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Protein

Transmembrane protein 182

Gene

TMEM182

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 182
Gene namesi
Name:TMEM182
ORF Names:UNQ6974/PRO21957
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170417.14
HGNCiHGNC:26391 TMEM182
neXtProtiNX_Q6ZP80

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 114ExtracellularSequence analysisAdd BLAST88
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 153CytoplasmicSequence analysisAdd BLAST18
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 200ExtracellularSequence analysisAdd BLAST26
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 229CytoplasmicSequence analysis8

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi130827
OpenTargetsiENSG00000170417
PharmGKBiPA162406075

Polymorphism and mutation databases

BioMutaiTMEM182
DMDMi313104025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000029022627 – 229Transmembrane protein 182Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZP80
PeptideAtlasiQ6ZP80
PRIDEiQ6ZP80
ProteomicsDBi68063
68064 [Q6ZP80-2]
68065 [Q6ZP80-3]

Expressioni

Gene expression databases

BgeeiENSG00000170417 Expressed in 156 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_TMEM182
ExpressionAtlasiQ6ZP80 baseline and differential
GenevisibleiQ6ZP80 HS

Organism-specific databases

HPAiHPA045861

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-10255122,EBI-7131783

Protein-protein interaction databases

BioGridi126258, 3 interactors
IntActiQ6ZP80, 14 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6ZP80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM182 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQ09 Eukaryota
ENOG4111FRX LUCA
GeneTreeiENSGT00390000017581
HOVERGENiHBG055162
InParanoidiQ6ZP80
OMAiTEVGKCS
OrthoDBiEOG091G0OD5
PhylomeDBiQ6ZP80
TreeFamiTF331344

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR026763 TMEM182
PANTHERiPTHR32012 PTHR32012, 1 hit
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q6ZP80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLNIAIFFG ALFGALGVLL FLVAFGSDYW LLATEVGRCS GEKNIENVTF
60 70 80 90 100
HHEGFFWRCW FNGIVEENDS NIWKFWYTNQ PPSKNCTHAY LSPYPFMRGE
110 120 130 140 150
HNSTSYDSAV IYRGFWAVLM LLGVVAVVIA SFLIICAAPF ASHFLYKAGG
160 170 180 190 200
GSYIAAGILF SLVVMLYVIW VQAVADMESY RNMKMKDCLD FTPSVLYGWS
210 220
FFLAPAGIFF SLLAGLLFLV VGWHIQIHH
Length:229
Mass (Da):25,879
Last modified:November 30, 2010 - v2
Checksum:iB96E01B4B28614F1
GO
Isoform 2 (identifier: Q6ZP80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:133
Mass (Da):14,734
Checksum:i4A3FCA6C31E9C261
GO
Isoform 3 (identifier: Q6ZP80-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):12,093
Checksum:i6FA218CF69D37BBB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZ71B8ZZ71_HUMAN
Transmembrane protein 182
TMEM182
186Annotation score:
A0A1W2PS41A0A1W2PS41_HUMAN
Transmembrane protein 182
TMEM182
72Annotation score:
A0A1W2PQA2A0A1W2PQA2_HUMAN
Transmembrane protein 182
TMEM182
100Annotation score:
C9IYX5C9IYX5_HUMAN
Transmembrane protein 182
TMEM182
80Annotation score:

Sequence cautioni

The sequence AAH73844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI07695 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032773223W → R3 PublicationsCorresponds to variant dbSNP:rs887987Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0261341 – 119Missing in isoform 3. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_0261351 – 96Missing in isoform 2. 2 PublicationsAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358262 mRNA Translation: AAQ88629.1
AK054856 mRNA Translation: BAB70815.1
AK129862 mRNA Translation: BAC85244.1
AC007251 Genomic DNA Translation: AAY14911.1
BC020898 mRNA Translation: AAH20898.1
BC073844 mRNA Translation: AAH73844.1 Different initiation.
BC107694 mRNA Translation: AAI07695.1 Different initiation.
BC130306 mRNA Translation: AAI30307.1
BC130308 mRNA Translation: AAI30309.1
CCDSiCCDS2064.1 [Q6ZP80-1]
CCDS82490.1 [Q6ZP80-2]
RefSeqiNP_001308274.1, NM_001321345.1
NP_653233.4, NM_144632.4
UniGeneiHs.436203

Genome annotation databases

EnsembliENST00000409528; ENSP00000387258; ENSG00000170417 [Q6ZP80-2]
ENST00000412401; ENSP00000394178; ENSG00000170417 [Q6ZP80-1]
GeneIDi130827
KEGGihsa:130827
UCSCiuc002tcd.5 human [Q6ZP80-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM182_HUMAN
AccessioniPrimary (citable) accession number: Q6ZP80
Secondary accession number(s): C9JML7
, Q3B7B8, Q53TT9, Q6GMU0, Q8WW45, Q96NR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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