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Protein

GDP-D-glucose phosphorylase 1

Gene

GDPGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.1 Publication

Miscellaneous

The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

Catalytic activityi

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.1 Publication

Kineticsi

kcat is 26 s(-1) at 31 degrees Celsius. The catalytic efficiency for GDP-D-glucose is 35-fold higher than for GDP-L-galactose.
  1. KM=2 µM for GDP-D-glucose (at 31 degrees Celsius)1 Publication
  2. KM=12 µM for GDP-L-galactose (at 31 degrees Celsius)1 Publication
  3. KM=42 µM for GDP-D-mannose (at 31 degrees Celsius)1 Publication
  4. KM=2.9 mM for inorganic phosphate (at 31 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei218Tele-GMP-histidine intermediateBy similarity1

    GO - Molecular functioni

    GO - Biological processi

    • glucose metabolic process Source: UniProtKB

    Keywordsi

    Molecular functionGuanine-nucleotide releasing factor, Hydrolase, Nucleotidyltransferase, Transferase
    LigandNucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:G66-31756-MONOMER
    BRENDAi2.7.7.78 2681

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-D-glucose phosphorylase 1 (EC:2.7.7.78)
    Gene namesi
    Name:GDPGP1
    Synonyms:C15orf58
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 15

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000183208.12
    HGNCiHGNC:34360 GDPGP1
    neXtProtiNX_Q6ZNW5

    Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    OpenTargetsiENSG00000183208
    PharmGKBiPA162378247

    Polymorphism and mutation databases

    BioMutaiGDPGP1
    DMDMi296434456

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003367501 – 385GDP-D-glucose phosphorylase 1Add BLAST385

    Proteomic databases

    EPDiQ6ZNW5
    MaxQBiQ6ZNW5
    PaxDbiQ6ZNW5
    PeptideAtlasiQ6ZNW5
    PRIDEiQ6ZNW5
    ProteomicsDBi68049

    PTM databases

    iPTMnetiQ6ZNW5
    PhosphoSitePlusiQ6ZNW5

    Expressioni

    Gene expression databases

    BgeeiENSG00000183208 Expressed in 114 organ(s), highest expression level in heart left ventricle
    CleanExiHS_C15orf58
    ExpressionAtlasiQ6ZNW5 baseline and differential
    GenevisibleiQ6ZNW5 HS

    Organism-specific databases

    HPAiHPA048189
    HPA059841

    Interactioni

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi133642, 11 interactors
    STRINGi9606.ENSP00000368405

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZNW5
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GDPGP1 family.Curated

    Phylogenomic databases

    eggNOGiKOG2720 Eukaryota
    ENOG4111FR6 LUCA
    GeneTreeiENSGT00390000016718
    HOVERGENiHBG106673
    InParanoidiQ6ZNW5
    KOiK15630
    OMAiLCELAGH
    OrthoDBiEOG091G0ARJ
    PhylomeDBiQ6ZNW5
    TreeFamiTF313615

    Family and domain databases

    InterProiView protein in InterPro
    IPR026506 GDPGP
    PANTHERiPTHR20884 PTHR20884, 1 hit

    Sequence (1+)i

    Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

    Q6ZNW5-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MALPHDSNET SYLLPPNNED WGRQTIPDFV YGQKDLMAEG IQWPRNAPGI
    60 70 80 90 100
    PDALPQSPFD AALCSAWKQR VELGLFRYRL RELQTQILPG AVGFVAQLNV
    110 120 130 140 150
    ERGVQRRPPQ TIKSVRQAFD PVQFNFNKIR PGEVLFRLHR EPDLPGTLLQ
    160 170 180 190 200
    EDILVVINVS PLEWGHVLLV PEPARQLPQR LLPGALRAGI EAVLLSLHPG
    210 220 230 240 250
    FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EQAPSEPLDP GGHLHLLQDL
    260 270 280 290 300
    PAPGFLFYTR GPGPDLESLI SRVCRATDYL TDHEIAHNLF VTRGAPPGKT
    310 320 330 340 350
    SPSSALTGVR VILWARKSSF GIKDGEAFNV ALCELAGHLP VKTSQDFSSL
    360 370 380
    TEAAAVALIQ DCRLPPSQAE DVQAALVALM SQEEQ
    Length:385
    Mass (Da):42,362
    Last modified:May 18, 2010 - v2
    Checksum:i921A656C721876EC
    GO

    Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0YN11H0YN11_HUMAN
    GDP-D-glucose phosphorylase 1
    GDPGP1
    214Annotation score:
    H0YL31H0YL31_HUMAN
    GDP-D-glucose phosphorylase 1
    GDPGP1
    49Annotation score:
    A0A0G2JL98A0A0G2JL98_HUMAN
    GDP-D-glucose phosphorylase 1
    GDPGP1
    10Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti23R → G in BAC85370 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_04355537M → T1 PublicationCorresponds to variant dbSNP:rs7171194Ensembl.1
    Natural variantiVAR_043556264P → T1 PublicationCorresponds to variant dbSNP:rs10152994Ensembl.1
    Natural variantiVAR_043557307T → I1 PublicationCorresponds to variant dbSNP:rs10153004Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK130527 mRNA Translation: BAC85370.1
    AC091167 Genomic DNA No translation available.
    CCDSiCCDS32327.1
    RefSeqiNP_001013679.2, NM_001013657.2
    NP_001309740.1, NM_001322811.1
    UniGeneiHs.304673

    Genome annotation databases

    EnsembliENST00000329600; ENSP00000368405; ENSG00000183208
    ENST00000558017; ENSP00000452793; ENSG00000183208
    GeneIDi390637
    KEGGihsa:390637
    UCSCiuc059ned.1 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiGDPP1_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZNW5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 18, 2010
    Last modified: September 12, 2018
    This is version 91 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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