |
Genome annotation databases
Ensembli | ENST00000443758; ENSP00000390190; ENSG00000163492 [Q6ZP82-2] |
GeneIDi | 285025 |
KEGGi | hsa:285025 |
UCSCi | uc002une.2, human [Q6ZP82-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC023270 Genomic DNA Translation: AAX88845.1 Sequence problems. AC093792 Genomic DNA No translation available. AC092640 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX11011.1 AK096821 mRNA Translation: BAC04869.1 Sequence problems. AK129847 mRNA Translation: BAC85242.1 Different initiation. BC115378 mRNA Translation: AAI15379.1 Different initiation. |
RefSeqi | NP_775919.3, NM_173648.3 [Q6ZP82-2] |
3D structure databases
SMRi | Q6ZP82 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130000, 6 interactors |
IntActi | Q6ZP82, 14 interactors |
STRINGi | 9606.ENSP00000395995 |
PTM databases
iPTMneti | Q6ZP82 |
PhosphoSitePlusi | Q6ZP82 |
Genetic variation databases
BioMutai | CCDC141 |
DMDMi | 74758754 |
Proteomic databases
EPDi | Q6ZP82 |
MassIVEi | Q6ZP82 |
PaxDbi | Q6ZP82 |
PeptideAtlasi | Q6ZP82 |
PRIDEi | Q6ZP82 |
ProteomicsDBi | 44366 68066 [Q6ZP82-1] 68067 [Q6ZP82-2] |
Protocols and materials databases
Antibodypediai | 2560, 96 antibodies |
Genome annotation databases
Ensembli | ENST00000443758; ENSP00000390190; ENSG00000163492 [Q6ZP82-2] |
GeneIDi | 285025 |
KEGGi | hsa:285025 |
UCSCi | uc002une.2, human [Q6ZP82-1] |
Organism-specific databases
CTDi | 285025 |
DisGeNETi | 285025 |
GeneCardsi | CCDC141 |
GeneReviewsi | CCDC141 |
HGNCi | HGNC:26821, CCDC141 |
MalaCardsi | CCDC141 |
MIMi | 616031, gene |
neXtProti | NX_Q6ZP82 |
OpenTargetsi | ENSG00000163492 |
Orphaneti | 478, Kallmann syndrome |
PharmGKBi | PA162381449 |
VEuPathDBi | HostDB:ENSG00000163492.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4240, Eukaryota |
GeneTreei | ENSGT00440000038972 |
HOGENOMi | CLU_251402_0_0_1 |
InParanoidi | Q6ZP82 |
OrthoDBi | 54602at2759 |
TreeFami | TF331580 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZP82 |
Miscellaneous databases
BioGRID-ORCSi | 285025, 3 hits in 112 CRISPR screens |
ChiTaRSi | CCDC141, human |
GenomeRNAii | 285025 |
Pharosi | Q6ZP82, Tbio |
PROi | PR:Q6ZP82 |
RNActi | Q6ZP82, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163492, Expressed in heart and 121 other tissues |
ExpressionAtlasi | Q6ZP82, baseline and differential |
Genevisiblei | Q6ZP82, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CC141_HUMAN | |
Accessioni | Q6ZP82Primary (citable) accession number: Q6ZP82 Secondary accession number(s): H7C0P1, J3KNW6, Q8N8H3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | November 26, 2014 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot