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Protein

RNA-binding protein 44

Gene

RBM44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 44
Alternative name(s):
RNA-binding motif protein 44
Gene namesi
Name:RBM44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000177483.11
HGNCiHGNC:24756 RBM44
neXtProtiNX_Q6ZP01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400774

Polymorphism and mutation databases

BioMutaiRBM44
DMDMi152060496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002941741 – 1051RNA-binding protein 44Add BLAST1051

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei388PhosphoserineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei546PhosphoserineBy similarity1
Modified residuei726PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZP01
PaxDbiQ6ZP01
PeptideAtlasiQ6ZP01
PRIDEiQ6ZP01
ProteomicsDBi68051

PTM databases

iPTMnetiQ6ZP01
PhosphoSitePlusiQ6ZP01

Expressioni

Gene expression databases

BgeeiENSG00000177483
ExpressionAtlasiQ6ZP01 baseline and differential

Organism-specific databases

HPAiHPA003298

Interactioni

Subunit structurei

Homodimer. Interacts with TEX14 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321179

Structurei

3D structure databases

ProteinModelPortaliQ6ZP01
SMRiQ6ZP01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini830 – 903RRMPROSITE-ProRule annotationAdd BLAST74

Phylogenomic databases

eggNOGiENOG410IG20 Eukaryota
ENOG410YPIM LUCA
HOGENOMiHOG000154081
HOVERGENiHBG108400
InParanoidiQ6ZP01
OMAiKYQVSEI
PhylomeDBiQ6ZP01
TreeFamiTF337508

Family and domain databases

CDDicd12248 RRM_RBM44, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034153 RBM44_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZP01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQATAVVETA SGKGYHSNGG NLQKDKPSNP KKENLLLSSN GCDEVKLTFP
60 70 80 90 100
DDDWNSSTLE QRANNKEISN IDKMDLLEPF FSVSQDTNTE STQFQSSELE
110 120 130 140 150
DSTDYAFLNK TYSIPYSESK LKKESLTPLS SELDPEVQKK EEVFFNILEH
160 170 180 190 200
QDKTVGLERI YNISDANYRE SAEDTQKHDT DEDSQQEYHS AEEQEYISNH
210 220 230 240 250
LSFDQTKALD ISNPEVVELG NSGYEVKCAS NVEDNRVNSG SGSIISFDSL
260 270 280 290 300
DVYGQEESLH VSKFQNSVML REYHDLKHEK YKEQETNSMY HTVFDGSVLR
310 320 330 340 350
SNSPGNQESQ SKSGSLSPQK VLKMKIYTEN MKSQINEGKD FCGNKIVENK
360 370 380 390 400
ILLHLENPST LPQDKALETL LQPCKDCQTS WTSVFDDSII SACGYYESLQ
410 420 430 440 450
NTADSALDFS AMLPKIAVRD NQAIEDNTSL KVAHSSTTKK TCFHNIGEMC
460 470 480 490 500
TKSLTDAASC TVTINQTVDV STDFRACFTT SRATSARPSV VSTSSNTEIT
510 520 530 540 550
MMNKKRPDEW QNEKQKSVAC STDWSYSEDC IDTQMAITKG SGKSLSVDSL
560 570 580 590 600
KPNGNFLNKD FLELRKACGI TDLKKHPERE FQLFKDTEKD LPSMCCQKIM
610 620 630 640 650
QRAIKAELHL LNVHYQMCRR HCCDIYKLVM ENREGLNMNL SSNSAKKELG
660 670 680 690 700
SALLSLLGDL KVRYVTLKEK IHKGIPLEEL PPLSLESKLL STFSTFASRL
710 720 730 740 750
MKKETHVFSE ADAEQDNQRA HDVDVSSNLK KTLSQMSLSS DNSHATQNIS
760 770 780 790 800
PKKDDFKNGD INADFSQLKL GDKDCRHYQE TSEDWSDAKE SLTGVDVSGT
810 820 830 840 850
QGNQVEQDTW NLDLTGEMKN VEPSQRDKGY LIHVGGLCPS VSEADLRSHF
860 870 880 890 900
QKYQVSEISI YDSTNYRYAS LAFTKNSDAK IAVKEMNGIE INGKSVNVWP
910 920 930 940 950
VKILGEYTSP LSSKNGNRIS SNNLEKSTNK QIHSEFSISR LPRTRPRQLG
960 970 980 990 1000
SEQDSEVFPS DQGVKKNCKQ IESAKLLPDT PVQFIPPNTL NLRSFTKIIK
1010 1020 1030 1040 1050
RLAELHPEVS RDHIINALQE VRIRHKGFLN GLSITTIVEM TSSLLKNSAS

S
Length:1,051
Mass (Da):117,985
Last modified:July 10, 2007 - v2
Checksum:i45400796EEAF1415
GO

Sequence cautioni

The sequence AAI26112 differs from that shown. Unlikely splicing event.Curated
The sequence BAC85324 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05724751D → H. Corresponds to variant dbSNP:rs13393001Ensembl.1
Natural variantiVAR_03314752D → H. Corresponds to variant dbSNP:rs13393001Ensembl.1
Natural variantiVAR_033148892N → H. Corresponds to variant dbSNP:rs10186505Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012076 Genomic DNA No translation available.
BC126111 mRNA Translation: AAI26112.1 Sequence problems.
AK130316 mRNA Translation: BAC85324.1 Different initiation.
RefSeqiNP_001073973.2, NM_001080504.2
XP_011509457.1, XM_011511155.1
UniGeneiHs.607265
Hs.720233

Genome annotation databases

EnsembliENST00000611254; ENSP00000483448; ENSG00000177483
GeneIDi375316
KEGGihsa:375316
UCSCiuc061ubp.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBM44_HUMAN
AccessioniPrimary (citable) accession number: Q6ZP01
Secondary accession number(s): A0AUW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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